Mehmet A Bedirhan - Academia.edu (original) (raw)

Papers by Mehmet A Bedirhan

Research paper thumbnail of Does mediastinal lymph node involvement influence the surgical outcome in malign pleural mesothelioma?

Acta Chirurgica Belgica, Jul 15, 2022

Research paper thumbnail of Long-Term Outcomes of Carinal Sleeve Resection in Non-Small Cell Lung Cancer

Thoracic and Cardiovascular Surgeon, Feb 26, 2019

Background Carinal resections for non-small cell lung cancer (NSCLC) invading the carina are chal... more Background Carinal resections for non-small cell lung cancer (NSCLC) invading the carina are challenging cases that require a therapeutic strategy. The aim of this study was to compare the oncologic outcomes and complications of patients who underwent carinal resection. Methods Sixty-four patients who underwent carinal resection between 2005 and 2016 were evaluated. Data were retrospectively reviewed for indications, complications, and factors influencing long-term survival. Results The study included 51 patients (79.7%) who underwent sleeve pneumonectomy (sP) and 13 patients who underwent carinal sleeve lobectomy (csL) as a curative therapy. Nine patients (14.1%) received induction chemotherapy. Complications were observed in 31 patients (48.8%), including 24 patients (47.1%) in the sP group and 7 patients (53.8%) in the csL group (p = 0.662). Six patients (9.4%) developed bronchopleural fistula. The 30-day mortality rate was 10.9% (n = 7). The 5- and 10-year survival rates were 42.2 and 23.1%, respectively. N2 and R1 were identified as factors affecting survival (p = 0.029 and p = 0.047). Conclusion Carinal resections have acceptable morbidity, mortality, and long-term survival outcomes in central NSCLC. The main factors affecting survival are complete resection and nodal status. The results of csL were similar to those of sP. Therefore, we believe that csL should be performed in all eligible patients.

Research paper thumbnail of Arteryel Tutulma İle Müraacat Eden Torasik Outlet'li Hastalara Ait Klinik ve Cerrahi Sonuçlar

DergiPark (Istanbul University), Feb 1, 1988

Research paper thumbnail of Travmatik sternum fraktürlerinde tanı ve tedavi

Research paper thumbnail of Clinical and surgical approaches for malignant pulmonary lesions after a previous extrapulmonary malignancy

Anz Journal of Surgery, Jun 28, 2021

In our study, since the operative histopathological distinction of new malignant pulmonary lesion... more In our study, since the operative histopathological distinction of new malignant pulmonary lesions as either a primary lung cancer or a pulmonary metastasis is difficult, we aimed to identify the clinical variables which might allow distinction between a new lung cancer and a pulmonary metastasis, and the appropriate surgical management.

Research paper thumbnail of Morbidity, mortality and survival rates of non-small cell lung cancer patients who underwent lobectomy with pulmonary artery reconstruction compared to those of the patients who underwent pneumonectomy

Current thoracic surgery, 2020

Morbidity, mortality and survival rates of non-small cell lung cancer patients who underwent lobe... more Morbidity, mortality and survival rates of non-small cell lung cancer patients who underwent lobectomy with pulmonary artery reconstruction compared to those of the patients who underwent pneumonectomy.

Research paper thumbnail of Primary Sternal Tuberculosis Mimicking an Anterior Chest Wall Tumor: A Case Report

Respiratory Case Reports, 2020

Sternum tüberkülozu tüm kemik-eklem tüberküloz olguların %1-3 oluştur ve oldukça nadir görülmekte... more Sternum tüberkülozu tüm kemik-eklem tüberküloz olguların %1-3 oluştur ve oldukça nadir görülmektedir. Tanı konulması, atipik prezantasyon nedeni ile sıklıkla gecikmektedir. Toraks MR, erken dönem ve atipik prezantasyonlarda tanı koydurucu olmaktadır. Yirmi üç yaşında kadın hasta, altı aydır göğüs ağrısı ve göğüs duvarında şişlik şikâyeti ile merkezimize başvurdu. Toraks BT ve MR 'ında 33x28x42 mm büyüklüğünde sternum korpusunu eroze eden kitle görüldü. Sternum rezeksiyon biyopsinin histopatolojik incelemesi tüberküloz ile uyumlu bulundu. Ülkemiz gibi tüberkülozun sık görüldüğü bölgelerde genç yaş grubunda sternum tüberkülozu göğüs duvarı kitlerinin ayırıcı tanısında düşünülmelidir. Göğüs duvarı tümörünü taklit eden ve sternal tüberküloz tanısı koyduğumuz bu olguyu sunduk.

Research paper thumbnail of Akciğer Kist Hidatiği - 36 Olgunun Sonuçları

DergiPark (Istanbul University), Mar 1, 1988

Research paper thumbnail of Factors affecting survival after resection of stage iib non-small cell lung cancer

Current thoracic surgery, 2022

Background: Our aim in this study was to evaluate prognostic factors affecting survival and disea... more Background: Our aim in this study was to evaluate prognostic factors affecting survival and diseasefree survival (DFS) in the subgroups of stage IIB NSCLCs. Materials and Methods: Patients with stage IIB NSCLC who underwent surgery in our hospital between January 2006 and December 2015 were included in the study. The patients were evaluated in two groups: T3N0 patients staged as IIB due to pN0 (Group A) and T1N1/T2N1 patients (Group B). Results: Of the 192 patients were included in the study. There were 47 patients in group A (24.5%) and 145 patients in group B (75.5%). 5-year survival rates was 58.2%. There was no statistically significant difference in survival according to T stage. The 5-year survival rates in the T1, T2, and T3 groups were 69%, 55.3%, and 54.6%, respectively (p = 0.34). The main prognostic factors affecting survival were advanced age (p = 0.02). The mean DFS was 72 months and the 5-year DFS rate was 54%. Advanced age and male sex, were identified as poor prognostic factors for DFS (p < 0.005). Conclusions: The stage IIB category remains heterogeneous despite the updated eighth edition IASCL staging system. The results of our study indicate that age was the main prognostic factors affecting survival in stage IIB NSCLC. However, the effect of visceral pleural invasion and lymph node involvement on survival in stage IIB subgroups was not detected, more comprehensive multicenter studies are still needed.

Research paper thumbnail of Lung Cancer Surgery Part K: Intraoperative Mediastinal Lymph Node Examination Techniques in Non-Small Cell Lung Cancer

BENTHAM SCIENCE PUBLISHERS eBooks, Jul 9, 2013

Research paper thumbnail of İliak Arter Rekonstrüksiyonlarının Penil Arter Akımı Üzerine Etkisi

Research paper thumbnail of The effect of transcutaneous electric nerve stimulation in patients with therapy-resistant hypertension

Journal of Human Hypertension, 2000

Objectives: Afferent nerve stimulation, such as acupuncture and transcutaneous electric nerve sti... more Objectives: Afferent nerve stimulation, such as acupuncture and transcutaneous electric nerve stimulation (TENS), has shown a blood pressure reduction in both animal and man. In the present open and non-controlled study we investigated the effect on 24-h ambulatory blood pressure of low frequency TENS in a group of hypertensive subjects who do not respond properly to pharmacological treatment. Method: Twelve patients were investigated. The patients were treated with TENS at two acupoints on both forearms for 30 min twice daily during 4 weeks. 24-hour ambulatory blood pressure monitoring was recorded 1 week before, at start, at the end and finally 1 week after the TENS treatment.

Research paper thumbnail of A case of surgically treated bilateral metachronous malignant pleural mesothelioma

The Turkish Journal of Thoracic and Cardiovascular Surgery, 2019

Bu yazıda, hastanemize sağ plevral efüzyon ve sağ taraflı göğüs ağrısı ile kabul edilen ve torase... more Bu yazıda, hastanemize sağ plevral efüzyon ve sağ taraflı göğüs ağrısı ile kabul edilen ve torasentez ve plevral biyopsi ile malign plevral mezotelyoma tanısı konulan 59 yaşında bir erkek hasta sunuldu. Hastanın ameliyat edilebilir olduğunun belirlenmesini takiben, sağ parietal plörektomi + perikardiyal rezeksiyon + diyafragma rezeksiyonu uygulandı ve adjuvan tedavi olarak dört siklus sisplatin ve pemetreksed kombinasyonu eklendi. Hasta üç buçuk yıl boyunca herhangi bir problem olmaksızın takip edildi. Bu dönemde, sol taraflı göğüs ağrısı ve sol taraflı efüzyon fark edildi. Torasentez ve plevral biyopside tümör negatif idi. Sonra, evre 1a malign plevral mezotelyoma ile sonuçlanan video yardımlı torakoskopik cerrahi gerçekleştirildi. Torakoskopik parietal plörektomi başarıyla uygulandı. Adjuvan tedavi olarak dört siklus pemetreksed tek ajan terapisi uygulandı. Hasta tümörsüzken birinci ameliyatın 57. ve ikincisinin 21. ayında kronik obstrüktif akciğer hastalığı ve kalp yetmezliği nedeniyle öldü. Bildiğimiz kadarıyla, bu olgu literatürdeki ilk ameliyat edilmiş iki taraflı metakron primer malign plevral mezotelyomadır. Anah tar söz cük ler: Asbestozis; malign plevral mezotelyoma; plevra tümörleri; cerrahi.

Research paper thumbnail of Elastofibroma dorsi: a review of 42 cases

Turkish Journal of Thoracic and Cardiovascular Surgery, 2014

Bu çalışmada, elastofibroma dorsiye yönelik cerrahi sonuçlarımız gözden geçirildi. Ça lış ma pla ... more Bu çalışmada, elastofibroma dorsiye yönelik cerrahi sonuçlarımız gözden geçirildi. Ça lış ma pla nı: Ocak 2005-Aralık 2012 tarihleri arasında kliniğimizde ameliyat edilen toplam 42 hasta (33 kadın, 9 erkek; ort. yaş 59.7 yıl; dağılım 31-77 yıl) çalışmaya alındı. Başka neden ile yapılan torakotomide rastlanan iki olgu dışında tüm olgularda ağrı, şişlik ya da omuz hareketlerinde kısıtlılık yakınmaları vardı. Tümörler 23 hastada iki taraflı idi (%55). Hastaların tümü ameliyat edildi. Bul gu lar: Ameliyat sonrası komplikasyon altı hastada seroma, bir hastada pnömotoraks, bir hastada da sekizinci ayda lokal nüks idi. So nuç: Elastofibroma dorsi olgularında tanı kesin ise ve klinik bulgu bulunmuyorsa, asemptomatik olgular takip edilebilir. Ancak semptomatik olgular veya tanıda şüphe olan olgular ameliyat edilmelidir. Anah tar söz cük ler: Göğüs duvarı tümörü; elastofibroma dorsi; yumuşak doku tümörü. Background: This study aims to review our surgical results of elastofibroma dorsi. Methods: Between January 2005 and December 2012, a total of 42 patients (33 females, 9 males; mean age 59.7 years; range 31 to 77 years) who were operated in our clinic were included. All patients were admitted with complaints of pain, swelling or limited range of motions of the shoulder range except two cases who underwent thoracotomy for other reasons. Twenty three patients (55%) had bilateral tumors. All patients were operated. Results: Postoperative complications were seroma in six patients, pneumothorax in one and local recurrence in one at eight months. Conclusion:If diagnosis is definitive without any clinical signs in elastofibroma dorsi cases, asymptomatic cases can be followed up. However, symptomatic cases or those with a suspected diagnosis should be operated.

Research paper thumbnail of Pneumonectomy for non-small cell lung cancer: factors affecting morbidity and mortality

Bu çal›flmada, küçük hücreli d›fl› akci¤er kanseri nedeniyle pnömonektomi uygulanan olgularda mor... more Bu çal›flmada, küçük hücreli d›fl› akci¤er kanseri nedeniyle pnömonektomi uygulanan olgularda morbidite ve mortaliteyi etkileyen faktorler retrospektif olarak araflt›r›ld›. KHDAK nedeniyle pnömenektomi yap›lan 97'si erkek, 4'u kad›n, ortalama yafllar› 56+9.6 (30-75 yafl) olan 101 hasta de¤erlendirildi. Morbidite oran› %52.5 (53 hasta), mortalite oran› %8.9 (9 hasta) olarak saptand›. Morbidite nedenleri olarak %77'si kalp ve solunum, %11 yara yeri infeksiyonu, %8 hemoraji ve %4 di¤er nedenler bulundu. Tek de¤iflkenli analiz (univariate analysis) ile kalp ve solunum morbiditesi için risk faktörü olan sebepler 60 yafl üzeri hastalar (p=0.006), FEV1<2L (p=0.029) ve bronkoplevral fistul (p=0.0001) olarak saptand›. Çok de¤iflkenli analiz (multivariate analysis) ile kalp ve solunum morbiditesi için risk faktörü olarak sadece 60 yafl üzeri hastalar (p=0.006) bulundu. Tek de¤iflkenli analiz ile mortalite için risk faktörleri sa¤ pnömonektomi (p=0.035), solunum morbiditesi (p=0.0001), kardiyak morbidite (p=0.003) ve hücre tipi (p=0.047) olarak saptand›. Çok de¤iflkenli analiz ile mortalite için risk faktörleri olarak sa¤ pnömonektomi (p=0.045) ve solunum morbiditesi (p=0.001) bulundu. Sonuç olarak; KHDAK nedeni ile yap›lan pnömonektomilerde morbidite ve mortalite multifaktöryeldir. Uygun hasta seçimi, dikkatli operasyon öncesi ve sonras› de¤erlendirme, pnömonektomilerde riskleri en az düzeye indirecektir.

Research paper thumbnail of Chylothorax: A Complication Following Lung Resection in Patients with NSCLC

Thoracic and Cardiovascular Surgeon, Dec 1, 2003

Chylothorax following lung resection is not as rare as a postoperative complication as previously... more Chylothorax following lung resection is not as rare as a postoperative complication as previously reported due to systematic lymph node dissection in patients undergoing lung resection for NSCLC. We retrospectively reviewed our cases that had undergone lung resection for NSCLC and investigated the frequency and outcome of chylothorax in these patients. The factors investigated were the site and type resection, technique of systematic lymph node dissection, tumour histology and disease stage. Seven of 673 patients that had undergone lung resection were complicated by chylothorax (1.04 %), following lobectomy in 5 (1.28 %) and pneumonectomy in 2 (0.7 %) (p = 0.36). The fistula closed spontaneously in 5 patients between 4 - 17 days postoperatively (71 %). One of the patients in the conservative management group died on the 28th day postoperatively due to pneumonia (14 %). The remaining 2 patients underwent rethoracotomy on the 5th and 6th days. These results suggest that the site of operation, type resection, and technique of systematic nodal dissection, tumour histology and disease stage do not influence the development of chylothorax in patients with NSCLC. The chylous fistula following lung resection for NSCLC tends to close spontaneously.

Research paper thumbnail of Bronşiyal karsinoid tümörlerde cerrahi tedavi sonrası uzun süreli izlem sonuçları

Toraks Dergisi, 2002

... S. İbrahim Dinçer, Güven Olgaç, Adalet Demir, Okan Solak, Tevrat Özalp, Hasan Akın, M. Ali Be... more ... S. İbrahim Dinçer, Güven Olgaç, Adalet Demir, Okan Solak, Tevrat Özalp, Hasan Akın, M. Ali Bedirhan, Aysun Ölçmen, Atilla Gürses. ... Görece küçük boyutta olmalarının yanı sıra, çok yavaş büyümeleri nedeniyle de bu semptomlar uzun yıllar devam edebilir 6 , 7 . Birçok seride ...

Research paper thumbnail of The diagnostic role of video-assisted thoracoscopic surgery in exudative pleural effusion and follow-up results in patients with nonspecific pleuritis

PubMed, Aug 1, 2019

Objective: To assess the diagnostic value of video-assisted thoracoscopic surgery in exudative pl... more Objective: To assess the diagnostic value of video-assisted thoracoscopic surgery in exudative pleural effusions, and to evaluated the frequency of malignancy development with long term follow-up of patients defined as nonspecific pleuritis after surgery. . Methods: The retrospective study was conducted at Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey, and comprised data of patients with undiagnosed exudative pleural effusions seen between January 2008 and December 2013. Data related to clinical, radiological, thoracoscopical, histopathological and follow-up periods were obtained from the hospital records. SPSS 15 was used for data analysis. Results: Of the 229 patients, 145(63.3%) were males and 84(36.7%) were females. The overall mean age was 54.5 }15.1 years. Malignancy was found in 84 (36.6%) patients, and tuberculosis in 26(11.4%). The remaining 119(52%) patients had nonspecific pleuritis and their mean follow-up period was 29.2}27.1 months (range: 1-103 months). Video-assisted thoracoscopic surgery was repeated in 3(2.52%) patients in the 1st, 4th and 16th months of followup period due to the recurrence of pleural effusion. Tuberculosis and mesothelioma were diagnosed in 1(0.8%) and 2(1.7%) cases, respectively. Conclusions: Video-assisted thoracoscopic surgery was found to be a valuable diagnostic procedure in patients with undiagnosed exudative pleural effusion.

Research paper thumbnail of Mature cystic teratoma, ectopic mediastinal pancreas: a case report

Research paper thumbnail of P2.18-14 The Role of Surgery in High Grade Neuroendocrine Tumors of the Lung

Journal of Thoracic Oncology, Oct 1, 2019

included in-situ carcinoma (n¼1, 6%) and invasive squamous cell carcinoma (n¼15, 94%). T staging ... more included in-situ carcinoma (n¼1, 6%) and invasive squamous cell carcinoma (n¼15, 94%). T staging was T1 in 10 (62.5%) patients, T2 in 3 (18.8%) patients and T4 in 1 (6.3%) patient. All patients had N0 staging. 2 patients had exclusive endobronchial disease. 6 patients received 3 (n¼3, 18.6%) and 4 (n¼3, 18.6%) fractions after external beam radiotherapy as a boost. 10 patients received 5 (n¼2, 12.5%) or 6 (n¼8, 50%) fractions as exclusive radical HDR-EB. 2 complications were reported: obstructive pneumonitis (n¼1) and bronchial stenosis (n¼1). Neither deaths nor haemoptysis occurred in relation with the technique. Mean follow-up was 29 (±21) months. Mean overall survival was 29.0 (±22) months. Mean disease free-survival was 24.9 (±21) months. 4 (25%) progressions were observed, of which 3 (19%) were local progression. Patients who received boost strategy HDR-EB showed an increased overall survival compared to radical intent (38.2 vs 24.8, p>0.05) and a increased median free-survival; which showed no statistical significance. Conclusion: HDR-EB is a safe technique applicable in radical intention. Longer survival has been described in patients who received boost strategy. Prospective studies are needed to determine long-term benefits.

Research paper thumbnail of Does mediastinal lymph node involvement influence the surgical outcome in malign pleural mesothelioma?

Acta Chirurgica Belgica, Jul 15, 2022

Research paper thumbnail of Long-Term Outcomes of Carinal Sleeve Resection in Non-Small Cell Lung Cancer

Thoracic and Cardiovascular Surgeon, Feb 26, 2019

Background Carinal resections for non-small cell lung cancer (NSCLC) invading the carina are chal... more Background Carinal resections for non-small cell lung cancer (NSCLC) invading the carina are challenging cases that require a therapeutic strategy. The aim of this study was to compare the oncologic outcomes and complications of patients who underwent carinal resection. Methods Sixty-four patients who underwent carinal resection between 2005 and 2016 were evaluated. Data were retrospectively reviewed for indications, complications, and factors influencing long-term survival. Results The study included 51 patients (79.7%) who underwent sleeve pneumonectomy (sP) and 13 patients who underwent carinal sleeve lobectomy (csL) as a curative therapy. Nine patients (14.1%) received induction chemotherapy. Complications were observed in 31 patients (48.8%), including 24 patients (47.1%) in the sP group and 7 patients (53.8%) in the csL group (p = 0.662). Six patients (9.4%) developed bronchopleural fistula. The 30-day mortality rate was 10.9% (n = 7). The 5- and 10-year survival rates were 42.2 and 23.1%, respectively. N2 and R1 were identified as factors affecting survival (p = 0.029 and p = 0.047). Conclusion Carinal resections have acceptable morbidity, mortality, and long-term survival outcomes in central NSCLC. The main factors affecting survival are complete resection and nodal status. The results of csL were similar to those of sP. Therefore, we believe that csL should be performed in all eligible patients.

Research paper thumbnail of Arteryel Tutulma İle Müraacat Eden Torasik Outlet'li Hastalara Ait Klinik ve Cerrahi Sonuçlar

DergiPark (Istanbul University), Feb 1, 1988

Research paper thumbnail of Travmatik sternum fraktürlerinde tanı ve tedavi

Research paper thumbnail of Clinical and surgical approaches for malignant pulmonary lesions after a previous extrapulmonary malignancy

Anz Journal of Surgery, Jun 28, 2021

In our study, since the operative histopathological distinction of new malignant pulmonary lesion... more In our study, since the operative histopathological distinction of new malignant pulmonary lesions as either a primary lung cancer or a pulmonary metastasis is difficult, we aimed to identify the clinical variables which might allow distinction between a new lung cancer and a pulmonary metastasis, and the appropriate surgical management.

Research paper thumbnail of Morbidity, mortality and survival rates of non-small cell lung cancer patients who underwent lobectomy with pulmonary artery reconstruction compared to those of the patients who underwent pneumonectomy

Current thoracic surgery, 2020

Morbidity, mortality and survival rates of non-small cell lung cancer patients who underwent lobe... more Morbidity, mortality and survival rates of non-small cell lung cancer patients who underwent lobectomy with pulmonary artery reconstruction compared to those of the patients who underwent pneumonectomy.

Research paper thumbnail of Primary Sternal Tuberculosis Mimicking an Anterior Chest Wall Tumor: A Case Report

Respiratory Case Reports, 2020

Sternum tüberkülozu tüm kemik-eklem tüberküloz olguların %1-3 oluştur ve oldukça nadir görülmekte... more Sternum tüberkülozu tüm kemik-eklem tüberküloz olguların %1-3 oluştur ve oldukça nadir görülmektedir. Tanı konulması, atipik prezantasyon nedeni ile sıklıkla gecikmektedir. Toraks MR, erken dönem ve atipik prezantasyonlarda tanı koydurucu olmaktadır. Yirmi üç yaşında kadın hasta, altı aydır göğüs ağrısı ve göğüs duvarında şişlik şikâyeti ile merkezimize başvurdu. Toraks BT ve MR 'ında 33x28x42 mm büyüklüğünde sternum korpusunu eroze eden kitle görüldü. Sternum rezeksiyon biyopsinin histopatolojik incelemesi tüberküloz ile uyumlu bulundu. Ülkemiz gibi tüberkülozun sık görüldüğü bölgelerde genç yaş grubunda sternum tüberkülozu göğüs duvarı kitlerinin ayırıcı tanısında düşünülmelidir. Göğüs duvarı tümörünü taklit eden ve sternal tüberküloz tanısı koyduğumuz bu olguyu sunduk.

Research paper thumbnail of Akciğer Kist Hidatiği - 36 Olgunun Sonuçları

DergiPark (Istanbul University), Mar 1, 1988

Research paper thumbnail of Factors affecting survival after resection of stage iib non-small cell lung cancer

Current thoracic surgery, 2022

Background: Our aim in this study was to evaluate prognostic factors affecting survival and disea... more Background: Our aim in this study was to evaluate prognostic factors affecting survival and diseasefree survival (DFS) in the subgroups of stage IIB NSCLCs. Materials and Methods: Patients with stage IIB NSCLC who underwent surgery in our hospital between January 2006 and December 2015 were included in the study. The patients were evaluated in two groups: T3N0 patients staged as IIB due to pN0 (Group A) and T1N1/T2N1 patients (Group B). Results: Of the 192 patients were included in the study. There were 47 patients in group A (24.5%) and 145 patients in group B (75.5%). 5-year survival rates was 58.2%. There was no statistically significant difference in survival according to T stage. The 5-year survival rates in the T1, T2, and T3 groups were 69%, 55.3%, and 54.6%, respectively (p = 0.34). The main prognostic factors affecting survival were advanced age (p = 0.02). The mean DFS was 72 months and the 5-year DFS rate was 54%. Advanced age and male sex, were identified as poor prognostic factors for DFS (p < 0.005). Conclusions: The stage IIB category remains heterogeneous despite the updated eighth edition IASCL staging system. The results of our study indicate that age was the main prognostic factors affecting survival in stage IIB NSCLC. However, the effect of visceral pleural invasion and lymph node involvement on survival in stage IIB subgroups was not detected, more comprehensive multicenter studies are still needed.

Research paper thumbnail of Lung Cancer Surgery Part K: Intraoperative Mediastinal Lymph Node Examination Techniques in Non-Small Cell Lung Cancer

BENTHAM SCIENCE PUBLISHERS eBooks, Jul 9, 2013

Research paper thumbnail of İliak Arter Rekonstrüksiyonlarının Penil Arter Akımı Üzerine Etkisi

Research paper thumbnail of The effect of transcutaneous electric nerve stimulation in patients with therapy-resistant hypertension

Journal of Human Hypertension, 2000

Objectives: Afferent nerve stimulation, such as acupuncture and transcutaneous electric nerve sti... more Objectives: Afferent nerve stimulation, such as acupuncture and transcutaneous electric nerve stimulation (TENS), has shown a blood pressure reduction in both animal and man. In the present open and non-controlled study we investigated the effect on 24-h ambulatory blood pressure of low frequency TENS in a group of hypertensive subjects who do not respond properly to pharmacological treatment. Method: Twelve patients were investigated. The patients were treated with TENS at two acupoints on both forearms for 30 min twice daily during 4 weeks. 24-hour ambulatory blood pressure monitoring was recorded 1 week before, at start, at the end and finally 1 week after the TENS treatment.

Research paper thumbnail of A case of surgically treated bilateral metachronous malignant pleural mesothelioma

The Turkish Journal of Thoracic and Cardiovascular Surgery, 2019

Bu yazıda, hastanemize sağ plevral efüzyon ve sağ taraflı göğüs ağrısı ile kabul edilen ve torase... more Bu yazıda, hastanemize sağ plevral efüzyon ve sağ taraflı göğüs ağrısı ile kabul edilen ve torasentez ve plevral biyopsi ile malign plevral mezotelyoma tanısı konulan 59 yaşında bir erkek hasta sunuldu. Hastanın ameliyat edilebilir olduğunun belirlenmesini takiben, sağ parietal plörektomi + perikardiyal rezeksiyon + diyafragma rezeksiyonu uygulandı ve adjuvan tedavi olarak dört siklus sisplatin ve pemetreksed kombinasyonu eklendi. Hasta üç buçuk yıl boyunca herhangi bir problem olmaksızın takip edildi. Bu dönemde, sol taraflı göğüs ağrısı ve sol taraflı efüzyon fark edildi. Torasentez ve plevral biyopside tümör negatif idi. Sonra, evre 1a malign plevral mezotelyoma ile sonuçlanan video yardımlı torakoskopik cerrahi gerçekleştirildi. Torakoskopik parietal plörektomi başarıyla uygulandı. Adjuvan tedavi olarak dört siklus pemetreksed tek ajan terapisi uygulandı. Hasta tümörsüzken birinci ameliyatın 57. ve ikincisinin 21. ayında kronik obstrüktif akciğer hastalığı ve kalp yetmezliği nedeniyle öldü. Bildiğimiz kadarıyla, bu olgu literatürdeki ilk ameliyat edilmiş iki taraflı metakron primer malign plevral mezotelyomadır. Anah tar söz cük ler: Asbestozis; malign plevral mezotelyoma; plevra tümörleri; cerrahi.

Research paper thumbnail of Elastofibroma dorsi: a review of 42 cases

Turkish Journal of Thoracic and Cardiovascular Surgery, 2014

Bu çalışmada, elastofibroma dorsiye yönelik cerrahi sonuçlarımız gözden geçirildi. Ça lış ma pla ... more Bu çalışmada, elastofibroma dorsiye yönelik cerrahi sonuçlarımız gözden geçirildi. Ça lış ma pla nı: Ocak 2005-Aralık 2012 tarihleri arasında kliniğimizde ameliyat edilen toplam 42 hasta (33 kadın, 9 erkek; ort. yaş 59.7 yıl; dağılım 31-77 yıl) çalışmaya alındı. Başka neden ile yapılan torakotomide rastlanan iki olgu dışında tüm olgularda ağrı, şişlik ya da omuz hareketlerinde kısıtlılık yakınmaları vardı. Tümörler 23 hastada iki taraflı idi (%55). Hastaların tümü ameliyat edildi. Bul gu lar: Ameliyat sonrası komplikasyon altı hastada seroma, bir hastada pnömotoraks, bir hastada da sekizinci ayda lokal nüks idi. So nuç: Elastofibroma dorsi olgularında tanı kesin ise ve klinik bulgu bulunmuyorsa, asemptomatik olgular takip edilebilir. Ancak semptomatik olgular veya tanıda şüphe olan olgular ameliyat edilmelidir. Anah tar söz cük ler: Göğüs duvarı tümörü; elastofibroma dorsi; yumuşak doku tümörü. Background: This study aims to review our surgical results of elastofibroma dorsi. Methods: Between January 2005 and December 2012, a total of 42 patients (33 females, 9 males; mean age 59.7 years; range 31 to 77 years) who were operated in our clinic were included. All patients were admitted with complaints of pain, swelling or limited range of motions of the shoulder range except two cases who underwent thoracotomy for other reasons. Twenty three patients (55%) had bilateral tumors. All patients were operated. Results: Postoperative complications were seroma in six patients, pneumothorax in one and local recurrence in one at eight months. Conclusion:If diagnosis is definitive without any clinical signs in elastofibroma dorsi cases, asymptomatic cases can be followed up. However, symptomatic cases or those with a suspected diagnosis should be operated.

Research paper thumbnail of Pneumonectomy for non-small cell lung cancer: factors affecting morbidity and mortality

Bu çal›flmada, küçük hücreli d›fl› akci¤er kanseri nedeniyle pnömonektomi uygulanan olgularda mor... more Bu çal›flmada, küçük hücreli d›fl› akci¤er kanseri nedeniyle pnömonektomi uygulanan olgularda morbidite ve mortaliteyi etkileyen faktorler retrospektif olarak araflt›r›ld›. KHDAK nedeniyle pnömenektomi yap›lan 97'si erkek, 4'u kad›n, ortalama yafllar› 56+9.6 (30-75 yafl) olan 101 hasta de¤erlendirildi. Morbidite oran› %52.5 (53 hasta), mortalite oran› %8.9 (9 hasta) olarak saptand›. Morbidite nedenleri olarak %77'si kalp ve solunum, %11 yara yeri infeksiyonu, %8 hemoraji ve %4 di¤er nedenler bulundu. Tek de¤iflkenli analiz (univariate analysis) ile kalp ve solunum morbiditesi için risk faktörü olan sebepler 60 yafl üzeri hastalar (p=0.006), FEV1<2L (p=0.029) ve bronkoplevral fistul (p=0.0001) olarak saptand›. Çok de¤iflkenli analiz (multivariate analysis) ile kalp ve solunum morbiditesi için risk faktörü olarak sadece 60 yafl üzeri hastalar (p=0.006) bulundu. Tek de¤iflkenli analiz ile mortalite için risk faktörleri sa¤ pnömonektomi (p=0.035), solunum morbiditesi (p=0.0001), kardiyak morbidite (p=0.003) ve hücre tipi (p=0.047) olarak saptand›. Çok de¤iflkenli analiz ile mortalite için risk faktörleri olarak sa¤ pnömonektomi (p=0.045) ve solunum morbiditesi (p=0.001) bulundu. Sonuç olarak; KHDAK nedeni ile yap›lan pnömonektomilerde morbidite ve mortalite multifaktöryeldir. Uygun hasta seçimi, dikkatli operasyon öncesi ve sonras› de¤erlendirme, pnömonektomilerde riskleri en az düzeye indirecektir.

Research paper thumbnail of Chylothorax: A Complication Following Lung Resection in Patients with NSCLC

Thoracic and Cardiovascular Surgeon, Dec 1, 2003

Chylothorax following lung resection is not as rare as a postoperative complication as previously... more Chylothorax following lung resection is not as rare as a postoperative complication as previously reported due to systematic lymph node dissection in patients undergoing lung resection for NSCLC. We retrospectively reviewed our cases that had undergone lung resection for NSCLC and investigated the frequency and outcome of chylothorax in these patients. The factors investigated were the site and type resection, technique of systematic lymph node dissection, tumour histology and disease stage. Seven of 673 patients that had undergone lung resection were complicated by chylothorax (1.04 %), following lobectomy in 5 (1.28 %) and pneumonectomy in 2 (0.7 %) (p = 0.36). The fistula closed spontaneously in 5 patients between 4 - 17 days postoperatively (71 %). One of the patients in the conservative management group died on the 28th day postoperatively due to pneumonia (14 %). The remaining 2 patients underwent rethoracotomy on the 5th and 6th days. These results suggest that the site of operation, type resection, and technique of systematic nodal dissection, tumour histology and disease stage do not influence the development of chylothorax in patients with NSCLC. The chylous fistula following lung resection for NSCLC tends to close spontaneously.

Research paper thumbnail of Bronşiyal karsinoid tümörlerde cerrahi tedavi sonrası uzun süreli izlem sonuçları

Toraks Dergisi, 2002

... S. İbrahim Dinçer, Güven Olgaç, Adalet Demir, Okan Solak, Tevrat Özalp, Hasan Akın, M. Ali Be... more ... S. İbrahim Dinçer, Güven Olgaç, Adalet Demir, Okan Solak, Tevrat Özalp, Hasan Akın, M. Ali Bedirhan, Aysun Ölçmen, Atilla Gürses. ... Görece küçük boyutta olmalarının yanı sıra, çok yavaş büyümeleri nedeniyle de bu semptomlar uzun yıllar devam edebilir 6 , 7 . Birçok seride ...

Research paper thumbnail of The diagnostic role of video-assisted thoracoscopic surgery in exudative pleural effusion and follow-up results in patients with nonspecific pleuritis

PubMed, Aug 1, 2019

Objective: To assess the diagnostic value of video-assisted thoracoscopic surgery in exudative pl... more Objective: To assess the diagnostic value of video-assisted thoracoscopic surgery in exudative pleural effusions, and to evaluated the frequency of malignancy development with long term follow-up of patients defined as nonspecific pleuritis after surgery. . Methods: The retrospective study was conducted at Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey, and comprised data of patients with undiagnosed exudative pleural effusions seen between January 2008 and December 2013. Data related to clinical, radiological, thoracoscopical, histopathological and follow-up periods were obtained from the hospital records. SPSS 15 was used for data analysis. Results: Of the 229 patients, 145(63.3%) were males and 84(36.7%) were females. The overall mean age was 54.5 }15.1 years. Malignancy was found in 84 (36.6%) patients, and tuberculosis in 26(11.4%). The remaining 119(52%) patients had nonspecific pleuritis and their mean follow-up period was 29.2}27.1 months (range: 1-103 months). Video-assisted thoracoscopic surgery was repeated in 3(2.52%) patients in the 1st, 4th and 16th months of followup period due to the recurrence of pleural effusion. Tuberculosis and mesothelioma were diagnosed in 1(0.8%) and 2(1.7%) cases, respectively. Conclusions: Video-assisted thoracoscopic surgery was found to be a valuable diagnostic procedure in patients with undiagnosed exudative pleural effusion.

Research paper thumbnail of Mature cystic teratoma, ectopic mediastinal pancreas: a case report

Research paper thumbnail of P2.18-14 The Role of Surgery in High Grade Neuroendocrine Tumors of the Lung

Journal of Thoracic Oncology, Oct 1, 2019

included in-situ carcinoma (n¼1, 6%) and invasive squamous cell carcinoma (n¼15, 94%). T staging ... more included in-situ carcinoma (n¼1, 6%) and invasive squamous cell carcinoma (n¼15, 94%). T staging was T1 in 10 (62.5%) patients, T2 in 3 (18.8%) patients and T4 in 1 (6.3%) patient. All patients had N0 staging. 2 patients had exclusive endobronchial disease. 6 patients received 3 (n¼3, 18.6%) and 4 (n¼3, 18.6%) fractions after external beam radiotherapy as a boost. 10 patients received 5 (n¼2, 12.5%) or 6 (n¼8, 50%) fractions as exclusive radical HDR-EB. 2 complications were reported: obstructive pneumonitis (n¼1) and bronchial stenosis (n¼1). Neither deaths nor haemoptysis occurred in relation with the technique. Mean follow-up was 29 (±21) months. Mean overall survival was 29.0 (±22) months. Mean disease free-survival was 24.9 (±21) months. 4 (25%) progressions were observed, of which 3 (19%) were local progression. Patients who received boost strategy HDR-EB showed an increased overall survival compared to radical intent (38.2 vs 24.8, p>0.05) and a increased median free-survival; which showed no statistical significance. Conclusion: HDR-EB is a safe technique applicable in radical intention. Longer survival has been described in patients who received boost strategy. Prospective studies are needed to determine long-term benefits.