Mehmet Murat Inal - Academia.edu (original) (raw)
Papers by Mehmet Murat Inal
adu.dergisi.org
Conclusion: Although barrier contraception and IUD are suggested method for women in perimenopaus... more Conclusion: Although barrier contraception and IUD are suggested method for women in perimenopausal period, only 20.1% of perimenopausalAegean region women appliying family planning unit of our hospital have chosen these methods. There is needed to further studies investigating ...
Evre I serviks kanseri nedeniyle tedavi edilen olgularda rekurrens riskini arttiran faktorlerin i... more Evre I serviks kanseri nedeniyle tedavi edilen olgularda rekurrens riskini arttiran faktorlerin incelenmesi ve yasam sansinin belirlenmesi. S.S.K. Ege Dogumevi ve Kadin Hastaliklari Egitim Hastanesi Onkoloji Departmani. 1986-1996 yillari arasinda serviks karsinomu tanisi alan 443 olgudan FIGO siniflamasina gore evre I grubunda 117 olgu (% 26.4) tedavi edildi. Risk faktoru tasiyan 77 (% 66) olguya radyoterapi uygulandi. Uygulanan tedavi modalitelen, histolojik tip, lenf nodu tutulumu, invazyon bulgulari ve rekurrensler dokumante edildi. 103 olguda (%88.4) epidermoid karsinom, 13 olguda (%10.7) adenokarsinom ve 1 olguda (%0.9) sarkom saptandi. 14 olgu evre Ia1, 9 olgu evre Ia2 ve 94 olgu evre Ib olarak degerlendirildi. Invazyon derinligi arttikca rekurrens ve lenf nodu tutulumunun arttigi gozlendi. Seride 5 yillik yasam sansi %88.56 olarak hesaplandi.
Gynecology Obstetrics and Reproductive Medicine, 2007
OBJECTIVE: To evaluate the distribution of Transforming Growth Factor (TGF)-s1, s2 and s3 in surg... more OBJECTIVE: To evaluate the distribution of Transforming Growth Factor (TGF)-s1, s2 and s3 in surgical specimens of the cases with endometriosis and follicular cysts. STUDY DESIGN: This prospective clinical study was carried out at Aegean Obstetrics and Gynecology Training and Research Hospital, a tertiary referral center. A total of 44 reproductive aged women operated because of adnexial masses and revealed pathologic diagnosis’ like endometriosis (Group I; n: 22 cases) and follicular cyst (Group II; n: 22 cases) were enrolled into the study. A semi-quantitative examination of immunohistochemical staining was evaluated as light (+), medium (++) and strong (+++). According to these staining levels, each case was scored as having one, two or three points; and mean scores were calculated for the groups. RESULTS: TGF-s1, TGF-s2 and TGF-s3 staining scores were (48.5±3.1), (25.4±2.3), and (43.7±2.9) in Group I; and (29.2±2.5), (26.5±2.2), and (41.1±3.0) in Group II, respectively. In contr...
Ege Tıp Dergisi, Sep 1, 2000
PubMed, Jan 12, 2004
Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a ... more Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a case of a uterine adenosarcoma that was diagnosed in February 2002.
Transplantation Proceedings, 2017
Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation i... more Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation in a tertiary center in Brazil. Methods Retrospective cohort of pregnancies in women with kidney transplantation at the Universidade Estadual de Campinas, from January 1995 until December 2017. Medical charts were reviewed, and maternal and perinatal outcomes were described as means and frequencies. Renal function and blood pressure were evaluated during pregnancy and postpartum. Results A total of 22 women had at least 1 pregnancy during the considered time interval, and 3 of them had > 1 pregnancy, totalizing 25 pregnancies. The mean age at transplantation was of 24.6 AE 4.2 years old, and the mean time interval until pregnancy was of 67.8 AE 46.3 months. The most frequent complication during pregnancy was hypertension, which affected 11 (64.7%) women. The gestational age at delivery was 34.7 AE 4 weeks, and 47% of these pregnancies were preterm (< 37 weeks). A total of 88.2% of the women delivered by cesarean section. Renal function, measured by serum creatinine, remained stable during pregnancy, and the systolic blood pressure increased significantly, while the diastolic blood pressure did not differ during pregnancy. Conclusion Pregnancy after kidney transplantation is a rare event. Pre-eclampsia and prematurity were frequent complications, and cesarean section rates were very high. A specialized antenatal and postpartum care with a multiprofessional approach and continuous monitoring of graft function are essential for the early diagnosis of complications and improved outcomes. Resumo Objetivo Avaliar os resultados maternos e perinatais de gestações em mulheres transplantadas renais em um centro terciário no Brasil.
medicalnetwork.com.tr
Dr. Muzaffer SANCI*, Dr. Esra Bahar GÜR*, Dr. M. Murat İNAL*, Dr. İbrahim SEKÜ*, Dr. Ebru ŞAHİN*,... more Dr. Muzaffer SANCI*, Dr. Esra Bahar GÜR*, Dr. M. Murat İNAL*, Dr. İbrahim SEKÜ*, Dr. Ebru ŞAHİN*, Dr. Seçil KURTULMUŞ*, Öğr.Üy.Dr. Hayal BOYACIOĞLU**, Dr. Ayşen KIZILYAR*. *SSK,Ege Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, İzmir **Ege Üniversitesi Tıp ...
adu.dergisi.org
Bu çalışmanın amacı Ege bölgesi'ndeki perimenopozal kadınlar tarafından tercih edilen kontra... more Bu çalışmanın amacı Ege bölgesi'ndeki perimenopozal kadınlar tarafından tercih edilen kontraseptif yöntemleri ve bu yöntemlerin devamlılık oranınısaptamaktır. Ağustos 2001 ve Nisan 2005 tarihleri arasında hastanemiz aile planlaması bölümüne kontrasepsiyon için başvuran toplam 442 ...
adutfdergi.org
Results: Groups were similar with respect to patients' demographic and reproductive characte... more Results: Groups were similar with respect to patients' demographic and reproductive characteristics, risk factors for preterm delivery, gestational week at the time of application and cervical length measured by ultrasound (p>0.05). Mean time between diagnosis and ...
Annals of medical research, 2007
marmaramedicaljournal.org
Reprodüktif çağdaki kadınlarda solid organ transplantasyonu sıklığı ve çeşitliliği her geçen yıl ... more Reprodüktif çağdaki kadınlarda solid organ transplantasyonu sıklığı ve çeşitliliği her geçen yıl artmaktadır. Transplantla ilişkili gebeliklerin çoğu böbrek allogreftli kadınlarda bildirilmesine rağmen; karaciğer, pankreas-böbrek, kalp, akciğer ve kalp-akciğer ...
Journal of Inonu …, 2010
... Clinicopathological features of ovarian carcinosarcomas: A single institution experience. Gyn... more ... Clinicopathological features of ovarian carcinosarcomas: A single institution experience. Gynecol Oncol 2005; 96: 136-42 Yazışma Adresi: Dr. Yusuf YILDIRIM Çalıkuşu Mah, 3208 sok, Aksa Apt, No 2, Kat 6, D:6 35380 Bozyaka, İzmir
Gynecological Surgery, 2006
To evaluate diagnostic efficacy of transvaginal saline infusion sonohysterography (TV-SHG) in the... more To evaluate diagnostic efficacy of transvaginal saline infusion sonohysterography (TV-SHG) in the evaluation of uterine cavities in tamoxifen (TAM) administered asymptomatic postmenopausal breast cancer patients with increased endometrial thickness, sixty asymptomatic postmenopausal breast cancer women receiving adjuvant TAM treatment for at least 6 months and with endometrial thickness' ≥5 mm measured in transvaginal ultrasonography (TVS) were enrolled. Each patient underwent TV-SHG, followed by outpatient hysteroscopy (HYS) with endometrial biopsy. TV-SHG application was accepted as unsuccessful in four cases (6.7%). When office HYS combined biopsy was considered as gold standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of TV-SHG were estimated as 90%, 100%, 100%, and 95%, respectively. Our findings showed that TV-SHG was a valuable diagnostic tool in the evaluation of uterine cavities of TAM administered asymptomatic postmenopausal patients having an increased endometrial thickness.
International Urology and Nephrology
Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide.... more Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide. While HPV is responsible for low-grade benign lesions in the anogenital area such as condyloma acuminatum, it is also strongly associated with cervical, anal, vulvar/vaginal, and penile carcinomas. In addition to being an oncogenic virus, HPV causes a substantial socioeconomic burden due to the recurrence of benign lesions, the lack of a definitive treatment option that provides a complete cure, and the high cost of treatment. The global incidence of HPV infection is rising, especially among young and sexually active individuals; as a result, in recent years these infections have also become increasingly conspicuous in urology practice, both as incidental findings and primary complaints. The aim of this review is to evaluate the pathogenesis, diagnosis, and treatment modalities of HPV infections in light of the current literature from the urologist’s perspective.
Journal of Advanced Biotechnology and Bioengineering, 2014
Introduction : Pre-eclampsia is a common and potentially dangerous disorder of human pregnancy. T... more Introduction : Pre-eclampsia is a common and potentially dangerous disorder of human pregnancy. The maternal syndrome of hypertension and proteinuria is part of a severe systemic inflammatory response that includes leukocyte and endothelial cell activation. PCT is a polypeptide consisting of 116 aminoacids and is the precursor of calcitonin. Over the last decade, PCT has become increasingly popular as a novel marker of infection in the intensive care unit setting. The aim of our study was to evaluate changes in serum levels of PCT in pregnancies complicated with mild pre-eclampsia or severe pre-eclampsia and further investigate the correlation with CRP. Methods : Throughout the study period, 80 pregnant women complicated with mild preeclampsia, 80 pregnant women complicated with severe preeclampsia and 80 healthy pregnant women as a control group, giving a total of 240 pregnant women were enrolled into study. Results : Both severe pre-eclampsia and mild pre-eclampsia groups showed significantly higher PCT values when compared with control healthy group (p<0.05). Also, severe pre-eclampsia group showed significantly higher PCT values when compared with mild pre-eclampsia group (p<0.05). A statistically significant correlation was observed in between presence of pre-eclampsia and procalcitonin positivity (p<0.05). And also severity of pre-eclampsia has shown a statistically significant correlation with high values of procalcitonin (p<0.05). Conclusion : Procalcitonin might be a diagnostic marker for investigating women especially with suspected severe preeclampsia.
The European Journal of Contraception and Reproductive Health Care, 2003
To determine the effect of oral versus vaginal misoprostol on cervical dilatation in first-trimes... more To determine the effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester intrauterine evacuation or menstrual regulation (MR). A total of 120 patients were randomly assigned to a double-blind prestudy. Four groups, each consisting of 30 cases, were administered one of four regimens: 200 microg misoprostol orally, 200 microg misoprostol intravaginally, placebo orally, or placebo intravaginally, 10 h before MR, respectively. Age, number of births and abortions, birth methods, date of last delivery and last abortion were recorded. The gestational age was determined by ultrasonography. Prior to MR, data regarding the time of the application of the drug, the presence of placenta in the cervical canal, the degree of cervical dilatation, the duration of MR and patients' complaints were recorded. The MRs were performed by the same physician. The statistical analyses were evaluated with the chi(2) test and Fisher's exact test in the Aegean University Science Faculty Department of Statistics. In the oral misoprostol group, four patients had cervical bleeding and one had intracervical placenta. In the intravaginal misoprostol group, cervical bleeding was observed in seven patients and intracervical placenta was recorded in four cases. Cervical bleeding was observed in one case and intracervical placenta was also observed in one case in the oral placebo group. Cervical dilatation reached 8 mm in seven patients in the oral misoprostol group and in three patients in the intravaginal group, with none in the placebo group. Symptoms such as pelvic pain, headache and nausea were observed in 11 cases in the oral and 14 cases in the vaginal misoprostol groups. Different methods of misoprostol administration may not be equivalent in terms of efficacy and side-effects. Therefore, we decided to extend the study to include more patients so as to achieve statistically significant results.
The European Journal of Contraception and Reproductive Health Care, 2005
To compare, using method type and application time, the demographic characteristics of women usin... more To compare, using method type and application time, the demographic characteristics of women using hormonal contraceptive methods administered after abortion or during the interval period with those of intrauterine device (IUD) users. The demographic characteristics of women to whom oral contraception (OC), monthly injection, depot medroxyprogesterone acetate (DMPA), or IUD were administered in the post-abortive and interval periods between January 1998 and September 2001 in our clinic, were evaluated with the help of a registration system based on the Microsoft Access software used in our clinic. Demographic characteristics recorded were: age, reproductive expectation, previous contraceptive method, education level, number of live children, number of induced and spontaneous abortuses. A total of 10 500 women were included in the study. Of these, 6601 women had taken a contraceptive method during the interval period, and 3899 women had taken a contraceptive method post-abortion. Only 4.6% of the cases were younger than 20 years, 48.3% were between 21 and 30 years, 37.2% were between 31 and 40 years and 9.9% were 41 years old or over. The DMPA-administered group contained the highest number of women > or = 41 years when compared to other groups (22.8%). In reproductive expectations, 65.8% of the cases wanted no more children; 1.3% wanted to have a baby within a 2-year period whereas 23.7% wanted a child after 2 years. The proportion of women wanting no more children was greatest in the DMPA-administered group (77.3%). No previous use of contraceptive methods was reported by 20.7% of women; 27% were using coitus interruptus. The education level of the women was as follows: 10% had no education, 58.3% had education to primary school level, 23.2% to secondary-high-school level and 2.1% to university level. The group of women who chose OC as their contraceptive method contained the highest proportion of university graduates (6.5%). Only 6.26% of the women had no children. The proportion of women in the DMPA-use group with three or more children was higher compared to that in other groups (33.2%). The evaluation of demographic characteristics plays an important role in counseling, and in the efficacy and continued use of contraceptive methods.
The European Journal of Contraception and Reproductive Health Care, 2005
To determine the factors affecting the pregnancies with intrauterine devices. The intrauterine de... more To determine the factors affecting the pregnancies with intrauterine devices. The intrauterine device (IUD) locations in pregnancies with IUDs referring to SSK Aegean Maternity Hospital were determined by ultrasonography (USG) in a 6 year period. Three hundred and eighteen pregnancy cases (pregnancy group) were observed together with intrauterine devices. All intervally applied IUDs were CeT380A. All demographic characteristics of the cases together with determination of IUD localizations were recorded, and these cases were compared with 300 cases (control group) using CuT380A and under routine follow-up in our clinic. Ultrasonographic examination revealed IUD dislocation in 64% of 318 cases, whereas only 11% of the control group had dislocated IUDs. The difference between two groups was statistically significant. Especially in cases where the pregnancy group was less than 20 years old, IUD dislocations were recorded in 87.5%. The statistical analysis revealed a significant correlation in the distribution of IUD pregnancies according to years. When the demographic characteristics of two groups were compared, no statistically significant correlation was observed between the demographic characteristics and pregnancies with IUDs. There were 89 cases (27.9%) who decided on the continuation of IUD pregnancies. Unfortunately, 40% of these cases resulted in abortion. Only in 27% of 56 cases after IUD extraction because of IUD dislocation was miscarriage recorded. Meanwhile, 77% of the 26 cases with IUD left in the uterine cavity presented with miscarriage. Of the total of 36 miscarriages, 33% were =6 weeks pregnancy, and 27% were over 10 weeks. IUD dislocation is a significant factor affecting IUD pregnancies. The fact that dislocation is most common in the first year reveals the necessity for more frequent controls in this period.
The Brazilian Journal of Infectious Diseases, 2013
The most common sexually transmitted disease (STD) is caused by Chlamydia trachomatis. Screening ... more The most common sexually transmitted disease (STD) is caused by Chlamydia trachomatis. Screening of different populations of women have shown prevalence rates of C. trachomatis of 1-25%. 1 C. trachomatis infections were associated with mucopurulent, cervicitis, endometritis, pelvic inflammatory disease (PID), salpingitis, postabortal pelvic sepsis and perihepatitis and long-term complications of PID, infertility and ectopic pregnancy. 2 Several risk factors were reported to be associated with C. trachomatis infections such as: age, sex, family status, education, ethnic status, initial age of sexual activity, number of sexual partners, oral contraceptives, or an intrauterine device, smoking, drug addiction had been reported as risk factors of infections. 3 The women who were admitted to Family Planning Department during the period from March 2003 to August 2004 were included in this study. In our study enrolment criteria were age older than 17 years; no previous history of gynecological operation. The patients who fulfilled the criteria were included in the study. Prior to enrollment, in the study, an informed consent was obtained from the patients and the study was approved by local ethical committee. All the patients were face to face interviewed and cervical smears and swabs for Chlamydial DNA study were obtained from all cases. Data were expressed as mean standard deviation and SPSS statistical software package (SPSS, version 12 for Windows; SPSS Inc., Chicago, IL, USA) was used for statistical analyses. The mean age of 1353 cases was 34.69 ± 8.16 years (ranging from 17 to 73 years). The overall Chlamydial-DNA positivity was 2.66% (36 cases) for C. trachomatis. Age, partner's age (p = 0.38), marriage duration (p = 0.81), frequency of sexual intercourse (p = 0.26), number of birth (p = 0.36), parity (p = 0.51), history of abortion (p = 0.31) and curettage (p = 0.34) revealed no statistically significant difference between the Chlamydia polymerase chain reaction (PCR) positive and negative groups (Table 1). Presence of pathologic vaginal discharge and vaginal
adu.dergisi.org
Conclusion: Although barrier contraception and IUD are suggested method for women in perimenopaus... more Conclusion: Although barrier contraception and IUD are suggested method for women in perimenopausal period, only 20.1% of perimenopausalAegean region women appliying family planning unit of our hospital have chosen these methods. There is needed to further studies investigating ...
Evre I serviks kanseri nedeniyle tedavi edilen olgularda rekurrens riskini arttiran faktorlerin i... more Evre I serviks kanseri nedeniyle tedavi edilen olgularda rekurrens riskini arttiran faktorlerin incelenmesi ve yasam sansinin belirlenmesi. S.S.K. Ege Dogumevi ve Kadin Hastaliklari Egitim Hastanesi Onkoloji Departmani. 1986-1996 yillari arasinda serviks karsinomu tanisi alan 443 olgudan FIGO siniflamasina gore evre I grubunda 117 olgu (% 26.4) tedavi edildi. Risk faktoru tasiyan 77 (% 66) olguya radyoterapi uygulandi. Uygulanan tedavi modalitelen, histolojik tip, lenf nodu tutulumu, invazyon bulgulari ve rekurrensler dokumante edildi. 103 olguda (%88.4) epidermoid karsinom, 13 olguda (%10.7) adenokarsinom ve 1 olguda (%0.9) sarkom saptandi. 14 olgu evre Ia1, 9 olgu evre Ia2 ve 94 olgu evre Ib olarak degerlendirildi. Invazyon derinligi arttikca rekurrens ve lenf nodu tutulumunun arttigi gozlendi. Seride 5 yillik yasam sansi %88.56 olarak hesaplandi.
Gynecology Obstetrics and Reproductive Medicine, 2007
OBJECTIVE: To evaluate the distribution of Transforming Growth Factor (TGF)-s1, s2 and s3 in surg... more OBJECTIVE: To evaluate the distribution of Transforming Growth Factor (TGF)-s1, s2 and s3 in surgical specimens of the cases with endometriosis and follicular cysts. STUDY DESIGN: This prospective clinical study was carried out at Aegean Obstetrics and Gynecology Training and Research Hospital, a tertiary referral center. A total of 44 reproductive aged women operated because of adnexial masses and revealed pathologic diagnosis’ like endometriosis (Group I; n: 22 cases) and follicular cyst (Group II; n: 22 cases) were enrolled into the study. A semi-quantitative examination of immunohistochemical staining was evaluated as light (+), medium (++) and strong (+++). According to these staining levels, each case was scored as having one, two or three points; and mean scores were calculated for the groups. RESULTS: TGF-s1, TGF-s2 and TGF-s3 staining scores were (48.5±3.1), (25.4±2.3), and (43.7±2.9) in Group I; and (29.2±2.5), (26.5±2.2), and (41.1±3.0) in Group II, respectively. In contr...
Ege Tıp Dergisi, Sep 1, 2000
PubMed, Jan 12, 2004
Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a ... more Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a case of a uterine adenosarcoma that was diagnosed in February 2002.
Transplantation Proceedings, 2017
Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation i... more Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation in a tertiary center in Brazil. Methods Retrospective cohort of pregnancies in women with kidney transplantation at the Universidade Estadual de Campinas, from January 1995 until December 2017. Medical charts were reviewed, and maternal and perinatal outcomes were described as means and frequencies. Renal function and blood pressure were evaluated during pregnancy and postpartum. Results A total of 22 women had at least 1 pregnancy during the considered time interval, and 3 of them had > 1 pregnancy, totalizing 25 pregnancies. The mean age at transplantation was of 24.6 AE 4.2 years old, and the mean time interval until pregnancy was of 67.8 AE 46.3 months. The most frequent complication during pregnancy was hypertension, which affected 11 (64.7%) women. The gestational age at delivery was 34.7 AE 4 weeks, and 47% of these pregnancies were preterm (< 37 weeks). A total of 88.2% of the women delivered by cesarean section. Renal function, measured by serum creatinine, remained stable during pregnancy, and the systolic blood pressure increased significantly, while the diastolic blood pressure did not differ during pregnancy. Conclusion Pregnancy after kidney transplantation is a rare event. Pre-eclampsia and prematurity were frequent complications, and cesarean section rates were very high. A specialized antenatal and postpartum care with a multiprofessional approach and continuous monitoring of graft function are essential for the early diagnosis of complications and improved outcomes. Resumo Objetivo Avaliar os resultados maternos e perinatais de gestações em mulheres transplantadas renais em um centro terciário no Brasil.
medicalnetwork.com.tr
Dr. Muzaffer SANCI*, Dr. Esra Bahar GÜR*, Dr. M. Murat İNAL*, Dr. İbrahim SEKÜ*, Dr. Ebru ŞAHİN*,... more Dr. Muzaffer SANCI*, Dr. Esra Bahar GÜR*, Dr. M. Murat İNAL*, Dr. İbrahim SEKÜ*, Dr. Ebru ŞAHİN*, Dr. Seçil KURTULMUŞ*, Öğr.Üy.Dr. Hayal BOYACIOĞLU**, Dr. Ayşen KIZILYAR*. *SSK,Ege Doğumevi ve Kadın Hastalıkları Eğitim Hastanesi, İzmir **Ege Üniversitesi Tıp ...
adu.dergisi.org
Bu çalışmanın amacı Ege bölgesi'ndeki perimenopozal kadınlar tarafından tercih edilen kontra... more Bu çalışmanın amacı Ege bölgesi'ndeki perimenopozal kadınlar tarafından tercih edilen kontraseptif yöntemleri ve bu yöntemlerin devamlılık oranınısaptamaktır. Ağustos 2001 ve Nisan 2005 tarihleri arasında hastanemiz aile planlaması bölümüne kontrasepsiyon için başvuran toplam 442 ...
adutfdergi.org
Results: Groups were similar with respect to patients' demographic and reproductive characte... more Results: Groups were similar with respect to patients' demographic and reproductive characteristics, risk factors for preterm delivery, gestational week at the time of application and cervical length measured by ultrasound (p>0.05). Mean time between diagnosis and ...
Annals of medical research, 2007
marmaramedicaljournal.org
Reprodüktif çağdaki kadınlarda solid organ transplantasyonu sıklığı ve çeşitliliği her geçen yıl ... more Reprodüktif çağdaki kadınlarda solid organ transplantasyonu sıklığı ve çeşitliliği her geçen yıl artmaktadır. Transplantla ilişkili gebeliklerin çoğu böbrek allogreftli kadınlarda bildirilmesine rağmen; karaciğer, pankreas-böbrek, kalp, akciğer ve kalp-akciğer ...
Journal of Inonu …, 2010
... Clinicopathological features of ovarian carcinosarcomas: A single institution experience. Gyn... more ... Clinicopathological features of ovarian carcinosarcomas: A single institution experience. Gynecol Oncol 2005; 96: 136-42 Yazışma Adresi: Dr. Yusuf YILDIRIM Çalıkuşu Mah, 3208 sok, Aksa Apt, No 2, Kat 6, D:6 35380 Bozyaka, İzmir
Gynecological Surgery, 2006
To evaluate diagnostic efficacy of transvaginal saline infusion sonohysterography (TV-SHG) in the... more To evaluate diagnostic efficacy of transvaginal saline infusion sonohysterography (TV-SHG) in the evaluation of uterine cavities in tamoxifen (TAM) administered asymptomatic postmenopausal breast cancer patients with increased endometrial thickness, sixty asymptomatic postmenopausal breast cancer women receiving adjuvant TAM treatment for at least 6 months and with endometrial thickness' ≥5 mm measured in transvaginal ultrasonography (TVS) were enrolled. Each patient underwent TV-SHG, followed by outpatient hysteroscopy (HYS) with endometrial biopsy. TV-SHG application was accepted as unsuccessful in four cases (6.7%). When office HYS combined biopsy was considered as gold standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of TV-SHG were estimated as 90%, 100%, 100%, and 95%, respectively. Our findings showed that TV-SHG was a valuable diagnostic tool in the evaluation of uterine cavities of TAM administered asymptomatic postmenopausal patients having an increased endometrial thickness.
International Urology and Nephrology
Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide.... more Human papillomavirus (HPV) is the most common pathogen of sexually transmitted disease worldwide. While HPV is responsible for low-grade benign lesions in the anogenital area such as condyloma acuminatum, it is also strongly associated with cervical, anal, vulvar/vaginal, and penile carcinomas. In addition to being an oncogenic virus, HPV causes a substantial socioeconomic burden due to the recurrence of benign lesions, the lack of a definitive treatment option that provides a complete cure, and the high cost of treatment. The global incidence of HPV infection is rising, especially among young and sexually active individuals; as a result, in recent years these infections have also become increasingly conspicuous in urology practice, both as incidental findings and primary complaints. The aim of this review is to evaluate the pathogenesis, diagnosis, and treatment modalities of HPV infections in light of the current literature from the urologist’s perspective.
Journal of Advanced Biotechnology and Bioengineering, 2014
Introduction : Pre-eclampsia is a common and potentially dangerous disorder of human pregnancy. T... more Introduction : Pre-eclampsia is a common and potentially dangerous disorder of human pregnancy. The maternal syndrome of hypertension and proteinuria is part of a severe systemic inflammatory response that includes leukocyte and endothelial cell activation. PCT is a polypeptide consisting of 116 aminoacids and is the precursor of calcitonin. Over the last decade, PCT has become increasingly popular as a novel marker of infection in the intensive care unit setting. The aim of our study was to evaluate changes in serum levels of PCT in pregnancies complicated with mild pre-eclampsia or severe pre-eclampsia and further investigate the correlation with CRP. Methods : Throughout the study period, 80 pregnant women complicated with mild preeclampsia, 80 pregnant women complicated with severe preeclampsia and 80 healthy pregnant women as a control group, giving a total of 240 pregnant women were enrolled into study. Results : Both severe pre-eclampsia and mild pre-eclampsia groups showed significantly higher PCT values when compared with control healthy group (p<0.05). Also, severe pre-eclampsia group showed significantly higher PCT values when compared with mild pre-eclampsia group (p<0.05). A statistically significant correlation was observed in between presence of pre-eclampsia and procalcitonin positivity (p<0.05). And also severity of pre-eclampsia has shown a statistically significant correlation with high values of procalcitonin (p<0.05). Conclusion : Procalcitonin might be a diagnostic marker for investigating women especially with suspected severe preeclampsia.
The European Journal of Contraception and Reproductive Health Care, 2003
To determine the effect of oral versus vaginal misoprostol on cervical dilatation in first-trimes... more To determine the effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester intrauterine evacuation or menstrual regulation (MR). A total of 120 patients were randomly assigned to a double-blind prestudy. Four groups, each consisting of 30 cases, were administered one of four regimens: 200 microg misoprostol orally, 200 microg misoprostol intravaginally, placebo orally, or placebo intravaginally, 10 h before MR, respectively. Age, number of births and abortions, birth methods, date of last delivery and last abortion were recorded. The gestational age was determined by ultrasonography. Prior to MR, data regarding the time of the application of the drug, the presence of placenta in the cervical canal, the degree of cervical dilatation, the duration of MR and patients' complaints were recorded. The MRs were performed by the same physician. The statistical analyses were evaluated with the chi(2) test and Fisher's exact test in the Aegean University Science Faculty Department of Statistics. In the oral misoprostol group, four patients had cervical bleeding and one had intracervical placenta. In the intravaginal misoprostol group, cervical bleeding was observed in seven patients and intracervical placenta was recorded in four cases. Cervical bleeding was observed in one case and intracervical placenta was also observed in one case in the oral placebo group. Cervical dilatation reached 8 mm in seven patients in the oral misoprostol group and in three patients in the intravaginal group, with none in the placebo group. Symptoms such as pelvic pain, headache and nausea were observed in 11 cases in the oral and 14 cases in the vaginal misoprostol groups. Different methods of misoprostol administration may not be equivalent in terms of efficacy and side-effects. Therefore, we decided to extend the study to include more patients so as to achieve statistically significant results.
The European Journal of Contraception and Reproductive Health Care, 2005
To compare, using method type and application time, the demographic characteristics of women usin... more To compare, using method type and application time, the demographic characteristics of women using hormonal contraceptive methods administered after abortion or during the interval period with those of intrauterine device (IUD) users. The demographic characteristics of women to whom oral contraception (OC), monthly injection, depot medroxyprogesterone acetate (DMPA), or IUD were administered in the post-abortive and interval periods between January 1998 and September 2001 in our clinic, were evaluated with the help of a registration system based on the Microsoft Access software used in our clinic. Demographic characteristics recorded were: age, reproductive expectation, previous contraceptive method, education level, number of live children, number of induced and spontaneous abortuses. A total of 10 500 women were included in the study. Of these, 6601 women had taken a contraceptive method during the interval period, and 3899 women had taken a contraceptive method post-abortion. Only 4.6% of the cases were younger than 20 years, 48.3% were between 21 and 30 years, 37.2% were between 31 and 40 years and 9.9% were 41 years old or over. The DMPA-administered group contained the highest number of women > or = 41 years when compared to other groups (22.8%). In reproductive expectations, 65.8% of the cases wanted no more children; 1.3% wanted to have a baby within a 2-year period whereas 23.7% wanted a child after 2 years. The proportion of women wanting no more children was greatest in the DMPA-administered group (77.3%). No previous use of contraceptive methods was reported by 20.7% of women; 27% were using coitus interruptus. The education level of the women was as follows: 10% had no education, 58.3% had education to primary school level, 23.2% to secondary-high-school level and 2.1% to university level. The group of women who chose OC as their contraceptive method contained the highest proportion of university graduates (6.5%). Only 6.26% of the women had no children. The proportion of women in the DMPA-use group with three or more children was higher compared to that in other groups (33.2%). The evaluation of demographic characteristics plays an important role in counseling, and in the efficacy and continued use of contraceptive methods.
The European Journal of Contraception and Reproductive Health Care, 2005
To determine the factors affecting the pregnancies with intrauterine devices. The intrauterine de... more To determine the factors affecting the pregnancies with intrauterine devices. The intrauterine device (IUD) locations in pregnancies with IUDs referring to SSK Aegean Maternity Hospital were determined by ultrasonography (USG) in a 6 year period. Three hundred and eighteen pregnancy cases (pregnancy group) were observed together with intrauterine devices. All intervally applied IUDs were CeT380A. All demographic characteristics of the cases together with determination of IUD localizations were recorded, and these cases were compared with 300 cases (control group) using CuT380A and under routine follow-up in our clinic. Ultrasonographic examination revealed IUD dislocation in 64% of 318 cases, whereas only 11% of the control group had dislocated IUDs. The difference between two groups was statistically significant. Especially in cases where the pregnancy group was less than 20 years old, IUD dislocations were recorded in 87.5%. The statistical analysis revealed a significant correlation in the distribution of IUD pregnancies according to years. When the demographic characteristics of two groups were compared, no statistically significant correlation was observed between the demographic characteristics and pregnancies with IUDs. There were 89 cases (27.9%) who decided on the continuation of IUD pregnancies. Unfortunately, 40% of these cases resulted in abortion. Only in 27% of 56 cases after IUD extraction because of IUD dislocation was miscarriage recorded. Meanwhile, 77% of the 26 cases with IUD left in the uterine cavity presented with miscarriage. Of the total of 36 miscarriages, 33% were =6 weeks pregnancy, and 27% were over 10 weeks. IUD dislocation is a significant factor affecting IUD pregnancies. The fact that dislocation is most common in the first year reveals the necessity for more frequent controls in this period.
The Brazilian Journal of Infectious Diseases, 2013
The most common sexually transmitted disease (STD) is caused by Chlamydia trachomatis. Screening ... more The most common sexually transmitted disease (STD) is caused by Chlamydia trachomatis. Screening of different populations of women have shown prevalence rates of C. trachomatis of 1-25%. 1 C. trachomatis infections were associated with mucopurulent, cervicitis, endometritis, pelvic inflammatory disease (PID), salpingitis, postabortal pelvic sepsis and perihepatitis and long-term complications of PID, infertility and ectopic pregnancy. 2 Several risk factors were reported to be associated with C. trachomatis infections such as: age, sex, family status, education, ethnic status, initial age of sexual activity, number of sexual partners, oral contraceptives, or an intrauterine device, smoking, drug addiction had been reported as risk factors of infections. 3 The women who were admitted to Family Planning Department during the period from March 2003 to August 2004 were included in this study. In our study enrolment criteria were age older than 17 years; no previous history of gynecological operation. The patients who fulfilled the criteria were included in the study. Prior to enrollment, in the study, an informed consent was obtained from the patients and the study was approved by local ethical committee. All the patients were face to face interviewed and cervical smears and swabs for Chlamydial DNA study were obtained from all cases. Data were expressed as mean standard deviation and SPSS statistical software package (SPSS, version 12 for Windows; SPSS Inc., Chicago, IL, USA) was used for statistical analyses. The mean age of 1353 cases was 34.69 ± 8.16 years (ranging from 17 to 73 years). The overall Chlamydial-DNA positivity was 2.66% (36 cases) for C. trachomatis. Age, partner's age (p = 0.38), marriage duration (p = 0.81), frequency of sexual intercourse (p = 0.26), number of birth (p = 0.36), parity (p = 0.51), history of abortion (p = 0.31) and curettage (p = 0.34) revealed no statistically significant difference between the Chlamydia polymerase chain reaction (PCR) positive and negative groups (Table 1). Presence of pathologic vaginal discharge and vaginal