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Papers by Mathilde Champeau

Frontiers in Chemistry

Poly (vinyl chloride) (PVC) is commonly used to manufacture biomedical devices and hospital compo... more Poly (vinyl chloride) (PVC) is commonly used to manufacture biomedical devices and hospital components, but it does not present antimicrobial activity enough to prevent biofouling. With the emergence of new microorganisms and viruses, such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that was responsible for the global pandemic caused by Coronavirus Disease 2019 (COVID-19), it is evident the importance of the development of self-disinfectant PVC for hospital environments and medical clinics where infected people remain for a long time. In this contribution, PVC nanocomposites with silver nanoparticles (AgNPs) were prepared in the molten state. AgNPs are well-known as antimicrobial agents suitable for designing antimicrobial polymer nanocomposites. Adding 0.1 to 0.5 wt% AgNPs significantly reduced Young’s modulus and ultimate tensile strength of PVC due to the emergence of microstructural defects in the PVC/AgNP nanocomposites, but the impact strength did not chang...

Processes

The development of active packaging for food storage containers is possible through impregnation ... more The development of active packaging for food storage containers is possible through impregnation of natural extracts by supercritical CO2-assisted impregnation processes. The challenge of scCO2-impregnation of natural extracts is to control the total loading and to ensure that the composition of the loaded extract may preserve the properties of the crude extract. This study aimed at investigating the scCO2-impregnation of clove extract (CE) in polycarbonate (PC) to develop antibacterial packaging. A design of experiments was applied to evaluate the influences of temperature (35–60 °C) and pressure (10–30 MPa) on the clove loading (CL%) and on the composition of the loaded extract. The CL% ranged from 6.8 to 18.5%, and the highest CL% was reached at 60 °C and 10 MPa. The composition of the impregnated extract was dependent on the impregnation conditions, and it differed from the crude extract, being richer in eugenol (81.31–86.28% compared to 70.06 in the crude extract). Differential...

The Journal of Supercritical Fluids

Journal of Raman Spectroscopy

The scCO2 impregnation process is a promising alternative to other manufacturing process to prepa... more The scCO2 impregnation process is a promising alternative to other manufacturing process to prepare drug-eluting polymer implants.This work enabled to rationalize the influence of the key parameters governing this process and to determine in which extent this process can be used to prepare drug-eluting implants. We have combined the information obtained with traditional polymer characterization techniques and a newly characterization set-up we have developed that is based on in situ FTIR micro-spectroscopy. We have worked on the impregnation of sutures made of PLLA, PP and PET with two anti-inflammatory drugs namely ketoprofen and aspirin.Firstly, the thermodynamic behaviors of the systems drug/CO2 (solubility and speciation of the drug) and polymer/CO2 (CO2 sorption, polymer swelling, evolution of the polymer microstructure and of the tensile properties) were studied as a function of pressure and temperature. Then, the scCO2 impregnation process was investigated. The impact of the ...

Soft Matter, 2021

Overview of BN-based nanocomposite hydrogel properties resulting from BN and hydrogels’ respectiv... more Overview of BN-based nanocomposite hydrogel properties resulting from BN and hydrogels’ respective characteristics and interactions, and their applications.

Le procede d’impregnation par voie CO2 supercritique est une solution prometteuse pour preparer d... more Le procede d’impregnation par voie CO2 supercritique est une solution prometteuse pour preparer des implants polymere a liberation controlee de medicaments.Ce travail a permis de comprendre l’influence des parametres gouvernant ce procede et de preciser dans quelle mesure ce procede peut etre utilise pour preparer des implants polymeres charges en medicament. Pour ce faire, nous avons combine les informations obtenues grâce aux techniques classiques de caracterisation de polymeres et a un dispositif que nous avons developpe base sur la micro-spectroscopie FTIR haute pression in situ.Dans cette etude, des fils de suture de PLLA, PP and PET ont ete impregne avec deux anti-inflammatoires (aspirine et ketoprofene).Tout d’abord, l’evolution du comportement des systemes binaires medicament/CO2 (solubilite et speciation) et polymere/CO2 (quantite de CO2 adsorbe, gonflement de la matrice, evolution de la microstructure et des proprietes de tension du polymere) a ete determine en fonction de...

Pharmaceutics

Polymeric implants loaded with drugs can overcome the disadvantages of oral or injection drug adm... more Polymeric implants loaded with drugs can overcome the disadvantages of oral or injection drug administration and deliver the drug locally. Several methods can load drugs into polymers. Herein, soaking and supercritical CO2 (scCO2) impregnation methods were employed to load aspirin into poly(l-lactic acid) (PLLA) and linear low-density polyethylene (LLDPE). Higher drug loadings (DL) were achieved with scCO2 impregnation compared to soaking and in a shorter time (3.4 ± 0.8 vs. 1.3 ± 0.4% for PLLA; and 0.4 ± 0.5 vs. 0.6 ± 0.5% for LLDPE), due to the higher swelling capacity of CO2. The higher affinity of aspirin explained the higher DL in PLLA than in LLDPE. Residual solvent was detected in LLDPE prepared by soaking, but within the FDA concentration limits. The solvents used in both methods acted as plasticizers and increased PLLA crystallinity. PLLA impregnated with aspirin exhibited faster hydrolysis in vitro due to the catalytic effect of aspirin. Finally, PLLA impregnated by soakin...

Journal of Applied Polymer Science, 2022

The Journal of Supercritical Fluids, 2020

Abstract The present work investigated the specific phenomena involved in the simultaneous scCO2 ... more Abstract The present work investigated the specific phenomena involved in the simultaneous scCO2 impregnation of two compounds in polymers. For this purpose, poly(L- lactic acid) and linear low density polyethylene were impregnated with three different combinations of two compounds among aspirin, ketoprofen and carvone. The loadings were studied regarding the effect of the impregnation conditions ({60 °C; 9 MPa} and {80 °C; 30 MPa}), the polymer/compounds and the scCO2/compound interactions using DSC, SEM and FTIR and compared to the loadings obtained when a single compound was impregnated. Two synergistic effects were observed and accounted to the plasticizing and cryogenic effect of ketoprofen and carvone that facilitated the diffusion of aspirin and ketoprofen, respectively. Chain mobility and polymer/compound interaction are necessary to the synergy. The preliminary study of in vitro release showed faster ketoprofen and aspirin release from the PLLA double impregnation samples, as a result of their increased free volume.

Journal of Applied Polymer Science, 2020

Journal of Drug Delivery Science and Technology, 2019

Poly(L-lactic acid) (PLLA) fibers were impregnated with the anti-inflammatory drug ketoprofen by ... more Poly(L-lactic acid) (PLLA) fibers were impregnated with the anti-inflammatory drug ketoprofen by supercritical CO 2 (scCO 2) assisted impregnation process, to develop drug-eluting absorbable sutures. This work indicates the possibility to tune not only the drug loading but also the release profile of ketoprofen from PLLA by modifying the impregnation (temperature and pressure) and depressurization (temperature and rate) conditions. Different PLLA sutures that release ketoprofen during 3 days up to 3 months were obtained. The release was shown to be governed by two parameters: the degradation rate of PLLA, that increases with the drug impregnation, and the sutures free volume, that was created due to scCO 2 sorbed and was partially conserved during depressurization. The degradation rate and the tensile strength loss of the suture are accelerated by ketoprofen since it catalyzes PLLA acid hydrolysis.

Acta biomaterialia, Jan 17, 2018

Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, deliverin... more Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, delivering NO to wounds at appropriate rates and doses requires new biomaterial-based strategies. Here, we describe the development of supramolecular interpolymer complex hydrogels comprising PEO-PPO-PEO (F127) micelles embedded in a poly(acrylic acid) (PAA) matrix, with S-nitrosoglutathione (GSNO) molecules dissolved in the hydrophilic domain. We show that PAA:F127/GSNO hydrogels start releasing NO upon hydration at rates controlled by their rates of water absorption. SAXS measurements indicate that the supramolecular structure of the hydrogels retains long-range order domains of F127 micelles. The PAA/F1227 hydrogels displayed dense morphologies and reduced rates of hydration. The NO release rates remain constant over the first 200 min, are directly correlated with the hydration rates of the PAA:F127/GSNO hydrogels, and can be modulated in the range of 40 nmol/g h to 1.5 μmol/g h by changing th...

Nitric Oxide Donors, 2017

With a plethora of confirmed and potential therapeutic effects in several diseases, nitric oxide ... more With a plethora of confirmed and potential therapeutic effects in several diseases, nitric oxide (NO) has been the focus of huge medical and pharmaceutical interests. However, NO itself is a small amphiphilic and highly diffusible gaseous molecule. Therefore, its administration relies on precursor molecules, which have to be incorporated into vehicles for applications. Topical applications of NO have deserved a special attention since they can promote exclusively local actions, in contrast to the systemic NO donors already on the market. The challenge for effective NO delivery in topical applications, is finding appropriate vehicles for appropriate NO donors. Hydrogels have emerged in this field as attractive options for topical NO delivery, since they are easy to apply and to remove and allow the use of several FDA-approved nonexpensive polymers. This chapter presents the main categories of experimental hydrogels for topical NO delivery, on the basis of current representative results from the literature.