Medi Eslani - Academia.edu (original) (raw)

Papers by Medi Eslani

Research paper thumbnail of A Reproducible in Vitro Assay to Measure Immunomodulatory Properties of Mesenchymal Stem Cell on the Corneal Epithelial Cells

Investigative Ophthalmology & Visual Science, Jun 11, 2015

Research paper thumbnail of Modulating the toxic effects of benzalkonium chloride on human corneal epithelial cells in vitro

Investigative Ophthalmology & Visual Science, Sep 26, 2016

Research paper thumbnail of Smoking and progressive retinal nerve fibre layer thinning in glaucoma

British Journal of Ophthalmology, Sep 13, 2022

Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rat... more Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rate of retinal nerve fibre layer (RNFL) thinning in patients with primary open angle glaucoma (POAG).MethodsIn this longitudinal study, patients with POAG who had at least 3 years of follow-up with a minimum of 5 visits of optical coherence tomography (OCT) were enrolled. The smoking intensity was calculated as the pack-year at the baseline OCT. Univariable and multivariable linear mixed models were used to determine the effect of each parameter on the rates of RNFL thinning over time. Non-linear least-squares estimation with piecewise regression model was used to investigate the cut-off point for the relationship between circumpapillary RNFL thinning and smoking intensity.ResultsA total of 466 eyes of 314 patients were included over the mean (95% CI) follow-up of 6.6 (6.4 to 6.7) years. Of the 314 patients, 121 (39%) had reported any history of smoking. Greater smoking intensity was associated with faster RNFL thinning (−0.06 (95% CI −0.11 to 0.00) µm/year per 10 pack-year higher; p=0.031) after adjusted for confounding factors. RNFL thinning became significantly faster when smoking intensity was >8 pack-year.ConclusionsSmoking intensity is associated with faster rates of RNFL thinning. Evaluation of smoking intensity might add information to the assessment of risk of glaucoma progression. Future studies are required to explore if withdrawing smoking as a modifiable risk factor can decrease progression in patients with glaucoma.

Research paper thumbnail of Intravitreal bevacizumab injection alone or combined with triamcinolone versus macular photocoagulation in bilateral diabetic macular edema; application of bivariate generalized linear mixed model with asymmetric random effects in a subgroup of a clinical trial

Journal of ophthalmic and vision research, 2014

Purpose: To compare the efficacy of intravitreal bevacizumab (IVB) injection alone or with intrav... more Purpose: To compare the efficacy of intravitreal bevacizumab (IVB) injection alone or with intravitreal triamcinolone acetonide (IVB/IVT) versus macular photocoagulation (MPC) in bilateral diabetic macular edema (DME). Methods: In this study we revisited data from a subset of subjects previously enrolled in a randomized clinical trial. The original study included 150 eyes randomized to three treatment arms: 1.25 mg IVB alone, combined injection of 1.25 mg IVB and 2 mg IVT, and focal or modified grid MPC. To eliminate the possible effects of systemic confounders, we selected fellow eyes of bilaterally treated subjects who had undergone different treatments; eventually 30 eyes of 15 patients were re-evaluated at baseline, 6, 12, 18, and 24 months. Using mixed model analysis, we compared the treatment protocols regarding visual acuity (VA) and central macular thickness (CMT). Results: Improvement in VA in the IVB group was significantly greater compared to MPC at months 6 and 12 (P = 0.037 and P = 0.035, respectively) but this difference did not persist thereafter up to 24 months. Other levels of VA were comparable at different follow-up intervals (all P > 0.05). The only significant difference in CMT was observed in favor of the IVB group as compared to IVB/IVT group at 24 months (P = 0.048). Conclusion: Overall VA was superior in IVB group as compared to MPC up to 12 months. Although the IVB group showed superiority regarding CMT reduction over 24 months as compared to IVB/IVT group, it was comparable to the MPC group through the same period of follow up.

Research paper thumbnail of Smoking and progressive retinal nerve fibre layer thinning in glaucoma

British Journal of Ophthalmology

Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rat... more Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rate of retinal nerve fibre layer (RNFL) thinning in patients with primary open angle glaucoma (POAG).MethodsIn this longitudinal study, patients with POAG who had at least 3 years of follow-up with a minimum of 5 visits of optical coherence tomography (OCT) were enrolled. The smoking intensity was calculated as the pack-year at the baseline OCT. Univariable and multivariable linear mixed models were used to determine the effect of each parameter on the rates of RNFL thinning over time. Non-linear least-squares estimation with piecewise regression model was used to investigate the cut-off point for the relationship between circumpapillary RNFL thinning and smoking intensity.ResultsA total of 466 eyes of 314 patients were included over the mean (95% CI) follow-up of 6.6 (6.4 to 6.7) years. Of the 314 patients, 121 (39%) had reported any history of smoking. Greater smoking intensity was assoc...

Research paper thumbnail of Perimetric Comparison Between the IMOvifa and Humphrey Field Analyzer

Journal of Glaucoma

Précis: IMO visual function analyzer (IMOvifa), a binocular perimeter, has similar output to the ... more Précis: IMO visual function analyzer (IMOvifa), a binocular perimeter, has similar output to the Humphrey Field Analyzer (HFA), but reduced the measurement time. Purpose: The purpose of this study is to evaluate the performance of IMOvifa, a perimeter that performs binocular visual field (VF) testing, and to compare its results with standard automated perimetry. Methods: All patients underwent HFA 24–2 SITA-Fast and IMOvifa 24–2 AIZE-Rapid on the same day. Mean deviation (MD), pattern SD (PSD), foveal threshold, and visual field index (VFI) were compared between the 2 perimeters using Wilcoxon signed-rank tests, Pearson correlation, and Bland-Altman plot. Measurement time for performing VF for both eyes was also collected for each device. Results: In this cross-sectional study, 138 eyes (including 25 healthy, 48 glaucoma suspects, and 65 primary open angle glaucoma) of 69 patients were evaluated. Measurement time was significantly faster for IMOvifa compared with HFA (256 vs. 419 s,...

Research paper thumbnail of Reply : Relationship between hydrodynamic parameters and endothelial cell loss after phacoemulsification

Journal of Cataract and Refractive Surgery, Dec 1, 2009

Research paper thumbnail of Effects of Smoking on Optic Nerve Head Microvasculature Density in Glaucoma

Research paper thumbnail of Efficient expansion of corneal mesenchymal stromal cells with preserved therapeutic effects

Investigative Ophthalmology & Visual Science, Jul 22, 2019

Research paper thumbnail of Review Article The Ocular Surface Chemical Burns

Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduct... more Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease. The goal of treatment is to restore the normal ocular surface anatomy and function. Limbal stem cell transplantation, amniotic membrane transplantation, and ultimately keratoprosthesis may be indicated depending on ...

Research paper thumbnail of Synergistic corneal wound healing effects of human mesenchymal stem cell secreted factors and hyaluronic acid-based viscoelastic gel

Investigative Ophthalmology & Visual Science, 2018

Research paper thumbnail of Characterization of bioorthogonally crosslinked collagen gels with encapsulated corneal stromal stem cells

Investigative Ophthalmology & Visual Science, 2019

Research paper thumbnail of The Effects of Prostaglandin Intra-Ocular Pressure Lowering Agents (Glaucoma Eye Drops) on Human Meibomian Gland Epithelial Cells

Investigative Ophthalmology & Visual Science, 2018

Research paper thumbnail of The role of Staphylococcus aureus alpha-toxin on corneal epithelial wound healing

Investigative Ophthalmology & Visual Science, 2018

Research paper thumbnail of Sex differences in the corneal disease in Notch1 conditional knockout mice

Investigative Ophthalmology & Visual Science, 2017

Research paper thumbnail of Rate of Proliferation in Corneal Limbal versus Bone Marrow Mesenchymal Stem Cells

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of The effect of rapamycin on autophagy in human corneal epithelial cells

Investigative Ophthalmology & Visual Science, 2017

Research paper thumbnail of Immunomodulatory Gene Expression Profile of Corneal-Limbal Versus Bone Marrow derived Mesenchymal Stem Cells

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of Human Corneal Limbal Stromal Cells provide a source of Mesenchymal Stem Cells

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of Comparative Effects of Corneal Limbal Versus Bone Marrow Derived Mesenchymal Stem Cell Secretome on Innate Immune Response of Corneal Epithelium

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of A Reproducible in Vitro Assay to Measure Immunomodulatory Properties of Mesenchymal Stem Cell on the Corneal Epithelial Cells

Investigative Ophthalmology & Visual Science, Jun 11, 2015

Research paper thumbnail of Modulating the toxic effects of benzalkonium chloride on human corneal epithelial cells in vitro

Investigative Ophthalmology & Visual Science, Sep 26, 2016

Research paper thumbnail of Smoking and progressive retinal nerve fibre layer thinning in glaucoma

British Journal of Ophthalmology, Sep 13, 2022

Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rat... more Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rate of retinal nerve fibre layer (RNFL) thinning in patients with primary open angle glaucoma (POAG).MethodsIn this longitudinal study, patients with POAG who had at least 3 years of follow-up with a minimum of 5 visits of optical coherence tomography (OCT) were enrolled. The smoking intensity was calculated as the pack-year at the baseline OCT. Univariable and multivariable linear mixed models were used to determine the effect of each parameter on the rates of RNFL thinning over time. Non-linear least-squares estimation with piecewise regression model was used to investigate the cut-off point for the relationship between circumpapillary RNFL thinning and smoking intensity.ResultsA total of 466 eyes of 314 patients were included over the mean (95% CI) follow-up of 6.6 (6.4 to 6.7) years. Of the 314 patients, 121 (39%) had reported any history of smoking. Greater smoking intensity was associated with faster RNFL thinning (−0.06 (95% CI −0.11 to 0.00) µm/year per 10 pack-year higher; p=0.031) after adjusted for confounding factors. RNFL thinning became significantly faster when smoking intensity was >8 pack-year.ConclusionsSmoking intensity is associated with faster rates of RNFL thinning. Evaluation of smoking intensity might add information to the assessment of risk of glaucoma progression. Future studies are required to explore if withdrawing smoking as a modifiable risk factor can decrease progression in patients with glaucoma.

Research paper thumbnail of Intravitreal bevacizumab injection alone or combined with triamcinolone versus macular photocoagulation in bilateral diabetic macular edema; application of bivariate generalized linear mixed model with asymmetric random effects in a subgroup of a clinical trial

Journal of ophthalmic and vision research, 2014

Purpose: To compare the efficacy of intravitreal bevacizumab (IVB) injection alone or with intrav... more Purpose: To compare the efficacy of intravitreal bevacizumab (IVB) injection alone or with intravitreal triamcinolone acetonide (IVB/IVT) versus macular photocoagulation (MPC) in bilateral diabetic macular edema (DME). Methods: In this study we revisited data from a subset of subjects previously enrolled in a randomized clinical trial. The original study included 150 eyes randomized to three treatment arms: 1.25 mg IVB alone, combined injection of 1.25 mg IVB and 2 mg IVT, and focal or modified grid MPC. To eliminate the possible effects of systemic confounders, we selected fellow eyes of bilaterally treated subjects who had undergone different treatments; eventually 30 eyes of 15 patients were re-evaluated at baseline, 6, 12, 18, and 24 months. Using mixed model analysis, we compared the treatment protocols regarding visual acuity (VA) and central macular thickness (CMT). Results: Improvement in VA in the IVB group was significantly greater compared to MPC at months 6 and 12 (P = 0.037 and P = 0.035, respectively) but this difference did not persist thereafter up to 24 months. Other levels of VA were comparable at different follow-up intervals (all P > 0.05). The only significant difference in CMT was observed in favor of the IVB group as compared to IVB/IVT group at 24 months (P = 0.048). Conclusion: Overall VA was superior in IVB group as compared to MPC up to 12 months. Although the IVB group showed superiority regarding CMT reduction over 24 months as compared to IVB/IVT group, it was comparable to the MPC group through the same period of follow up.

Research paper thumbnail of Smoking and progressive retinal nerve fibre layer thinning in glaucoma

British Journal of Ophthalmology

Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rat... more Background/AimsTo investigate the relationship between smoking and smoking intensity, and the rate of retinal nerve fibre layer (RNFL) thinning in patients with primary open angle glaucoma (POAG).MethodsIn this longitudinal study, patients with POAG who had at least 3 years of follow-up with a minimum of 5 visits of optical coherence tomography (OCT) were enrolled. The smoking intensity was calculated as the pack-year at the baseline OCT. Univariable and multivariable linear mixed models were used to determine the effect of each parameter on the rates of RNFL thinning over time. Non-linear least-squares estimation with piecewise regression model was used to investigate the cut-off point for the relationship between circumpapillary RNFL thinning and smoking intensity.ResultsA total of 466 eyes of 314 patients were included over the mean (95% CI) follow-up of 6.6 (6.4 to 6.7) years. Of the 314 patients, 121 (39%) had reported any history of smoking. Greater smoking intensity was assoc...

Research paper thumbnail of Perimetric Comparison Between the IMOvifa and Humphrey Field Analyzer

Journal of Glaucoma

Précis: IMO visual function analyzer (IMOvifa), a binocular perimeter, has similar output to the ... more Précis: IMO visual function analyzer (IMOvifa), a binocular perimeter, has similar output to the Humphrey Field Analyzer (HFA), but reduced the measurement time. Purpose: The purpose of this study is to evaluate the performance of IMOvifa, a perimeter that performs binocular visual field (VF) testing, and to compare its results with standard automated perimetry. Methods: All patients underwent HFA 24–2 SITA-Fast and IMOvifa 24–2 AIZE-Rapid on the same day. Mean deviation (MD), pattern SD (PSD), foveal threshold, and visual field index (VFI) were compared between the 2 perimeters using Wilcoxon signed-rank tests, Pearson correlation, and Bland-Altman plot. Measurement time for performing VF for both eyes was also collected for each device. Results: In this cross-sectional study, 138 eyes (including 25 healthy, 48 glaucoma suspects, and 65 primary open angle glaucoma) of 69 patients were evaluated. Measurement time was significantly faster for IMOvifa compared with HFA (256 vs. 419 s,...

Research paper thumbnail of Reply : Relationship between hydrodynamic parameters and endothelial cell loss after phacoemulsification

Journal of Cataract and Refractive Surgery, Dec 1, 2009

Research paper thumbnail of Effects of Smoking on Optic Nerve Head Microvasculature Density in Glaucoma

Research paper thumbnail of Efficient expansion of corneal mesenchymal stromal cells with preserved therapeutic effects

Investigative Ophthalmology & Visual Science, Jul 22, 2019

Research paper thumbnail of Review Article The Ocular Surface Chemical Burns

Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduct... more Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease. The goal of treatment is to restore the normal ocular surface anatomy and function. Limbal stem cell transplantation, amniotic membrane transplantation, and ultimately keratoprosthesis may be indicated depending on ...

Research paper thumbnail of Synergistic corneal wound healing effects of human mesenchymal stem cell secreted factors and hyaluronic acid-based viscoelastic gel

Investigative Ophthalmology & Visual Science, 2018

Research paper thumbnail of Characterization of bioorthogonally crosslinked collagen gels with encapsulated corneal stromal stem cells

Investigative Ophthalmology & Visual Science, 2019

Research paper thumbnail of The Effects of Prostaglandin Intra-Ocular Pressure Lowering Agents (Glaucoma Eye Drops) on Human Meibomian Gland Epithelial Cells

Investigative Ophthalmology & Visual Science, 2018

Research paper thumbnail of The role of Staphylococcus aureus alpha-toxin on corneal epithelial wound healing

Investigative Ophthalmology & Visual Science, 2018

Research paper thumbnail of Sex differences in the corneal disease in Notch1 conditional knockout mice

Investigative Ophthalmology & Visual Science, 2017

Research paper thumbnail of Rate of Proliferation in Corneal Limbal versus Bone Marrow Mesenchymal Stem Cells

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of The effect of rapamycin on autophagy in human corneal epithelial cells

Investigative Ophthalmology & Visual Science, 2017

Research paper thumbnail of Immunomodulatory Gene Expression Profile of Corneal-Limbal Versus Bone Marrow derived Mesenchymal Stem Cells

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of Human Corneal Limbal Stromal Cells provide a source of Mesenchymal Stem Cells

Investigative Ophthalmology & Visual Science, 2016

Research paper thumbnail of Comparative Effects of Corneal Limbal Versus Bone Marrow Derived Mesenchymal Stem Cell Secretome on Innate Immune Response of Corneal Epithelium

Investigative Ophthalmology & Visual Science, 2016