Meor Affandi - Academia.edu (original) (raw)

Papers by Meor Affandi

Research paper thumbnail of Formulation development and bioavailability evaluation of astaxanthin emulsion / Meor Mohd Redzuan Meor Mohd Affandi

Research paper thumbnail of Potential of Rebaudioside-A as a healthy table sugar substitute with anti-insulin resistance properties for patient with diabetic disorder

Research paper thumbnail of Bachelor of Pharmacy Industrial Training: Performance and Preceptor Perception

International Research Journal of Pharmacy, 2013

Research paper thumbnail of Development of Simple High Performance Liquid Chromatographic Method for the Determination of Astaxanthin in Human Plasma

Food Science and Technology Research, 2012

A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of ... more A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of astaxanthin in human plasma was developed and validated. The method involved direct injection of plasma sample after deproteinization using a 1:9 mixture of ethanol-tetrahydrofuran. The mobile phase comprised methanol:water:ethyl acetate (82:8:10% (v/v)) with a total run time of 5 min. Analysis was run at a flow rate of 1.5 mL/min with the detector set at 474nm. This method is specific and sensitive, with a quantification limit of approximately 0.25 µg/mL. The calibration curve was linear over a concentration range of 0.39 − 50.0 µg/mL. The method have a mean absolute recovery of 99%, while the within-day and between day coefficients of variation and percentage errors were all less than 3%. The speed, specificity, sensitivity, reproducibility and stability of this method make it suitable for the determination of human plasma astaxanthin in routine analysis.

Research paper thumbnail of Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction

Food Science and Technology Research, 2012

Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong ant... more Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion against oil solution formulation. The nanosized emulsion shows increased C max and AUC 0-∞ and decreased T max values with a reduction of the emulsion globule size. The AUC 0-∞ of nanosize compared to macrosize emulsion and oil solution was increased by 110% − 140% and 140% − 200% respectively.

Research paper thumbnail of Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses

Evidence-Based Complementary and Alternative Medicine, 2011

Zingiber zerumbet Sm., locally known to the Malay as "Lempoyang," is a perennial herb found in ma... more Zingiber zerumbet Sm., locally known to the Malay as "Lempoyang," is a perennial herb found in many tropical countries, including Malaysia. The rhizomes of Z. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory-and pain-mediated diseases, worm infestation and diarrhea). Research carried out using different in vitro and in vivo assays of biological evaluation support most of these claims. The active pharmacological component of Z. zerumbet rhizomes most widely studied is zerumbone. This paper presents the botany, traditional uses, chemistry, and pharmacology of this medicinal plant.

Research paper thumbnail of Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review

Evidence-Based Complementary and Alternative Medicine, 2012

Melastoma malabathricum L. (Melastomaceae) is one of the 22 species found in the Southeast Asian ... more Melastoma malabathricum L. (Melastomaceae) is one of the 22 species found in the Southeast Asian region, including Malaysia. Considered as native to tropical and temperate Asia and the Pacific Islands, this commonly found small shrub has gained herbal status in the Malay folklore belief as well as the Indian, Chinese and Indonesian folk medicines. Ethnopharmacologically, the leaves, shoots, barks, seeds and roots of M. malabathricum have been used to treat diarrhoea, dysentery, hemorrhoids, cuts and wounds, toothache and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabthricum, such as antinociceptive, anti-inflammatory, wound healing, antidiarrheal, cytotoxic and antioxidant activities. Various types of phytochemical constituents have also been isolated and identifed from different parts of M. malabathricum. Thus, the aim of the present review is to present comprehensive information on ethnomedicinal uses, phytochemical constituents and pharmacological activities of M. malabathricum.

Research paper thumbnail of Solubility enhancement of simvastatin by arginine: thermodynamics, solute-solvent interactions, and spectral analysis

Drug design, development and therapy, 2016

We examined the solubility of simvastatin in water in 0.01 mol·dm(-3), 0.02 mol·dm(-3), 0.04 mol·... more We examined the solubility of simvastatin in water in 0.01 mol·dm(-3), 0.02 mol·dm(-3), 0.04 mol·dm(-3), 0.09 mol·dm(-3), 0.18 mol·dm(-3), 0.36 mol·dm(-3), and 0.73 mol·dm(-3) arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a higher extent of solubility enhancement for simvastatin. The aforementioned system was subjected to conductometric and volumetric measurements at temperatures (T) of 298.15 K, 303.15 K, 308.15 K, and 313.15 K to illustrate the thermodynamics involved and related solute-solvent interactions. The conductance values were used to evaluate the limiting molar conductance and association constants. Thermodynamic parameters (ΔG (0), ΔH (0), ΔS (0), and E s) for the association process of the solute in the aqueous solutions of ARG were calculated. Limiting partial molar volumes and expansibilities were evaluated from the density values. These values are discussed in terms of the solute-...

Research paper thumbnail of Formulation development and bioavailability evaluation of astaxanthin emulsion / Meor Mohd Redzuan Meor Mohd Affandi

Research paper thumbnail of Potential of Rebaudioside-A as a healthy table sugar substitute with anti-insulin resistance properties for patient with diabetic disorder

Research paper thumbnail of Bachelor of Pharmacy Industrial Training: Performance and Preceptor Perception

International Research Journal of Pharmacy, 2013

Research paper thumbnail of Development of Simple High Performance Liquid Chromatographic Method for the Determination of Astaxanthin in Human Plasma

Food Science and Technology Research, 2012

A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of ... more A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of astaxanthin in human plasma was developed and validated. The method involved direct injection of plasma sample after deproteinization using a 1:9 mixture of ethanol-tetrahydrofuran. The mobile phase comprised methanol:water:ethyl acetate (82:8:10% (v/v)) with a total run time of 5 min. Analysis was run at a flow rate of 1.5 mL/min with the detector set at 474nm. This method is specific and sensitive, with a quantification limit of approximately 0.25 µg/mL. The calibration curve was linear over a concentration range of 0.39 − 50.0 µg/mL. The method have a mean absolute recovery of 99%, while the within-day and between day coefficients of variation and percentage errors were all less than 3%. The speed, specificity, sensitivity, reproducibility and stability of this method make it suitable for the determination of human plasma astaxanthin in routine analysis.

Research paper thumbnail of Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction

Food Science and Technology Research, 2012

Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong ant... more Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion against oil solution formulation. The nanosized emulsion shows increased C max and AUC 0-∞ and decreased T max values with a reduction of the emulsion globule size. The AUC 0-∞ of nanosize compared to macrosize emulsion and oil solution was increased by 110% − 140% and 140% − 200% respectively.

Research paper thumbnail of Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses

Evidence-Based Complementary and Alternative Medicine, 2011

Zingiber zerumbet Sm., locally known to the Malay as "Lempoyang," is a perennial herb found in ma... more Zingiber zerumbet Sm., locally known to the Malay as "Lempoyang," is a perennial herb found in many tropical countries, including Malaysia. The rhizomes of Z. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory-and pain-mediated diseases, worm infestation and diarrhea). Research carried out using different in vitro and in vivo assays of biological evaluation support most of these claims. The active pharmacological component of Z. zerumbet rhizomes most widely studied is zerumbone. This paper presents the botany, traditional uses, chemistry, and pharmacology of this medicinal plant.

Research paper thumbnail of Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review

Evidence-Based Complementary and Alternative Medicine, 2012

Melastoma malabathricum L. (Melastomaceae) is one of the 22 species found in the Southeast Asian ... more Melastoma malabathricum L. (Melastomaceae) is one of the 22 species found in the Southeast Asian region, including Malaysia. Considered as native to tropical and temperate Asia and the Pacific Islands, this commonly found small shrub has gained herbal status in the Malay folklore belief as well as the Indian, Chinese and Indonesian folk medicines. Ethnopharmacologically, the leaves, shoots, barks, seeds and roots of M. malabathricum have been used to treat diarrhoea, dysentery, hemorrhoids, cuts and wounds, toothache and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabthricum, such as antinociceptive, anti-inflammatory, wound healing, antidiarrheal, cytotoxic and antioxidant activities. Various types of phytochemical constituents have also been isolated and identifed from different parts of M. malabathricum. Thus, the aim of the present review is to present comprehensive information on ethnomedicinal uses, phytochemical constituents and pharmacological activities of M. malabathricum.

Research paper thumbnail of Solubility enhancement of simvastatin by arginine: thermodynamics, solute-solvent interactions, and spectral analysis

Drug design, development and therapy, 2016

We examined the solubility of simvastatin in water in 0.01 mol·dm(-3), 0.02 mol·dm(-3), 0.04 mol·... more We examined the solubility of simvastatin in water in 0.01 mol·dm(-3), 0.02 mol·dm(-3), 0.04 mol·dm(-3), 0.09 mol·dm(-3), 0.18 mol·dm(-3), 0.36 mol·dm(-3), and 0.73 mol·dm(-3) arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies illustrated a higher extent of solubility enhancement for simvastatin. The aforementioned system was subjected to conductometric and volumetric measurements at temperatures (T) of 298.15 K, 303.15 K, 308.15 K, and 313.15 K to illustrate the thermodynamics involved and related solute-solvent interactions. The conductance values were used to evaluate the limiting molar conductance and association constants. Thermodynamic parameters (ΔG (0), ΔH (0), ΔS (0), and E s) for the association process of the solute in the aqueous solutions of ARG were calculated. Limiting partial molar volumes and expansibilities were evaluated from the density values. These values are discussed in terms of the solute-...