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Papers by Mauricio Torres
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Nowadays, the use of translucent or transparent façades as lining of another façade is increasing... more Nowadays, the use of translucent or transparent façades as lining of another façade is increasing. This is done with the purpose of creating a ventilated air chamber façade, or renovating the building appearance without giving up the vision of their original aspect or with the objective of incorporating sustainable approaches and bio-climatic improvements to the building. This is the case of the Headquarters of the National Securities Market Commission, a very representative administrative building located in the centre of Madrid whose redevelopment will be carried out by the architecture office FERNANDEZ DEL CASTILLO ARQ, SL. The most significant and differentiating aspect in this redevelopment consists on the application of a ventilated double skin façade (VDSF) in the central atrium of the building in order to offer a more modern design and to help the entrance of daylight in the interior spaces.
Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year stud... more Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year study using TAS simulation software was carried out for a Double Skin Façade corporative office building. It is a typical office building with an extended working hours schedule for acclimatization. Four different cavity widths were simulated -40cm, 60cm, 80cm, 100cm -as well as three different external opening areas for cavity's natural ventilation purpose. Two Double Skin Façade typologies were simulated -a corridor façade and a multistory façade. Simulations showed cooling loads are much greater than heating loads on a double glazed skin façade building south oriented in a Mediterranean climate town like Barcelona. Results demonstrated that a Multistory Façade, depending on its configuration, might save up to 5% on annual cooling loads respect to a Corridor Façade. Different opening areas and cavity depths shall be used for different typologies in order to obtaining good energy results.
Nowadays, the use of translucent or transparent façades as lining of another façade is increasing... more Nowadays, the use of translucent or transparent façades as lining of another façade is increasing. This is done with the purpose of creating a ventilated air chamber façade, or renovating the building appearance without giving up the vision of their original aspect or with the objective of incorporating sustainable approaches and bio-climatic improvements to the building. This is the case of the Headquarters of the National Securities Market Commission, a very representative administrative building located in the centre of Madrid whose redevelopment will be carried out by the architecture office FERNANDEZ DEL CASTILLO ARQ, SL. The most significant and differentiating aspect in this redevelopment consists on the application of a ventilated double skin façade (VDSF) in the central atrium of the building in order to offer a more modern design and to help the entrance of daylight in the interior spaces.
Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year stud... more Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year study using TAS simulation software was carried out for a Double Skin Façade corporative office building. It is a typical office building with an extended working hours schedule for acclimatization. Four different cavity widths were simulated -40cm, 60cm, 80cm, 100cm -as well as three different external opening areas for cavity's natural ventilation purpose. Two Double Skin Façade typologies were simulated -a corridor façade and a multistory façade. Simulations showed cooling loads are much greater than heating loads on a double glazed skin façade building south oriented in a Mediterranean climate town like Barcelona. Results demonstrated that a Multistory Façade, depending on its configuration, might save up to 5% on annual cooling loads respect to a Corridor Façade. Different opening areas and cavity depths shall be used for different typologies in order to obtaining good energy results.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Journal of Medical Virology, 2007
Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelo... more Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). High HTLV-I provirus load and tax mRNA level have been suggested as predictors of disease progression in patients with HAM/TSP, but little is known about the temporal variation in patients. To clarify the role of high proviral and tax mRNA loads and their fluctuations in the pathogenesis of HAM/TSP, we measured proviral load and tax mRNA in serially collected peripheral blood mononuclear cells (PBMCs) from nine patients with HAM/TSP during a long-term follow-up, by use of real-time polymerase chain reaction using tax primers. The real-time PCR quantitation revealed a wide range of variation of proviral loads (7.82–97.13 copies per 100 PBMCs) and tax mRNA (0.20–245.30 copies) among HAM/TSP patients. Patients showed three different patterns of HTLV-I tax mRNA loads during the course of the disease. Tax mRNA load showed a separate evolution with respect to the disease. The dynamic patterns of proviral load and mRNA Tax expression suggest that only the permanent presence of a basal level of tax mRNA, rather than the tax mRNA load, is related to the development of HAM/TSP. To our knowledge, this is the first longitudinal study to determine tax mRNA expression at different clinical stages. J. Med. Virol. 79: 782–790, 2007. © 2007 Wiley-Liss, Inc.
Nowadays, the use of translucent or transparent façades as lining of another façade is increasing... more Nowadays, the use of translucent or transparent façades as lining of another façade is increasing. This is done with the purpose of creating a ventilated air chamber façade, or renovating the building appearance without giving up the vision of their original aspect or with the objective of incorporating sustainable approaches and bio-climatic improvements to the building. This is the case of the Headquarters of the National Securities Market Commission, a very representative administrative building located in the centre of Madrid whose redevelopment will be carried out by the architecture office FERNANDEZ DEL CASTILLO ARQ, SL. The most significant and differentiating aspect in this redevelopment consists on the application of a ventilated double skin façade (VDSF) in the central atrium of the building in order to offer a more modern design and to help the entrance of daylight in the interior spaces.
Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year stud... more Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year study using TAS simulation software was carried out for a Double Skin Façade corporative office building. It is a typical office building with an extended working hours schedule for acclimatization. Four different cavity widths were simulated -40cm, 60cm, 80cm, 100cm -as well as three different external opening areas for cavity's natural ventilation purpose. Two Double Skin Façade typologies were simulated -a corridor façade and a multistory façade. Simulations showed cooling loads are much greater than heating loads on a double glazed skin façade building south oriented in a Mediterranean climate town like Barcelona. Results demonstrated that a Multistory Façade, depending on its configuration, might save up to 5% on annual cooling loads respect to a Corridor Façade. Different opening areas and cavity depths shall be used for different typologies in order to obtaining good energy results.
Nowadays, the use of translucent or transparent façades as lining of another façade is increasing... more Nowadays, the use of translucent or transparent façades as lining of another façade is increasing. This is done with the purpose of creating a ventilated air chamber façade, or renovating the building appearance without giving up the vision of their original aspect or with the objective of incorporating sustainable approaches and bio-climatic improvements to the building. This is the case of the Headquarters of the National Securities Market Commission, a very representative administrative building located in the centre of Madrid whose redevelopment will be carried out by the architecture office FERNANDEZ DEL CASTILLO ARQ, SL. The most significant and differentiating aspect in this redevelopment consists on the application of a ventilated double skin façade (VDSF) in the central atrium of the building in order to offer a more modern design and to help the entrance of daylight in the interior spaces.
Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year stud... more Taking into account Mediterranean climate particularities for Barcelona, Spain, a whole year study using TAS simulation software was carried out for a Double Skin Façade corporative office building. It is a typical office building with an extended working hours schedule for acclimatization. Four different cavity widths were simulated -40cm, 60cm, 80cm, 100cm -as well as three different external opening areas for cavity's natural ventilation purpose. Two Double Skin Façade typologies were simulated -a corridor façade and a multistory façade. Simulations showed cooling loads are much greater than heating loads on a double glazed skin façade building south oriented in a Mediterranean climate town like Barcelona. Results demonstrated that a Multistory Façade, depending on its configuration, might save up to 5% on annual cooling loads respect to a Corridor Façade. Different opening areas and cavity depths shall be used for different typologies in order to obtaining good energy results.