May Chun Mei Wong - Academia.edu (original) (raw)

Papers by May Chun Mei Wong

JAMA Network Open

ImportancePlatelet transfusion is commonly performed in infants to correct severe thrombocytopeni... more ImportancePlatelet transfusion is commonly performed in infants to correct severe thrombocytopenia or prevent bleeding. Exploring the associations of platelet transfusion, platelet count (PC), and mean platelet volume (MPV) with intraventricular hemorrhage (IVH) and in-hospital mortality in preterm infants can provide evidence for the establishment of future practices.ObjectivesTo evaluate the associations of platelet transfusion, PC, and MPV with IVH and in-hospital mortality and to explore whether platelet transfusion–associated IVH and mortality risks vary with PC and MPV levels at the time of transfusion.Design, Setting, and ParticipantsThis retrospective cohort study included preterm infants who were transferred to the neonatal intensive care unit on their day of birth and received ventilation during their hospital stay. The study was conducted at a neonatal intensive care unit referral center in Beijing, China, between May 2016 and October 2017. Data were retrieved and analyze...

Frontiers in Cellular and Infection Microbiology

AimTo provide a dynamic description of the oral microbial composition in mothers with and without... more AimTo provide a dynamic description of the oral microbial composition in mothers with and without dental caries and their children aging 12-24 months.MethodologyA total of 20 pairs of mothers and their children aged 12 months were included and followed up at 18 and 24 months of age. Ten mothers with dental caries(MEG) and their children(CEG) were in the exposure group, and ten caries-free mothers(MCG) and their children(CCG)in control group. Supragingival plaque biofilm samples were collected and DNA was extracted for bacterial 16S rRNA gene sequencing.ResultsA total of 18 pairs completed follow-ups. At a 3% divergence level, the number of common operational taxonomic units found between the mothers and children increased as the children aged. Proteobacteria, Bacteroidetes, Firmicutes, Fusobacteria, and Actinobacteria accounted for more than 80% phyla of each group. A microbial community structure analysis showed that the differences between mothers and children were significant in ...

Journal of the Institute of Health Education, 1996

AbstractWhen developing dental health programmes for pre-school children involvement of kindergar... more AbstractWhen developing dental health programmes for pre-school children involvement of kindergarten teachers must be considered as important. It becomes critical to assess the teachers' dental health knowledge and attitudes, because they will exert influence on the children and thus on the programme outcome. The purpose of the present study was to assess possible changes in the dental visit habits and the dental health knowledge of Chinese kindergarten teachers prior to their involvement in a kindergarten-based daily toothbrushing programme and after they had received dental health education from dental health professionals. Self-completed questionnaires were collected from two groups of kindergarten teachers of which one group received dental health education, whereas the other did not receive any information. The teachers were similar in age, education, experience and responsibilities. No difference in the dental visit pattern was found between the groups, but statistically significantly higher dental ...

PloS one, 2017

Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP)... more Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP). However, these findings are controversial. This meta-analysis was aimed at clarifying the association between herpesviruses and AgP. We identified eligible case-control studies evaluating the association between herpesviruses and AgP from PubMed and Embase databases in October 2015. Original data were extracted and quality assessment was done. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Random-effects model was determined. The stability was evaluated by sensitivity analysis. Finally, Egger's funnel plot was used to investigate the publication bias. Twelve case-control studies involving 322 patients and 342 controls were included in the present meta-analysis. The included case-control studies were assessed as high quality. The quantitative synthesis results for Epstein-Barr virus (EBV) showed significance (10 studies: p = 0.0008, OR = 6.11, 95% CI = ...

Cochrane Database of Systematic Reviews, 2017

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess... more This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of silver diamine fluoride in arresting and preventing caries in deciduous and permanent teeth (coronal and root caries) compared to any other intervention including placebo or no treatment. B A C K G R O U N D Description of the condition Dental caries is the globe's most prevalent disease (Marcenes 2013; Kassebaum 2015). Scoping reviews indicate that cost-effective preventive agents, that can be applied by families or community health workers are available, but underused (Niederman 2015). Caries affects far more than a person's oral health. The range of associated issues with untreated caries and toothaches range from reduced quality of life to poor school performance (

Journal of Oral Hygiene & Health, 2013

Early Childhood Caries (ECC) is defi ned as the presence of one or more decayed tooth surfaces in... more Early Childhood Caries (ECC) is defi ned as the presence of one or more decayed tooth surfaces in any primary tooth in children 71 months of age or younger. ECC is the most common chronic illness among children and adolescents. Studies have found caries prevalence among preschool children varies greatly in different countries, ranging from 17 to 94%. However, in most of the studies; over 90% of decayed teeth were left untreated. Caries progression can lead to pain and reduced ability to chew and eat, which may also lead to iron defi ciency due to malnutrition. Reduction of quality of life for children with ECC, resulting from disturbed sleeping and concentration problems, has been reported. Children with severe caries may experience reduced weight and delayed growth. This paper provides an updated literature review of ECC. The aetiology, clinical features, caries prevalence in recent literature, consequences of caries infection and management of ECC are discussed.

PLOS ONE, 2015

Objective Numerous studies have investigated the associations between herpesviruses and chronic p... more Objective Numerous studies have investigated the associations between herpesviruses and chronic periodontitis; however, the results remain controversial. To derive a more precise estimation, a meta-analysis on all available studies was performed to identify the association between herpesviruses and chronic periodontitis.

Trials, 2015

Background: The application of 38 % silver diamine fluoride (SDF) has been shown to be effective ... more Background: The application of 38 % silver diamine fluoride (SDF) has been shown to be effective in arresting early childhood caries (ECC). Since SDF is not available in certain countries, some dentists use adjunctive application of 25 % silver nitrate (AgNO 3) and 5 % sodium fluoride (NaF) to arrest ECC. This randomised controlled trial will systematically compare the efficacy of a 25 % AgNO 3 solution followed by 5 % NaF varnish with that of a 38 % SDF solution in arresting ECC when applied at half-yearly intervals over a 30-month period. Methods/Design: This study is a randomised, double-blinded, non-inferiority clinical trial. The hypothesis tested is that adjunctive application of 25 % AgNO 3 followed by 5 % NaF is at least not appreciably worse than a 38 % SDF in arresting ECC. Approximately 3100 kindergarten children aged 3-4 years will be screened and at least 1070 children with caries will be recruited. This sample size is sufficient for an appropriate statistical analysis (power at 90 % (β = 0.10) with a 2-sided type-I error of α = 0.05), allowing for an overall 20 % drop-out rate. The children will be randomly allocated into 2 groups to treat their caries over a 30-month period: Group Abiannual adjunctive application of a 25 % AgNO 3 solution and a 5 % NaF varnish, and Group Bbiannual adjunctive application of a 38 % SDF solution followed by a placebo varnish. Clinical examinations will be conducted at 6-month intervals. Primary outcome measured is the number of active caries surfaces which are arrested. Information on confounding factors such as oral hygiene habits will be collected through a parental questionnaire. Discussion: We expect that adjunctive application of 25 % AgNO 3 solution and 5 % NaF varnish and of 38 % SDF solution can both effectively arrest ECC. Lower concentrations of silver and fluoride are contained in 25 % AgNO 3 and 5 % NaF, respectively, than in 38 % SDF; therefore, AgNO 3 /NaF are more favourable for use in young children. Because its use for caries management is painless, simple, low-cost, and approved in many countries, AgNO 3 /NaF could be widely recommended and promoted as an alternative treatment to conventional invasive management of ECC.

Conventional restorative management of early childhood caries (ECC) is unlikely to tackle this pr... more Conventional restorative management of early childhood caries (ECC) is unlikely to tackle this prevalent disease, and arresting caries treatment using silver diamine fluoride (SDF) has become a pragmatic strategy, particularly for young and apprehensive children. Arrested caries is clinically characterized by its increase in hardness and a dark brown to black coloration. Subsequent restorative procedures can be carried out if necessary. This review article discusses the rationale of arresting caries treatment, mechanism of action of SDF, and safety and complications of SDF treatment. A literature search using PubMed was performed to review the clinical trials using SDF to manage ECC. Results found 6 clinical trials published in English since 1980. The studies suggested that one-off application of 12% SDF is not effective in arresting caries in children, but 38% SDF is. The main disadvantage of SDF treatment is black staining of the arrested lesion, but significant complications were not reported. In general, the studies concluded that topical application of SDF is a simple and low cost method to arrest ECC. This treatment strategy therefore increases access for children in developing countries to receive affordable dental treatment.

Community Dentistry and Oral Epidemiology, 2002

Objectives: The aim of this study was to evaluate the reliability and validity of the the Chinese... more Objectives: The aim of this study was to evaluate the reliability and validity of the the Chinese version of the Oral Health Impact Profile for TMDs (OHIP-TMDs-C). Study Design: The OHIP-TMDs was initially translated and cross-culturally adapted to Chinese following international guidelines; then subsequently validated for the psychometric characteristics of reliability and validity. In total, 156 participants with temporomandibular disorders (TMDs) were recruited to complete the questionnaire. The reliability of the OHIP-TMDs-C was evaluated using internal consistency and test-retest methods. The validity of the OHIP-TMDs-C was analysed by construct validity and convergent validity. Construct validity was determined based on factor analysis, and convergent validity by analyzing the correlation between OHIP-TMDs-C subscale scores and the global rating of oral health question. Results: Cronbach's alpha value (internal reliability) for the total OHIP-TMDs-C score was 0.917 and the intraclass correlation coefficient (ICC) value (test-retest reliability) was 0.899. Construct validity was determined by factor analysis, extracting five factors, accounting for 78.6% of the variance. All items had factor loadings above 0.40. In terms of convergent validity, the OHIP-TMDs-C subscale was significant correlated to the global oral health rating. Conclusions: The results suggest that the OHIP-TMDs-C has good reliability and validity and thus may be used as a valuable instrument for patients with TMDs in China.

Clinical Cancer Research, 2006

Purpose: This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) a... more Purpose: This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non–small cell lung cancers in Hong Kong and determined their relation with smoking history and other clinicopathologic features. Experimental Design: Mutational profile of exons 18 to 21 of EGFR and codons 12, 13, and 61 of KRAS were determined in 215 adenocarcinomas, 15 squamous cell (SCC), and 11 EBV-associated lymphoepithelioma-like carcinomas (LELC). Results: EGFR mutations were prevalent in adenocarcinomas (115 of 215), uncommon in LELC (1 of 11), and not found in SCC (P < 0.001). Among adenocarcinomas, mutations were associated with nonsmokers (83 of 111; P < 0.001), female gender (87 of 131; P < 0.001), and well-differentiated (55 of 86) compared with poorly differentiated (11 of 41) tumors (P < 0.001). Decreasing mutation rates with increasing direct tobacco exposure was observed, with 74.8% (83 of 111) in nonsmokers, 61.1% (11 of 18) in passive, 35.7% (10...

British Dental Journal, 1999

Clinical Oral Implants Research, 2013

ObjectivesTo determine the effect of various systemic antibiotic prophylaxis regimes on patient‐r... more ObjectivesTo determine the effect of various systemic antibiotic prophylaxis regimes on patient‐reported outcomes and postsurgical complications in patients undergoing conventional implant installation.Material and methodsThree hundred and twenty‐nine healthy adults in need of conventional implant installation were randomly assigned to one of four groups: (i) preoperatively 2 g of amoxycillin 1 h before surgery (positive control, PC), (ii) postoperatively 2 g of amoxycillin immediately following surgery (test 1, T1), (iii) preoperatively 2 g of amoxycillin 1 h before and 500 mg thrice daily on days 2 and 3 after surgery (test 2, T2), (iv) preoperatively 2 g of placebo 1 h before surgery (negative control, NC). Subjects were examined clinically by blinded examiners over 8 weeks after implant installation. In addition, Visual Analogue Scales (VAS) for pain, swelling, bruising and bleeding were obtained over 14 days. ANOVA was performed for the VAS. Chi‐square tests were applied for po...

Trials

Background Due to some unique physical, social and psychological features in the adolescent popul... more Background Due to some unique physical, social and psychological features in the adolescent population, adolescents can be a time of heightened caries activity and periodontal disease. Oral health-related behaviors can be modified to improve oral health status. The family networks and the built environment can promote or inhibit health behaviors. The aim of this study is to implement and evaluate a behavior theory-based, integrated family intervention via mobile messaging to improve oral health of adolescents. Methods This is a three-arm parallel-design cluster-randomized controlled trial. This trial will allocate 12 local secondary schools (clusters) in Hong Kong to three test or comparison groups with a ratio 1:1:1. The enrolled Form II to IV students (ages 12 to 15) will be eligible for participation. The intervention to three study groups will be (i) Health Belief Model (HBM)-based mobile messaging to the adolescents and their parents, which will consist of several blocks of HBM...

BMC Oral Health, 2021

Background This longitudinal study aimed to evaluate the longitudinal validity and reliability of... more Background This longitudinal study aimed to evaluate the longitudinal validity and reliability of the Oral Health Impact on Daily Living (OHIDL) transition scale and measure the perceived change in oral health-related quality of life (OHRQoL) after dental treatments among older adults. Methods OHIDL was administered to older adults who sought dental treatments. Participants were asked to assess changes in impact for each OHIDL item retrospectively compared with that before the treatment. The responsiveness, minimal clinically important difference (MCID), internal consistency and test–retest reliability of the OHIDL transition scale were evaluated. Multiple linear regression was employed to predict the change in oral health impacts after dental treatment. Beta coefficients (β) and 95% confidence intervals (CI) were reported. Results One hundred and seventy-six participants were followed-up with upon completing their dental treatments. The follow-up rate was 70.4% (176/250). The OHIDL...

Journal of Evidence Based Dental Practice, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Objectives: Poor oral hygiene and higher hormone levels during pregnancy always lead to poor peri... more Objectives: Poor oral hygiene and higher hormone levels during pregnancy always lead to poor periodontal health. Oral health education of the pregnant women to improve the periodontal outcomes might be ineffective and inconsistent. The aim of this study was to assess the effectiveness of a family-centered behavioral and educational counselling program on the pregnant women’s periodontal health and long-term effect after delivery. Methods: A randomized controlled trial was conducted among first-time pregnant women (10~20th gestational-week) in Hong Kong. Participating families were randomized into test and control group. The intervention in test group included: explanation on oral health education pamphlets, oral hygiene practice training by the “tell-show-do” technique, individualized feedback, and proposed solutions to overcome barriers on self-care. Reinforcement was implemented by interview, phone call or messaging to assess performance, identify barriers and to encourage partici...

BMC Oral Health, 2020

Background Silver diamine fluoride (SDF) solution gains increasing popularity in arresting dentin... more Background Silver diamine fluoride (SDF) solution gains increasing popularity in arresting dentine caries in clinical practice. The aim of this systematic review was to summarize the findings from laboratory studies on the influence of SDF application on the bond strength of dentine to various adhesives and to glass ionomer cements (GICs). Methods Two independent reviewers conducted a literature search in the databases Medline, Ovid, PubMed and Web of Science until 15th August 2019 using the search keywords [‘bond strength’] AND [‘silver diamine fluoride’ OR ‘silver diammine fluoride’ OR ‘SDF’ OR ‘silver fluoride’ OR ‘diamine silver fluoride’]. Articles investigating the effect of SDF application on the bond strength of dentine to various adhesives and to GICs were included in this review. Information on how SDF application influenced the bond strength was extracted from the included articles. Besides, related information, e.g. test method of bond strength, concentration and brand o...

BMC Oral Health, 2018

Background: A number of studies on oral microbial diversity of early childhood caries (ECC) have ... more Background: A number of studies on oral microbial diversity of early childhood caries (ECC) have tended to focus on mid-or late-stage of ECC, with a lack of research into early stage of tooth eruption and maternal influence. The aims of this study are to compare the supragingival plaque biofilm microbiota diversity between mothers with or without dental caries and their 12-month-old infants, and to explore the relationship of microbial diversity between infants and their mothers, using sequencing analysis. Methods: Supragingival plaque biofilm samples were collected from 20 pairs of mothers and their infants aged 12 months (10 mothers with dental caries and their 10 infants vs. 10 caries-free mothers and their 10 infants). The basic information of the mothers and infants had been collected through self-completed questionnaire. Pooled plaque biofilm DNA was extracted and DNA amplicons of the V4-V5 hypervariable region of the bacterial 16S rRNA gene were generated. Ilumina Miseq PE300 was used for 16S rRNA sequencing. Results: The results showed that high bacterial diversity was noted in the plaque biofilm of infants and their mothers with or without dental caries (dental caries mothers vs. caries-free mothers: 774 operational taxonomical units (OTUs) vs. 761 OTUs at a 3% divergence; infants whose mothers have dental caries vs. infants whose mothers are caries-free: 815 OTUs vs. 684 OTUs at 3% divergence). The Shannon microbial diversity index showed no statistically significant differences both on infants and their mothers between two groups (p > 0.05). Mother's microbial diversity was higher than infants' based on Shannon index (p < 0.05). Significant positive correlations were found between mothers' and their infants' Shannon index (r = 0.656, p = 0.002). Conclusion: Oral microbial diversity is significantly different between mothers and infants regardless of dental caries status, but no significant difference was found between mothers with and without dental caries or between their infants. Mother's oral microbial diversity has an overall impact on the infants aged 12 months.

Caries research, Jan 23, 2018

Oral epidemiology involves studying and investigating the distribution and determinants of dental... more Oral epidemiology involves studying and investigating the distribution and determinants of dental-related diseases in a specified population group to inform decisions in the management of health problems. In oral epidemiology studies, the hypothesis is typically followed by a cogent study design and data collection. Appropriate statistical analysis is essential to demonstrate the scientific association between the independent factors and the target variable. Analysis also helps to develop and build a statistical model. Poisson regression and its extensions have gained more attention in caries epidemiology than other working models such as logistic regression. This review discusses the fundamental principles and basic knowledge of Poisson regression models. It also introduces the use of a robust variance estimator with a focus on the "robust" interpretation of the model. In addition, extensions of regression models, including the zero-inflated model, hurdle model, and negat...