Mercy Bamigboye - Academia.edu (original) (raw)
Papers by Mercy Bamigboye
Research on chemical intermediates, May 10, 2024
At the nanoscale level, several biological processes take place, owing to the potential that engi... more At the nanoscale level, several biological processes take place, owing to the potential that engineered nanomaterials might interrelate with bio-molecules and cellular procedures. This study aimed to synthesize cadmium oxide nanoparticles via a one-step calcination process of tetradentate Schiff base-Cd(II) complex at different temperature ranges. The as-synthesized compounds were carried out via a viz UV-visible, elemental analysis, 1 H NMR, molar conductivity, transmission electron microscopy (TEM), FT-IR spectroscopy, and X-ray diffraction (PXRD). The band gap energy and average particle sizes of the CdO particles are respectively (2.69 eV, 3.54 eV), 26.88 nm for CdO@250, and (3.20 eV, 3.57 eV), 25.67 nm for CdO@300, while CdO@350 exhibited the 3.78 eV and 28.42 nm values. The antioxidant accomplishments of the test samples through the scavenging activity of DPPH radicals showed CdO@300 to possess (IC 50 = 5.18 ± 0.56 µg/mL). Similarly, the as-synthesized CdO nanoparticles exhibited higher antibacterial activities against S. aureus and E. coli as compared to the corresponding Cd-HMB and ligand (HMB), while ciprofloxacin acted as a standard antibiotic. Furthermore, HMB and its complex Cd-HMB were docked against the DNA gyrase enzymes of S. aureus (PDB IDs: 5CDQ) and E. coli (PDB IDs: 6F86) as receptors. The binding sites docking results showed that the binding energies of HMB and Cd-HMB to 5CDQ ranged from − 3.44 to − 4.99 kcal/mol and from − 6.45 to − 6.64 kcal/mol, while the binding energies related to the target 6F86 are in the ranges of (− 3.64, − 4.76) kcal/ mol and (− 6.08, − 6.09) kcal/mol respectively. Therefore, the significant antioxidant and antibacterial activities of the ligand (HMB), Cd-HMB, and CdO NPs review the broad application prospects of these compounds as therapeutic agents for wideranging biomedical applications.
Journal of Molecular Structure, Feb 29, 2024
Notulae Scientia Biologicae, Sep 29, 2020
This research work aimed at synthesizing and investigating the antimicrobial activities of a meta... more This research work aimed at synthesizing and investigating the antimicrobial activities of a metallic oxide nanoparticle complex of Moringa oleifera leaves extracts against some microorganisms. Moringa oleifera leaves were washed, dried and blended. They were extracted with distilled water and ethanol using standard methods. The nanoparticle was synthesized by coordinating with manganese oxide. The physicochemical properties were determined following standard procedures. The phytochemical screening was carried out by standard methods. The antibacterial activities were done using agar well diffusion method. Antifungal activity was carried out following the plate technique. The leaves extract had a 75% yield and melting point of 116 °C while the nanoparticle had a yield of 60% and melted at 78 °C with pH of 3.46. The molar conductance of the nanoparticle revealed at 10.6 Ω −1 cm 2 mol −1. The ethanolic extract of the leaves showed the presence of alkaloids, tannin, steroids and saponins. The ethanolic extract of M. oleifera exhibited the highest antibacterial activity of 33.05±0.10 mm against Bacillus subtilis while its antifungal activity revealed the highest inhibition of 48.40±0.53 mm at 30 mg/mL against Aspergillus niger. Staphylococcus aureus had a zone of inhibition of 19.00±0.16 a using the aqueous extract. The ethanolic extract of M. oleifera nanoparticles showed antibacterial and antifungal activity against B. megaterium and A. niger with a zone of inhibition of 49.21±0.32 mm and 50.35±0.29 mm respectively while the aqueous extract showed antibacterial activity against S. aureus with a zone of 26.00±0.38mm. As it was concluded ethanolic extract in both leaves extract and its nanoparticle, possessed higher antibacterial and antifungal activities than the aqueous extract.
Notulae Scientia Biologicae, 2020
The present research aimed at screening various soils within Ilorin metropolis for antibiotic pro... more The present research aimed at screening various soils within Ilorin metropolis for antibiotic producing actinomycetes. The objectives of the study were to determine physiochemical parameters of soils, the occurrence of actinomycetes in soils, antibacterial potentials and identity of isolates. Soil parameters such as pH, temperature, moisture, organic matter and soil type were evaluated following standard procedures. Selective isolation to determine the occurrence of actinomycetes was performed by soil dilution using pour plate technique on starch casein agar. Preliminary antibacterial screening against 10 clinical test bacteria was performed using cross streak method. All isolates were initially identified based on morphological and biochemical characteristics, while the most bioactive isolates were further identified by molecular means. The soils were alkaline, with temperatures between 29 °C and 31 °C, moisture was in range of 0.72 ± 0.07c and 6.62 ± 0.42b. Highest organic matter ...
Bayero Journal of Pure and Applied Sciences, Apr 16, 2018
A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been syn... more A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been synthesized and characterised using microanalytical technique, elemental analysis, FT-IR spectroscopy and magnetic measurement. The results of the analytical and spectroscopic data revealed that both amodiaquine and citric acid acted as bidentate ligands in their mode of coordination with the metal ions.The citric acid bound through the carbonyl (C=O) and hydroxyl groups to the metal ions while, amodiaquine coordinated through the nitrogen atom of the amine and oxygen donor atom of hydroxyl group; resulted in structures with octahedral geometry. Percentage composition and magnetic Bohr moment data indicated that all metal complexes were paramagnetic. Molar conductance measurement indicates that the complexes are non-electrolytes in nature. The antimicrobial activity of the ligands and their mixed complexes was carried out against g(+)Pseudomonas aeruginosa, g(+)E. coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The citric acid and amodiaquine result showed low or moderate value from (0.6-0.8) for all the metal complexes with the exception of the Cu (II) complex having inhibitory zones ranging from 1-0-1.3, 0.7-0.9 at 200 ppm respectively. Moreover, the free ligands were found being less active compared with their mixed complexes.
Tanzania journal of science, Dec 30, 2021
Most variants of bacteria are resistant to traditional antibiotics which are organic. To overcome... more Most variants of bacteria are resistant to traditional antibiotics which are organic. To overcome the growing infections, bacteria resistant infections, and multiple drug resistance (MDR) rates, transition metals with biological importance were coordinated to organic ligands (Ibuprofen and Salicylic acid) with anti-inflammatory properties. In this study, metal complexes of mixed Ibuprofen and Salicylic acid were prepared using a standard method to give of the type [M(Ibu)(Sal)X] (where M = Fe 2+, Ni 2+ , Cu 2+ , and X = Cl 2 , Ibu = Ibuprofen, Sal = Salicylic acid). The complexes were characterized by UV-visible spectroscopy, conductivity measurements, melting points, FT-IR, and X-ray diffraction. The metal ions are coordinated to the ligands via the carboxylato oxygen donor atoms of both ligands. From the physicochemical data, the complexes are non-electrolytes. The XRD study suggested that the metal complexes possess a well-defined crystalline structure with average crystallite sizes of < 62 nm. Evaluations of the antimicrobial activities of the ligands and their complexes against gram-positive bacteria (S. aureus, B. subtilis, S. faecalis) and gram-negative bacteria (K. pneumonia, E. coli, and P. aeroginosa) via standard method were utilized to determine the zones of inhibition. The complexes exhibited a higher zone of inhibition, indicating higher antimicrobial activities when compared to the parent ligand. The results revealed that the metal-drug complexes are promising chemotherapeutic agents with wide spectrum of activities.
A new series of Ni(II), Co(II) and Mn(II) chloride complexes of mixed Cloxacillin and Vitamin C w... more A new series of Ni(II), Co(II) and Mn(II) chloride complexes of mixed Cloxacillin and Vitamin C were synthesized using Refluxing method. Characterization of the ligands and their complexes were carried out by Molar conductivity, Elemental analysis and FT-Infrared spectroscopy. Antibacterial activity of the ligands and their metal complexes were investigated against selected test bacteria ( Escherichia coli , Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa ). The stoichiometry of the reaction between the ligands and the metal ions was determined following standard procedures. Based on the mobility of ions, the complexes were non-electrolytic in nature. The percentage elemental composition of the complexes and ligands indicated that they are in good agreement with each other. The FT-IR data showed a bathochromic shift in the band of the complexes observed at 1670 cm -1 which is attributed to nitrogen of azomethine and oxygen of carbonyl group in cloxacillin. In...
A Search for Antibacterial Agents, 2012
Ninety elements occur naturally on earth. Out of these, nine are radioactive and among the remain... more Ninety elements occur naturally on earth. Out of these, nine are radioactive and among the remaining eighty one that could support life, sixty one are metals. Our bodies are 3% metal. Thus, it is surprising that some of the most serious challenges to human life, externally, the pollutants cadmium, mercury and lead are attracting more attention, whereas internally, there is a constant battle against sodium and calcium that are rejected by cells and accumulated elsewhere in the body during the ageing process. Furthermore, some diseases release metals into the blood stream. Their use in the fight against diseases was first described by Schubert in 1965. Man just like other vertebrates requires cations of the metals to facilitate a great many essential life processes. Moreover, many of the metals are essential for all other forms of life process. Around 5000 years ago the Egyptians used copper metal to sterilize water and gold was used in a variety of medicines in Arabian and China, but the practice emanated from the value of pure metal rather than from therapeutic effects. Metals have played an important role in medicine for years, ever since human being started to walk on the planet. Many are essential to our diets in varying quantities, although people have only recently realized their significance. This could probably be attributed to our increased awareness of personal and family health. Most of the major classes of pharmaceutical agents contain examples of metal compounds which are in current clinical use. Inorganic compounds (metal complexes) have been used to treat various diseases and ailments for many centuries.
Tanzania Journal of Science
Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexe... more Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexes have been synthesized and characterized by different spectroscopic techniques such as FT-IR, elemental analysis, molar conductivity, and magnetic measurements. Both ligands used for this research work act as bidentate ligands towards the central metal ions coordinating through the nitrogen atoms of >C=N-, NH2 groups of Sulphadiazine and oxygen atoms of OH, CO groups of Vitamin C. Tetrahedral and square-planar geometries have been proposed for the complexes. The complexes are stable under atmospheric conditions. The ligands and their complexes were screened for antimicrobial activities against some isolated organisms: Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis to evaluate their microbial inhibiting potential. The derived complexes were found to exhibit an increased inhibitory action against the o...
Tanzania Journal of Science
Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexe... more Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexes have been synthesized and characterized by different spectroscopic techniques such as FT-IR, elemental analysis, molar conductivity, and magnetic measurements. Both ligands used for this research work act as bidentate ligands towards the central metal ions coordinating through the nitrogen atoms of >C=N-, NH2 groups of Sulphadiazine and oxygen atoms of OH, CO groups of Vitamin C. Tetrahedral and square-planar geometries have been proposed for the complexes. The complexes are stable under atmospheric conditions. The ligands and their complexes were screened for antimicrobial activities against some isolated organisms: Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis to evaluate their microbial inhibiting potential. The derived complexes were found to exhibit an increased inhibitory action against the o...
Proceedings of the Nigerian Academy of Science
Studies on transitional metal compounds of Schiff base ligands have been of great significance du... more Studies on transitional metal compounds of Schiff base ligands have been of great significance due to their spectral properties and wide applications. Tetradentate Schiff base-Zn (II) complex was prepared and used as a precursor for the synthesis of Zinc oxide (ZnO) nanoparticles through a one-step calcination process at a different temperature: 250-350 °C. The influence of temperature on the antioxidant activities of synthesized nanoparticles was investigated. The precursor (zinc complexes) was characterized by melting point, thermogravimetric analysis, UV-Vis, FT-IR spectroscopy. elemental analysis, and thermogravimetric analysis (TGA) of tridentate Schiff base was synthesized and characterized using The structural studies of synthesized metal oxides were carried out with powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), FTIR, and UV-visible. The energy band gap of the nanoparticles was 3.15 eV for ZnO@250, 3.31 eV for ZnO@300, while ZnO@350 was found as 3.1...
Daffodil International University, Jan 18, 2021
Nigerian Journal of Pharmaceutical and Applied Science Research, 2017
Bulletin of Pharmaceutical Sciences. Assiut, 2021
Background: The use of metal-drug complexes in medicine has encouraged researchers in the quest f... more Background: The use of metal-drug complexes in medicine has encouraged researchers in the quest for novel chemotherapeutic agents against toxicity, bacterial and other infections. Methods: Four new mixed metal-drug complexes of amodiaquine and anthranilic acid have been prepared using Ni(II), Cd(II), Mn(II), and Cu(II) metal ions. The synthesized complexes were characterized by physicochemical and spectroscopic techniques such as melting point, elemental analysis, molar conductance, magnetic moment, AAS, FT-IR, and electronic spectroscopy. Results: The IR spectra revealed that in amodiaquine, coordination occurred through the nitrogen of the amino and oxygen of hydroxyl groups, and the oxygen of the carbonyl and nitrogen of the amino groups in anthranilic acid. Antibacterial assay of the complexes exhibited better activities than the free ligands against selected organisms. [Mn(ANT)(AMO)Cl 2 ] displayed the highest antibacterial activity against B. subtilis strains at a concentration of 30 µg/ml with a zone of inhibition of 48 mm. The toxicological effect of the compounds in serum and liver homogenate of albino rats (Rattus novergicuss) was investigated.Conclusion: Alkaline phosphate (ALP) concentrations for the metal complexes in the liver and serum homogenates were significantly different when compared to the control group after the study period at (P< 0.05). The antibacterial assay of the complexes showed better activities than the free ligands, indicating them to be potential chemotherapeutic agents.
Research on chemical intermediates, May 10, 2024
At the nanoscale level, several biological processes take place, owing to the potential that engi... more At the nanoscale level, several biological processes take place, owing to the potential that engineered nanomaterials might interrelate with bio-molecules and cellular procedures. This study aimed to synthesize cadmium oxide nanoparticles via a one-step calcination process of tetradentate Schiff base-Cd(II) complex at different temperature ranges. The as-synthesized compounds were carried out via a viz UV-visible, elemental analysis, 1 H NMR, molar conductivity, transmission electron microscopy (TEM), FT-IR spectroscopy, and X-ray diffraction (PXRD). The band gap energy and average particle sizes of the CdO particles are respectively (2.69 eV, 3.54 eV), 26.88 nm for CdO@250, and (3.20 eV, 3.57 eV), 25.67 nm for CdO@300, while CdO@350 exhibited the 3.78 eV and 28.42 nm values. The antioxidant accomplishments of the test samples through the scavenging activity of DPPH radicals showed CdO@300 to possess (IC 50 = 5.18 ± 0.56 µg/mL). Similarly, the as-synthesized CdO nanoparticles exhibited higher antibacterial activities against S. aureus and E. coli as compared to the corresponding Cd-HMB and ligand (HMB), while ciprofloxacin acted as a standard antibiotic. Furthermore, HMB and its complex Cd-HMB were docked against the DNA gyrase enzymes of S. aureus (PDB IDs: 5CDQ) and E. coli (PDB IDs: 6F86) as receptors. The binding sites docking results showed that the binding energies of HMB and Cd-HMB to 5CDQ ranged from − 3.44 to − 4.99 kcal/mol and from − 6.45 to − 6.64 kcal/mol, while the binding energies related to the target 6F86 are in the ranges of (− 3.64, − 4.76) kcal/ mol and (− 6.08, − 6.09) kcal/mol respectively. Therefore, the significant antioxidant and antibacterial activities of the ligand (HMB), Cd-HMB, and CdO NPs review the broad application prospects of these compounds as therapeutic agents for wideranging biomedical applications.
Journal of Molecular Structure, Feb 29, 2024
Notulae Scientia Biologicae, Sep 29, 2020
This research work aimed at synthesizing and investigating the antimicrobial activities of a meta... more This research work aimed at synthesizing and investigating the antimicrobial activities of a metallic oxide nanoparticle complex of Moringa oleifera leaves extracts against some microorganisms. Moringa oleifera leaves were washed, dried and blended. They were extracted with distilled water and ethanol using standard methods. The nanoparticle was synthesized by coordinating with manganese oxide. The physicochemical properties were determined following standard procedures. The phytochemical screening was carried out by standard methods. The antibacterial activities were done using agar well diffusion method. Antifungal activity was carried out following the plate technique. The leaves extract had a 75% yield and melting point of 116 °C while the nanoparticle had a yield of 60% and melted at 78 °C with pH of 3.46. The molar conductance of the nanoparticle revealed at 10.6 Ω −1 cm 2 mol −1. The ethanolic extract of the leaves showed the presence of alkaloids, tannin, steroids and saponins. The ethanolic extract of M. oleifera exhibited the highest antibacterial activity of 33.05±0.10 mm against Bacillus subtilis while its antifungal activity revealed the highest inhibition of 48.40±0.53 mm at 30 mg/mL against Aspergillus niger. Staphylococcus aureus had a zone of inhibition of 19.00±0.16 a using the aqueous extract. The ethanolic extract of M. oleifera nanoparticles showed antibacterial and antifungal activity against B. megaterium and A. niger with a zone of inhibition of 49.21±0.32 mm and 50.35±0.29 mm respectively while the aqueous extract showed antibacterial activity against S. aureus with a zone of 26.00±0.38mm. As it was concluded ethanolic extract in both leaves extract and its nanoparticle, possessed higher antibacterial and antifungal activities than the aqueous extract.
Notulae Scientia Biologicae, 2020
The present research aimed at screening various soils within Ilorin metropolis for antibiotic pro... more The present research aimed at screening various soils within Ilorin metropolis for antibiotic producing actinomycetes. The objectives of the study were to determine physiochemical parameters of soils, the occurrence of actinomycetes in soils, antibacterial potentials and identity of isolates. Soil parameters such as pH, temperature, moisture, organic matter and soil type were evaluated following standard procedures. Selective isolation to determine the occurrence of actinomycetes was performed by soil dilution using pour plate technique on starch casein agar. Preliminary antibacterial screening against 10 clinical test bacteria was performed using cross streak method. All isolates were initially identified based on morphological and biochemical characteristics, while the most bioactive isolates were further identified by molecular means. The soils were alkaline, with temperatures between 29 °C and 31 °C, moisture was in range of 0.72 ± 0.07c and 6.62 ± 0.42b. Highest organic matter ...
Bayero Journal of Pure and Applied Sciences, Apr 16, 2018
A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been syn... more A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been synthesized and characterised using microanalytical technique, elemental analysis, FT-IR spectroscopy and magnetic measurement. The results of the analytical and spectroscopic data revealed that both amodiaquine and citric acid acted as bidentate ligands in their mode of coordination with the metal ions.The citric acid bound through the carbonyl (C=O) and hydroxyl groups to the metal ions while, amodiaquine coordinated through the nitrogen atom of the amine and oxygen donor atom of hydroxyl group; resulted in structures with octahedral geometry. Percentage composition and magnetic Bohr moment data indicated that all metal complexes were paramagnetic. Molar conductance measurement indicates that the complexes are non-electrolytes in nature. The antimicrobial activity of the ligands and their mixed complexes was carried out against g(+)Pseudomonas aeruginosa, g(+)E. coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The citric acid and amodiaquine result showed low or moderate value from (0.6-0.8) for all the metal complexes with the exception of the Cu (II) complex having inhibitory zones ranging from 1-0-1.3, 0.7-0.9 at 200 ppm respectively. Moreover, the free ligands were found being less active compared with their mixed complexes.
Tanzania journal of science, Dec 30, 2021
Most variants of bacteria are resistant to traditional antibiotics which are organic. To overcome... more Most variants of bacteria are resistant to traditional antibiotics which are organic. To overcome the growing infections, bacteria resistant infections, and multiple drug resistance (MDR) rates, transition metals with biological importance were coordinated to organic ligands (Ibuprofen and Salicylic acid) with anti-inflammatory properties. In this study, metal complexes of mixed Ibuprofen and Salicylic acid were prepared using a standard method to give of the type [M(Ibu)(Sal)X] (where M = Fe 2+, Ni 2+ , Cu 2+ , and X = Cl 2 , Ibu = Ibuprofen, Sal = Salicylic acid). The complexes were characterized by UV-visible spectroscopy, conductivity measurements, melting points, FT-IR, and X-ray diffraction. The metal ions are coordinated to the ligands via the carboxylato oxygen donor atoms of both ligands. From the physicochemical data, the complexes are non-electrolytes. The XRD study suggested that the metal complexes possess a well-defined crystalline structure with average crystallite sizes of < 62 nm. Evaluations of the antimicrobial activities of the ligands and their complexes against gram-positive bacteria (S. aureus, B. subtilis, S. faecalis) and gram-negative bacteria (K. pneumonia, E. coli, and P. aeroginosa) via standard method were utilized to determine the zones of inhibition. The complexes exhibited a higher zone of inhibition, indicating higher antimicrobial activities when compared to the parent ligand. The results revealed that the metal-drug complexes are promising chemotherapeutic agents with wide spectrum of activities.
A new series of Ni(II), Co(II) and Mn(II) chloride complexes of mixed Cloxacillin and Vitamin C w... more A new series of Ni(II), Co(II) and Mn(II) chloride complexes of mixed Cloxacillin and Vitamin C were synthesized using Refluxing method. Characterization of the ligands and their complexes were carried out by Molar conductivity, Elemental analysis and FT-Infrared spectroscopy. Antibacterial activity of the ligands and their metal complexes were investigated against selected test bacteria ( Escherichia coli , Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa ). The stoichiometry of the reaction between the ligands and the metal ions was determined following standard procedures. Based on the mobility of ions, the complexes were non-electrolytic in nature. The percentage elemental composition of the complexes and ligands indicated that they are in good agreement with each other. The FT-IR data showed a bathochromic shift in the band of the complexes observed at 1670 cm -1 which is attributed to nitrogen of azomethine and oxygen of carbonyl group in cloxacillin. In...
A Search for Antibacterial Agents, 2012
Ninety elements occur naturally on earth. Out of these, nine are radioactive and among the remain... more Ninety elements occur naturally on earth. Out of these, nine are radioactive and among the remaining eighty one that could support life, sixty one are metals. Our bodies are 3% metal. Thus, it is surprising that some of the most serious challenges to human life, externally, the pollutants cadmium, mercury and lead are attracting more attention, whereas internally, there is a constant battle against sodium and calcium that are rejected by cells and accumulated elsewhere in the body during the ageing process. Furthermore, some diseases release metals into the blood stream. Their use in the fight against diseases was first described by Schubert in 1965. Man just like other vertebrates requires cations of the metals to facilitate a great many essential life processes. Moreover, many of the metals are essential for all other forms of life process. Around 5000 years ago the Egyptians used copper metal to sterilize water and gold was used in a variety of medicines in Arabian and China, but the practice emanated from the value of pure metal rather than from therapeutic effects. Metals have played an important role in medicine for years, ever since human being started to walk on the planet. Many are essential to our diets in varying quantities, although people have only recently realized their significance. This could probably be attributed to our increased awareness of personal and family health. Most of the major classes of pharmaceutical agents contain examples of metal compounds which are in current clinical use. Inorganic compounds (metal complexes) have been used to treat various diseases and ailments for many centuries.
Tanzania Journal of Science
Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexe... more Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexes have been synthesized and characterized by different spectroscopic techniques such as FT-IR, elemental analysis, molar conductivity, and magnetic measurements. Both ligands used for this research work act as bidentate ligands towards the central metal ions coordinating through the nitrogen atoms of >C=N-, NH2 groups of Sulphadiazine and oxygen atoms of OH, CO groups of Vitamin C. Tetrahedral and square-planar geometries have been proposed for the complexes. The complexes are stable under atmospheric conditions. The ligands and their complexes were screened for antimicrobial activities against some isolated organisms: Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis to evaluate their microbial inhibiting potential. The derived complexes were found to exhibit an increased inhibitory action against the o...
Tanzania Journal of Science
Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexe... more Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexes have been synthesized and characterized by different spectroscopic techniques such as FT-IR, elemental analysis, molar conductivity, and magnetic measurements. Both ligands used for this research work act as bidentate ligands towards the central metal ions coordinating through the nitrogen atoms of >C=N-, NH2 groups of Sulphadiazine and oxygen atoms of OH, CO groups of Vitamin C. Tetrahedral and square-planar geometries have been proposed for the complexes. The complexes are stable under atmospheric conditions. The ligands and their complexes were screened for antimicrobial activities against some isolated organisms: Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis to evaluate their microbial inhibiting potential. The derived complexes were found to exhibit an increased inhibitory action against the o...
Proceedings of the Nigerian Academy of Science
Studies on transitional metal compounds of Schiff base ligands have been of great significance du... more Studies on transitional metal compounds of Schiff base ligands have been of great significance due to their spectral properties and wide applications. Tetradentate Schiff base-Zn (II) complex was prepared and used as a precursor for the synthesis of Zinc oxide (ZnO) nanoparticles through a one-step calcination process at a different temperature: 250-350 °C. The influence of temperature on the antioxidant activities of synthesized nanoparticles was investigated. The precursor (zinc complexes) was characterized by melting point, thermogravimetric analysis, UV-Vis, FT-IR spectroscopy. elemental analysis, and thermogravimetric analysis (TGA) of tridentate Schiff base was synthesized and characterized using The structural studies of synthesized metal oxides were carried out with powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), FTIR, and UV-visible. The energy band gap of the nanoparticles was 3.15 eV for ZnO@250, 3.31 eV for ZnO@300, while ZnO@350 was found as 3.1...
Daffodil International University, Jan 18, 2021
Nigerian Journal of Pharmaceutical and Applied Science Research, 2017
Bulletin of Pharmaceutical Sciences. Assiut, 2021
Background: The use of metal-drug complexes in medicine has encouraged researchers in the quest f... more Background: The use of metal-drug complexes in medicine has encouraged researchers in the quest for novel chemotherapeutic agents against toxicity, bacterial and other infections. Methods: Four new mixed metal-drug complexes of amodiaquine and anthranilic acid have been prepared using Ni(II), Cd(II), Mn(II), and Cu(II) metal ions. The synthesized complexes were characterized by physicochemical and spectroscopic techniques such as melting point, elemental analysis, molar conductance, magnetic moment, AAS, FT-IR, and electronic spectroscopy. Results: The IR spectra revealed that in amodiaquine, coordination occurred through the nitrogen of the amino and oxygen of hydroxyl groups, and the oxygen of the carbonyl and nitrogen of the amino groups in anthranilic acid. Antibacterial assay of the complexes exhibited better activities than the free ligands against selected organisms. [Mn(ANT)(AMO)Cl 2 ] displayed the highest antibacterial activity against B. subtilis strains at a concentration of 30 µg/ml with a zone of inhibition of 48 mm. The toxicological effect of the compounds in serum and liver homogenate of albino rats (Rattus novergicuss) was investigated.Conclusion: Alkaline phosphate (ALP) concentrations for the metal complexes in the liver and serum homogenates were significantly different when compared to the control group after the study period at (P< 0.05). The antibacterial assay of the complexes showed better activities than the free ligands, indicating them to be potential chemotherapeutic agents.