Mayang Lestari - Academia.edu (original) (raw)

Papers by Mayang Lestari

The Lancet

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as ind... more Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs. Methods First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assessment (surgical preparedness index; SPI). Second, we measured surgical preparedness across a global network of hospitals in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) to explore the distribution of the SPI at national, subnational, and hospital levels. Finally, using COVID-19 as an example of an external system shock, we compared hospitals' SPI to their planned surgical volume ratio (SVR; ie, operations for which the decision for surgery was made before hospital admission), calculated as the ratio of the observed surgical volume over a 1-month assessment period between June 6 and Aug 5, 2021, against the expected surgical volume based on hospital administrative data from the same period in 2019 (ie, a pre-pandemic baseline). A linear mixed-effects regression model was used to determine the effect of increasing SPI score. Findings In the first phase, from a longlist of 103 candidate indicators, 23 were prioritised as core indicators of elective surgical system preparedness by 69 clinicians (23 [33%] women; 46 [67%] men; 41 from HICs, 22 from MICs, and six from LICs) from 32 countries. The multidomain SPI included 11 indicators on facilities and consumables, two on staffing, two on prioritisation, and eight on systems. Hospitals were scored from 23 (least prepared) to 115 points (most prepared). In the second phase, surgical preparedness was measured in 1632 hospitals by 4714 clinicians from 119 countries. 745 (45•6%) of 1632 hospitals were in MICs or LICs. The mean SPI score was 84•5 (95% CI 84•1-84•9), which varied between HIC (88•5 [89•0-88•0]), MIC (81•8 [82•5-81•1]), and LIC (66•8 [64•9-68•7]) settings. In the third phase, 1217 (74•6%) hospitals did not maintain their expected SVR during the COVID-19 pandemic, of which 625 (51•4%) were from HIC, 538 (44•2%) from MIC, and 54 (4•4%) from LIC settings. In the mixed-effects model, a 10-point increase in SPI corresponded to a 3•6% (95% CI 3•0-4•1; p<0•0001) increase in SVR. This was consistent in HIC (4•8% [4•1-5•5]; p<0•0001), MIC (2•8 [2•0-3•7]; p<0•0001), and LIC (3•8 [1•3-6•7%]; p<0•0001) settings. Interpretation The SPI contains 23 indicators that are globally applicable, relevant across different system stressors, vary at a subnational level, and are collectable by front-line teams. In the case study of COVID-19, a higher SPI was associated with an increased planned surgical volume ratio independent of country income status, COVID-19 burden, and hospital type. Hospitals should perform annual self-assessment of their surgical preparedness to identify areas that can be improved, create resilience in local surgical systems, and upscale capacity to address elective surgery backlogs.

Journal of Clinical Medicine

Background: The COVID-19 pandemic continues to have an impact on geriatric patients worldwide sin... more Background: The COVID-19 pandemic continues to have an impact on geriatric patients worldwide since geriatrics itself is an age group with a high risk due to declined physiological function and many comorbidities, especially for those who undergo surgery. In this study, we determine the association between perioperative factors with 30-day mortality and a survival rate of geriatric patients undergoing surgery during COVID-19 pandemic. Methods: A prospective cohort study was conducted at 14 central hospitals in Indonesia. The recorded variables were perioperative factors, 30-day mortality, and survival rate. Analyses of associations between variables and 30-day mortality were performed using univariate/multivariable logistic regression, and survival rates were determined with Kaplan–Meier survival analysis. Results: We analyzed 1621 elderly patients. The total number of patients who survived within 30 days of observation was 4.3%. Several perioperative factors were associated with 30...

Majalah Anestesia dan Critical Care, Jun 1, 2017

Penyebab utama kematian pada sepsis adalah gagal multipel organ yang berhubungan dengan kerusakan... more Penyebab utama kematian pada sepsis adalah gagal multipel organ yang berhubungan dengan kerusakan glikokaliks endotel. Hyaluronan dan syndecan-1 merupakan komponen glikokaliks yang dapat dijadikan marker kerusakan pada glikokaliks. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar hyaluronan dan syndecan-1 dengan angka mortalitas pada pasien sepsis di ICU. Penelitian ini merupakan penelitian cross sectional observasional analitik pada pasien sepsis yang dirawat di ICU RSUP Dr. Mohammad Hoesin Palembang. Sampel darah dari 22 pasien diambil dan dilakukan pemeriksaan hyaluronan dan syndecan-1 pada hari perawatan pertama dan ketiga. Data ditampilkan secara deskriptif lalu dilakukan analisis uji statistik variabel kontinyu mengggunakan uji T tidak berpasangan, data dikotomi dengan uji chi square untuk menilai korelasi kadar hyaluronan dan syndecan-1 dengan angka mortalitas. Didapatkan rerata kadar hyaluronan dan syndecan-1 pada hari pertama dan ketiga perawatan pasien yang meninggal dalam perawatan 28 hari lebih tinggi dari pasien yang hidup. Namun, secara statistik hanya kadar syndecan-1 hari pertama yang didapatkan perbedaan yang bermakna (p=0,002) dengan korelasi yang sangat kuat (r=0,818) dengan mortalitas. Ada korelasi antara kadar syndecan-1 pada hari pertama perawatan dengan angka mortalitas pada pasien sepsis di ICU.

Terapi cairan merupakan landasan penting dalam merawat pasien kritis di intensive care unit (ICU)... more Terapi cairan merupakan landasan penting dalam merawat pasien kritis di intensive care unit (ICU), termasuk pasien sepsis. Terapi liberal dan goal-directed dianjurkan untuk mencapai tekanan arteri rata-rata lebih dari 65 mmHg pada tahap awal syok. Meskipun demikian, resusitasi cairan berlebihan meningkatkan tekanan hidrostatik mikrovaskular dan dapat menyebabkan akumulasi cairan interstitial. Resusitasi cairan yang memanjang berhubungan dengan kelebihan cairan dan meningkatkan mortalitas. Penelitian ini bertujuan untuk menilai seberapa besar hubungan antara kelebihan cairan dan angka mortalitas. Melalui studi case control, data dikumpulkan secara retrospektif dari Desember 2013 berdasarkan rekam medik di ICU RSUP Dr. Mohammad Hoesin Palembang sampai jumlah sampel tercukupi. Subjek penelitian adalah pasien sepsis berat dan syok septik yang mendapat resusitasi early goal directed therapy. Enam puluh subjek yang memenuhi kriteria yang dibagi menjadi kelompok survivors dan non-urvivors....

JPMA. The Journal of the Pakistan Medical Association, 2021

OBJECTIVE Lactate is a useful prognostic marker, as its level increases in hypoxic tissue and/or ... more OBJECTIVE Lactate is a useful prognostic marker, as its level increases in hypoxic tissue and/or during accelerated aerobic glycolysis due to excessive beta-adrenergic stimulation and decreased lactate clearance. The Surviving Sepsis Campaign Bundle 2018 Update suggested re-measurement of lactate within 2-4 hours so as to conduct/ help/administer /introduce lactate-guided resuscitation to reduce mortality due to sepsis. The aim of this study was to compare initial lactate levels and lactate clearance at 4 h of recognition of sepsis as mortality predictors in sepsis. Methods It was a prospective study performed with ethical approval in a single tertiary care centre. Patients aged 18 years or older who were diagnosed with sepsis by the Sepsis-3 definition were included in the study while patients who were not admitted to the ICU were excluded Dropout criteria was death of pateints within 4 hours of recognition of sepsis. Baseline demographic data was obtained and subjects were treated...

Background As life expectancy increases, the worldwide population aged 60 years and older increas... more Background As life expectancy increases, the worldwide population aged 60 years and older increases year by year. Consequently, more older people receive medical attention, especially those who undergo surgery. In addition, the COVID-19 pandemic has had a global impact on elderly patients, especially those undergoing surgery. This study aims to describe the characteristics and analyze the survival rate of elderly patients who receive anesthesia services, especially those with comorbidities and COVID-19. Methods A prospective cohort study at 14 central hospitals in Indonesia analyzed 1621 elderly patients (67.1 ± 6.2 years old). The variables that were recorded included patient characteristics, comorbidities, the COVID-19 status, and the survival rate, including 30-day mortality. Results The 30-day mortality was 4.4%. The most comorbidity was hypertension (30.0). Patients with a Charlson's Comorbidity Index Score of 3-4 had a higher death rate (15.3%). The highest mortality rates...

Ventilator-associated pneumonia (VAP) adalah infeksi nosokomial tersering di ruang Intensive Care... more Ventilator-associated pneumonia (VAP) adalah infeksi nosokomial tersering di ruang Intensive Care Unit (ICU) RSUP Dr. Moh. Hoesin (RSMH) Palembang, angka kejadiannya pada bulan Juli 2011–Juni 2012 cukup tinggi (31,69%) dengan angka mortalitas 54,7%. Mekanisme utama dalam patogenesis VAP ialah aspirasi bakteri gram positif dan negatif patogenik yang berkoloni di daerah orofaring. Tindakan modulasi kolonisasi tersebut sangat bermakna dalam mencegah VAP. Pemberian povidon iodin 1% dan klorheksidin 0,2% sudah sering dilakukan namun belum ada penelitian mengenai hubungannya terhadap kejadian VAP. Penelitian ini bertujuan untuk mengetahui hubungan antara klorheksidin 0,2% dan povidoneiodine 1% terhadap kejadian VAP. Studi kohort telah dilakukan di ICU RSMH pada bulan Februari – Juli 2014. Terdapat 32 subjek penelitian yang memenuhi kriteria inklusi dan dibagi menjadi dua kelompok, yaitu yang mendapatkan klorheksidin 0,2% dan povidoneiodine 1%. Dilakukan uji χ2 menggunakan statistical prog...

Background: With the more advanced science in the field of medicine and disease management, the p... more Background: With the more advanced science in the field of medicine and disease management, the population of geriatric intensive care patients is increasing. The COVID-19 pandemic has impacted healthcare management around the globe, especially on critically-ill elderly patients. We aim to analyse the relationship between underlying illnesses, including COVID-19, and the survival rate of elderly patients who are treated in the intensive care setting.Methods: We conducted a prospective cohort study at 14 teaching hospitals for Anaesthesiology and Intensive Therapy Education in Indonesia. We selected all subjects with 60 years of age or older in the period between February to May 2021. Variables recorded included subject characteristics, comorbidities, and COVID-19 status. Subjects were followed for 30-day mortality as an outcome. We analysed the data using Kaplan-Meier survival analysis.Results: We recruited 982 elderly patients, and 728 subjects were in the final analysis (60.7% mal...

Intensive Care Medicine, 2020

Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. ... more Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICUacquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9-27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6-16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score < 19, ICU stay > 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2-1.8), stage II (OR 1.6; 95% CI 1.4-1.9), and stage III or worse (OR 2.8; 95% CI 2.3-3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat.

Journal of Anesthesiology and Clinical Research, 2020

Introduction. In patients suffering from heart disease, pregnancy is a risk factor for mortality.... more Introduction. In patients suffering from heart disease, pregnancy is a risk factor for mortality. Heart disease in pregnant women can be in form of rheumatic heart disease, cardiomyopathy, or congenital heart disease. This case report is about the successful spinal anesthesia technique in cesarean section (C-section) patients with congestive heart failure due to congenital atrial septal defect, and pulmonary hypertension (PH). Case presentation. A pregnant woman, 24 years old, planned to have an emergency C-section. She complained about shortness of breath for 2 days before admission. Three months ago, the patient started to feel shortness of breath during activity and also complained her legs swelled. She has a history of congenital heart i.e. atrial septal defect (ASD), but not routinely been treated. Her examination showed tachypnea, murmur, bibasilar fine crackles lung sound, and pretibial pitting edema. Echocardiography showed ASD with pulmonary hypertension. Spinal Anesthesia ...

International Journal of Applied Pharmaceutics, 2020

Objective: Sepsis remains an unsolved problem in hospitals since its mortality rate is not signif... more Objective: Sepsis remains an unsolved problem in hospitals since its mortality rate is not significantly reduced despite considerable therapy efforts. The most used prognostic tool is the Sepsis-related Organ Function (SOFA) score, which requires several clinical and laboratory examinations; our recent studies also showed that the protein carbonyl level (PCO) has prognostic value in predicting sepsis mortality. Methods: This prospective study was designed to assess the correlation between PCO values and the SOFA score following ethical approval. Adult patients aged>18 y who met the Sepsis-3 definition were included. Exclusion criteria were patients not admitted to the intensive care unit. Dropout criteria included mortality within the 1h bundle protocol. Baseline demographic data and blood collection were measured for all subjects. Subjects were treated with the 1h bundle protocol and observed for 28 d. Results: Fifty-nine subjects were included, with no significant differences i...

The Lancet

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as ind... more Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs. Methods First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assessment (surgical preparedness index; SPI). Second, we measured surgical preparedness across a global network of hospitals in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) to explore the distribution of the SPI at national, subnational, and hospital levels. Finally, using COVID-19 as an example of an external system shock, we compared hospitals' SPI to their planned surgical volume ratio (SVR; ie, operations for which the decision for surgery was made before hospital admission), calculated as the ratio of the observed surgical volume over a 1-month assessment period between June 6 and Aug 5, 2021, against the expected surgical volume based on hospital administrative data from the same period in 2019 (ie, a pre-pandemic baseline). A linear mixed-effects regression model was used to determine the effect of increasing SPI score. Findings In the first phase, from a longlist of 103 candidate indicators, 23 were prioritised as core indicators of elective surgical system preparedness by 69 clinicians (23 [33%] women; 46 [67%] men; 41 from HICs, 22 from MICs, and six from LICs) from 32 countries. The multidomain SPI included 11 indicators on facilities and consumables, two on staffing, two on prioritisation, and eight on systems. Hospitals were scored from 23 (least prepared) to 115 points (most prepared). In the second phase, surgical preparedness was measured in 1632 hospitals by 4714 clinicians from 119 countries. 745 (45•6%) of 1632 hospitals were in MICs or LICs. The mean SPI score was 84•5 (95% CI 84•1-84•9), which varied between HIC (88•5 [89•0-88•0]), MIC (81•8 [82•5-81•1]), and LIC (66•8 [64•9-68•7]) settings. In the third phase, 1217 (74•6%) hospitals did not maintain their expected SVR during the COVID-19 pandemic, of which 625 (51•4%) were from HIC, 538 (44•2%) from MIC, and 54 (4•4%) from LIC settings. In the mixed-effects model, a 10-point increase in SPI corresponded to a 3•6% (95% CI 3•0-4•1; p<0•0001) increase in SVR. This was consistent in HIC (4•8% [4•1-5•5]; p<0•0001), MIC (2•8 [2•0-3•7]; p<0•0001), and LIC (3•8 [1•3-6•7%]; p<0•0001) settings. Interpretation The SPI contains 23 indicators that are globally applicable, relevant across different system stressors, vary at a subnational level, and are collectable by front-line teams. In the case study of COVID-19, a higher SPI was associated with an increased planned surgical volume ratio independent of country income status, COVID-19 burden, and hospital type. Hospitals should perform annual self-assessment of their surgical preparedness to identify areas that can be improved, create resilience in local surgical systems, and upscale capacity to address elective surgery backlogs.

Journal of Clinical Medicine

Background: The COVID-19 pandemic continues to have an impact on geriatric patients worldwide sin... more Background: The COVID-19 pandemic continues to have an impact on geriatric patients worldwide since geriatrics itself is an age group with a high risk due to declined physiological function and many comorbidities, especially for those who undergo surgery. In this study, we determine the association between perioperative factors with 30-day mortality and a survival rate of geriatric patients undergoing surgery during COVID-19 pandemic. Methods: A prospective cohort study was conducted at 14 central hospitals in Indonesia. The recorded variables were perioperative factors, 30-day mortality, and survival rate. Analyses of associations between variables and 30-day mortality were performed using univariate/multivariable logistic regression, and survival rates were determined with Kaplan–Meier survival analysis. Results: We analyzed 1621 elderly patients. The total number of patients who survived within 30 days of observation was 4.3%. Several perioperative factors were associated with 30...

Majalah Anestesia dan Critical Care, Jun 1, 2017

Penyebab utama kematian pada sepsis adalah gagal multipel organ yang berhubungan dengan kerusakan... more Penyebab utama kematian pada sepsis adalah gagal multipel organ yang berhubungan dengan kerusakan glikokaliks endotel. Hyaluronan dan syndecan-1 merupakan komponen glikokaliks yang dapat dijadikan marker kerusakan pada glikokaliks. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar hyaluronan dan syndecan-1 dengan angka mortalitas pada pasien sepsis di ICU. Penelitian ini merupakan penelitian cross sectional observasional analitik pada pasien sepsis yang dirawat di ICU RSUP Dr. Mohammad Hoesin Palembang. Sampel darah dari 22 pasien diambil dan dilakukan pemeriksaan hyaluronan dan syndecan-1 pada hari perawatan pertama dan ketiga. Data ditampilkan secara deskriptif lalu dilakukan analisis uji statistik variabel kontinyu mengggunakan uji T tidak berpasangan, data dikotomi dengan uji chi square untuk menilai korelasi kadar hyaluronan dan syndecan-1 dengan angka mortalitas. Didapatkan rerata kadar hyaluronan dan syndecan-1 pada hari pertama dan ketiga perawatan pasien yang meninggal dalam perawatan 28 hari lebih tinggi dari pasien yang hidup. Namun, secara statistik hanya kadar syndecan-1 hari pertama yang didapatkan perbedaan yang bermakna (p=0,002) dengan korelasi yang sangat kuat (r=0,818) dengan mortalitas. Ada korelasi antara kadar syndecan-1 pada hari pertama perawatan dengan angka mortalitas pada pasien sepsis di ICU.

Terapi cairan merupakan landasan penting dalam merawat pasien kritis di intensive care unit (ICU)... more Terapi cairan merupakan landasan penting dalam merawat pasien kritis di intensive care unit (ICU), termasuk pasien sepsis. Terapi liberal dan goal-directed dianjurkan untuk mencapai tekanan arteri rata-rata lebih dari 65 mmHg pada tahap awal syok. Meskipun demikian, resusitasi cairan berlebihan meningkatkan tekanan hidrostatik mikrovaskular dan dapat menyebabkan akumulasi cairan interstitial. Resusitasi cairan yang memanjang berhubungan dengan kelebihan cairan dan meningkatkan mortalitas. Penelitian ini bertujuan untuk menilai seberapa besar hubungan antara kelebihan cairan dan angka mortalitas. Melalui studi case control, data dikumpulkan secara retrospektif dari Desember 2013 berdasarkan rekam medik di ICU RSUP Dr. Mohammad Hoesin Palembang sampai jumlah sampel tercukupi. Subjek penelitian adalah pasien sepsis berat dan syok septik yang mendapat resusitasi early goal directed therapy. Enam puluh subjek yang memenuhi kriteria yang dibagi menjadi kelompok survivors dan non-urvivors....

JPMA. The Journal of the Pakistan Medical Association, 2021

OBJECTIVE Lactate is a useful prognostic marker, as its level increases in hypoxic tissue and/or ... more OBJECTIVE Lactate is a useful prognostic marker, as its level increases in hypoxic tissue and/or during accelerated aerobic glycolysis due to excessive beta-adrenergic stimulation and decreased lactate clearance. The Surviving Sepsis Campaign Bundle 2018 Update suggested re-measurement of lactate within 2-4 hours so as to conduct/ help/administer /introduce lactate-guided resuscitation to reduce mortality due to sepsis. The aim of this study was to compare initial lactate levels and lactate clearance at 4 h of recognition of sepsis as mortality predictors in sepsis. Methods It was a prospective study performed with ethical approval in a single tertiary care centre. Patients aged 18 years or older who were diagnosed with sepsis by the Sepsis-3 definition were included in the study while patients who were not admitted to the ICU were excluded Dropout criteria was death of pateints within 4 hours of recognition of sepsis. Baseline demographic data was obtained and subjects were treated...

Background As life expectancy increases, the worldwide population aged 60 years and older increas... more Background As life expectancy increases, the worldwide population aged 60 years and older increases year by year. Consequently, more older people receive medical attention, especially those who undergo surgery. In addition, the COVID-19 pandemic has had a global impact on elderly patients, especially those undergoing surgery. This study aims to describe the characteristics and analyze the survival rate of elderly patients who receive anesthesia services, especially those with comorbidities and COVID-19. Methods A prospective cohort study at 14 central hospitals in Indonesia analyzed 1621 elderly patients (67.1 ± 6.2 years old). The variables that were recorded included patient characteristics, comorbidities, the COVID-19 status, and the survival rate, including 30-day mortality. Results The 30-day mortality was 4.4%. The most comorbidity was hypertension (30.0). Patients with a Charlson's Comorbidity Index Score of 3-4 had a higher death rate (15.3%). The highest mortality rates...

Ventilator-associated pneumonia (VAP) adalah infeksi nosokomial tersering di ruang Intensive Care... more Ventilator-associated pneumonia (VAP) adalah infeksi nosokomial tersering di ruang Intensive Care Unit (ICU) RSUP Dr. Moh. Hoesin (RSMH) Palembang, angka kejadiannya pada bulan Juli 2011–Juni 2012 cukup tinggi (31,69%) dengan angka mortalitas 54,7%. Mekanisme utama dalam patogenesis VAP ialah aspirasi bakteri gram positif dan negatif patogenik yang berkoloni di daerah orofaring. Tindakan modulasi kolonisasi tersebut sangat bermakna dalam mencegah VAP. Pemberian povidon iodin 1% dan klorheksidin 0,2% sudah sering dilakukan namun belum ada penelitian mengenai hubungannya terhadap kejadian VAP. Penelitian ini bertujuan untuk mengetahui hubungan antara klorheksidin 0,2% dan povidoneiodine 1% terhadap kejadian VAP. Studi kohort telah dilakukan di ICU RSMH pada bulan Februari – Juli 2014. Terdapat 32 subjek penelitian yang memenuhi kriteria inklusi dan dibagi menjadi dua kelompok, yaitu yang mendapatkan klorheksidin 0,2% dan povidoneiodine 1%. Dilakukan uji χ2 menggunakan statistical prog...

Background: With the more advanced science in the field of medicine and disease management, the p... more Background: With the more advanced science in the field of medicine and disease management, the population of geriatric intensive care patients is increasing. The COVID-19 pandemic has impacted healthcare management around the globe, especially on critically-ill elderly patients. We aim to analyse the relationship between underlying illnesses, including COVID-19, and the survival rate of elderly patients who are treated in the intensive care setting.Methods: We conducted a prospective cohort study at 14 teaching hospitals for Anaesthesiology and Intensive Therapy Education in Indonesia. We selected all subjects with 60 years of age or older in the period between February to May 2021. Variables recorded included subject characteristics, comorbidities, and COVID-19 status. Subjects were followed for 30-day mortality as an outcome. We analysed the data using Kaplan-Meier survival analysis.Results: We recruited 982 elderly patients, and 728 subjects were in the final analysis (60.7% mal...

Intensive Care Medicine, 2020

Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. ... more Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICUacquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9-27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6-16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score < 19, ICU stay > 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2-1.8), stage II (OR 1.6; 95% CI 1.4-1.9), and stage III or worse (OR 2.8; 95% CI 2.3-3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat.

Journal of Anesthesiology and Clinical Research, 2020

Introduction. In patients suffering from heart disease, pregnancy is a risk factor for mortality.... more Introduction. In patients suffering from heart disease, pregnancy is a risk factor for mortality. Heart disease in pregnant women can be in form of rheumatic heart disease, cardiomyopathy, or congenital heart disease. This case report is about the successful spinal anesthesia technique in cesarean section (C-section) patients with congestive heart failure due to congenital atrial septal defect, and pulmonary hypertension (PH). Case presentation. A pregnant woman, 24 years old, planned to have an emergency C-section. She complained about shortness of breath for 2 days before admission. Three months ago, the patient started to feel shortness of breath during activity and also complained her legs swelled. She has a history of congenital heart i.e. atrial septal defect (ASD), but not routinely been treated. Her examination showed tachypnea, murmur, bibasilar fine crackles lung sound, and pretibial pitting edema. Echocardiography showed ASD with pulmonary hypertension. Spinal Anesthesia ...

International Journal of Applied Pharmaceutics, 2020

Objective: Sepsis remains an unsolved problem in hospitals since its mortality rate is not signif... more Objective: Sepsis remains an unsolved problem in hospitals since its mortality rate is not significantly reduced despite considerable therapy efforts. The most used prognostic tool is the Sepsis-related Organ Function (SOFA) score, which requires several clinical and laboratory examinations; our recent studies also showed that the protein carbonyl level (PCO) has prognostic value in predicting sepsis mortality. Methods: This prospective study was designed to assess the correlation between PCO values and the SOFA score following ethical approval. Adult patients aged>18 y who met the Sepsis-3 definition were included. Exclusion criteria were patients not admitted to the intensive care unit. Dropout criteria included mortality within the 1h bundle protocol. Baseline demographic data and blood collection were measured for all subjects. Subjects were treated with the 1h bundle protocol and observed for 28 d. Results: Fifty-nine subjects were included, with no significant differences i...