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Papers by Matteo Piciucchi

Research paper thumbnail of Proposal of coeliac disease management during Covid-19 pandemia

Clinical and Medical Investigations

Research paper thumbnail of Preliminary considerations regarding the risk of COVID-19 and disease severity in chronic gastrointestinal conditions

Annals of Gastroenterology

Research paper thumbnail of Recurrent biliary acute pancreatitis is frequent in a real-world setting

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2018

Data about recurrent acute pancreatitis (RAP) are limited. To evaluate the rate of RAP and associ... more Data about recurrent acute pancreatitis (RAP) are limited. To evaluate the rate of RAP and associated factors. Single-centre prospective study of consecutive patients at first episode of acute pancreatitis (AP) being followed-up. Of 266 consecutive AP patients, (47% biliary, 15.4% alcoholic, 14.3% idiopathic) 66 (24.8%) had RAP in a mean follow-up of 42 months; 17.9% of recurrences occurred within 30 days from discharge. Age, gender, smoking and severity of first AP were not associated with RAP risk. The rate of biliary RAP was 31.3% in patients who did not receive any treatment, 18% in those treated with ERCP only, 16% in those who received cholecystectomy only, and 0% in those treated both with surgery and ERCP. Patients with biliary AP who received cholecystectomy had a significantly longer time of recurrence-free survival and reduced recurrence risk (HR = 0.45). In patients with alcoholic AP, the rate of recurrence was lower in those who quit drinking (5.8% vs 33%; p = 0.05). Th...

Research paper thumbnail of The Neutrophil/Lymphocyte Ratio at Diagnosis Is Significantly Associated with Survival in Metastatic Pancreatic Cancer Patients

International Journal of Molecular Sciences

Different inflammation-based scores such as the neutrophil/lymphocyte ratio (NLR), the Odonera Pr... more Different inflammation-based scores such as the neutrophil/lymphocyte ratio (NLR), the Odonera Prognostic Nutritional Index (PNI), the Glasgow Prognostic Score, the platelet/lymphocyte ratio, and the C-reactive protein/albumin ratio have been found to be significantly associated with pancreatic cancer (PDAC) prognosis. However, most studies have investigated patients undergoing surgery, and few of them have compared these scores. We aimed at evaluating the association between inflammatory-based scores and PDAC prognosis. In a single center cohort study, inflammatory-based scores were assessed at diagnosis and their prognostic relevance as well as that of clinic-pathological variables were evaluated through multiple logistic regression and survival probability analysis. In 206 patients, age, male sex, tumor size, presence of distant metastasis, access to chemotherapy, and an NLR > 5 but not other scores were associated with overall survival (OS) at multivariate analysis. Patients with an NLR < 5 had a median survival of 12 months compared to 4 months in those with an NLR > 5. In the 81 patients with distant metastasis at diagnosis, an NLR > 5 resulted in the only variable significantly associated with survival. Among patients with metastatic disease who received chemotherapy, the median survival was 3 months in patients with an NLR > 5 and 7 months in those with an NLR < 5. The NLR might drive therapeutic options in PDAC patients, especially in the setting of metastatic disease.

Research paper thumbnail of Cachexia is an Insidious Symptom of Pancreatic Ductal Adenocarcinoma Associated with Delayed Diagnosis and Advanced Stage of Disease

Jop Journal of the Pancreas, Sep 15, 2013

Research paper thumbnail of OC.11.2: Risk Factors for Intraductal Papillary Mucinous Neoplasm (Ipmn) of the Pancreas: Preliminary Results of a Prospective Italian Multicentre Case-Control Study

Research paper thumbnail of 849 Statins but Not Aspirin, Neither Their Combination, Are Protective for the Onset of Pancreatic Cancer

Research paper thumbnail of Small Intestine Bacterial Overgrowth Is not Related with Disease Severity and Symptoms in Patients with Chronic Pancreatitis

Jop Journal of the Pancreas, Sep 20, 2012

Research paper thumbnail of Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study

Scientific reports, Jan 12, 2017

Data on the association between aspirin and statin use and Pancreatic Ductal AdenoCarcinoma (PDAC... more Data on the association between aspirin and statin use and Pancreatic Ductal AdenoCarcinoma (PDAC) risk are conflicting. These drugs are often co-prescribed, but no studies evaluated the potential combined or confounding effect of the two at the same time. We aimed to investigate the association between aspirin and statin exclusive and combined use and PDAC occurrence. Data on environmental factors, family and medical history were screened in a case-control study. PDAC cases were matched to controls for age and gender. Power calculation performed ahead. Odds ratios (OR) and 95% confidence intervals(CI) were obtained from multivariable logistic regression analysis. In 408 PDAC patients and 816 matched controls, overall statin (OR 0.61; 95%CI,0.43-0.88), but not aspirin use was associated to reduced PDAC risk. Compared to non-users, exclusive statin (OR 0.51; 95%CI,0.32-0.80) and exclusive aspirin users (OR 0.64; 95%CI,0.40-1.01) had reduced PDAC risk. Concomitant statin and aspirin u...

Research paper thumbnail of New PRSS1 and common CFTR mutations in a child with acute recurrent pancreatitis, could be considered an

Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even m... more Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even more difficult when this disease develops in a child.

Research paper thumbnail of Secretin-enhanced MRCP in the evaluation of IPMN

Any information contained in this pdf file is automatically generated from digital material submi... more Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to third-party sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expe...

Research paper thumbnail of The risk of recurrent acute pancreatitis is associated with failure to treat the biliary aetiology

Research paper thumbnail of Elevation of Neutrophil-lymphocyte ratio at diagnosis is a biomarker of nutritional impairment and poor prognosis in pancreatic cancer patients

Research paper thumbnail of Aspirin, statins and pancreatic cancer: Is there room for a chemopreventive effect?

Research paper thumbnail of 44 Elevated Neutrophil-Lymphocyte Ratio at Diagnosis Is Associated With Worse Nutritional Status and Survival, Irrespective of Stage in Pancreatic Cancer

Research paper thumbnail of 921 Small Intestinal Bacterial Overgrowth in Chronic Pancreatitis: Systematic Review and Meta-Analysis

Research paper thumbnail of Exocrine Pancreatic Insufficiency in Diabetic Patients: Prevalence, Mechanisms, and Treatment

International Journal of Endocrinology, 2015

Research paper thumbnail of The use of doxorubicin is a risk factor for the incidence of acute pancreatitis after liver embolization/transartherial chemoembolization

Research paper thumbnail of Liver biopsy: Analysis of results of two specialist teams

World journal of gastrointestinal pathophysiology, Jan 15, 2014

To analyze the safety and the adequacy of a sample of liver biopsies (LB) obtained by gastroenter... more To analyze the safety and the adequacy of a sample of liver biopsies (LB) obtained by gastroenterologist (G) and interventional radiologist (IR) teams. Medical records of consecutive patients evaluated at our GI unit from 01/01/2004 to 31/12/2010 for whom LB was considered necessary to diagnose and/or stage liver disease, both in the setting of day hospital and regular admission (RA) care, were retrieved and the data entered in a database. Patients were divided into two groups: one undergoing an ultrasonography (US)-assisted procedure by the G team and one undergoing US-guided biopsy by the IR team. For the first group, an intercostal approach (US-assisted) and a Menghini modified type needle 16 G (length 90 mm) were used. The IR team used a subcostal approach (US-guided) and a semiautomatic modified Menghini type needle 18 G (length 150 mm). All the biopsies were evaluated for appropriateness according to the current guidelines. The number of portal tracts present in each biopsy wa...

Research paper thumbnail of Small Intestinal Bacterial Overgrowth in Patients With Chronic Pancreatitis

Journal of Clinical Gastroenterology, 2014

To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis ... more To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis (CP), and analyze factors related with SIBO in CP. SIBO is to be considered a factor that worsens symptoms and nutritional status in patients with CP. However, the few studies evaluating the rate of SIBO in CP patients used nonuniform and nonstandardized procedures, and reported a wide range of positivity (0% to 92%). Those studies often investigated CP patients with previous resection surgery (cause of SIBO per se). CP patients and controls evaluated for SIBO by the H2 glucose breath test with a standard protocol. For CP patients, the relationship between test results, abdominal symptoms, and clinical and biochemical variables was analyzed. A total of 43 CP patients and 43 controls were enrolled. Of the CP patients, 8 had advanced disease (defined by M-ANNHEIM index) and none had undergone previous surgery. The glucose breath test positivity rate was higher in the CP patients than in the controls (21% vs. 14%), albeit without a significant difference (P=0.57). Mean fasting H2 excretion and mean H2 excretion at 120 minutes also had a trend toward higher levels in CP patients. There were no clinical differences between CP patients with or without SIBO, but there were nutritional differences for lower levels of vitamin D and higher levels of folate in these patients with SIBO. Our findings suggest that SIBO is not uncommon in uncomplicated CP patients. The lack of a significant difference compared with controls might be due to the study being underpowered. SIBO in CP patients does not seem to be related to peculiar clinical features, but it might affect nutritional status.

Research paper thumbnail of Proposal of coeliac disease management during Covid-19 pandemia

Clinical and Medical Investigations

Research paper thumbnail of Preliminary considerations regarding the risk of COVID-19 and disease severity in chronic gastrointestinal conditions

Annals of Gastroenterology

Research paper thumbnail of Recurrent biliary acute pancreatitis is frequent in a real-world setting

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2018

Data about recurrent acute pancreatitis (RAP) are limited. To evaluate the rate of RAP and associ... more Data about recurrent acute pancreatitis (RAP) are limited. To evaluate the rate of RAP and associated factors. Single-centre prospective study of consecutive patients at first episode of acute pancreatitis (AP) being followed-up. Of 266 consecutive AP patients, (47% biliary, 15.4% alcoholic, 14.3% idiopathic) 66 (24.8%) had RAP in a mean follow-up of 42 months; 17.9% of recurrences occurred within 30 days from discharge. Age, gender, smoking and severity of first AP were not associated with RAP risk. The rate of biliary RAP was 31.3% in patients who did not receive any treatment, 18% in those treated with ERCP only, 16% in those who received cholecystectomy only, and 0% in those treated both with surgery and ERCP. Patients with biliary AP who received cholecystectomy had a significantly longer time of recurrence-free survival and reduced recurrence risk (HR = 0.45). In patients with alcoholic AP, the rate of recurrence was lower in those who quit drinking (5.8% vs 33%; p = 0.05). Th...

Research paper thumbnail of The Neutrophil/Lymphocyte Ratio at Diagnosis Is Significantly Associated with Survival in Metastatic Pancreatic Cancer Patients

International Journal of Molecular Sciences

Different inflammation-based scores such as the neutrophil/lymphocyte ratio (NLR), the Odonera Pr... more Different inflammation-based scores such as the neutrophil/lymphocyte ratio (NLR), the Odonera Prognostic Nutritional Index (PNI), the Glasgow Prognostic Score, the platelet/lymphocyte ratio, and the C-reactive protein/albumin ratio have been found to be significantly associated with pancreatic cancer (PDAC) prognosis. However, most studies have investigated patients undergoing surgery, and few of them have compared these scores. We aimed at evaluating the association between inflammatory-based scores and PDAC prognosis. In a single center cohort study, inflammatory-based scores were assessed at diagnosis and their prognostic relevance as well as that of clinic-pathological variables were evaluated through multiple logistic regression and survival probability analysis. In 206 patients, age, male sex, tumor size, presence of distant metastasis, access to chemotherapy, and an NLR > 5 but not other scores were associated with overall survival (OS) at multivariate analysis. Patients with an NLR < 5 had a median survival of 12 months compared to 4 months in those with an NLR > 5. In the 81 patients with distant metastasis at diagnosis, an NLR > 5 resulted in the only variable significantly associated with survival. Among patients with metastatic disease who received chemotherapy, the median survival was 3 months in patients with an NLR > 5 and 7 months in those with an NLR < 5. The NLR might drive therapeutic options in PDAC patients, especially in the setting of metastatic disease.

Research paper thumbnail of Cachexia is an Insidious Symptom of Pancreatic Ductal Adenocarcinoma Associated with Delayed Diagnosis and Advanced Stage of Disease

Jop Journal of the Pancreas, Sep 15, 2013

Research paper thumbnail of OC.11.2: Risk Factors for Intraductal Papillary Mucinous Neoplasm (Ipmn) of the Pancreas: Preliminary Results of a Prospective Italian Multicentre Case-Control Study

Research paper thumbnail of 849 Statins but Not Aspirin, Neither Their Combination, Are Protective for the Onset of Pancreatic Cancer

Research paper thumbnail of Small Intestine Bacterial Overgrowth Is not Related with Disease Severity and Symptoms in Patients with Chronic Pancreatitis

Jop Journal of the Pancreas, Sep 20, 2012

Research paper thumbnail of Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study

Scientific reports, Jan 12, 2017

Data on the association between aspirin and statin use and Pancreatic Ductal AdenoCarcinoma (PDAC... more Data on the association between aspirin and statin use and Pancreatic Ductal AdenoCarcinoma (PDAC) risk are conflicting. These drugs are often co-prescribed, but no studies evaluated the potential combined or confounding effect of the two at the same time. We aimed to investigate the association between aspirin and statin exclusive and combined use and PDAC occurrence. Data on environmental factors, family and medical history were screened in a case-control study. PDAC cases were matched to controls for age and gender. Power calculation performed ahead. Odds ratios (OR) and 95% confidence intervals(CI) were obtained from multivariable logistic regression analysis. In 408 PDAC patients and 816 matched controls, overall statin (OR 0.61; 95%CI,0.43-0.88), but not aspirin use was associated to reduced PDAC risk. Compared to non-users, exclusive statin (OR 0.51; 95%CI,0.32-0.80) and exclusive aspirin users (OR 0.64; 95%CI,0.40-1.01) had reduced PDAC risk. Concomitant statin and aspirin u...

Research paper thumbnail of New PRSS1 and common CFTR mutations in a child with acute recurrent pancreatitis, could be considered an

Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even m... more Background: acute recurrent pancreatitis is a complex multigenic disease, the diagnosis is even more difficult when this disease develops in a child.

Research paper thumbnail of Secretin-enhanced MRCP in the evaluation of IPMN

Any information contained in this pdf file is automatically generated from digital material submi... more Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to third-party sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expe...

Research paper thumbnail of The risk of recurrent acute pancreatitis is associated with failure to treat the biliary aetiology

Research paper thumbnail of Elevation of Neutrophil-lymphocyte ratio at diagnosis is a biomarker of nutritional impairment and poor prognosis in pancreatic cancer patients

Research paper thumbnail of Aspirin, statins and pancreatic cancer: Is there room for a chemopreventive effect?

Research paper thumbnail of 44 Elevated Neutrophil-Lymphocyte Ratio at Diagnosis Is Associated With Worse Nutritional Status and Survival, Irrespective of Stage in Pancreatic Cancer

Research paper thumbnail of 921 Small Intestinal Bacterial Overgrowth in Chronic Pancreatitis: Systematic Review and Meta-Analysis

Research paper thumbnail of Exocrine Pancreatic Insufficiency in Diabetic Patients: Prevalence, Mechanisms, and Treatment

International Journal of Endocrinology, 2015

Research paper thumbnail of The use of doxorubicin is a risk factor for the incidence of acute pancreatitis after liver embolization/transartherial chemoembolization

Research paper thumbnail of Liver biopsy: Analysis of results of two specialist teams

World journal of gastrointestinal pathophysiology, Jan 15, 2014

To analyze the safety and the adequacy of a sample of liver biopsies (LB) obtained by gastroenter... more To analyze the safety and the adequacy of a sample of liver biopsies (LB) obtained by gastroenterologist (G) and interventional radiologist (IR) teams. Medical records of consecutive patients evaluated at our GI unit from 01/01/2004 to 31/12/2010 for whom LB was considered necessary to diagnose and/or stage liver disease, both in the setting of day hospital and regular admission (RA) care, were retrieved and the data entered in a database. Patients were divided into two groups: one undergoing an ultrasonography (US)-assisted procedure by the G team and one undergoing US-guided biopsy by the IR team. For the first group, an intercostal approach (US-assisted) and a Menghini modified type needle 16 G (length 90 mm) were used. The IR team used a subcostal approach (US-guided) and a semiautomatic modified Menghini type needle 18 G (length 150 mm). All the biopsies were evaluated for appropriateness according to the current guidelines. The number of portal tracts present in each biopsy wa...

Research paper thumbnail of Small Intestinal Bacterial Overgrowth in Patients With Chronic Pancreatitis

Journal of Clinical Gastroenterology, 2014

To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis ... more To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis (CP), and analyze factors related with SIBO in CP. SIBO is to be considered a factor that worsens symptoms and nutritional status in patients with CP. However, the few studies evaluating the rate of SIBO in CP patients used nonuniform and nonstandardized procedures, and reported a wide range of positivity (0% to 92%). Those studies often investigated CP patients with previous resection surgery (cause of SIBO per se). CP patients and controls evaluated for SIBO by the H2 glucose breath test with a standard protocol. For CP patients, the relationship between test results, abdominal symptoms, and clinical and biochemical variables was analyzed. A total of 43 CP patients and 43 controls were enrolled. Of the CP patients, 8 had advanced disease (defined by M-ANNHEIM index) and none had undergone previous surgery. The glucose breath test positivity rate was higher in the CP patients than in the controls (21% vs. 14%), albeit without a significant difference (P=0.57). Mean fasting H2 excretion and mean H2 excretion at 120 minutes also had a trend toward higher levels in CP patients. There were no clinical differences between CP patients with or without SIBO, but there were nutritional differences for lower levels of vitamin D and higher levels of folate in these patients with SIBO. Our findings suggest that SIBO is not uncommon in uncomplicated CP patients. The lack of a significant difference compared with controls might be due to the study being underpowered. SIBO in CP patients does not seem to be related to peculiar clinical features, but it might affect nutritional status.