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Papers by Meike Rachmawati

Bandung Conference Series. Medical Science, Feb 12, 2024

Bandung Conference Series. Medical Science, Feb 12, 2024

Bandung Conference Series. Medical Science, Feb 12, 2024

Cigarettes are a health problem that is the main focus in Indonesia, Indonesia is still in 3rd pl... more Cigarettes are a health problem that is the main focus in Indonesia, Indonesia is still in 3rd place with the highest number of smokers in the world. The habit of consuming cigarettes can cause serious problems such as stroke, cancer and coronary heart disease. Long-term exposure to dangerous compounds in cigarettes such as tar, nicotine, bensopyrene can cause dysplasia that occurs in the mucosal epithelium of the oral cavity. This study aims to see differences in the quantity of cellular content of buccal mucosal smears between smokers and non-smokers. This research uses an analytical observational method through an approachcross sectional which was carried out on 20 people in the work environment of Bandung Islamic University. Data were obtained from the results of buccal mucosal swabs stained with dyepap smear(Pap) and observed under a light microscope. Data were analyzed using univariate and bivariate tests and tests were carried outT Independent andmann whitney. This research found that the characteristics of non-smokers were an average age of 46 years, a bachelor's degree, married with a middle income. Characteristics of smokers, the average age is 38 years, high school education, married with low income, Ujit independent get no difference in cell numbers between smokers and nonsmokers, testmann whitney shows that there is a difference in the number of lymphocyte cells between the two populations with a P value of 0.009 (<0.05). Smoking does not cause changes in the quantity of cellular content of the buccal mucosa, but smoking can cause chronic inflammation and lead to mutations and malignancy in buccal mucosal cells.

Bandung Conference Series. Medical Science, Feb 12, 2024

S. aureus infections often occur in a community or hospital environment and management is still d... more S. aureus infections often occur in a community or hospital environment and management is still difficult due to the emergence of strains that are resistant to many antibiotics such as Methicillin-resistant Staphylococcus aureus (MRSA). Herbal medicine is an alternative treatment that is often used, including Arabica Coffee (Coffea Arabica) and black tea (Camelia Sinensis). Arabica coffee and black Tea contain polyphenols known as caffeine, chlorogenic acid and catechins. The catechins in black tea, namely epigallocatechin gallate (EGCG) and chlorogenic acid in coffee, have been proven to have antibacterial power against gram-positive bacteria. In gram-positive bacteria, EGCG and chlorogenic acid are able to inhibit the synthesis of the bacterial wall. This research used an experimental in vitro study with the method used by Kirby Bauer disc diffusion with 5 samples, Arabica coffee water extract and black tea water extract in two concentrations, 50% and 100% as treatment, and the antibiotic Vancomycin with a concentration of 100% as a positive control. The research results showed that Arabica coffee water extract had an average zone of inhibition, at a concentration of 100% (14.2 mm) and a concentration of 50% (9.7 mm) with a probability value (p-value) of 0.009 (p≤0, 01), while an inhibition zone was found in black tea water extract at a concentration of 100% (16.2 mm) and a concentration of 50% (11.5 mm) with a probability value (p-value) of 0.009 (p≤0.01) against Methicillin-resistant S. aureus. In conclusion, the inhibitory power of Black Tea water extract is stronger than that of Arabica coffee water extract against Methicillin-resistant Staphylococcus aureus bacteria.

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is the second... more Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is the second leading cause of death from an infectious disease. Indonesia has the highest TB cases in West Java, East Java, and Central Java. Tuberculosis lymphadenitis (TBL) represents about 30-40% of cases of extrapulmonary tuberculosis. The study aimed to study the clinical and histopathological characteristics of TBL patients. The research design in this study used an exploratory, descriptive method. Data was taken from Al Islam Hospital Bandung as medical records from January 2019 to December 2020. The result showed that TBL primarily affects patients aged 6-11 years (28%), male gender (57%), patients not working (25%), and those residing in the East Bandung area (34%). Histopathological appearance showed granulomas of caseous necrosis, epithelioid cells, and Langhan's cells, indicated by types 1, 2, and 3. The most common type was type 1 (47%), which was more widely distributed in the right neck (46%) with size 1-3 cm. In conclusion, the frequency of TBL is higher in boys aged 6-11 years, residents of the East Bandung area, and patients who did not work. Well-formed granuloma of enlarged lymph nodes in the right neck with size 1-3 cm is most commonly found in TBL.

Prosiding Farmasi, Aug 9, 2019

Abstract. A peptic ulcer is one of the problems of digestive tract disorders that often occur in ... more Abstract. A peptic ulcer is one of the problems of digestive tract disorders that often occur in the community. Binahong leaves is used traditionally reduce occurrence of a peptic ulcer. This study aimed to determine the activity and the effective dosage of the ethanolic extract of binahong leaves ( Anredera cordifolia (Ten.) Steenis) on male Wistar rats induced by aspirin at a dose of 750 mg/kg BW in vivo. Testing ethanol extracts as stomach ulcers were carried out orally at a dose of 60 mg/kg BW, 80 mg/kg BW, 100 mg/kg BW, and sucralfate at doe of 180 mg/kg BW was used as a comparison. The test was carried out for 14 days, on the 8 th day, induction was given without stopping the administration of the dosage forms. Observations were made on the parameters of the number and severity of ulcers and pH of gastric fluid. From the test results, the three dosages of the binahong leaves ethanol extract test had anti gastric ulcer activity. The best test dose is 100 mg / kgBB with an ulcer index of 18 and percent prevention power of 7.69%. Statistically the number of ulcers (p = 0.682) and ulcer severity (p = 0.096) had activities that were not significantly different from sucralfate and have a pH gastric fluid is 3,81. Keyword : Peptic ulcer, binahong leaves , antipeptic ulcer Abstrak. Tukak lambung merupakan salah satu masalah gangguan saluran pencernaan yang sering terjadi di masyarakat. Daun binahong secara tradisional dapat membantu mengurangi terjadinya tukak lambung. Penelitian ini bertujuan untuk mengetahui aktivitas antitukak lambung dan menentukan dosis yang efektif dari ekstrak etanol daun binahong ( Anredera cordifolia (Ten.) Steenis) terhadap tikus Wistar jantan yang diinduksi aspirin dengan dosis 750 mg/kgBB secara in vivo . Pengujian ekstrak etanol daun binahong sebagai antitukak lambung dilakukan seecara oral dengan dosis 60 mg/kg BB, 80 mg/kgBB, 100 mg/kgBB, dan pembanding yang digunakan adalah sukralfat dengan dosis 180 mg/kgBB. Pengujian dilakukan selama 14 hari, pada hari ke-8 diberikan induksi tanpa menghentikan pemberian sediaan. Pengamatan dilakukan terhadap parameter jumlah dan keparahan tukak serta pH cairan lambung. Dari hasil pengujian, ketiga dosis sediaan uji ekstrak etanol daun binahong memiliki aktivitas antitukak lambung. Dosis uji yang yang paling baik adalah 100 mg/kgBB dengan indeks tukak sebesar 18 dan persen daya pencegahan sebesar 7,69 %. Secara statistik jumlah tukak (p=0,682) dan keparahan tukak (p=0,096) memiliki aktivitas yang tidak berbeda bermakna terhadap sukralfat serta memiliki pH cairan lambung yaitu 3.81. Kata kunci : Tukak lambung, daun binahong, aktivitas antitukak

Bandung Conference Series. Medical Science, Feb 17, 2024

Acne vulgaris is an inflammatory disease that affects various age groups, especially teenagers. B... more Acne vulgaris is an inflammatory disease that affects various age groups, especially teenagers. Based on the course of the disease, acne vulgaris is a primary inflammatory disease that affects the pilosebaceous unit and one of the causes is Cutibacterium acnes or previously known as Propionibacterium acnes. The prevalence of acne vulgaris in the world ranks 8th in terms of the total prevalence of skin diseases. In Indonesia, the prevalence of this disease is 80-85%, which occurs in adolescence with a peak at the age of 15-18 years. It is felt that the use of antibiotics as main line therapy has side effects that are considered to be detrimental to longterm health, namely resistance. The aim of this research is to analyze and compare the benefits of coffee as an alternative therapy for acne vulgaris. This research uses a Scoping review study to analyze, analyze and publish scientific papers through data sources, Pubmed, SpringerLink, Science Direct, ProQuest, and Garuda that meet the inclusion, exclusion and eligibility criteria using the JBI Critical Appraisal Checklist summarized in the PRISMA diagram. 17,508 articles were generated from 5 data sources, 487 articles met the inclusion criteria and 3 articles met the exclusion and eligibility criteria. The results of 3 articles stated that there were research results showing that the active substances in coffee, especially in the Coffea Canephora (robusta) variety, were effective in inhibiting the growth of Propionibacterium acnes bacteria which is the main etiology of acne vulgaris. The antibacterial ability of coffee has been proven to be quite good, with the level of effectiveness increasing with higher concentrations of coffee extract.

Prosiding Pendidikan Dokter, Jan 24, 2021

Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number ... more Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number prevalence of the disease keep increasing every year. According to WHO 2014, diabetes mellitus patient reach 422 milions people besides of the prevalence continues to grow, diabetes mellitus would be more difficult if complication occur. One of the possibility is Diabetic cataract that is included in microvascular complication. A person's knowledge of a disease can be the basis for one's perception of choosing a disease prevention plan. The purpose of this study was to describe the relationship between the level of knowledge about type 2 diabetes mellitus and Perception of prevention Diabetic Cataract. This research uses the Analytic method with the cross-sectional approach. The subjects of this study were adults in the Cimayang Village, Bogor Regency, taken from 40 people and the sample used the simple random sampling method. The data of this research were obtained using a questionnaire for the level of knowledge of type 2 diabetes mellitus and a questionnaire on the Perception of Cataract Complications Prevention in the form of google. Data analysis used the Chi-square test. The result of study Adult showed a high of knowledge were 37 person and positive Perception of prevalention Diabetic cataract complication 35 patient with p-value is p =0,036. The conclusion shows there is relationship between the level of type 2 diabetes mellitus knowledge and Perception of prevention Diabetic Cataract Key words: Diabetic Cataract, Type 2 Diabetes Mellitus, Prevention, Perception, level of knowledge Abstrak. Diabetes melitus masih menjadi masalah kesehatan utama di dunia disebabkan angka prevalensi DM yang terus meningkat. Menurut data WHO 2014, penderita DM saat ini mengalami peningkatan menjadi 422 juta jiwa. Prevalensi DM yang semakin meningkat diperparah dengan meningkatnya komplikasi Katarak Diabetik yang termasuk ke dalam komplikasi mikrovaskuler. Pengetahuan Seseorang terhadap suatu penyakit, dapat menjadi dasar persepsi seseorang memiliih perencanaan pencegahan penyakit. Tujuan dari penelitian ini untuk mengetahui hubungan antara tingkat pengetahuan diabetes melitus tipe 2 dengan Persepsi terhadap Pencegahan Komplikasi katarak pada Orang dewasa. Metode penelitian ini menggunakan metode analitik dengan pendekatan cross-sectional . Subjek penelitian ini adalah Orang dewasa di Kelurahan Cimayang Kabupaten Bogor yang berjumlah 40 orang dan sampel tersebut diambil dengan menggunakan metode simple random sampling . Data penelitian ini di peroleh menggunakan Kuesioner tingkat pengetahuan DM tipe 2 dan Kuesioner Persepsi Pencegahan Komplikasi Katarak dalam bentuk google form. Analisis data menggunakan uji Chi-square . Hasil penelitian yang diperoleh Pada Orang Dewasa yang terbanyak adalah memiliki pengetahuan yang baik tentang DM tipe 2 sebanyak 37 orang dan Persepsi positif pencegahan komplikasi Katarak Diabetik sebanyak 35 orang dengan nilai p=0,036. Kesimpulan penelitian ini adalah terdapat adanya hubungan antara tingkat pengetahuan DM tipe 2 dengan Persepsi Pencegahan Komplikasi Katarak Diabetik. Kata kunci: Diabetes melitus Tipe 2, Pencegahan, Persepsi, Katarak Diabetik, Tingkat Pengetahuan

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang

Massage therapy has been shown to be highly effective in preventing premature birth, encouraging ... more Massage therapy has been shown to be highly effective in preventing premature birth, encouraging infant growth, increasing attention, reducing depression and aggression, treating motor problems, and reducing discomfort. Daycare is a partner institution for parents in childcare that synergizes in observing the growth and development of children's mental health. This community service program aims to increase knowledge about children's mental health, and training and mentoring regarding relaxing massage for children. This service activity plan consists of the preparation, implementation, and evaluation stages. The methods to be carried out vary from giving interactive materials, demonstrations, discussions, and practice. This activity was attended by 24 caregivers, 2 presenters, and 6 community service teams. This program was attended by caregivers aged between 22-50 years, with most of them being married, the highest education level being high school (75%), and the most work ...

Advances in social science, education and humanities research, 2022

Bandung Conference Series: Medical Science, Feb 1, 2023

Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affec... more Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affects men over 60 years old in Indonesia. BPH is the second most common disease found in urology clinics in Indonesia. The quality of life of BPH patients is disrupted due to persistent irritative and obstructive symptoms. Histopathological picture of hyperplasia of prostate gland cells. The purpose of this study was to assess the clinical and histopathological features of BPH patients at RSAU dr. M. Bandung City. The sampling technique for this study used total sampling using 36 medical records of BPH patients at RSAU dr. M. Salamun Bandung City. This research uses descriptive method. The results of the study from 36 total samples, the clinical picture of 13 people (36.1%) patients experienced intermittent, 20 patients (55.6%) experienced weak flow, 30 people experienced hesitancy, 13 people (36.1%) experienced dysuria , 12 people (33.3%) had BAK that was not light and a further 13 people (36.1%) had nocturia. Histopathology showed that 19 patients (52.8%) had prostatic acini dilatation, 17 patients (47.2%) had prostatic acini hyperplasia, 16 patients (44.4%) had acini lumen containing corpora amylase, 21 patients (58.3%) had hyperplastic acini epithelial cells, then 32 people (88.9%) had nuclei within normal limits. The conclusion of this study is to get the most clinical picture of Benign Prostatic Hyperplasia is experiencing a weak bladder flow and hesitancy. The histopathological picture shows that most of the prostatic acini are dilated, the acini epithelial cells are hyperplastic, the nuclei are within normal limits.

Bandung Conference Series: Medical Science

Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affec... more Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affects men over 60 years old in Indonesia. BPH is the second most common disease found in urology clinics in Indonesia. The quality of life of BPH patients is disrupted due to persistent irritative and obstructive symptoms. Histopathological picture of hyperplasia of prostate gland cells. The purpose of this study was to assess the clinical and histopathological features of BPH patients at RSAU dr. M. Bandung City. The sampling technique for this study used total sampling using 36 medical records of BPH patients at RSAU dr. M. Salamun Bandung City. This research uses descriptive method. The results of the study from 36 total samples, the clinical picture of 13 people (36.1%) patients experienced intermittent, 20 patients (55.6%) experienced weak flow, 30 people experienced hesitancy, 13 people (36.1%) experienced dysuria , 12 people (33.3%) had BAK that was not light and a further 13 people (36.1%) had nocturia. Histopathology showed that 19 patients (52.8%) had prostatic acini dilatation, 17 patients (47.2%) had prostatic acini hyperplasia, 16 patients (44.4%) had acini lumen containing corpora amylase, 21 patients (58.3%) had hyperplastic acini epithelial cells, then 32 people (88.9%) had nuclei within normal limits. The conclusion of this study is to get the most clinical picture of Benign Prostatic Hyperplasia is experiencing a weak bladder flow and hesitancy. The histopathological picture shows that most of the prostatic acini are dilated, the acini epithelial cells are hyperplastic, the nuclei are within normal limits.

Prosiding Pendidikan Dokter, Aug 8, 2015

Obesity is a condition excess of fat in body. Acording to WHO in 2005 about 1,6 bilion overweight... more Obesity is a condition excess of fat in body. Acording to WHO in 2005 about 1,6 bilion overweight person aged more than 15 years and among 400 milion adult were obese. Causes of obesity are excess of food intake and less of physical activity. The food that contain much fat is fries food. Fat distribution indicator is waist circumference. Other factor that can interfere waist circumference is smoking. Nicotin in tobacco can cause lipolysis, decrease appetite and increase energy expenditure. Study design is analytic descriptif with cross-sectional method to analyse corelation between number and variation fried food consumption as morning snack and waist circumference in smoker and non smoker group. The population is TNI AU Lanud Wiriadinata. The analytic result show that no correlation between amount fried food consumption with waist circumference in smoker and non smoker (P=1,00). The same result show that no correlation between variation fried food consumption with waist circumference in smoker and non smoker (p=0,91) This result is caused by good physical activity. The Result show that smoking group have smaller waist circumference. This is caused by nikotin in tobacco. Smoking cause waist cicumference become smaller but tobacco can cause cardiovascular disease.

Prosiding Pendidikan Dokter, Aug 8, 2015

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang, 2022

Since the COVID-19 pandemic first emerged in December 2019 and was confirmed in Indonesia in Marc... more Since the COVID-19 pandemic first emerged in December 2019 and was confirmed in Indonesia in March 2020, the Indonesian government has imposed a strict lockdown. The number of confirmed cases is increasing all the time. Efforts to prevent transmission must be carried out immediately, including improving health protocols. The activity aims to create trained troops Santri, by providing insight into COVID-19 which consists of training to implement health protocols and soft skills for making new normal kits, namely hand sanitizers and cloth masks. The activities were carried out at the Manarul Huda Islamic Boarding School, Bandung to 31 Santri. The new normal kit manufacturing training is accompanied by an expert. The training of Santri produces cadres with a level of knowledge about COVID-19 most highly with a fair category (51,61%). Based on the percentage of the group, age17 years, male gender, and education level graduated from school have a higher level of good knowledge than other...

Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number ... more Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number prevalence of the disease keep increasing every year. According to WHO 2014, diabetes mellitus patient reach 422 milions people besides of the prevalence continues to grow, diabetes mellitus would be more difficult if complication occur. One of the possibility is Diabetic cataract that is included in microvascular complication. A person's knowledge of a disease can be the basis for one's perception of choosing a disease prevention plan. The purpose of this study was to describe the relationship between the level of knowledge about type 2 diabetes mellitus and Perception of prevention Diabetic Cataract. This research uses the Analytic method with the cross-sectional approach. The subjects of this study were adults in the Cimayang Village, Bogor Regency, taken from 40 people and the sample used the simple random sampling method. The data of this research were obtained using a quest...

Obesity Research & Clinical Practice, Oct 1, 2013

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamo... more The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma. APMIS 2018. The aim of this study was to investigate the associations among the immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) tissues and the clinicopathological characteristics, and prognostic factors in patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were examined in 76 LSCC tissue samples using immunohistochemical staining on tissue microarray slides, and compared to those in normal lip mucosa adjacent to venous lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), and recurrent tumors. Associations between immunoexpression levels and clinicopathological characteristics were analyzed using the Student's t-test. The prognostic factors were analyzed using Cox regression. The immunoexpression levels of Mn-SOD, GPx, and MPO were significantly different among the normal controls, NTACTs, tumors, and recurrent tumors (Mn-SOD: p = 0.001, GPx: p < 0.001, MPO: p < 0.001). Lower lip cancer was associated with higher Mn-SOD immunoexpression levels (p = 0.04) and probably indicated higher oxidative stress. Lymph node involvement with a lower immunoexpression level of MPO (p = 0.007) indicated compensatory mechanism to attenuate oxidative damage. A low Mn-SOD immunoexpression level was borderline significantly associated with a worse prognosis for disease-specific survival, and it was probably related to a lower capacity for coping with oxidative stress.

Obesity Research & Clinical Practice, 2013

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamo... more The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma. APMIS 2018. The aim of this study was to investigate the associations among the immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) tissues and the clinicopathological characteristics, and prognostic factors in patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were examined in 76 LSCC tissue samples using immunohistochemical staining on tissue microarray slides, and compared to those in normal lip mucosa adjacent to venous lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), and recurrent tumors. Associations between immunoexpression levels and clinicopathological characteristics were analyzed using the Student's t-test. The prognostic factors were analyzed using Cox regression. The immunoexpression levels of Mn-SOD, GPx, and MPO were significantly different among the normal controls, NTACTs, tumors, and recurrent tumors (Mn-SOD: p = 0.001, GPx: p < 0.001, MPO: p < 0.001). Lower lip cancer was associated with higher Mn-SOD immunoexpression levels (p = 0.04) and probably indicated higher oxidative stress. Lymph node involvement with a lower immunoexpression level of MPO (p = 0.007) indicated compensatory mechanism to attenuate oxidative damage. A low Mn-SOD immunoexpression level was borderline significantly associated with a worse prognosis for disease-specific survival, and it was probably related to a lower capacity for coping with oxidative stress.

Jurnal Riset Kedokteran

Kanker serviks memiliki angka mortalitas tertinggi ketiga di dunia dari keseluruhan kasus kanker.... more Kanker serviks memiliki angka mortalitas tertinggi ketiga di dunia dari keseluruhan kasus kanker. Angka ini dapat dicegah melalui pemeriksaan pap smear. Penelitian ini bertujuan mengumpulkan data memadai mengenai pap smear sebagai metode deteksi dini kanker serviks. Metode yang digunakan adalah studi literatur dengan mengumpulkan beberapa penelitian terdahulu tentang pap smear sebagai metode deteksi dini kanker serviks. Hasil dari penelitian ini menjelaskan pap smear mulai dari sejarah, definisi, prinsip, tujuan, manfaat, rekomendasi, prosedur pemeriksaan, dan interpretasi hasil. Dengan demikian dappat disimpulkan pap smear merupakan suatu pemeriksaan yang bertujuan untuk melihat lesi pre kanker yang direkomendasikan bagi wanita usia 30-60 tahun setiap tiga tahun sekali untuk mencegah kejadian kanker serviks.

Bandung Conference Series. Medical Science, Feb 12, 2024

Bandung Conference Series. Medical Science, Feb 12, 2024

Bandung Conference Series. Medical Science, Feb 12, 2024

Cigarettes are a health problem that is the main focus in Indonesia, Indonesia is still in 3rd pl... more Cigarettes are a health problem that is the main focus in Indonesia, Indonesia is still in 3rd place with the highest number of smokers in the world. The habit of consuming cigarettes can cause serious problems such as stroke, cancer and coronary heart disease. Long-term exposure to dangerous compounds in cigarettes such as tar, nicotine, bensopyrene can cause dysplasia that occurs in the mucosal epithelium of the oral cavity. This study aims to see differences in the quantity of cellular content of buccal mucosal smears between smokers and non-smokers. This research uses an analytical observational method through an approachcross sectional which was carried out on 20 people in the work environment of Bandung Islamic University. Data were obtained from the results of buccal mucosal swabs stained with dyepap smear(Pap) and observed under a light microscope. Data were analyzed using univariate and bivariate tests and tests were carried outT Independent andmann whitney. This research found that the characteristics of non-smokers were an average age of 46 years, a bachelor's degree, married with a middle income. Characteristics of smokers, the average age is 38 years, high school education, married with low income, Ujit independent get no difference in cell numbers between smokers and nonsmokers, testmann whitney shows that there is a difference in the number of lymphocyte cells between the two populations with a P value of 0.009 (<0.05). Smoking does not cause changes in the quantity of cellular content of the buccal mucosa, but smoking can cause chronic inflammation and lead to mutations and malignancy in buccal mucosal cells.

Bandung Conference Series. Medical Science, Feb 12, 2024

S. aureus infections often occur in a community or hospital environment and management is still d... more S. aureus infections often occur in a community or hospital environment and management is still difficult due to the emergence of strains that are resistant to many antibiotics such as Methicillin-resistant Staphylococcus aureus (MRSA). Herbal medicine is an alternative treatment that is often used, including Arabica Coffee (Coffea Arabica) and black tea (Camelia Sinensis). Arabica coffee and black Tea contain polyphenols known as caffeine, chlorogenic acid and catechins. The catechins in black tea, namely epigallocatechin gallate (EGCG) and chlorogenic acid in coffee, have been proven to have antibacterial power against gram-positive bacteria. In gram-positive bacteria, EGCG and chlorogenic acid are able to inhibit the synthesis of the bacterial wall. This research used an experimental in vitro study with the method used by Kirby Bauer disc diffusion with 5 samples, Arabica coffee water extract and black tea water extract in two concentrations, 50% and 100% as treatment, and the antibiotic Vancomycin with a concentration of 100% as a positive control. The research results showed that Arabica coffee water extract had an average zone of inhibition, at a concentration of 100% (14.2 mm) and a concentration of 50% (9.7 mm) with a probability value (p-value) of 0.009 (p≤0, 01), while an inhibition zone was found in black tea water extract at a concentration of 100% (16.2 mm) and a concentration of 50% (11.5 mm) with a probability value (p-value) of 0.009 (p≤0.01) against Methicillin-resistant S. aureus. In conclusion, the inhibitory power of Black Tea water extract is stronger than that of Arabica coffee water extract against Methicillin-resistant Staphylococcus aureus bacteria.

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is the second... more Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is the second leading cause of death from an infectious disease. Indonesia has the highest TB cases in West Java, East Java, and Central Java. Tuberculosis lymphadenitis (TBL) represents about 30-40% of cases of extrapulmonary tuberculosis. The study aimed to study the clinical and histopathological characteristics of TBL patients. The research design in this study used an exploratory, descriptive method. Data was taken from Al Islam Hospital Bandung as medical records from January 2019 to December 2020. The result showed that TBL primarily affects patients aged 6-11 years (28%), male gender (57%), patients not working (25%), and those residing in the East Bandung area (34%). Histopathological appearance showed granulomas of caseous necrosis, epithelioid cells, and Langhan's cells, indicated by types 1, 2, and 3. The most common type was type 1 (47%), which was more widely distributed in the right neck (46%) with size 1-3 cm. In conclusion, the frequency of TBL is higher in boys aged 6-11 years, residents of the East Bandung area, and patients who did not work. Well-formed granuloma of enlarged lymph nodes in the right neck with size 1-3 cm is most commonly found in TBL.

Prosiding Farmasi, Aug 9, 2019

Abstract. A peptic ulcer is one of the problems of digestive tract disorders that often occur in ... more Abstract. A peptic ulcer is one of the problems of digestive tract disorders that often occur in the community. Binahong leaves is used traditionally reduce occurrence of a peptic ulcer. This study aimed to determine the activity and the effective dosage of the ethanolic extract of binahong leaves ( Anredera cordifolia (Ten.) Steenis) on male Wistar rats induced by aspirin at a dose of 750 mg/kg BW in vivo. Testing ethanol extracts as stomach ulcers were carried out orally at a dose of 60 mg/kg BW, 80 mg/kg BW, 100 mg/kg BW, and sucralfate at doe of 180 mg/kg BW was used as a comparison. The test was carried out for 14 days, on the 8 th day, induction was given without stopping the administration of the dosage forms. Observations were made on the parameters of the number and severity of ulcers and pH of gastric fluid. From the test results, the three dosages of the binahong leaves ethanol extract test had anti gastric ulcer activity. The best test dose is 100 mg / kgBB with an ulcer index of 18 and percent prevention power of 7.69%. Statistically the number of ulcers (p = 0.682) and ulcer severity (p = 0.096) had activities that were not significantly different from sucralfate and have a pH gastric fluid is 3,81. Keyword : Peptic ulcer, binahong leaves , antipeptic ulcer Abstrak. Tukak lambung merupakan salah satu masalah gangguan saluran pencernaan yang sering terjadi di masyarakat. Daun binahong secara tradisional dapat membantu mengurangi terjadinya tukak lambung. Penelitian ini bertujuan untuk mengetahui aktivitas antitukak lambung dan menentukan dosis yang efektif dari ekstrak etanol daun binahong ( Anredera cordifolia (Ten.) Steenis) terhadap tikus Wistar jantan yang diinduksi aspirin dengan dosis 750 mg/kgBB secara in vivo . Pengujian ekstrak etanol daun binahong sebagai antitukak lambung dilakukan seecara oral dengan dosis 60 mg/kg BB, 80 mg/kgBB, 100 mg/kgBB, dan pembanding yang digunakan adalah sukralfat dengan dosis 180 mg/kgBB. Pengujian dilakukan selama 14 hari, pada hari ke-8 diberikan induksi tanpa menghentikan pemberian sediaan. Pengamatan dilakukan terhadap parameter jumlah dan keparahan tukak serta pH cairan lambung. Dari hasil pengujian, ketiga dosis sediaan uji ekstrak etanol daun binahong memiliki aktivitas antitukak lambung. Dosis uji yang yang paling baik adalah 100 mg/kgBB dengan indeks tukak sebesar 18 dan persen daya pencegahan sebesar 7,69 %. Secara statistik jumlah tukak (p=0,682) dan keparahan tukak (p=0,096) memiliki aktivitas yang tidak berbeda bermakna terhadap sukralfat serta memiliki pH cairan lambung yaitu 3.81. Kata kunci : Tukak lambung, daun binahong, aktivitas antitukak

Bandung Conference Series. Medical Science, Feb 17, 2024

Acne vulgaris is an inflammatory disease that affects various age groups, especially teenagers. B... more Acne vulgaris is an inflammatory disease that affects various age groups, especially teenagers. Based on the course of the disease, acne vulgaris is a primary inflammatory disease that affects the pilosebaceous unit and one of the causes is Cutibacterium acnes or previously known as Propionibacterium acnes. The prevalence of acne vulgaris in the world ranks 8th in terms of the total prevalence of skin diseases. In Indonesia, the prevalence of this disease is 80-85%, which occurs in adolescence with a peak at the age of 15-18 years. It is felt that the use of antibiotics as main line therapy has side effects that are considered to be detrimental to longterm health, namely resistance. The aim of this research is to analyze and compare the benefits of coffee as an alternative therapy for acne vulgaris. This research uses a Scoping review study to analyze, analyze and publish scientific papers through data sources, Pubmed, SpringerLink, Science Direct, ProQuest, and Garuda that meet the inclusion, exclusion and eligibility criteria using the JBI Critical Appraisal Checklist summarized in the PRISMA diagram. 17,508 articles were generated from 5 data sources, 487 articles met the inclusion criteria and 3 articles met the exclusion and eligibility criteria. The results of 3 articles stated that there were research results showing that the active substances in coffee, especially in the Coffea Canephora (robusta) variety, were effective in inhibiting the growth of Propionibacterium acnes bacteria which is the main etiology of acne vulgaris. The antibacterial ability of coffee has been proven to be quite good, with the level of effectiveness increasing with higher concentrations of coffee extract.

Prosiding Pendidikan Dokter, Jan 24, 2021

Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number ... more Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number prevalence of the disease keep increasing every year. According to WHO 2014, diabetes mellitus patient reach 422 milions people besides of the prevalence continues to grow, diabetes mellitus would be more difficult if complication occur. One of the possibility is Diabetic cataract that is included in microvascular complication. A person's knowledge of a disease can be the basis for one's perception of choosing a disease prevention plan. The purpose of this study was to describe the relationship between the level of knowledge about type 2 diabetes mellitus and Perception of prevention Diabetic Cataract. This research uses the Analytic method with the cross-sectional approach. The subjects of this study were adults in the Cimayang Village, Bogor Regency, taken from 40 people and the sample used the simple random sampling method. The data of this research were obtained using a questionnaire for the level of knowledge of type 2 diabetes mellitus and a questionnaire on the Perception of Cataract Complications Prevention in the form of google. Data analysis used the Chi-square test. The result of study Adult showed a high of knowledge were 37 person and positive Perception of prevalention Diabetic cataract complication 35 patient with p-value is p =0,036. The conclusion shows there is relationship between the level of type 2 diabetes mellitus knowledge and Perception of prevention Diabetic Cataract Key words: Diabetic Cataract, Type 2 Diabetes Mellitus, Prevention, Perception, level of knowledge Abstrak. Diabetes melitus masih menjadi masalah kesehatan utama di dunia disebabkan angka prevalensi DM yang terus meningkat. Menurut data WHO 2014, penderita DM saat ini mengalami peningkatan menjadi 422 juta jiwa. Prevalensi DM yang semakin meningkat diperparah dengan meningkatnya komplikasi Katarak Diabetik yang termasuk ke dalam komplikasi mikrovaskuler. Pengetahuan Seseorang terhadap suatu penyakit, dapat menjadi dasar persepsi seseorang memiliih perencanaan pencegahan penyakit. Tujuan dari penelitian ini untuk mengetahui hubungan antara tingkat pengetahuan diabetes melitus tipe 2 dengan Persepsi terhadap Pencegahan Komplikasi katarak pada Orang dewasa. Metode penelitian ini menggunakan metode analitik dengan pendekatan cross-sectional . Subjek penelitian ini adalah Orang dewasa di Kelurahan Cimayang Kabupaten Bogor yang berjumlah 40 orang dan sampel tersebut diambil dengan menggunakan metode simple random sampling . Data penelitian ini di peroleh menggunakan Kuesioner tingkat pengetahuan DM tipe 2 dan Kuesioner Persepsi Pencegahan Komplikasi Katarak dalam bentuk google form. Analisis data menggunakan uji Chi-square . Hasil penelitian yang diperoleh Pada Orang Dewasa yang terbanyak adalah memiliki pengetahuan yang baik tentang DM tipe 2 sebanyak 37 orang dan Persepsi positif pencegahan komplikasi Katarak Diabetik sebanyak 35 orang dengan nilai p=0,036. Kesimpulan penelitian ini adalah terdapat adanya hubungan antara tingkat pengetahuan DM tipe 2 dengan Persepsi Pencegahan Komplikasi Katarak Diabetik. Kata kunci: Diabetes melitus Tipe 2, Pencegahan, Persepsi, Katarak Diabetik, Tingkat Pengetahuan

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang

Massage therapy has been shown to be highly effective in preventing premature birth, encouraging ... more Massage therapy has been shown to be highly effective in preventing premature birth, encouraging infant growth, increasing attention, reducing depression and aggression, treating motor problems, and reducing discomfort. Daycare is a partner institution for parents in childcare that synergizes in observing the growth and development of children's mental health. This community service program aims to increase knowledge about children's mental health, and training and mentoring regarding relaxing massage for children. This service activity plan consists of the preparation, implementation, and evaluation stages. The methods to be carried out vary from giving interactive materials, demonstrations, discussions, and practice. This activity was attended by 24 caregivers, 2 presenters, and 6 community service teams. This program was attended by caregivers aged between 22-50 years, with most of them being married, the highest education level being high school (75%), and the most work ...

Advances in social science, education and humanities research, 2022

Bandung Conference Series: Medical Science, Feb 1, 2023

Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affec... more Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affects men over 60 years old in Indonesia. BPH is the second most common disease found in urology clinics in Indonesia. The quality of life of BPH patients is disrupted due to persistent irritative and obstructive symptoms. Histopathological picture of hyperplasia of prostate gland cells. The purpose of this study was to assess the clinical and histopathological features of BPH patients at RSAU dr. M. Bandung City. The sampling technique for this study used total sampling using 36 medical records of BPH patients at RSAU dr. M. Salamun Bandung City. This research uses descriptive method. The results of the study from 36 total samples, the clinical picture of 13 people (36.1%) patients experienced intermittent, 20 patients (55.6%) experienced weak flow, 30 people experienced hesitancy, 13 people (36.1%) experienced dysuria , 12 people (33.3%) had BAK that was not light and a further 13 people (36.1%) had nocturia. Histopathology showed that 19 patients (52.8%) had prostatic acini dilatation, 17 patients (47.2%) had prostatic acini hyperplasia, 16 patients (44.4%) had acini lumen containing corpora amylase, 21 patients (58.3%) had hyperplastic acini epithelial cells, then 32 people (88.9%) had nuclei within normal limits. The conclusion of this study is to get the most clinical picture of Benign Prostatic Hyperplasia is experiencing a weak bladder flow and hesitancy. The histopathological picture shows that most of the prostatic acini are dilated, the acini epithelial cells are hyperplastic, the nuclei are within normal limits.

Bandung Conference Series: Medical Science

Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affec... more Globally there were 11.26 million cases of Benign Prostatic Hyperplasia in 2019. BPH mostly affects men over 60 years old in Indonesia. BPH is the second most common disease found in urology clinics in Indonesia. The quality of life of BPH patients is disrupted due to persistent irritative and obstructive symptoms. Histopathological picture of hyperplasia of prostate gland cells. The purpose of this study was to assess the clinical and histopathological features of BPH patients at RSAU dr. M. Bandung City. The sampling technique for this study used total sampling using 36 medical records of BPH patients at RSAU dr. M. Salamun Bandung City. This research uses descriptive method. The results of the study from 36 total samples, the clinical picture of 13 people (36.1%) patients experienced intermittent, 20 patients (55.6%) experienced weak flow, 30 people experienced hesitancy, 13 people (36.1%) experienced dysuria , 12 people (33.3%) had BAK that was not light and a further 13 people (36.1%) had nocturia. Histopathology showed that 19 patients (52.8%) had prostatic acini dilatation, 17 patients (47.2%) had prostatic acini hyperplasia, 16 patients (44.4%) had acini lumen containing corpora amylase, 21 patients (58.3%) had hyperplastic acini epithelial cells, then 32 people (88.9%) had nuclei within normal limits. The conclusion of this study is to get the most clinical picture of Benign Prostatic Hyperplasia is experiencing a weak bladder flow and hesitancy. The histopathological picture shows that most of the prostatic acini are dilated, the acini epithelial cells are hyperplastic, the nuclei are within normal limits.

Prosiding Pendidikan Dokter, Aug 8, 2015

Obesity is a condition excess of fat in body. Acording to WHO in 2005 about 1,6 bilion overweight... more Obesity is a condition excess of fat in body. Acording to WHO in 2005 about 1,6 bilion overweight person aged more than 15 years and among 400 milion adult were obese. Causes of obesity are excess of food intake and less of physical activity. The food that contain much fat is fries food. Fat distribution indicator is waist circumference. Other factor that can interfere waist circumference is smoking. Nicotin in tobacco can cause lipolysis, decrease appetite and increase energy expenditure. Study design is analytic descriptif with cross-sectional method to analyse corelation between number and variation fried food consumption as morning snack and waist circumference in smoker and non smoker group. The population is TNI AU Lanud Wiriadinata. The analytic result show that no correlation between amount fried food consumption with waist circumference in smoker and non smoker (P=1,00). The same result show that no correlation between variation fried food consumption with waist circumference in smoker and non smoker (p=0,91) This result is caused by good physical activity. The Result show that smoking group have smaller waist circumference. This is caused by nikotin in tobacco. Smoking cause waist cicumference become smaller but tobacco can cause cardiovascular disease.

Prosiding Pendidikan Dokter, Aug 8, 2015

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang, 2022

Since the COVID-19 pandemic first emerged in December 2019 and was confirmed in Indonesia in Marc... more Since the COVID-19 pandemic first emerged in December 2019 and was confirmed in Indonesia in March 2020, the Indonesian government has imposed a strict lockdown. The number of confirmed cases is increasing all the time. Efforts to prevent transmission must be carried out immediately, including improving health protocols. The activity aims to create trained troops Santri, by providing insight into COVID-19 which consists of training to implement health protocols and soft skills for making new normal kits, namely hand sanitizers and cloth masks. The activities were carried out at the Manarul Huda Islamic Boarding School, Bandung to 31 Santri. The new normal kit manufacturing training is accompanied by an expert. The training of Santri produces cadres with a level of knowledge about COVID-19 most highly with a fair category (51,61%). Based on the percentage of the group, age17 years, male gender, and education level graduated from school have a higher level of good knowledge than other...

Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number ... more Abstract. Diabetes mellitus is one of disease that still towering in the world, caused by number prevalence of the disease keep increasing every year. According to WHO 2014, diabetes mellitus patient reach 422 milions people besides of the prevalence continues to grow, diabetes mellitus would be more difficult if complication occur. One of the possibility is Diabetic cataract that is included in microvascular complication. A person's knowledge of a disease can be the basis for one's perception of choosing a disease prevention plan. The purpose of this study was to describe the relationship between the level of knowledge about type 2 diabetes mellitus and Perception of prevention Diabetic Cataract. This research uses the Analytic method with the cross-sectional approach. The subjects of this study were adults in the Cimayang Village, Bogor Regency, taken from 40 people and the sample used the simple random sampling method. The data of this research were obtained using a quest...

Obesity Research & Clinical Practice, Oct 1, 2013

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamo... more The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma. APMIS 2018. The aim of this study was to investigate the associations among the immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) tissues and the clinicopathological characteristics, and prognostic factors in patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were examined in 76 LSCC tissue samples using immunohistochemical staining on tissue microarray slides, and compared to those in normal lip mucosa adjacent to venous lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), and recurrent tumors. Associations between immunoexpression levels and clinicopathological characteristics were analyzed using the Student's t-test. The prognostic factors were analyzed using Cox regression. The immunoexpression levels of Mn-SOD, GPx, and MPO were significantly different among the normal controls, NTACTs, tumors, and recurrent tumors (Mn-SOD: p = 0.001, GPx: p < 0.001, MPO: p < 0.001). Lower lip cancer was associated with higher Mn-SOD immunoexpression levels (p = 0.04) and probably indicated higher oxidative stress. Lymph node involvement with a lower immunoexpression level of MPO (p = 0.007) indicated compensatory mechanism to attenuate oxidative damage. A low Mn-SOD immunoexpression level was borderline significantly associated with a worse prognosis for disease-specific survival, and it was probably related to a lower capacity for coping with oxidative stress.

Obesity Research & Clinical Practice, 2013

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamo... more The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma. APMIS 2018. The aim of this study was to investigate the associations among the immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) tissues and the clinicopathological characteristics, and prognostic factors in patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were examined in 76 LSCC tissue samples using immunohistochemical staining on tissue microarray slides, and compared to those in normal lip mucosa adjacent to venous lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), and recurrent tumors. Associations between immunoexpression levels and clinicopathological characteristics were analyzed using the Student's t-test. The prognostic factors were analyzed using Cox regression. The immunoexpression levels of Mn-SOD, GPx, and MPO were significantly different among the normal controls, NTACTs, tumors, and recurrent tumors (Mn-SOD: p = 0.001, GPx: p < 0.001, MPO: p < 0.001). Lower lip cancer was associated with higher Mn-SOD immunoexpression levels (p = 0.04) and probably indicated higher oxidative stress. Lymph node involvement with a lower immunoexpression level of MPO (p = 0.007) indicated compensatory mechanism to attenuate oxidative damage. A low Mn-SOD immunoexpression level was borderline significantly associated with a worse prognosis for disease-specific survival, and it was probably related to a lower capacity for coping with oxidative stress.

Jurnal Riset Kedokteran

Kanker serviks memiliki angka mortalitas tertinggi ketiga di dunia dari keseluruhan kasus kanker.... more Kanker serviks memiliki angka mortalitas tertinggi ketiga di dunia dari keseluruhan kasus kanker. Angka ini dapat dicegah melalui pemeriksaan pap smear. Penelitian ini bertujuan mengumpulkan data memadai mengenai pap smear sebagai metode deteksi dini kanker serviks. Metode yang digunakan adalah studi literatur dengan mengumpulkan beberapa penelitian terdahulu tentang pap smear sebagai metode deteksi dini kanker serviks. Hasil dari penelitian ini menjelaskan pap smear mulai dari sejarah, definisi, prinsip, tujuan, manfaat, rekomendasi, prosedur pemeriksaan, dan interpretasi hasil. Dengan demikian dappat disimpulkan pap smear merupakan suatu pemeriksaan yang bertujuan untuk melihat lesi pre kanker yang direkomendasikan bagi wanita usia 30-60 tahun setiap tiga tahun sekali untuk mencegah kejadian kanker serviks.