H. Mazumdar - Academia.edu (original) (raw)
Papers by H. Mazumdar
Journal of Physics E: Scientific Instruments, 1980
A linear temperature programmer is fabricated based on the design described by Mills et al. (1977... more A linear temperature programmer is fabricated based on the design described by Mills et al. (1977). In this note the authors indicate a few simple additions to the original design which makes the system capable of temperature auto-hold and temperature auto-cut-off operations. A few minor refinements in the original design are also described later. This system has been successfully operated for one year.
Journal of Pharmaceutical and Biomedical Analysis, 1998
The use of artificial neural networks (ANNs) for response surface modelling in HPLC method develo... more The use of artificial neural networks (ANNs) for response surface modelling in HPLC method development for amiloride and methychlothiazide separation is reported. The independent input variables were pH and methanol percentage in mobile phase. The outputs were capacity factors. The results were compared with a statistical method (multiple nonlinear regression analysis). Networks were able to predict the experimental responses more accurately than the regression analysis.
Scientific Reports, 2016
A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donova... more A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donovani Topoisomerase 1 (LdTop1) where the active molecules displayed considerable inhibition with single digit micromolar EC50 values. This molecular library was designed via intuitive scaffold hopping and bioisosteric modification of known topoisomerase 1 inhibitors such as camptothecin, edotecarin and etc. The design was rationalized by molecular docking analysis of the compound prototype with human topoisomerase 1 (HTop1) and Leishmania donovani topoisomerase 1(LdTop1). The most active compound 4 displayed no cytotoxicity against normal mammalian COS7 cell line (~100 fold less inhibition at the EC50). Similar to camptothecin, 4 interacted with free LdTop1 as observed in the preincubation DNA relaxation inhibition experiment. It also displayed anti-protozoal activity against Leishmania donovani promastigote. Crystal structure investigation of 4 and its molecular modelling with LdTop1 revealed putative binding sites in the enzyme that could be harnessed to generate molecules with better potency.
Bulletin of the Astronomical Society of India
ABSTRACT
Indian journal of pediatrics, 1975
ABSTRACT We derive an approximate solution to the problem of steady laminar flow of viscous incom... more ABSTRACT We derive an approximate solution to the problem of steady laminar flow of viscous incompressible electrically conducting fluid over a stretching sheet. The approach is based on the stretching of variables, and then on using least squares method to minimise the residual of a differential equation. The effects of magnetic field on flow characteristics are demonstrated through numerical computations; the results are discussed.
Physica Scripta, 1996
It is well accepted that axisymmetric turbulent air-bubble plume in water can be described by any... more It is well accepted that axisymmetric turbulent air-bubble plume in water can be described by any two of the three equations e.g. continuity equation, momentum equation and the kinetic energy equation. The approach in this paper, is based on the first two of these equations and the assumption that the width of the plume grows exponentially with the vertical distance
IEEE International Conference on Intelligent Robots and Systems, 2006
A new concept of a solar cell powering with integrated Global Positioning System (GPS) for micror... more A new concept of a solar cell powering with integrated Global Positioning System (GPS) for microrobots is proposed. The main idea is to use a projector to transfer energy and to provide global positioning information to the robots that are equipped with multi-segment solar cells on their top. First tests with a 3000 ANSI lumens beamer projecting a white image showed a scavenged power of 7.1 and 27.8 µW/mm 2 for commercially available crystalline silicon solar cells and for thin film amorphous silicon solar cell respectively. Regarding the global positioning system, the projector sends regularly a sequence of 17 images and the robot decodes them using two independent solar cell segments acting as photodiodes in order to calculate its own position and orientation inside a defined arena. First experimental results on a large scale prototype are presented. For 2.65 x 2.65 mm 2 photodiodes the x, y and angular resolution are 4 mm, 3 mm and 6 degrees respectively inside an arena of 512x384 mm 2 and the duration of the sequence is 0.85 s.
The simulation of runoff from a Himalayan glacier basin using artificial neural network (ANN) is ... more The simulation of runoff from a Himalayan glacier basin using artificial neural network (ANN) is presented. The performance of ANN model is found superior compared to the energy balance model and the multiple regression model. The ANN is faster in learning and exhibits excellent system generalization characteristics.
Journal of Applied Mathematics and Computing, 2002
Fluid Dynamics Research, 1998
... 1 @2pp @ri@ri =−2ÿ @ @r1 pu2 − @2 @ri @rk puiuk + 23 @ @r1 pu2 − 23 @ @r2 pu1; (1) ... It fol... more ... 1 @2pp @ri@ri =−2ÿ @ @r1 pu2 − @2 @ri @rk puiuk + 23 @ @r1 pu2 − 23 @ @r2 pu1; (1) ... It follows from Eq. (12) that 22(k;0) = 2Ak2 1 . Let us now express the wave number vector in spherical coordinates, ie k =(k cos sin Â; k sin sin Â; k cos Â). Eq. (10) can thus be written as ...
Pramana, 1986
The measurements of the ionizadon states, composition, energy spectra and spatial distribution of... more The measurements of the ionizadon states, composition, energy spectra and spatial distribution of heavy ions of helium to iron of energies 10-100 MeV/amu in the anomalous cosmic rays are of major importance in understanding their origin which is unknown at present. Anuradha (IONS) cosmic ray experiment in Spaceiab-3 was designed to determine the above properties in near earth space and this had a highly suoeessful flight and operations aboard the shuttle Challenger at an orbital altitude of 352 km during 29 April to 6 May 1985. The instrument employs solid state nuclear track detectors (CR-39) of high sensitivity and large collecting area of about 800 cm 2 and determines the arrival time information of particles with active elements. Experimental methods, flight operations and preliminary results are briefly described. Initial results indicate that relatively high fluxes of low energy cosmic ray ,,-particles, oxygen group and heavier ions were obtained. The flight period corresponded to that of quiet Sun and the level of solar activity was close to solar minimum. It is estimated that about 10,000 events of low energy cosmic ray alpha particles with time annotation are recorded in the detector together with similar number of events of oxygen and heavier ions of low energy cosmic rays.
Journal of Physics E: Scientific Instruments, 1980
A linear temperature programmer is fabricated based on the design described by Mills et al. (1977... more A linear temperature programmer is fabricated based on the design described by Mills et al. (1977). In this note the authors indicate a few simple additions to the original design which makes the system capable of temperature auto-hold and temperature auto-cut-off operations. A few minor refinements in the original design are also described later. This system has been successfully operated for one year.
Journal of Pharmaceutical and Biomedical Analysis, 1998
The use of artificial neural networks (ANNs) for response surface modelling in HPLC method develo... more The use of artificial neural networks (ANNs) for response surface modelling in HPLC method development for amiloride and methychlothiazide separation is reported. The independent input variables were pH and methanol percentage in mobile phase. The outputs were capacity factors. The results were compared with a statistical method (multiple nonlinear regression analysis). Networks were able to predict the experimental responses more accurately than the regression analysis.
Scientific Reports, 2016
A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donova... more A library of arylidenefuropyridinediones was discovered as potent inhibitors of Leishmania donovani Topoisomerase 1 (LdTop1) where the active molecules displayed considerable inhibition with single digit micromolar EC50 values. This molecular library was designed via intuitive scaffold hopping and bioisosteric modification of known topoisomerase 1 inhibitors such as camptothecin, edotecarin and etc. The design was rationalized by molecular docking analysis of the compound prototype with human topoisomerase 1 (HTop1) and Leishmania donovani topoisomerase 1(LdTop1). The most active compound 4 displayed no cytotoxicity against normal mammalian COS7 cell line (~100 fold less inhibition at the EC50). Similar to camptothecin, 4 interacted with free LdTop1 as observed in the preincubation DNA relaxation inhibition experiment. It also displayed anti-protozoal activity against Leishmania donovani promastigote. Crystal structure investigation of 4 and its molecular modelling with LdTop1 revealed putative binding sites in the enzyme that could be harnessed to generate molecules with better potency.
Bulletin of the Astronomical Society of India
ABSTRACT
Indian journal of pediatrics, 1975
ABSTRACT We derive an approximate solution to the problem of steady laminar flow of viscous incom... more ABSTRACT We derive an approximate solution to the problem of steady laminar flow of viscous incompressible electrically conducting fluid over a stretching sheet. The approach is based on the stretching of variables, and then on using least squares method to minimise the residual of a differential equation. The effects of magnetic field on flow characteristics are demonstrated through numerical computations; the results are discussed.
Physica Scripta, 1996
It is well accepted that axisymmetric turbulent air-bubble plume in water can be described by any... more It is well accepted that axisymmetric turbulent air-bubble plume in water can be described by any two of the three equations e.g. continuity equation, momentum equation and the kinetic energy equation. The approach in this paper, is based on the first two of these equations and the assumption that the width of the plume grows exponentially with the vertical distance
IEEE International Conference on Intelligent Robots and Systems, 2006
A new concept of a solar cell powering with integrated Global Positioning System (GPS) for micror... more A new concept of a solar cell powering with integrated Global Positioning System (GPS) for microrobots is proposed. The main idea is to use a projector to transfer energy and to provide global positioning information to the robots that are equipped with multi-segment solar cells on their top. First tests with a 3000 ANSI lumens beamer projecting a white image showed a scavenged power of 7.1 and 27.8 µW/mm 2 for commercially available crystalline silicon solar cells and for thin film amorphous silicon solar cell respectively. Regarding the global positioning system, the projector sends regularly a sequence of 17 images and the robot decodes them using two independent solar cell segments acting as photodiodes in order to calculate its own position and orientation inside a defined arena. First experimental results on a large scale prototype are presented. For 2.65 x 2.65 mm 2 photodiodes the x, y and angular resolution are 4 mm, 3 mm and 6 degrees respectively inside an arena of 512x384 mm 2 and the duration of the sequence is 0.85 s.
The simulation of runoff from a Himalayan glacier basin using artificial neural network (ANN) is ... more The simulation of runoff from a Himalayan glacier basin using artificial neural network (ANN) is presented. The performance of ANN model is found superior compared to the energy balance model and the multiple regression model. The ANN is faster in learning and exhibits excellent system generalization characteristics.
Journal of Applied Mathematics and Computing, 2002
Fluid Dynamics Research, 1998
... 1 @2pp @ri@ri =−2ÿ @ @r1 pu2 − @2 @ri @rk puiuk + 23 @ @r1 pu2 − 23 @ @r2 pu1; (1) ... It fol... more ... 1 @2pp @ri@ri =−2ÿ @ @r1 pu2 − @2 @ri @rk puiuk + 23 @ @r1 pu2 − 23 @ @r2 pu1; (1) ... It follows from Eq. (12) that 22(k;0) = 2Ak2 1 . Let us now express the wave number vector in spherical coordinates, ie k =(k cos sin Â; k sin sin Â; k cos Â). Eq. (10) can thus be written as ...
Pramana, 1986
The measurements of the ionizadon states, composition, energy spectra and spatial distribution of... more The measurements of the ionizadon states, composition, energy spectra and spatial distribution of heavy ions of helium to iron of energies 10-100 MeV/amu in the anomalous cosmic rays are of major importance in understanding their origin which is unknown at present. Anuradha (IONS) cosmic ray experiment in Spaceiab-3 was designed to determine the above properties in near earth space and this had a highly suoeessful flight and operations aboard the shuttle Challenger at an orbital altitude of 352 km during 29 April to 6 May 1985. The instrument employs solid state nuclear track detectors (CR-39) of high sensitivity and large collecting area of about 800 cm 2 and determines the arrival time information of particles with active elements. Experimental methods, flight operations and preliminary results are briefly described. Initial results indicate that relatively high fluxes of low energy cosmic ray ,,-particles, oxygen group and heavier ions were obtained. The flight period corresponded to that of quiet Sun and the level of solar activity was close to solar minimum. It is estimated that about 10,000 events of low energy cosmic ray alpha particles with time annotation are recorded in the detector together with similar number of events of oxygen and heavier ions of low energy cosmic rays.