Linda Mayes - Academia.edu (original) (raw)

Papers by Linda Mayes

Research paper thumbnail of Romantic attraction and conflict negotiation among late adolescent and early adult romantic couples

Journal of Adolescence, 2008

In a sample of 35 couples (college students, aged 18-24) who were dating for no longer than six m... more In a sample of 35 couples (college students, aged 18-24) who were dating for no longer than six months, each partner was given a semi-structured interview to assess the nature and intensity of romantic preoccupation with his or her lover. In addition, partners were jointly given a revealed differences task in which they were asked to discuss the issue of their highest disagreement and to arrive at an agreement. Findings suggested that higher levels of romantic preoccupation are related to partners' inclination to downplay their disagreement and to negotiate their differences less successfully. The same assessment six weeks later showed that where levels of romantic preoccupation among romantic partners stayed stable, the partners showed an increasing capability to recognize and face their disagreements and even a tendency to better negotiate disagreements started to emerge. Findings of this study suggest that two processes operate within a bond between romantic partners. The first process refers to the attraction or preoccupation between partners and the second refers to the quality of conflict negotiation that evolves over time. Where at the initial stage of a romantic bond the attraction process overshadows partners' ability to acknowledge and deal with differences, the two processes develop differently over time.

Research paper thumbnail of Play it again: neural responses to reunion with excluders predicted by attachment patterns,

Reunion behavior following stressful separations from caregivers is often considered the single m... more Reunion behavior following stressful separations from caregivers is often considered the single most sensitive clue to infant attachment patterns. Extending these ideas to middle childhood/early adolescence, we examined participants' neural responses to reunion with peers who had previously excluded them. We recorded event-related potentials among nineteen 11- to 15-year-old youth previously classified on attachment interviews (11 secure and 8 insecure-dismissing) while they played a virtual ball-toss game (Cyberball) with peers that involved fair play, exclusion and reunion phases. Compared to secure participants, dismissing participants displayed a greater increment in the N2 during reunion relative to fair play, a neural marker commonly linked to expectancy violation. These data suggest a greater tendency toward continued expectations of rejection among dismissing children, even after cessation of social exclusion. In turn, the link between self-reported ostracism distress and neural signs of negative expectancy at reunion was moderated by attachment, such that self-reports were discordant with the neural index of expectancy violation for dismissing, but not for secure children.

A video abstract of this article can be viewed at http://www.youtube.com/watch?v=qzoRel5c-4s.

Research paper thumbnail of Social exclusion modulates event-related frontal theta and tracks ostracism distress in children

NeuroImage, Jan 3, 2015

Social exclusion is a potent elicitor of distress. Previous studies have shown that medial fronta... more Social exclusion is a potent elicitor of distress. Previous studies have shown that medial frontal theta oscillations are modulated by the experience of social exclusion. Using the Cyberball paradigm, we examined event-related dynamics of theta power in the EEG at medial frontal sites while children aged 8-12 years were exposed to conditions of fair play and social exclusion. Using an event-related design, we found that medial frontal theta oscillations (4-8Hz) increase during both early (i.e., 200-400ms) and late (i.e., 400-800ms) processing of rejection events during social exclusion relative to perceptually identical "not my turn" events during inclusion. Importantly, we show that only for the later time window (400-800ms) slow-wave theta power tracks self-reported ostracism distress. Specifically, greater theta power at medial frontal sites to "rejection" events predicted higher levels of ostracism distress. Alpha and beta oscillations for rejection events we...

Research paper thumbnail of Kin rejection: social signals, neural response and perceived distress during social exclusion

Developmental Science, 2014

Across species, kin bond together to promote survival. We sought to understand the dyadic effect ... more Across species, kin bond together to promote survival. We sought to understand the dyadic effect of exclusion by kin (as opposed to non-kin strangers) on brain activity of the mother and her child and their subjective distress. To this end, we probed mother-child relationships with a computerized ball-toss game Cyberball. When excluded by one another, rather than by a stranger, both mothers and children exhibited a significantly pronounced frontal P2. Moreover, upon kin rejection versus stranger rejection, both mothers and children showed incremented left frontal positive slow waves for rejection events. Children reported more distress upon exclusion than their own mothers. Similar to past work, relatively augmented negative frontal slow wave activity predicted greater self-reported ostracism distress. This effect, generalized to the P2, was limited to mother- or child-rejection by kin, with comparable magnitude of effect across kin identity (mothers vs. children). For both mothers and children, the frontal P2 peak was significantly pronounced for kin rejection versus stranger rejection. Taken together, our results document the rapid categorization of social signals as kin relevant and the specificity of early and late neural markers for predicting felt ostracism.

Research paper thumbnail of An exploratory examination of marijuana use, problem-gambling severity, and health correlates among adolescents

Journal of behavioral addictions, 2014

Background and aims: Gambling is common in adolescents and at-risk and problem/pathological gambl... more Background and aims: Gambling is common in adolescents and at-risk and problem/pathological gambling (ARPG) is associated with adverse measures of health and functioning in this population. Although ARPG commonly co-occurs with marijuana use, little is known how marijuana use influences the relationship between problem-gambling severity and health-and gambling-related measures. Methods: Survey data from 2,252 Connecticut high school students were analyzed using chi-square and logistic regression analyses. Results: ARPG was found more frequently in adolescents with lifetime marijuana use than in adolescents denying marijuana use. Marijuana use was associated with more severe and a higher frequency of gambling-related behaviors and different motivations for gambling. Multiple health/functioning impairments were differentially associated with problem-gambling severity amongst adolescents with and without marijuana use. Significant marijuana-use-by-problem-gambling-severity-group interactions were observed for low-average grades (OR = 0.39, 95% CI = [0.20, 0.77]), cigarette smoking (OR = 0.38, 95% CI = [0.17, 0.83]), current alcohol use (OR = 0.36, 95% CI = [0.14, 0.91]), and gambling with friends (OR = 0.47, 95% CI = [0.28, 0.77]). In all cases, weaker associations between problem-gambling severity and health/functioning correlates were observed in the marijuana-use group as compared to the marijuana-non-use group. Conclusions: Some academic, substance use, and social factors related to problem-gambling severity may be partially accounted for by a relationship with marijuana use. Identifying specific factors that underlie the relationships between specific attitudes and behaviors with gambling problems and marijuana use may help improve intervention strategies.

Research paper thumbnail of Reward feedback processing in children and adolescents: medial frontal theta oscillations

Brain and cognition, 2014

We examined event-related electroencephalography (EEG) oscillations, including event-related spec... more We examined event-related electroencephalography (EEG) oscillations, including event-related spectral perturbations (ERSP) and intertrial coherence (ITC), to compare feedback processing during a chance-based reward vs. non-reward task in groups of 10-12-year-old (n=42), 13-14-year-old (n=34) and 15-17-year-olds (n=32). Because few, if any studies have applied these analytic methods to examine feedback processing in children or adolescents, we used a fine-grained approach that explored one half hertz by 16ms increments during feedback (no win vs. win events) in the theta (4-8Hz) frequency band. Complex wavelet frequency decomposition revealed that no win feedback was associated with enhanced theta power and phase coherence. We observed condition and age-based differences for both ERSP and ITC, with stronger effects for ITC. The transition from childhood to early adolescence (13-14yrs.) was a point of increased differentiation of ITC favoring no win vs. wins feedback and also compared to children or older adolescents, a point of heightened ITC for no win feedback (quadratic effect).

Research paper thumbnail of Event-related potentials in cocaine-exposed children during a Stroop task

Neurotoxicology and teratology

Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functi... more Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

Research paper thumbnail of Blunted feedback processing during risk-taking in adolescents with features of problematic Internet use

Addictive behaviors, Jan 20, 2015

While the conceptualization of problematic Internet use (PIU) as a &a... more While the conceptualization of problematic Internet use (PIU) as a "behavioral addiction" resembling substance-use disorders is debated, the neurobiological underpinnings of PIU remain understudied. This study examined whether adolescents displaying features of PIU (at-risk PIU; ARPIU) are more impulsive and exhibit blunted responding in the neural mechanisms underlying feedback processing and outcome evaluation during risk-taking. Event-related potentials (ERPs) elicited by positive (i.e. reward) and negative (i.e. loss) feedback were recorded during performance on a modified version of the Balloon Analogue Risk Task (BART) among ARPIU (n=39) and non-ARPIU subjects (n=27). Compared to non-ARPIU, ARPIU adolescents displayed higher levels of urgency and lack of perseverance on the UPPS Impulsive Behavior Scale. Although no between-group difference in BART performance was observed, ERPs demonstrated overall decreased sensitivity to feedback in ARPIU compared to non-ARPIU adolescents, as indexed by blunted feedback-related negativity (FRN) and P300 amplitudes to both negative and positive feedback. The present study provides evidence for feedback processing during risk-taking as a neural correlate of ARPIU. Given recent concerns regarding the growing prevalence of PIU as a health concern, future work should examine the extent to which feedback processing may represent a risk factor for PIU, a consequence of PIU, or possibly both.

Research paper thumbnail of Language Abilities of Preschool-Age Children Living with Cocaine-Using Mothers

American Journal on Addictions, 1994

Research paper thumbnail of Differentiating pervasive developmental disorder not otherwise specified from autism and language disorders

Journal of Autism and Developmental Disorders, 1993

Features useful in distinguishing choldren with pervasive developmental disorder (PDD) from those... more Features useful in distinguishing choldren with pervasive developmental disorder (PDD) from those with autism or language disorder were developed from a retrospective chart review using groups of children with PDD-NOS and MA-and sex-matched autistic and language-disordered groups. Charts were reviewed using a list of 80 items compiled from various sources. Items that had adequate interrater reliability and significantly discriminated the PDD-NOS cases from the language-disordered or autistic cases were then evaluated using a second set of cases and signal detection methods. Fewer items significantly discriminated cases with autism from those with PDD-NOS as compared to cases with language disorder. Clinical implications are discussed.

Research paper thumbnail of Implementation of False Discovery Rate for Exploring Novel Paradigms and Trait Dimensions With ERPs

Developmental Neuropsychology, 2012

False discovery rate (FDR) is a multiple comparison procedure that targets the expected proportio... more False discovery rate (FDR) is a multiple comparison procedure that targets the expected proportion of false discoveries among the discoveries. Employing FDR methods in event-related potential (ERP) research provides an approach to explore new ERP paradigms and ERP-psychological trait/behavior relations. In Study 1, we examined neural responses to escape behavior from an aversive noise. In Study 2, we correlated a relatively unexplored trait dimension, ostracism, with neural response. In both situations we focused on the frontal cortical region, applying a channel by time plots to display statistically significant uncorrected data and FDR corrected data, controlling for multiple comparisons.

Research paper thumbnail of Investigating the impact of parental status and depression symptoms on the early perceptual coding of infant faces: An event-related potential study

Social Neuroscience, 2012

Infant faces are highly salient social stimuli that appear to elicit intuitive parenting behavior... more Infant faces are highly salient social stimuli that appear to elicit intuitive parenting behaviors in healthy adult women. Behavioral and observational studies indicate that this effect may be modulated by experiences of reproduction, caregiving, and psychiatric symptomatology that affect normative attention and reward processing of infant cues. However, relatively little is known about the neural correlates of these effects. Using the event-related potential (ERP) technique, this study investigated the impact of parental status (mother, non-mother) and depression symptoms on early visual processing of infant faces in a community sample of adult women. Specifically, the P1 and N170 ERP components elicited in response to infant face stimuli were examined. While characteristics of the N170 were not modulated by parental status, a statistically significant positive correlation was observed between depression symptom severity and N170 amplitude. This relationship was not observed for the P1. These results suggest that depression symptoms may modulate early neurophysiological responsiveness to infant cues, even at sub-clinical levels.

Research paper thumbnail of Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice

Neuron, Jan 8, 2014

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalit... more Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause. Hdc knockout mice exhibited potentiated tic-like stereotypies, recapitulating core phenomenology of TS; these were mitigated by the dopamine (DA) D2 antagonist haloperidol, a proven pharmacotherapy, and by HA infusion into the brain. Prepulse inhibition was impaired in both mice and humans carrying Hdc mutations. HA infusion reduced striatal DA levels; in Hdc knockout mice, striatal DA was increased and the DA-regulated immediate early gene Fos was upregulated. DA D2/D3 receptor binding was altered both in mice and in humans carrying the Hdc mutation. These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology.

Research paper thumbnail of The development of associate learning in school age children

PloS one, 2014

Associate learning is fundamental to the acquisition of knowledge and plays a critical role in th... more Associate learning is fundamental to the acquisition of knowledge and plays a critical role in the everyday functioning of the developing child, though the developmental course is still unclear. This study investigated the development of visual associate learning in 125 school age children using the Continuous Paired Associate Learning task. As hypothesized, younger children made more errors than older children across all memory loads and evidenced decreased learning efficiency as memory load increased. Results suggest that age-related differences in performance largely reflect continued development of executive function in the context of relatively developed memory processes.

Research paper thumbnail of Adolescent Balloon Analog Risk Task and Behaviors that Influence Risk of Motor Vehicle Crash Injury

Annals of advances in automotive medicine / Annual Scientific Conference ... Association for the Advancement of Automotive Medicine. Association for the Advancement of Automotive Medicine. Scientific Conference, 2013

Risk-taking propensity is a pivotal facet of motor vehicle crash involvement and subsequent traum... more Risk-taking propensity is a pivotal facet of motor vehicle crash involvement and subsequent traumatic injury in adolescents. Clinical encounters are important opportunities to identify teens with high risk-taking propensity who may later experience serious injury. Our objective was to compare self-reports of health risk behavior with performance on the Balloon Analog Risk Task (BART), a validated metric of risk-taking propensity, in adolescents during a clinical encounter. 100 adolescent patients from a hospital emergency department and adolescent health clinic completed a computer-based survey of self-reported risk behaviors including substance use behaviors and behaviors that influence crash involvement. They then completed the BART, a validated laboratory-based risk task in which participants earn points by pumping up a computer-generated balloon with greater pumps leading to increased chance of balloon explosion. 20 trials were undertaken. Mean number of pumps on the BART showed a correlation of .243 (p=.015) with self-reported driver/passenger behaviors and attitudes towards driving that influence risk of crash injury. Regression analyses showed that self-reports of substance use and mean number of pumps on the BART uniquely predict self-reports of behaviors influencing the risk of crash injury. The BART is a promising correlate of real-world risk-taking behavior related to traffic safety. It remains a valid predictor of behaviors influencing risk of crash injury when using just 10 trials, suggesting its utility as a quick and effective screening measure for use in busy clinical environments. This tool may be an important link to prevention interventions for those most at-risk for future motor vehicle crash involvement and injury.

Research paper thumbnail of Social exclusion in middle childhood: Rejection events, slow-wave neural activity, and ostracism distress

Social Neuroscience, 2010

This study examined neural activity with event-related potentials (ERPs) in middle childhood duri... more This study examined neural activity with event-related potentials (ERPs) in middle childhood during a computer-simulated ball-toss game, Cyberball. After experiencing fair play initially, children were ultimately excluded by the other players. We focused specifically on “not my turn” events within fair play and rejection events within social exclusion. Dense-array ERPs revealed that rejection events are perceived rapidly. Condition differences (“not my turn” vs. rejection) were evident in a posterior ERP peaking at 420 ms consistent, with a larger P3 effect for rejection events indicating that in middle childhood rejection events are differentiated in <500 ms. Condition differences were evident for slow-wave activity (500-900 ms) in the medial frontal cortical region and the posterior occipital-parietal region, with rejection events more negative frontally and more positive posteriorly. Distress from the rejection experience was associated with a more negative frontal slow wave and a larger late positive slow wave, but only for rejection events. Source modeling with Geosouce software suggested that slow-wave neural activity in cortical regions previously identified in functional imaging studies of ostracism, including subgenual cortex, ventral anterior cingulate cortex, and insula, was greater for rejection events vs. “not my turn” events.

Research paper thumbnail of The Development of Mentalisation in Children From a Theory of Mind Perspective

Psychoanalytic Inquiry, 2010

For psychoanalysts, a key developmental question is how children&... more For psychoanalysts, a key developmental question is how children's mentalisation capacities develop, that is, how they come to understand the feelings and intentions of others, as well as themselves, and how that understanding is integrated over the course of development into their feelings for and expectations of others. Broadly stated, this question has been the subject of productive lines of

Research paper thumbnail of Effects of trauma and PTSD on parenting in mothers with preschool age children

Comprehensive Psychiatry, 2011

Research paper thumbnail of Prenatal Cocaine Exposure and Young Children's Development

Annals of The American Academy of Political and Social Science - ANN AMER ACAD POLIT SOC SCI, 1992

... nant Ewe and Fetus," American Journal of Obstetrics and Gynecology, 155:883-88 (1986... more ... nant Ewe and Fetus," American Journal of Obstetrics and Gynecology, 155:883-88 (1986); James R. Woods, Mark A. Plessinger, and Ken-neth E ... Infants Exposed to Cocaine In Utero," Journal of Pediatrics, 117:627-29 (1990); L. Shih, B. Cone-Wesson, and B. Reddix, "Effects of ...

Research paper thumbnail of The Practice of Psychoanalytic Parent-Infant Psychotherapy: Claiming the Baby

Journal of the American Academy of Child & Adolescent Psychiatry, 2006

... by Dilys Daws, Tavistock Clinic, Allan N Schore. ... theory of parent-infant psychotherapy In... more ... by Dilys Daws, Tavistock Clinic, Allan N Schore. ... theory of parent-infant psychotherapy Introduction ANGELA JOYCE 1 The parent-infant relationship and infant mental health ANGELA JOYCE 2 The theory of psychoanalytic parent-infant psychotherapy TESSA BARADON AND ...

Research paper thumbnail of Romantic attraction and conflict negotiation among late adolescent and early adult romantic couples

Journal of Adolescence, 2008

In a sample of 35 couples (college students, aged 18-24) who were dating for no longer than six m... more In a sample of 35 couples (college students, aged 18-24) who were dating for no longer than six months, each partner was given a semi-structured interview to assess the nature and intensity of romantic preoccupation with his or her lover. In addition, partners were jointly given a revealed differences task in which they were asked to discuss the issue of their highest disagreement and to arrive at an agreement. Findings suggested that higher levels of romantic preoccupation are related to partners' inclination to downplay their disagreement and to negotiate their differences less successfully. The same assessment six weeks later showed that where levels of romantic preoccupation among romantic partners stayed stable, the partners showed an increasing capability to recognize and face their disagreements and even a tendency to better negotiate disagreements started to emerge. Findings of this study suggest that two processes operate within a bond between romantic partners. The first process refers to the attraction or preoccupation between partners and the second refers to the quality of conflict negotiation that evolves over time. Where at the initial stage of a romantic bond the attraction process overshadows partners' ability to acknowledge and deal with differences, the two processes develop differently over time.

Research paper thumbnail of Play it again: neural responses to reunion with excluders predicted by attachment patterns,

Reunion behavior following stressful separations from caregivers is often considered the single m... more Reunion behavior following stressful separations from caregivers is often considered the single most sensitive clue to infant attachment patterns. Extending these ideas to middle childhood/early adolescence, we examined participants' neural responses to reunion with peers who had previously excluded them. We recorded event-related potentials among nineteen 11- to 15-year-old youth previously classified on attachment interviews (11 secure and 8 insecure-dismissing) while they played a virtual ball-toss game (Cyberball) with peers that involved fair play, exclusion and reunion phases. Compared to secure participants, dismissing participants displayed a greater increment in the N2 during reunion relative to fair play, a neural marker commonly linked to expectancy violation. These data suggest a greater tendency toward continued expectations of rejection among dismissing children, even after cessation of social exclusion. In turn, the link between self-reported ostracism distress and neural signs of negative expectancy at reunion was moderated by attachment, such that self-reports were discordant with the neural index of expectancy violation for dismissing, but not for secure children.

A video abstract of this article can be viewed at http://www.youtube.com/watch?v=qzoRel5c-4s.

Research paper thumbnail of Social exclusion modulates event-related frontal theta and tracks ostracism distress in children

NeuroImage, Jan 3, 2015

Social exclusion is a potent elicitor of distress. Previous studies have shown that medial fronta... more Social exclusion is a potent elicitor of distress. Previous studies have shown that medial frontal theta oscillations are modulated by the experience of social exclusion. Using the Cyberball paradigm, we examined event-related dynamics of theta power in the EEG at medial frontal sites while children aged 8-12 years were exposed to conditions of fair play and social exclusion. Using an event-related design, we found that medial frontal theta oscillations (4-8Hz) increase during both early (i.e., 200-400ms) and late (i.e., 400-800ms) processing of rejection events during social exclusion relative to perceptually identical "not my turn" events during inclusion. Importantly, we show that only for the later time window (400-800ms) slow-wave theta power tracks self-reported ostracism distress. Specifically, greater theta power at medial frontal sites to "rejection" events predicted higher levels of ostracism distress. Alpha and beta oscillations for rejection events we...

Research paper thumbnail of Kin rejection: social signals, neural response and perceived distress during social exclusion

Developmental Science, 2014

Across species, kin bond together to promote survival. We sought to understand the dyadic effect ... more Across species, kin bond together to promote survival. We sought to understand the dyadic effect of exclusion by kin (as opposed to non-kin strangers) on brain activity of the mother and her child and their subjective distress. To this end, we probed mother-child relationships with a computerized ball-toss game Cyberball. When excluded by one another, rather than by a stranger, both mothers and children exhibited a significantly pronounced frontal P2. Moreover, upon kin rejection versus stranger rejection, both mothers and children showed incremented left frontal positive slow waves for rejection events. Children reported more distress upon exclusion than their own mothers. Similar to past work, relatively augmented negative frontal slow wave activity predicted greater self-reported ostracism distress. This effect, generalized to the P2, was limited to mother- or child-rejection by kin, with comparable magnitude of effect across kin identity (mothers vs. children). For both mothers and children, the frontal P2 peak was significantly pronounced for kin rejection versus stranger rejection. Taken together, our results document the rapid categorization of social signals as kin relevant and the specificity of early and late neural markers for predicting felt ostracism.

Research paper thumbnail of An exploratory examination of marijuana use, problem-gambling severity, and health correlates among adolescents

Journal of behavioral addictions, 2014

Background and aims: Gambling is common in adolescents and at-risk and problem/pathological gambl... more Background and aims: Gambling is common in adolescents and at-risk and problem/pathological gambling (ARPG) is associated with adverse measures of health and functioning in this population. Although ARPG commonly co-occurs with marijuana use, little is known how marijuana use influences the relationship between problem-gambling severity and health-and gambling-related measures. Methods: Survey data from 2,252 Connecticut high school students were analyzed using chi-square and logistic regression analyses. Results: ARPG was found more frequently in adolescents with lifetime marijuana use than in adolescents denying marijuana use. Marijuana use was associated with more severe and a higher frequency of gambling-related behaviors and different motivations for gambling. Multiple health/functioning impairments were differentially associated with problem-gambling severity amongst adolescents with and without marijuana use. Significant marijuana-use-by-problem-gambling-severity-group interactions were observed for low-average grades (OR = 0.39, 95% CI = [0.20, 0.77]), cigarette smoking (OR = 0.38, 95% CI = [0.17, 0.83]), current alcohol use (OR = 0.36, 95% CI = [0.14, 0.91]), and gambling with friends (OR = 0.47, 95% CI = [0.28, 0.77]). In all cases, weaker associations between problem-gambling severity and health/functioning correlates were observed in the marijuana-use group as compared to the marijuana-non-use group. Conclusions: Some academic, substance use, and social factors related to problem-gambling severity may be partially accounted for by a relationship with marijuana use. Identifying specific factors that underlie the relationships between specific attitudes and behaviors with gambling problems and marijuana use may help improve intervention strategies.

Research paper thumbnail of Reward feedback processing in children and adolescents: medial frontal theta oscillations

Brain and cognition, 2014

We examined event-related electroencephalography (EEG) oscillations, including event-related spec... more We examined event-related electroencephalography (EEG) oscillations, including event-related spectral perturbations (ERSP) and intertrial coherence (ITC), to compare feedback processing during a chance-based reward vs. non-reward task in groups of 10-12-year-old (n=42), 13-14-year-old (n=34) and 15-17-year-olds (n=32). Because few, if any studies have applied these analytic methods to examine feedback processing in children or adolescents, we used a fine-grained approach that explored one half hertz by 16ms increments during feedback (no win vs. win events) in the theta (4-8Hz) frequency band. Complex wavelet frequency decomposition revealed that no win feedback was associated with enhanced theta power and phase coherence. We observed condition and age-based differences for both ERSP and ITC, with stronger effects for ITC. The transition from childhood to early adolescence (13-14yrs.) was a point of increased differentiation of ITC favoring no win vs. wins feedback and also compared to children or older adolescents, a point of heightened ITC for no win feedback (quadratic effect).

Research paper thumbnail of Event-related potentials in cocaine-exposed children during a Stroop task

Neurotoxicology and teratology

Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functi... more Prenatal cocaine-exposure may interfere with the ontogeny of prefrontal cortical executive functions due to cocaine's effect on the developing monoaminergic system. This study presents findings regarding cortical functioning in 29 prenatally cocaine-exposed (CE) and non-drug-exposed (NDE) 7- to 9-year-old children participating in event related potential (ERP) studies. ERPs were recorded using 128-electrode high-density arrays while children responded to a standard Stroop paradigm. In the Stroop paradigm, CE children generated prolonged responses to the words while the NDE children produced briefer responses. Effects were noted in the region of the initial positive peak (P1), the second negative peak (N2) and the later positive peak (P3). Early cocaine exposure may inhibit the specialization and streamlining of brain region involvement during cognitive processing such that task processing is slower to begin, requires more diverse cortical involvement, and requires more time to complete. ERP methodology has considerable potential for studying frontal maturation and may provide additional information to clarify generally the specific effects of prenatal CE on cortical functioning and the developmental course of cognitive functions.

Research paper thumbnail of Blunted feedback processing during risk-taking in adolescents with features of problematic Internet use

Addictive behaviors, Jan 20, 2015

While the conceptualization of problematic Internet use (PIU) as a &a... more While the conceptualization of problematic Internet use (PIU) as a "behavioral addiction" resembling substance-use disorders is debated, the neurobiological underpinnings of PIU remain understudied. This study examined whether adolescents displaying features of PIU (at-risk PIU; ARPIU) are more impulsive and exhibit blunted responding in the neural mechanisms underlying feedback processing and outcome evaluation during risk-taking. Event-related potentials (ERPs) elicited by positive (i.e. reward) and negative (i.e. loss) feedback were recorded during performance on a modified version of the Balloon Analogue Risk Task (BART) among ARPIU (n=39) and non-ARPIU subjects (n=27). Compared to non-ARPIU, ARPIU adolescents displayed higher levels of urgency and lack of perseverance on the UPPS Impulsive Behavior Scale. Although no between-group difference in BART performance was observed, ERPs demonstrated overall decreased sensitivity to feedback in ARPIU compared to non-ARPIU adolescents, as indexed by blunted feedback-related negativity (FRN) and P300 amplitudes to both negative and positive feedback. The present study provides evidence for feedback processing during risk-taking as a neural correlate of ARPIU. Given recent concerns regarding the growing prevalence of PIU as a health concern, future work should examine the extent to which feedback processing may represent a risk factor for PIU, a consequence of PIU, or possibly both.

Research paper thumbnail of Language Abilities of Preschool-Age Children Living with Cocaine-Using Mothers

American Journal on Addictions, 1994

Research paper thumbnail of Differentiating pervasive developmental disorder not otherwise specified from autism and language disorders

Journal of Autism and Developmental Disorders, 1993

Features useful in distinguishing choldren with pervasive developmental disorder (PDD) from those... more Features useful in distinguishing choldren with pervasive developmental disorder (PDD) from those with autism or language disorder were developed from a retrospective chart review using groups of children with PDD-NOS and MA-and sex-matched autistic and language-disordered groups. Charts were reviewed using a list of 80 items compiled from various sources. Items that had adequate interrater reliability and significantly discriminated the PDD-NOS cases from the language-disordered or autistic cases were then evaluated using a second set of cases and signal detection methods. Fewer items significantly discriminated cases with autism from those with PDD-NOS as compared to cases with language disorder. Clinical implications are discussed.

Research paper thumbnail of Implementation of False Discovery Rate for Exploring Novel Paradigms and Trait Dimensions With ERPs

Developmental Neuropsychology, 2012

False discovery rate (FDR) is a multiple comparison procedure that targets the expected proportio... more False discovery rate (FDR) is a multiple comparison procedure that targets the expected proportion of false discoveries among the discoveries. Employing FDR methods in event-related potential (ERP) research provides an approach to explore new ERP paradigms and ERP-psychological trait/behavior relations. In Study 1, we examined neural responses to escape behavior from an aversive noise. In Study 2, we correlated a relatively unexplored trait dimension, ostracism, with neural response. In both situations we focused on the frontal cortical region, applying a channel by time plots to display statistically significant uncorrected data and FDR corrected data, controlling for multiple comparisons.

Research paper thumbnail of Investigating the impact of parental status and depression symptoms on the early perceptual coding of infant faces: An event-related potential study

Social Neuroscience, 2012

Infant faces are highly salient social stimuli that appear to elicit intuitive parenting behavior... more Infant faces are highly salient social stimuli that appear to elicit intuitive parenting behaviors in healthy adult women. Behavioral and observational studies indicate that this effect may be modulated by experiences of reproduction, caregiving, and psychiatric symptomatology that affect normative attention and reward processing of infant cues. However, relatively little is known about the neural correlates of these effects. Using the event-related potential (ERP) technique, this study investigated the impact of parental status (mother, non-mother) and depression symptoms on early visual processing of infant faces in a community sample of adult women. Specifically, the P1 and N170 ERP components elicited in response to infant face stimuli were examined. While characteristics of the N170 were not modulated by parental status, a statistically significant positive correlation was observed between depression symptom severity and N170 amplitude. This relationship was not observed for the P1. These results suggest that depression symptoms may modulate early neurophysiological responsiveness to infant cues, even at sub-clinical levels.

Research paper thumbnail of Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice

Neuron, Jan 8, 2014

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalit... more Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause. Hdc knockout mice exhibited potentiated tic-like stereotypies, recapitulating core phenomenology of TS; these were mitigated by the dopamine (DA) D2 antagonist haloperidol, a proven pharmacotherapy, and by HA infusion into the brain. Prepulse inhibition was impaired in both mice and humans carrying Hdc mutations. HA infusion reduced striatal DA levels; in Hdc knockout mice, striatal DA was increased and the DA-regulated immediate early gene Fos was upregulated. DA D2/D3 receptor binding was altered both in mice and in humans carrying the Hdc mutation. These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology.

Research paper thumbnail of The development of associate learning in school age children

PloS one, 2014

Associate learning is fundamental to the acquisition of knowledge and plays a critical role in th... more Associate learning is fundamental to the acquisition of knowledge and plays a critical role in the everyday functioning of the developing child, though the developmental course is still unclear. This study investigated the development of visual associate learning in 125 school age children using the Continuous Paired Associate Learning task. As hypothesized, younger children made more errors than older children across all memory loads and evidenced decreased learning efficiency as memory load increased. Results suggest that age-related differences in performance largely reflect continued development of executive function in the context of relatively developed memory processes.

Research paper thumbnail of Adolescent Balloon Analog Risk Task and Behaviors that Influence Risk of Motor Vehicle Crash Injury

Annals of advances in automotive medicine / Annual Scientific Conference ... Association for the Advancement of Automotive Medicine. Association for the Advancement of Automotive Medicine. Scientific Conference, 2013

Risk-taking propensity is a pivotal facet of motor vehicle crash involvement and subsequent traum... more Risk-taking propensity is a pivotal facet of motor vehicle crash involvement and subsequent traumatic injury in adolescents. Clinical encounters are important opportunities to identify teens with high risk-taking propensity who may later experience serious injury. Our objective was to compare self-reports of health risk behavior with performance on the Balloon Analog Risk Task (BART), a validated metric of risk-taking propensity, in adolescents during a clinical encounter. 100 adolescent patients from a hospital emergency department and adolescent health clinic completed a computer-based survey of self-reported risk behaviors including substance use behaviors and behaviors that influence crash involvement. They then completed the BART, a validated laboratory-based risk task in which participants earn points by pumping up a computer-generated balloon with greater pumps leading to increased chance of balloon explosion. 20 trials were undertaken. Mean number of pumps on the BART showed a correlation of .243 (p=.015) with self-reported driver/passenger behaviors and attitudes towards driving that influence risk of crash injury. Regression analyses showed that self-reports of substance use and mean number of pumps on the BART uniquely predict self-reports of behaviors influencing the risk of crash injury. The BART is a promising correlate of real-world risk-taking behavior related to traffic safety. It remains a valid predictor of behaviors influencing risk of crash injury when using just 10 trials, suggesting its utility as a quick and effective screening measure for use in busy clinical environments. This tool may be an important link to prevention interventions for those most at-risk for future motor vehicle crash involvement and injury.

Research paper thumbnail of Social exclusion in middle childhood: Rejection events, slow-wave neural activity, and ostracism distress

Social Neuroscience, 2010

This study examined neural activity with event-related potentials (ERPs) in middle childhood duri... more This study examined neural activity with event-related potentials (ERPs) in middle childhood during a computer-simulated ball-toss game, Cyberball. After experiencing fair play initially, children were ultimately excluded by the other players. We focused specifically on “not my turn” events within fair play and rejection events within social exclusion. Dense-array ERPs revealed that rejection events are perceived rapidly. Condition differences (“not my turn” vs. rejection) were evident in a posterior ERP peaking at 420 ms consistent, with a larger P3 effect for rejection events indicating that in middle childhood rejection events are differentiated in <500 ms. Condition differences were evident for slow-wave activity (500-900 ms) in the medial frontal cortical region and the posterior occipital-parietal region, with rejection events more negative frontally and more positive posteriorly. Distress from the rejection experience was associated with a more negative frontal slow wave and a larger late positive slow wave, but only for rejection events. Source modeling with Geosouce software suggested that slow-wave neural activity in cortical regions previously identified in functional imaging studies of ostracism, including subgenual cortex, ventral anterior cingulate cortex, and insula, was greater for rejection events vs. “not my turn” events.

Research paper thumbnail of The Development of Mentalisation in Children From a Theory of Mind Perspective

Psychoanalytic Inquiry, 2010

For psychoanalysts, a key developmental question is how children&... more For psychoanalysts, a key developmental question is how children's mentalisation capacities develop, that is, how they come to understand the feelings and intentions of others, as well as themselves, and how that understanding is integrated over the course of development into their feelings for and expectations of others. Broadly stated, this question has been the subject of productive lines of

Research paper thumbnail of Effects of trauma and PTSD on parenting in mothers with preschool age children

Comprehensive Psychiatry, 2011

Research paper thumbnail of Prenatal Cocaine Exposure and Young Children's Development

Annals of The American Academy of Political and Social Science - ANN AMER ACAD POLIT SOC SCI, 1992

... nant Ewe and Fetus," American Journal of Obstetrics and Gynecology, 155:883-88 (1986... more ... nant Ewe and Fetus," American Journal of Obstetrics and Gynecology, 155:883-88 (1986); James R. Woods, Mark A. Plessinger, and Ken-neth E ... Infants Exposed to Cocaine In Utero," Journal of Pediatrics, 117:627-29 (1990); L. Shih, B. Cone-Wesson, and B. Reddix, "Effects of ...

Research paper thumbnail of The Practice of Psychoanalytic Parent-Infant Psychotherapy: Claiming the Baby

Journal of the American Academy of Child & Adolescent Psychiatry, 2006

... by Dilys Daws, Tavistock Clinic, Allan N Schore. ... theory of parent-infant psychotherapy In... more ... by Dilys Daws, Tavistock Clinic, Allan N Schore. ... theory of parent-infant psychotherapy Introduction ANGELA JOYCE 1 The parent-infant relationship and infant mental health ANGELA JOYCE 2 The theory of psychoanalytic parent-infant psychotherapy TESSA BARADON AND ...