Mehmet Celegen - Academia.edu (original) (raw)

Papers by Mehmet Celegen

Health Sciences Quarterly, 2021

Acute poisoning is a critical and emergent public health problem worldwide among pediatric age gr... more Acute poisoning is a critical and emergent public health problem worldwide among pediatric age group. The common epidemiological observation is required to understand the characteristics of the pediatric intoxication for each location and important for management the poisoning cases. This retrospective study researched the epidemiology of poisoning among children. This study represented the epidemiology of poisonings of children admitted to the pediatric intensive care unit at Afyonkarahisar Health Science University Faculty of Medicine between February 2020 and May 2021. Fifty one pediatric patients were reffered to the PICU due to acute intoxication. 58.9% of the analyzed patients were male and 41.1% were female. The mean age of all patients was 8.57±7.6. The majority of cases were due to drug-related poisonings. The average age of cases of suicidal poisoning was higher than accidental intoxication cases. Paracetamol was the most prevalent cause of drug-related intoxication and mo...

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the a... more Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a generalized pustular rash often accompanied by fever. There is a history of drug use in 90% of the cases. Here we have reported a 15-year-old male patient with sickle cell anemia who developed AGEP after the use of ceftriaxone. Our patient was hospitalized because of vaso-occlusive crisis and on the third day of ceftriaxone treatment, erythematous pustular lesions accompanied with fever were observed on the body and extremities. Resolution of symptoms followed discontinuation of ceftriaxone. Sensitivity to ceftriaxone was shown with a patch test. The AGEP was considered due to clinical and histopathological findings. This is the first pediatric case of AGEP due to ceftriaxone.

Turkish Archives of Pediatrics

International Journal of Clinical Practice

AIM OF THE STUDY Successful cardiopulmonary resuscitation and early defibrillation are critical i... more AIM OF THE STUDY Successful cardiopulmonary resuscitation and early defibrillation are critical in survival after in- or out-of-hospital cardiopulmonary arrest. The scope of this multi-center study is to a) assess skills of pediatric health care providers (HCPs) concerning two domains: 1) recognizing rhythm abnormalities, 2) the use of defibrillator devices, and b) to evaluate the impact of certified basic-life-support (BLS) and advanced-life-support (ALS) training to offer solutions for quality of improvement in several pediatric emergency cares and intensive care settings of Turkey. METHODS This cross-sectional and multi-center survey study included several pediatric emergency care and intensive care settings from different regions of Turkey. this is a survey and is cross-sectional RESULTS: A total of 716 HCPs participated in the study (physicians: 69.4%, healthcare staff: 30.6%). The median age was 29 (27-33) years. Certified BLS-ALS training was received in 61% (n=303/497) of the physicians and 45.2% (n=99/219) of the non-physician healthcare staff (p<0.001). The length of professional experience had favorable outcome towards an increased self-confidence in the physicians (p<0.01, p<0.001). Both physicians and non-physician healthcare staff improved their theoretical knowledge in the practice of synchronized cardioversion defibrillation (p<0.001, p<0.001). Non-certified healthcare providers were less likely to manage the initial doses of synchronized cardioversion and defibrillation: the correct responses remained at 32.5% and 9.2% for synchronized cardioversion and 44.8% and 16.7% for defibrillation in the physicians and healthcare staff respectively. The indications for defibrillation were correctly answered in the physicians who had acquired a certificate of BLS-ALS training (p=0.047, p=0.003). CONCLUSIONS The professional experience is significant in the correct use of a defibrillator and related procedures. Given the importance of early defibrillation in survival, the importance and proper use of defibrillators should be emphasized in Certified BLS - ALS programs. Certified BLS - ALS programs increase the level of knowledge and self-confidence towards synchronized cardioversion - defibrillation procedures.

Pediatric neurology, 2015

Our primary aim was to determine the short-term effects of a ketogenic diet on cardiac ventricula... more Our primary aim was to determine the short-term effects of a ketogenic diet on cardiac ventricular function in patients with refractory epilepsy. Thirty-eight drug-resistant epileptic patients who were treated with a ketogenic diet were enrolled in this prospective study. Echocardiography was performed on all patients before beginning the ketogenic diet and after the sixth month of therapy. Two-dimensional, M-mode, color flow, spectral Doppler, and pulsed-wave tissue Doppler imaging measurements were performed on all patients. The median age of the 32 patients was 45.5 months, and 22 (57.8%) of them were male. Body weight, height, and body mass index increased significantly at the sixth month of therapy when compared with baseline values (P < 0.05). Baseline variables assessed by conventional M-mode echocardiography showed no significant difference at month 6 (P > 0.05). Doppler flow indices of mitral annulus and tricuspid annulus velocity of patients at baseline and month 6 s...

Turkish Journal of Biochemistry, 2013

Advances in Dermatology and Allergology, 2014

Eosinophilic cellulitis (Wells' syndrome) is an uncommon condition of unknown etiology. Wells' sy... more Eosinophilic cellulitis (Wells' syndrome) is an uncommon condition of unknown etiology. Wells' syndrome is usually seen in adulthood but very rare in childhood. Although pathogenesis of the disease is not very clear, it is a hypersensitivity reaction developing against a variety of exogenous and endogenous antigenic stimuli. Paraphenylenediamine is a strong allergen frequently used as a temporary henna tattoo, which makes the color darker. Here, a 9-year-old male patient with Wells' syndrome is presented, which developed following a temporary henna tattoo and shown by the patch test sensitivity to paraphenylenediamine.

Vector-Borne and Zoonotic Diseases, 2013

Brucella infections have a wide spectrum of symptoms especially in children, making the diagnosis... more Brucella infections have a wide spectrum of symptoms especially in children, making the diagnosis a complicated process. The gold standard for the final diagnosis for brucellosis is to identify the Brucella spp. isolated from blood or bone marrow cultures. The main purpose of this work was to evaluate the factors affecting the isolation of Brucella spp. from blood cultures. In our study, the ratio of fever, presence of hepatomegaly, and splenomegaly were found to be higher in the bacteremic group. In addition, C-reactive protein levels and liver function enzymes were found to be higher in the bacteremic group. In our opinion, while evaluating the febrile child with suspected Brucella infection, we highly recommend sampling blood cultures regardless of the history of previous antimicrobial therapy and duration of the symptoms.

Pediatric Cardiology, 2014

Rheumatic fever (RF) is an inflammatory disease caused by autoimmune response to a preceding grou... more Rheumatic fever (RF) is an inflammatory disease caused by autoimmune response to a preceding group A streptococcal infection. Mean platelet volume (MPV) reflects the platelet size and the rate of platelet production in bone marrow, and it may be used as an indicator of platelet activation and severity of inflammation. Fifty-three consecutive patients diagnosed with acute rheumatic carditis and 53 control subjects were enrolled into this study. Leukocyte and platelet counts were significantly higher in patients with acute carditis before treatment compared with controls, whereas MPV and platelet distribution width (PDW) values were not significantly different between groups. Platelet counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) values were decreased significantly in patients with RF after treatment. There was not a significant difference in terms of platelet count between the controls and the patient group after treatment. ESR was found to be correlated with CRP in patients before and after treatment. In conclusion, the results of our study showed that MPV and PDW levels do not change during acute rheumatic carditis before and after treatment.

European Journal of Paediatric Neurology, 2014

Headaches are common in children and brain magnetic resonance imaging (MRI) studies are widely us... more Headaches are common in children and brain magnetic resonance imaging (MRI) studies are widely used in everyday clinical practice because of increasing demands by parents. To determine headache types and to evaluate the frequency and clinical significance of brain MRI abnormalities in children with headache. A total of 449 children (261 male and 188 female with a mean age of 11.16 ± 3.22 years) with headache were included into the study. The criteria defined by International Headache Society were used to classify the headache types. The causes of headache were migraine in 247 (55.0%), tension-type in 133 (29.6%), secondary in 48 (10.7%), and unspecified headaches in 21 (4.7%) patients. Overall, 324 (72.2%) patients underwent cerebral MRI, which revealed abnormalities in 68 (21.0%) patients. Two (0.6%) patients had cerebral MRI abnormalities relevant to headache, including tumor and hydrocephalus each 1 (0.3%). Twenty-nine (8.9%) patients had incidental cerebral MRI abnormalities including 14 (4.3%) white-matter hyperintensities, 4 (1.2%) old infarcts, 3 (0.9%) Chiari malformations, arachnoid cysts and demyelinating lesions each 2 (0.6%), and subdural hygroma, fibrous dysplasia, pineal cyst and perivascular widening, each 1 (0.3%). Remaining 36 (11.1%) patients had extra-cerebral MRI abnormalities including 34 (10.5%) sinus disease, and 2 (0.6%) adenoid vegetation. Indications for brain MRI were atypical headache pattern or presence of neurologic abnormalities in 59 (18.2%) patients and parents&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; concerns in 265 (81.8%) patients. The rates of abnormal MRI findings were similar between these 2 groups. The most frequent cause of headache in children is migraine. Despite the high rate of imaging abnormalities, the yield of brain MRI is not contributory to the diagnostic and therapeutic approach.

Annales de Dermatologie et de Vénéréologie, 2009

In most cases, acute generalized exanthematous pustulosis (AGEP) is a drug reaction. Even if seve... more In most cases, acute generalized exanthematous pustulosis (AGEP) is a drug reaction. Even if several systemic drugs have been reported to be a causative agent, this clinical case has rarely been observed with a topical treatment. We report here a case of AGEP after topical application of Algipan. A 51-year-old man consulted us for a skin rash with fever which started 72 h earlier. His personal history consisted only of lumbar pain and he was not under any oral medication. The skin rash was initially limited to the left hand and the back but quickly spread to the entire skin with multiple non-follicular pustules emerging on widespread and inflamed erythema. No systemic treatment was being taken prior the eruption. Nevertheless, 3 days before the skin rash appeared, the patient had applied Algipan to the lumbar area with his left hand. The whole clinical presentation leads us to diagnose Algipan-induced AGEP. The clinical signs improved rapidly. Patch tests performed 3 months later were positive for the whole product, thereby confirming our diagnosis. AGEP is drug-induced in more than 90% of cases, mostly after antibiotics, especially beta-lactams and macrolides. Algipan is a topical treatment containing mephenesin used for its analgesic and anti-inflammatory properties in adult muscular pain. No severe skin drug reactions due to this drug have been reported to date. Cases of AGEP induced by topical agents are rarely reported and our case is the first involving mephenesin. Our study suggests that topical mephenesin should be noted as a drug that may cause AGEP.

Postȩpy dermatologii i alergologii, 2014