Maurice Aknin - Academia.edu (original) (raw)

Papers by Maurice Aknin

Research paper thumbnail of Sterol and fatty acid distribution in red algae from the senegalese coast

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1990

... Pergamon Press pie STEROL AND FATTY ACID DISTRIBUTION IN RED ALGAE FROM THE SENEGALESE COAST ... more ... Pergamon Press pie STEROL AND FATTY ACID DISTRIBUTION IN RED ALGAE FROM THE SENEGALESE COAST MAURICE AKNIN,* JOSEPH MIRALLES'~ and ... Napolitano GE, Ratnayake WMN and Ackman RG (1988) All cis-3,6,9,12,15 octadccapentaenoic acid: a problem ...

Research paper thumbnail of ChemInform Abstract: Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp

ChemInform Abstract: Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp

ChemInform, 2009

Research paper thumbnail of A new alkaloid from the purple Indian Ocean tunicate Eudistoma bituminis

Tetrahedron Letters, 2001

Research paper thumbnail of 24-O-Ethylmanoalide, a Manoalide-related Sesterterpene from the Marine sponge Luffariella cf. variabilis

24-O-Ethylmanoalide, a Manoalide-related Sesterterpene from the Marine sponge Luffariella cf. variabilis

Molecules, 2008

A new manoalide-related sesterterpene, 24-O-ethylmanoalide (3), was isolated from the Indian Ocea... more A new manoalide-related sesterterpene, 24-O-ethylmanoalide (3), was isolated from the Indian Ocean sponge Luffariella cf. variabilis, together with the known compounds manoalide (1), seco-manoalide, manoalide monoacetate and 24-O-methylmanoalide (2). The structure of compound 3 was elucidated by interpretation of its spectroscopic data.

Research paper thumbnail of Netamines A—G: Seven New Tricyclic Guanidine Alkaloids from the Marine Sponge Biemna laboutei

ChemInform, 2007

In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtO... more In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI 50 values in the micromolar range.

Research paper thumbnail of Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp

Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp

Tetrahedron, 2010

... Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp... more ... Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp. ... Seven new nitrogenous macrolides, designated salarins D–J (4–10), closely related to salarins A–C (1–3), have been isolated from the Madagascar Fascaplysinopsis sp. ...

Research paper thumbnail of Fatty acid composition of twelve species of chlorophyceae from the senegalese coast

Phytochemistry, 1992

algal species belonging to three orders of Chlorophyceae from the Senegalese coast were investiga... more algal species belonging to three orders of Chlorophyceae from the Senegalese coast were investigated for their fatty acid content by capillary GC. Our results, as well as other published data, show that fatty acid composition offers discriminant features for the chemotaxonomic classification of this algal class. High contents of 16: 303 distinguish the Siphonales from the Ulotrichales and the Cladophorales which are rich in 16:4w3. A ratio of cis-vaccenic to oleic acid higher than one and the presence of large amounts of 18:4w3 distinguish the Ulotrichales from the Cladophorales.

Table 1. Fatty acid composition (%) of 12 species of Chlorophyceae from the Senegalese coast

Research paper thumbnail of Tausalarin C: A New Bioactive Marine Sponge-Derived Nitrogenous Bismacrolide

Organic Letters, 2009

A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar s... more A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.

Research paper thumbnail of Hydroquinone Antioxidants from the Indian Ocean Tunicate Aplidium savignyi

Journal of Agricultural and Food Chemistry, 1999

Research paper thumbnail of A New Cytotoxic Diterpene with the Dolabellane Skeleton from the Marine SpongeSigmosceptrella quadrilobata

European Journal of Organic Chemistry, 1999

Research paper thumbnail of Nor-sterols in Axinella proliferans, sponge from the Indian Ocean

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996

Research paper thumbnail of Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Marine Drugs, 2013

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenou... more Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.

Research paper thumbnail of Sterol and fatty acid distribution in red algae from the senegalese coast

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1990

... Pergamon Press pie STEROL AND FATTY ACID DISTRIBUTION IN RED ALGAE FROM THE SENEGALESE COAST ... more ... Pergamon Press pie STEROL AND FATTY ACID DISTRIBUTION IN RED ALGAE FROM THE SENEGALESE COAST MAURICE AKNIN,* JOSEPH MIRALLES'~ and ... Napolitano GE, Ratnayake WMN and Ackman RG (1988) All cis-3,6,9,12,15 octadccapentaenoic acid: a problem ...

Research paper thumbnail of ChemInform Abstract: Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp

ChemInform Abstract: Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp

ChemInform, 2009

Research paper thumbnail of A new alkaloid from the purple Indian Ocean tunicate Eudistoma bituminis

Tetrahedron Letters, 2001

Research paper thumbnail of 24-O-Ethylmanoalide, a Manoalide-related Sesterterpene from the Marine sponge Luffariella cf. variabilis

24-O-Ethylmanoalide, a Manoalide-related Sesterterpene from the Marine sponge Luffariella cf. variabilis

Molecules, 2008

A new manoalide-related sesterterpene, 24-O-ethylmanoalide (3), was isolated from the Indian Ocea... more A new manoalide-related sesterterpene, 24-O-ethylmanoalide (3), was isolated from the Indian Ocean sponge Luffariella cf. variabilis, together with the known compounds manoalide (1), seco-manoalide, manoalide monoacetate and 24-O-methylmanoalide (2). The structure of compound 3 was elucidated by interpretation of its spectroscopic data.

Research paper thumbnail of Netamines A—G: Seven New Tricyclic Guanidine Alkaloids from the Marine Sponge Biemna laboutei

ChemInform, 2007

In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtO... more In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI 50 values in the micromolar range.

Research paper thumbnail of Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp

Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp

Tetrahedron, 2010

... Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp... more ... Salarins D–J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp. ... Seven new nitrogenous macrolides, designated salarins D–J (4–10), closely related to salarins A–C (1–3), have been isolated from the Madagascar Fascaplysinopsis sp. ...

Research paper thumbnail of Fatty acid composition of twelve species of chlorophyceae from the senegalese coast

Phytochemistry, 1992

algal species belonging to three orders of Chlorophyceae from the Senegalese coast were investiga... more algal species belonging to three orders of Chlorophyceae from the Senegalese coast were investigated for their fatty acid content by capillary GC. Our results, as well as other published data, show that fatty acid composition offers discriminant features for the chemotaxonomic classification of this algal class. High contents of 16: 303 distinguish the Siphonales from the Ulotrichales and the Cladophorales which are rich in 16:4w3. A ratio of cis-vaccenic to oleic acid higher than one and the presence of large amounts of 18:4w3 distinguish the Ulotrichales from the Cladophorales.

Table 1. Fatty acid composition (%) of 12 species of Chlorophyceae from the Senegalese coast

Research paper thumbnail of Tausalarin C: A New Bioactive Marine Sponge-Derived Nitrogenous Bismacrolide

Organic Letters, 2009

A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar s... more A novel nitrogenous bismacrolide, designated tausalarin C (1), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra. It is suggested that tausalarin C is assembled from salarin A (2) and pretaumycin A. The relative configuration of the chiral centers of salarin A was determined by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed.

Research paper thumbnail of Hydroquinone Antioxidants from the Indian Ocean Tunicate Aplidium savignyi

Journal of Agricultural and Food Chemistry, 1999

Research paper thumbnail of A New Cytotoxic Diterpene with the Dolabellane Skeleton from the Marine SpongeSigmosceptrella quadrilobata

European Journal of Organic Chemistry, 1999

Research paper thumbnail of Nor-sterols in Axinella proliferans, sponge from the Indian Ocean

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996

Research paper thumbnail of Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Marine Drugs, 2013

Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenou... more Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.