Meenal Hastak - Academia.edu (original) (raw)

Papers by Meenal Hastak

PubMed, May 1, 2008

Aggressive angiomyxoma is an uncommon neoplasm that preferentially involves the pelvic and perian... more Aggressive angiomyxoma is an uncommon neoplasm that preferentially involves the pelvic and perianal regions of reproductive age females. These tumors are rare in men and merit a wider recognition in male urologic pathology. We report a case of a 65 year old male who presented with a swelling in the left perineal region since 2 years which gradually increased in size to 10 x 10 x 8 cms. CT scan revealed a well defined lobulated heterogenous minimally enhancing mass in the left ischiorectal fossa extending upto the subcutaneous plane. Microscopically stellate to spindle shaped cells arranged in a loose myxoid stroma with numerous thin to thick walled vessels were seen. There was no evidence of pleomorphism, hyperchromatism or mitotic activity. This case is reported because of its rarity in males. It is a benign tumor and requires a wide excisional surgery.

Adenocarcinoma of rete testis, a rare tumour warrants a distinctive diagnosis and needs to be dif... more Adenocarcinoma of rete testis, a rare tumour warrants a distinctive diagnosis and needs to be differentiated from other malignant tumours of testis in view of its poor prognosis and the fact that no form of therapy can influence the final outcome. These tumour almost immediately metastasize to various sites and the expected survival is less than one year. They have a distinctive gross appearance as they are centred in the region of hilus of testis and the tumour is distinct from the testicular parenchyma. W e report a case of a 50 year old male who presented with a painless, hard scrotal swelling. Microscopic examination revealed a papillary adenocarcinoma of rete testis.

Indian Journal of Urology, Feb 25, 2023

Introduction: Robot-assisted radical cystectomy (RARC) is a standrad approach for surgical manage... more Introduction: Robot-assisted radical cystectomy (RARC) is a standrad approach for surgical management of bladder cancer. Currently, most literature on RARC is in men, possibly due to the higher incidence of bladder cancer in males. We reviewed the perioperative, oncological and survival outcomes in 41 women who underwent RARC by a single surgeon at a tertiary health-care center. Methods: Out of 225 RARC and urinary diversion procedures performed from 2012 to 2020, a retrospective analysis of 41 women was performed. Baseline demographic and perioperative details, oncological data, and survival were recorded and analyzed. Kaplan-Meir analysis was done for survival outcomes and prognostic factors were assessed by log rank test. Results: Thirty-eight patients underwent intracorporeal urinary diversion, while three underwent extracorporeal diversion. One patient underwent organ preserving cystectomy. Clavien-Dindo 30-day postoperative complications were Grade I in 8 (19.5%), Grade II in 4 (9.8%), and Grade IIIa in 3 (7.3%) patients with no mortality. During the median follow-up of 34 months (range: 6-87 months), 7 patients died of disease recurrence. Five-year survival was 74% (95% confidence interval [CI]: 59-82) and 35% (95% CI: 10-91) in transitional cell carcinoma (TCC) and non-TCC group, respectively, with P = 0.04. There was no mortality in Stages 0 and 1 disease. Five-year survival was 78% in Stage 2 and 41% in Stage 3 and 4. Conclusion: Our study demonstrates acceptable clinical, perioperative, and oncological outcomes of robotic radical cystectomy in females, thus highlighting its safety and feasibility.

Journal of biomedical research & environmental sciences, 2023

Journal of Biomedical Research & Environmental Sciences main aim is to enhance the importance of ... more Journal of Biomedical Research & Environmental Sciences main aim is to enhance the importance of science and technology to the scientifi c community and also to provide an equal opportunity to seek and share ideas to all our researchers and scientists without any barriers to develop their career and helping in their development of discovering the world.

International Journal of Environmental Research and Public Health

Lung cancer is the world’s leading cause of cancer-related deaths. Epidermal growth factor recept... more Lung cancer is the world’s leading cause of cancer-related deaths. Epidermal growth factor receptor (EGFR) is one of the critical oncogenes and plays a significant role in tumor proliferation and metastasis. Patients with sensitizing mutations in the EGFR gene have better clinical outcomes when treated with tyrosine kinase inhibitors (TKI). This study expands our knowledge of the spectrum of EGFR mutations among lung cancer patients in the Indian scenario. This is a retrospective descriptive study of all newly diagnosed patients with lung cancer in tertiary care hospital in India. All the samples were subjected to real-time PCR (q-PCR) analysis and confirmation of rare novel mutations was done using Sanger sequencing. Clinicopathological characteristics, mutational EGFR status, and location on the exon and metastatic sites were evaluated. An analysis of total 212 samples showed mutations in 38.67% of cases. Among these, five (5.9%) samples had mutations in exon 18, 41 (48.8%) sample...

The Journal of the Association of Physicians of India, 2008

Bombay Hospital Journal, 2010

Introduction aragonimiasisis is common in South East Asia. Reports of lung paragonimiasis are des... more Introduction aragonimiasisis is common in South East Asia. Reports of lung paragonimiasis are described in Arunachal Pradesh and Manipur states in India. However, cases of cerebral paragonimiasis are not described in the Indian literature. Hence, we are reporting this case on account of ...

Indian Journal of Medical Sciences, 2007

Granulocytic sarcoma is a rare extramedullary tumor composed of immature myeloid cells. It is usu... more Granulocytic sarcoma is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast is an uncommon site of presentation and requires a high index of suspicion for diagnosis. We report such a case in a 45-year-old female, who presented with nontender left breast lump of 6 months' duration. A peripheral smear and bone marrow examination at that time was normal. A lumpectomy was done. An H and E diagnosis of lobular carcinoma vs. non-Hodgkin's lymphoma was entertained. Immunostains, however, revealed myeloperoxidase, naphthol AS-D chloroacetate esterase and CD43 positivity, indicating a diagnosis of granulocytic sarcoma. It appears that early initiation of systemic AML-type chemotherapy is beneficial and may delay or avert the development of AML in bone marrow and blood. Eight months later, the patient presented with an orbital mass;...

Indian Journal of Medical and Paediatric Oncology, 2014

Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-... more Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A proforma recorded the morphologic and immunohistochemical features perceived during the initial independent diagnosis followed by a consensus meeting for discussion on morphology and additional information pertinent to the case. Statistical analysis and Results: The concordance was poor for independent diagnosis among all the pathologists with kappa statistics (±SE) of 0.168 (±0.018). Expert lymphoma pathologists had the highest (albeit only fair) concordance (kappa = 0.373 ± 0.071) and general pathologists the lowest concordance (kappa = 0.138 ± 0.035). Concordance for morphological diagnosis was highest among expert lymphoma pathologists (kappa = 0.356 ± 0.127). Revision of diagnoses after consensus meeting was highest for B-cell lymphoma intermediate between DLB and BL. To conclude, interobserver variation is a significant problem in BL in the post WHO 2008 classification era. Experience with a larger number of cases and joint discussion exercises such as the one we conducted are needed as they represent a simple and effective way of improving diagnostic accuracy of pathologists working in a resource-limited setup.

Journal of Medical Imaging and Radiation Oncology, 2020

Nasopharyngeal gliomas are congenital masses of heterotopic glial tissue. Our case report describ... more Nasopharyngeal gliomas are congenital masses of heterotopic glial tissue. Our case report describes an infant with respiratory distress produced by a nasopharyngeal glioma with a persistent craniopharyngeal canal (CPC). The identification of CPC is important for medical and surgical management of possible pituitary dysfunction and preventing operative and post‐operative complications.

Indian pediatrics, 2013

A rapidly growing soft tissue mass in the axilla of an infant raises the suspicion of a lipoblast... more A rapidly growing soft tissue mass in the axilla of an infant raises the suspicion of a lipoblastoma or a liposarcoma. Excisional/incisional biopsy is vital in confirming the diagnosis and hence avoiding aggressive extirpation. This case report highlights the role of histopathology and immunohistochemistry as the gold standard in differentiating a lipoblastoma from a liposarcoma. In some cases where the histopathology is inconclusive, genetic rearrangement of the PLAG1 (pleomorphic adenoma gene 1) oncogene on chromosome 8q12 helps in confirming the diagnosis of lipoblastoma.

Simultaneous occurrence of adenocarcinoma and neuroendocrine carcinoma is rare in tumours of gast... more Simultaneous occurrence of adenocarcinoma and neuroendocrine carcinoma is rare in tumours of gastrointestinal tract, but even rarer in tumours of the gall bladder. We report a similar case in 57 year male admitted with pain in abdomen, intermittent jaundice, and loose motions since 1 year. Per abdomen examination revealed a palpable mass in the right hypochondriac region. C T scan revealed a distended gall bladder with mildly enhancing lobulated, polypoidal mass in fundal region. Gross examination of the specimen revealed enlarged gall bladder with a lobulated, polypoidal, fundic mass measuring 4 cm in diameter. On cut surface it, was greyish white to yellow infiltrating the wall to reach serosa. revealed a tumour showing glandular (adenocarcinoma) and neuroendocrine differentiation. Immunohistochemical stains were positive for both glandular and neuroendocrine elements. Malignant tumours of the gall bladder are uncommon with mixed tumours being even rarer. The histogenesis of compo...

Annals of Indian Academy of Neurology, 2021

International Journal of Medical and Biomedical Studies, Jan 11, 2020

A generic diagnosis of 'small cell or non-small cell carcinoma' was sufficient in the past when t... more A generic diagnosis of 'small cell or non-small cell carcinoma' was sufficient in the past when there was no clinical demand for sub classification as it had no impact on therapy. Patients with advanced stage non-small cell lung carcinoma who received chemotherapy were typically treated with a 'platinum doublet' of cisplatin plus gemcitabine irrespective of histological subtype. At present, in contrast, sub classification of non-small cell lung carcinoma has significant treatment implications, especially for advanced stage tumors for which chemotherapy or targeted therapy is being considered. Consequently, pathologists are asked to subtype the tumor. The demand for sub typing is driven by oncologists, who now have several new targeted therapies, the efficacy of which varies by histological subtype. In view of demand of sub typing of lung carcinomas as well as the guidelines given by WHO 2015 classification which emphasises the importance of a separate classification for biopsies and cytology on one side and the resection specimen on the other, we have taken up this study.

Journal of Indian Association of Pediatric Surgeons, 2007

Indian Pediatrics, 2013

We present a 15-year-old boy who developed severe rhabdomyolysis and acute renal failure followin... more We present a 15-year-old boy who developed severe rhabdomyolysis and acute renal failure following influenza B infection. His renal function was restored after appropriate therapy for rhabdomyolysis. Although rapidly progressive pneumonia, respiratory failure, and acute respiratory distress syndrome are the most common severe complications of influenza B infection, clinicians should be aware that influenza B may be complicated with rhabdomyolysis and acute renal failure in children.