Meenakshi Bajpai - Academia.edu (original) (raw)
Papers by Meenakshi Bajpai
Pediatric Malnutrition and Natural Dietary Supplementary Food to Overcome it: A Review
Current Nutrition & Food Science
: Malnutrition is described by the World Health Organization (WHO) as a person's energy and/o... more : Malnutrition is described by the World Health Organization (WHO) as a person's energy and/or nutrient consumption being insufficient, excessive, or out of proportion. Health officials in India are quite concerned about malnutrition in children under five. Recent research revealed a significant frequency of undernutrition among children under the age of five. It is estimated that malnutrition affects roughly 2/3 of India's population under the age of five and that 5-8% of those children are severely malnourished. It could be argued that it is one of the most prevalent issues affecting children's health in the nation. Mothers' nutritional health, breastfeeding habits, women's education, and cleanliness are all factors that contribute to malnutrition. The use of dietary supplements is widespread, and they are a class of ingestible goods that can be distinguished from common meals and medications. Over the past few decades, the demand for phytonutrients has increased, and individuals are now using them to meet their nutritional needs. This review enlightens and explores the prevalence of undernutrition, its causes, and the necessary countermeasures, treatments for malnutrition among children under the age of five in India and nutritional diversification of food and other benefits which make it a better choice to use in our daily diet to combat pediatric malnutrition.
Bacoside A: A Promising Medication for Treatment of Various Disorders
Current Traditional Medicine
: Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monni... more : Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monnieri Linn., Scrophulariaceae. It is a glabrous and succulent herb used traditionally for centuries in treating various illnesses, mainly as a cardiotonic and nerve tonic, and has been considered an eminent Ayurvedic medicine. Various studies reported that the herb consists of a wide range of potentially bioactive, phytochemical constituents with synergistic effects. Bacoside A is a major constituent of B. monnieri, with diverse biological functions and significant therapeutic potential, as given by various researchers and preclinical studies. It possesses various biological activities such as hepatoprotective, anti-osteoporotic, anti-ulcerogenic, anti-inflammatory, anti-tumor, wound healing, and neuroprotective effects. This review compiled the preclinical evidence-based studies and present knowledge of bacoside A's potential benefits and fruitful impact on human health, and we provided a comprehensive perspective of bacoside A in various disease treatments.
Nutraceuticals a Food for Thought in the Treatment of Parkinson’s Disease
Current Nutrition & Food Science
Background: Brain disorders are presently one of the most serious and challenging health issues i... more Background: Brain disorders are presently one of the most serious and challenging health issues in the world. A significant portion of morbidities and fatalities worldwide are caused by these brain disorders. Parkinson's disease (PD) is a neurological condition that develops when dopaminergic neurons are lost in the substantia nigra, causing cognitive and motor impairment. Objectives: Conventional treatment modalities, including dopamine replacement therapy and optimization of dopaminergic transmission approaches, don’t address the pathogenic processes primary to the symptoms of PD and usually become the least essential with time. Researchers are aiming to provide effective treatment in treating PD with minimizing adverse consequences. In the past few years, a number of studies on nutraceuticals have been conducted to produce foods with fewer adverse effects and increased therapeutic effectiveness. The use of these nutraceuticals is typically risk-free and can be coupled with th...
Correspondence to Author
mechanical, chemicals, herbals, gingivitis, essential oils
Indian Journal of Pharmaceutical Education and Research
Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves... more Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves of Kachnar (Phanera variegata) and to compare the binding efficacy of the isolated mucilage with acacia gum. Methods: Extraction and isolation of mucilages from the leaves of Phanera variegata were carried out by the maceration method. The isolated mucilage was analyzed for phytochemical, microbial andvarious physico-chemical properties for acceptability as a novel excipient for the formulation of tablets. Uncoated paracetamol tablets of different batches (F1-F4) were prepared by preparing granules (different concentrations) of isolated mucilage (3%, 5%, 10% and 15% w/v respectively) using wet granulation technique.The formulated tablets were evaluated: pre-compression (Micromeritics properties) and post-compression parameters (size, hardness, friability, weight uniformity, content uniformity, disintegration and in vitro dissolution profile.) For comparison purposes, acacia gum was used as a binder and different batches of tablets (A1-A4) were prepared similarly and evaluated for pre-compression and postcompression parameters. Results: The formulated tablets using isolated mucilage had a good appearance, on increasing the concentration of binder hardness of tablets were also increased, all the formulations fall within the limit for friability and disintegration according to official standards, in vitro dissolution profile of optimized formulation F2 showed 98.28% drug release within 20 min. Conclusion: According to the observation, isolated mucilage can opt as an alternative natural excipient (binding agent) for the formulation of uncoated tablets. Phanera variegata is a novel plant with less or almost no reported data.
To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Es... more To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Esomeprazole nanosuspensions were prepared by evaporative precipitation-ultrasonication method using F68 (Poloxamer 188) and F127 (Poloxamer 407) as stabilizers. Formulation and process variables (concentration of stabilizers and drug, power input and duration of ultrasonication) affecting the characteristics of nanosuspensions were optimized. The nanosuspensions were characterized for particle size, shape, zeta potential, stability and in vitro drug release study. Results: For optimization of esomeprazole nanosuspension, the effect of some important parameters, including concentration of F68, concentration of esomeprazole, precipitation temperature, duration of ultrasonication and power input, on particle size were investigated, and the optimal values were 0.4% w/v, 3.5 mg/ml, 4 o C, 20 min and 60% W, respectively. Particle size was in the range of 125-184 nm with good zeta potential (15.9-25.5 mV). In vitro dissolution rate of esomeprazole was enhanced 4-fold (100% in 60 min) compared with crude esomeprazole (24% in 60 min), and this was due to decrease in particle size. The stability results indicate that nanoformulations stored at 4 o C for two months showed maximum stability. Conclusion: The results indicate the suitability of evaporative-precipitation-ultrasonication method for preparation of nanosuspensions of poorly soluble drugs with improved in vitro dissolution rate, thus potentially capable of enhancing fast onset of therapeutic activity, and bioavailability.
Nanosuspension Technology: A Strategic Approach for Poorly Soluble Drugs
Nanoscience and Nanotechnology - Asia
ABSTRACT
Mechanical, chemical and herbal aspects of periodontitis
ABSTRACT
International Journal of Pharmacology, 2008
Recent Developments for Oral Time Controlled Drug Delivery by Pelletization Techniques: An Overview
Journal of Pharmaceutical Sciences and Pharmacology, 2014
Development and evaluation of a self-emulsifying drug delivery system of amphotericin B
Asian Journal of Pharmaceutics, 2012
ABSTRACT
Nanosuspension Technology: A Strategic Approach for Poorly Soluble Drugs
Nanoscience &Nanotechnology-Asia, 2013
ABSTRACT
Stability Issues Related to Nanosuspensions: A Review
Pharmaceutical Nanotechnology, 2013
Journal of Advanced Pharmaceutical Technology & Research, 2014
Considering the emerging problem of drug resistance in tuberculosis, there is an urgent need of d... more Considering the emerging problem of drug resistance in tuberculosis, there is an urgent need of development of new analogs that are useful in curing drug resistant tuberculosis. In India, tuberculosis continues to remain one of the most pressing health problems. India is the highest tuberculosis burden country in the world, accounting one fifth of global incidence-estimated 2.0-2.5 million cases annually. In 2011, approximately 8.7 million new cases of tuberculosis and 1.4 million people die from tuberculosis each year worldwide. Current antitubercular therapies are successful against normal tuberculosis but it is not suitable for drug resistant tuberculosis. In this study Plumbagin analogs, obtained from Plumbago zeylanica (Family-Plumbaginaceae), have been synthesized. Out of the various synthesized analogs, the antitubercular activity of compound a and b was evaluated using standard H 37 Rv and S, H, R, and E sensitive M tuberculosis strains using LRF assay method. Compound a showed strong activity against both standard H 37 Rv and S, H, R and E sensitive M. tuberculosis strains as compared to standard Rifampicin. The other compounds are proved to be more active against standard H 37 Rv and S, H, R and E sensitive M. tuberculosis strain as compared to Rifampicin.
Determination of bacoside A by HPTLC in Bacopa monnieri extract
International Journal of Green Pharmacy, 2008
Abstract A simple sensitive HPTLC method developed for the determination of bacoside A in the pla... more Abstract A simple sensitive HPTLC method developed for the determination of bacoside A in the plant Bacopa monnieri extracts. The stationary phase was precoated silica gel GF254. The mobile phase used was dichloromethane: methanol: water (4.5: 1.0: 0.1 v/v/v). The ...
Synthesis and study of anti-bacterial activity of complexes of diallyldisulphide from garlic
International Journal of Green Pharmacy, 2012
ABSTRACT
Investigation of Formulation and Process Parameters for the Production of Esomeprazole Nanosuspension by Anti Solvent Precipitation Ultasonication Technique
Current Nanoscience, 2013
Novel Micropelletization Technique: Highly Improved Dissolution, Wettability and Micromeritic Behavior of Domperidone
Current Drug Delivery, 2006
The aim of the investigation is to improve the dissolution, wettability, and micromeritic behavio... more The aim of the investigation is to improve the dissolution, wettability, and micromeritic behavior of domperidone, a dopamine antagonist, used in the treatment of nausea and vomiting. Micropelletization technique, a possible approach for ensuring maximum dissolution with enhanced wettability, and uniform pellet size almost spherical so as to achieve the smooth gastric transit of drug have been estimated. Micropellets were prepared utilizing solvent diffusion technique and all the process parameters such as solvent-non-solvent ratio, stirring speed, temperature, and effect of aggregating agent on the micropellets formulation have been optimized. The addition of an aggregating agent (10%v/v of isopropyl alcohol) improved the uniform micropellets formation and the method was reproducible. The micromeritic properties such as size distribution, surface property (using Scalar-USB digital photomicroscope), packability, and flowability of the formulated micropellets were characterized. Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetric (DSC) analysis were performed to explain the results. Formulated micropellets showed clear and highly improved in vivo dissolution behavior, probably due to high wettability. The micropelletized drug was stable at room temperature, 25 degrees C/60% relative humidity (RH), and 45 degrees C/70% RH, after 12 weeks.
Oral Bioavailability and Stability Study of a Self-Emulsifying Drug Delivery System (SEDDS) of Amphotericin B
Current Drug Delivery, 2013
Amphotericin B (AmB) is a poorly water soluble polyene antifungal antibiotic which is negligibly ... more Amphotericin B (AmB) is a poorly water soluble polyene antifungal antibiotic which is negligibly absorbed from the gastro intestinal tract after oral administration. The objective of this research work was to study the oral bioavailability and stability of a self-emulsifying drug delivery system (SEDDS) of amphotericin B (AmB). The SEDDS formulation consisted of glyceryl monooleate, tween 80, polyethylene glycol 400 (PEG 400) and propylene glycol and had AmB content of about 8 mg per ml. The stability of the SEDDS formulation was studied in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) in comparison to pure drug. Oral bioavailability of the SEDDS formulation was studied in rats in comparison to the pure drug. The formulation was filled in two different types of capsule shell, namely HPMC capsule and hard gelatin capsule and stability of the formulation was studied for 3 months. The SEDDS formulation resulted in a mean AUC value of 40.57µg/ml.hr with mean peak plasma concentration of 6.17µg/ml reached after 2 hours after oral administration in rats, whereas concentration of AmB in plasma was not detectable after administration of the pure drug. The formulation filled in hard gelatin capsule shell was physically and chemically stable for more than 3 months under refrigeration (4°C). The study demonstrates that SEDDS approach can be successfully utilized for oral delivery of AmB.
Pediatric Malnutrition and Natural Dietary Supplementary Food to Overcome it: A Review
Current Nutrition & Food Science
: Malnutrition is described by the World Health Organization (WHO) as a person's energy and/o... more : Malnutrition is described by the World Health Organization (WHO) as a person's energy and/or nutrient consumption being insufficient, excessive, or out of proportion. Health officials in India are quite concerned about malnutrition in children under five. Recent research revealed a significant frequency of undernutrition among children under the age of five. It is estimated that malnutrition affects roughly 2/3 of India's population under the age of five and that 5-8% of those children are severely malnourished. It could be argued that it is one of the most prevalent issues affecting children's health in the nation. Mothers' nutritional health, breastfeeding habits, women's education, and cleanliness are all factors that contribute to malnutrition. The use of dietary supplements is widespread, and they are a class of ingestible goods that can be distinguished from common meals and medications. Over the past few decades, the demand for phytonutrients has increased, and individuals are now using them to meet their nutritional needs. This review enlightens and explores the prevalence of undernutrition, its causes, and the necessary countermeasures, treatments for malnutrition among children under the age of five in India and nutritional diversification of food and other benefits which make it a better choice to use in our daily diet to combat pediatric malnutrition.
Bacoside A: A Promising Medication for Treatment of Various Disorders
Current Traditional Medicine
: Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monni... more : Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monnieri Linn., Scrophulariaceae. It is a glabrous and succulent herb used traditionally for centuries in treating various illnesses, mainly as a cardiotonic and nerve tonic, and has been considered an eminent Ayurvedic medicine. Various studies reported that the herb consists of a wide range of potentially bioactive, phytochemical constituents with synergistic effects. Bacoside A is a major constituent of B. monnieri, with diverse biological functions and significant therapeutic potential, as given by various researchers and preclinical studies. It possesses various biological activities such as hepatoprotective, anti-osteoporotic, anti-ulcerogenic, anti-inflammatory, anti-tumor, wound healing, and neuroprotective effects. This review compiled the preclinical evidence-based studies and present knowledge of bacoside A's potential benefits and fruitful impact on human health, and we provided a comprehensive perspective of bacoside A in various disease treatments.
Nutraceuticals a Food for Thought in the Treatment of Parkinson’s Disease
Current Nutrition & Food Science
Background: Brain disorders are presently one of the most serious and challenging health issues i... more Background: Brain disorders are presently one of the most serious and challenging health issues in the world. A significant portion of morbidities and fatalities worldwide are caused by these brain disorders. Parkinson's disease (PD) is a neurological condition that develops when dopaminergic neurons are lost in the substantia nigra, causing cognitive and motor impairment. Objectives: Conventional treatment modalities, including dopamine replacement therapy and optimization of dopaminergic transmission approaches, don’t address the pathogenic processes primary to the symptoms of PD and usually become the least essential with time. Researchers are aiming to provide effective treatment in treating PD with minimizing adverse consequences. In the past few years, a number of studies on nutraceuticals have been conducted to produce foods with fewer adverse effects and increased therapeutic effectiveness. The use of these nutraceuticals is typically risk-free and can be coupled with th...
Correspondence to Author
mechanical, chemicals, herbals, gingivitis, essential oils
Indian Journal of Pharmaceutical Education and Research
Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves... more Objectives: The present study is aimed to isolate, evaluate the mucilage obtained from the leaves of Kachnar (Phanera variegata) and to compare the binding efficacy of the isolated mucilage with acacia gum. Methods: Extraction and isolation of mucilages from the leaves of Phanera variegata were carried out by the maceration method. The isolated mucilage was analyzed for phytochemical, microbial andvarious physico-chemical properties for acceptability as a novel excipient for the formulation of tablets. Uncoated paracetamol tablets of different batches (F1-F4) were prepared by preparing granules (different concentrations) of isolated mucilage (3%, 5%, 10% and 15% w/v respectively) using wet granulation technique.The formulated tablets were evaluated: pre-compression (Micromeritics properties) and post-compression parameters (size, hardness, friability, weight uniformity, content uniformity, disintegration and in vitro dissolution profile.) For comparison purposes, acacia gum was used as a binder and different batches of tablets (A1-A4) were prepared similarly and evaluated for pre-compression and postcompression parameters. Results: The formulated tablets using isolated mucilage had a good appearance, on increasing the concentration of binder hardness of tablets were also increased, all the formulations fall within the limit for friability and disintegration according to official standards, in vitro dissolution profile of optimized formulation F2 showed 98.28% drug release within 20 min. Conclusion: According to the observation, isolated mucilage can opt as an alternative natural excipient (binding agent) for the formulation of uncoated tablets. Phanera variegata is a novel plant with less or almost no reported data.
To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Es... more To prepare and optimize esomeprazole nanosuspension to enhance drug dissolution rate. Methods: Esomeprazole nanosuspensions were prepared by evaporative precipitation-ultrasonication method using F68 (Poloxamer 188) and F127 (Poloxamer 407) as stabilizers. Formulation and process variables (concentration of stabilizers and drug, power input and duration of ultrasonication) affecting the characteristics of nanosuspensions were optimized. The nanosuspensions were characterized for particle size, shape, zeta potential, stability and in vitro drug release study. Results: For optimization of esomeprazole nanosuspension, the effect of some important parameters, including concentration of F68, concentration of esomeprazole, precipitation temperature, duration of ultrasonication and power input, on particle size were investigated, and the optimal values were 0.4% w/v, 3.5 mg/ml, 4 o C, 20 min and 60% W, respectively. Particle size was in the range of 125-184 nm with good zeta potential (15.9-25.5 mV). In vitro dissolution rate of esomeprazole was enhanced 4-fold (100% in 60 min) compared with crude esomeprazole (24% in 60 min), and this was due to decrease in particle size. The stability results indicate that nanoformulations stored at 4 o C for two months showed maximum stability. Conclusion: The results indicate the suitability of evaporative-precipitation-ultrasonication method for preparation of nanosuspensions of poorly soluble drugs with improved in vitro dissolution rate, thus potentially capable of enhancing fast onset of therapeutic activity, and bioavailability.
Nanosuspension Technology: A Strategic Approach for Poorly Soluble Drugs
Nanoscience and Nanotechnology - Asia
ABSTRACT
Mechanical, chemical and herbal aspects of periodontitis
ABSTRACT
International Journal of Pharmacology, 2008
Recent Developments for Oral Time Controlled Drug Delivery by Pelletization Techniques: An Overview
Journal of Pharmaceutical Sciences and Pharmacology, 2014
Development and evaluation of a self-emulsifying drug delivery system of amphotericin B
Asian Journal of Pharmaceutics, 2012
ABSTRACT
Nanosuspension Technology: A Strategic Approach for Poorly Soluble Drugs
Nanoscience &Nanotechnology-Asia, 2013
ABSTRACT
Stability Issues Related to Nanosuspensions: A Review
Pharmaceutical Nanotechnology, 2013
Journal of Advanced Pharmaceutical Technology & Research, 2014
Considering the emerging problem of drug resistance in tuberculosis, there is an urgent need of d... more Considering the emerging problem of drug resistance in tuberculosis, there is an urgent need of development of new analogs that are useful in curing drug resistant tuberculosis. In India, tuberculosis continues to remain one of the most pressing health problems. India is the highest tuberculosis burden country in the world, accounting one fifth of global incidence-estimated 2.0-2.5 million cases annually. In 2011, approximately 8.7 million new cases of tuberculosis and 1.4 million people die from tuberculosis each year worldwide. Current antitubercular therapies are successful against normal tuberculosis but it is not suitable for drug resistant tuberculosis. In this study Plumbagin analogs, obtained from Plumbago zeylanica (Family-Plumbaginaceae), have been synthesized. Out of the various synthesized analogs, the antitubercular activity of compound a and b was evaluated using standard H 37 Rv and S, H, R, and E sensitive M tuberculosis strains using LRF assay method. Compound a showed strong activity against both standard H 37 Rv and S, H, R and E sensitive M. tuberculosis strains as compared to standard Rifampicin. The other compounds are proved to be more active against standard H 37 Rv and S, H, R and E sensitive M. tuberculosis strain as compared to Rifampicin.
Determination of bacoside A by HPTLC in Bacopa monnieri extract
International Journal of Green Pharmacy, 2008
Abstract A simple sensitive HPTLC method developed for the determination of bacoside A in the pla... more Abstract A simple sensitive HPTLC method developed for the determination of bacoside A in the plant Bacopa monnieri extracts. The stationary phase was precoated silica gel GF254. The mobile phase used was dichloromethane: methanol: water (4.5: 1.0: 0.1 v/v/v). The ...
Synthesis and study of anti-bacterial activity of complexes of diallyldisulphide from garlic
International Journal of Green Pharmacy, 2012
ABSTRACT
Investigation of Formulation and Process Parameters for the Production of Esomeprazole Nanosuspension by Anti Solvent Precipitation Ultasonication Technique
Current Nanoscience, 2013
Novel Micropelletization Technique: Highly Improved Dissolution, Wettability and Micromeritic Behavior of Domperidone
Current Drug Delivery, 2006
The aim of the investigation is to improve the dissolution, wettability, and micromeritic behavio... more The aim of the investigation is to improve the dissolution, wettability, and micromeritic behavior of domperidone, a dopamine antagonist, used in the treatment of nausea and vomiting. Micropelletization technique, a possible approach for ensuring maximum dissolution with enhanced wettability, and uniform pellet size almost spherical so as to achieve the smooth gastric transit of drug have been estimated. Micropellets were prepared utilizing solvent diffusion technique and all the process parameters such as solvent-non-solvent ratio, stirring speed, temperature, and effect of aggregating agent on the micropellets formulation have been optimized. The addition of an aggregating agent (10%v/v of isopropyl alcohol) improved the uniform micropellets formation and the method was reproducible. The micromeritic properties such as size distribution, surface property (using Scalar-USB digital photomicroscope), packability, and flowability of the formulated micropellets were characterized. Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetric (DSC) analysis were performed to explain the results. Formulated micropellets showed clear and highly improved in vivo dissolution behavior, probably due to high wettability. The micropelletized drug was stable at room temperature, 25 degrees C/60% relative humidity (RH), and 45 degrees C/70% RH, after 12 weeks.
Oral Bioavailability and Stability Study of a Self-Emulsifying Drug Delivery System (SEDDS) of Amphotericin B
Current Drug Delivery, 2013
Amphotericin B (AmB) is a poorly water soluble polyene antifungal antibiotic which is negligibly ... more Amphotericin B (AmB) is a poorly water soluble polyene antifungal antibiotic which is negligibly absorbed from the gastro intestinal tract after oral administration. The objective of this research work was to study the oral bioavailability and stability of a self-emulsifying drug delivery system (SEDDS) of amphotericin B (AmB). The SEDDS formulation consisted of glyceryl monooleate, tween 80, polyethylene glycol 400 (PEG 400) and propylene glycol and had AmB content of about 8 mg per ml. The stability of the SEDDS formulation was studied in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) in comparison to pure drug. Oral bioavailability of the SEDDS formulation was studied in rats in comparison to the pure drug. The formulation was filled in two different types of capsule shell, namely HPMC capsule and hard gelatin capsule and stability of the formulation was studied for 3 months. The SEDDS formulation resulted in a mean AUC value of 40.57µg/ml.hr with mean peak plasma concentration of 6.17µg/ml reached after 2 hours after oral administration in rats, whereas concentration of AmB in plasma was not detectable after administration of the pure drug. The formulation filled in hard gelatin capsule shell was physically and chemically stable for more than 3 months under refrigeration (4°C). The study demonstrates that SEDDS approach can be successfully utilized for oral delivery of AmB.