Melike Aloglu - Academia.edu (original) (raw)

Papers by Melike Aloglu

The Egyptian Journal of Bronchology

Background Small cell lung cancer (SCLC) is a malignant disease that spreads quickly. There is li... more Background Small cell lung cancer (SCLC) is a malignant disease that spreads quickly. There is limited research on the relationship between tumor diameter and distant metastatic patterns in extensive stage small cell lung cancer (ES-SCLC). This study aimed to investigate the relationship between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer. Method Patients over the age of 18 who applied to Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital with the diagnosis of small cell lung cancer and distant organ metastasis between January 2015 and December 2019 were retrospectively analyzed. Results The study comprised a total of 178 patients, with 12 women (6.7%) and 166 men (93.3%) participating. The patient was followed for a period of 1 to 36 months, with a median value of 7 months. The univariate model showed that pancreatic metastasis, single metastasis, tumor diameter, and tumor N stage had a significant (...

Indian Journal of Respiratory Care, 2022

Objective: While malignant pleural effusion (MPE) is generally observed in non-small cell lung ca... more Objective: While malignant pleural effusion (MPE) is generally observed in non-small cell lung cancer (SCLC) patients, its prevalence in SCLC has not been reported. Methods: Patients over 18 who were admitted to our hospital between January 2015 and December 2019 and diagnosed with SCLC histologically were retrospectively studied. Demographic data, tumor location, tumor stage, pleural fluid characteristics, radiological findings, and overall survival were recorded from hospital records. Results: Our study included 59 patients (48 [81.4%] men and 11 [18.6%] women), with a median age of 67. Forty-seven (79.7%) patients had a history of smoking. The patients had median tumor standardized uptake values (SUV) max levels of 11.9, a tumor diameter of 6 cm, and a follow-up period of 7 months. Protein levels in pleural fluid of the metastasizing group were significantly higher than in the nonmetastatic group (P = 0.049). In the univariate model, age, N stage, pleural fluid glucose, and pleur...

Scandinavian Journal of Clinical and Laboratory Investigation, 2016

Abstract Background In critical care patients, the diagnosis of subclinical acute kidney injury (... more Abstract Background In critical care patients, the diagnosis of subclinical acute kidney injury (AKI) might be difficult with measurements of serum creatinine and estimated glomerular filtration rate (eGFR). Their ‘sensitive kidneys’ can easily be affected from sepsis, underlying diseases, medications and volume status and if they can be detected earlier, some preventive measures might be taken. In this study we aimed to determine whether admission serum cystatin C (sCys-C) and other clinical parameters can identify subclinical AKI in medical intensive care unit (ICU) patients with normal creatinine-based eGFR at admission. Methods A prospective cohort study, performed in an adult ICU of a university hospital between January 2008 and March 2013. The blood samples were obtained within the first 24-48 hours of admission and sCys-C levels were analyzed with particle-enhanced immunonephelometric assay. AKI development was assessed according to RIFLE criteria. The cutoff value of sCys-C for the prediction of AKI was determined with receiver operating characteristic (ROC) curve analysis. Results A total of 72 patients were included in the study and 19 (26%) of them developed AKI. Among the patients with AKI admission sCys-C levels were significantly higher when compared with non-AKI patients (1.06 ± 0.29 vs. 0.89 ± 0.28 respectively, p = 0.026). With ROC curve analysis, the threshold level for sCys-C was 0.94 mg/L with 63% sensitivity and 66% specificity [AUC: 0.67, p = 0.026]. With logistic regression analysis ‘high sCys-C levels at admission’ (OR = 4.73; 95%CI 1.03–21.5, p = 0.044) was found as one of the independent variables for the prediction of AKI development, in addition to ‘being intubated before ICU admission’ (OR = 10.2; 95%CI 1.72–60.4, p = 0.01) and ‘hypotension during ICU follow-up’ (OR = 12.3; 95%CI 2.5–60.1, p = 0.002). Conclusion In this cohort of patients, a high sCys-C level at admission was found to be a predictor of subclinical AKI arising during their ICU stay. If supported with further studies, it might be used to provide more accurate and earlier knowledge about renal dysfunction and to take appropriate preventive measures.

4.2 Sleep and Control of Breathing, 2016

Determination of obstructive sleep apnea syndrome (OSAS) types is important for treatment decisio... more Determination of obstructive sleep apnea syndrome (OSAS) types is important for treatment decision. There are two different definitions for position and rapid eye movement (REM) related OSAS in literature. One of them provides the criteria that non-supine and/or non-REM apnea hypopnea index (AHI) below 5, the other does not. In our study these two definitions are named as “strict definition” and “loose definition”. This study is designed to identify which definition is more beneficial to use, and the prognostic value of the definitions by comparing demographic and polysomnographic parameters of patient groups composed due to both definitions. This is the first study investigating this issue. Obstructive AHI >5 of all adult patients admitted to our Sleep Disorders Center between September 2012 - October 2014 were included to this retrospective cohort study. 280 (73.7%) of the patients were male, 100 (26.3%) were female, with mean age of 49.9, body mass index (BMI) of 30.4 and neck circumference of 43.2. The patients had mean Epworth sleepiness scale score: 13.5, mean AHI: 32.3, mean arousal index: 27.1, mean peripheral capillary oxygen saturation (SpO 2 ): 90.6, and mean minimum SpO 2 : 78.7.In groups with OSAS aggravated by REM and/or position total AHI, apnea index, hypopnea index, minimum SpO 2 and desaturation percentage were all found significantly worse than REM and/or position dependent groups (p

The Journal of Association of Chest Physicians, 2022

Eurasian Journal of Pulmonology, 2020

INTRODUCTION: Determination of clinical obstructive sleep apnea syndrome (OSAS) types is importan... more INTRODUCTION: Determination of clinical obstructive sleep apnea syndrome (OSAS) types is important for treatment decision. In the literature, there are two different criteria for the diagnosis of position and rapid eye movement (REM) related OSAS. One of them provides the criteria that nonsupine and/or non-REM apnea-hypopnea index (AHI) below 5, the other does not. In this study, these two definitions are named as “strict definition” and “loose definition.” This study is designed to identify which definition is more beneficial to use, and the prognostic value of the definitions by using OSAS severity according to AHI. This is the first study which investigates those issues. MATERIALS AND METHODS: This study is a retrospective cohort study. Obstructive AHI >5 of all adult patients admitted to our sleep disorders center between September 2012 and October 2014 were included to this study. The patients were grouped due to both strict and loose definitions. Patient groups were named a...

International Journal of Clinical Practice, 2021