Luciano Merlini - Academia.edu (original) (raw)
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Papers by Luciano Merlini
Acta Neuropathologica, 2000
Abstract Muscle biopsy tissue from a patient with chronic hepatitis, who was hepatitis C virus (H... more Abstract Muscle biopsy tissue from a patient with chronic hepatitis, who was hepatitis C virus (HCV) posi-tive and showed slight weakness of the right arm and leg associated with increased serum creatine kinase levels, was studied using immunocytochemical and polymerase ...
BMC Medical Genetics, 2012
Frontiers in Aging Neuroscience, 2015
Neuromuscular disorders : NMD, 1998
Journal of submicroscopic cytology and pathology, 1997
Using specific monoclonal antibodies against different subunits of laminin, we studied the differ... more Using specific monoclonal antibodies against different subunits of laminin, we studied the differential distribution pattern of several laminin chains in the central (CNS) and peripheral (PNS) nervous system. Laminin chains alpha 1, beta 1 and gamma 1, were found in the basement membrane (BM) of blood vessels in both CNS and PNS. In contrast, laminin alpha 2 though present in the BM of capillaries in the CNS, was completely absent from PNS capillaries. Laminins alpha 2, beta 1, gamma 1 could be detected in peripheral nerve, in the BM of Schwann cells, which did not contain Laminin alpha 1. The possible importance of laminin alpha 2 for myelination in the PNS as well as in the function of the blood-brain barrier in the CNS, and its potential relevance to the pathology of congenital muscular dystrophy associated with deficiency of this laminin chain, is discussed.
La Chirurgia degli organi di movimento
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 1990
A traditional knee-ankle-foot orthosis (KAFO) for myopathic patients has been studied for the ass... more A traditional knee-ankle-foot orthosis (KAFO) for myopathic patients has been studied for the assessment of loads and fatigue resistance. Starting from this basis a thermoplastic matrix carbon fibre reinforced plastic composite (CFRP) KAFO has been developed in order to reduce the weight. A finite-element simulation programme for deformation analysis was used to compare the behaviour of conventional and CFRP orthosis. There were no breakages either of the prototype or of its parts. The CFRP orthosis allows a weight reduction of more than 40 per cent.
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Neuromuscular disorders : NMD, 2014
European journal of histochemistry : EJH
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly s... more The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins. A common feature of these diseases, named laminopathies, is the occurrence of major chromatin defects. We previously reported that cells from laminopathic patients show an altered nuclear profile, and loss or detachment of heterochromatin from the nuclear envelope. Recent evidence indicates that processing of the lamin A precursor is altered in laminopathies featuring pre-mature aging and/or lipodystrophy phenotype. In these cases, pre-lamin A is accumulated in the nucleus and heterochromatin is severely disorganized. Here we report evidence indicating that pre-lamin A is mis-localized in the nuclei of Emery-Dreifuss muscular dystrophy fibroblasts, either bearing lamin A/C or emerin mutations. Abnormal pre-lamin A-containing structures are formed following treatment with a farnesyl-transfer...
Spinal cord, 2000
The surgical correction of spinal deformities carries a small but significant risk of injury to t... more The surgical correction of spinal deformities carries a small but significant risk of injury to the spinal cord. To detect the onset and possibly reverse the effects of surgical complication, a variety of neurophysiological monitoring procedures can be employed. The purpose of this review is to provide information regarding the various methodologies available for monitoring spinal cord and nerve root function during orthopaedic procedures. Intra-operative monitoring of cortically recorded somatosensory evoked potentials (SEPs) by peripheral nerve stimulation is of value during orthopaedic surgery and is the state-of-the-art in terms of non-invasiveness, versatility, time requirement, lateral discrimination, and ease of electrode placement. Monitoring of motor evoked potentials (MEPs) is useful particularly in combination with SEPs but is still considered investigational. Root function monitoring has limited application and requires more clinical research.
Current opinion in neurology and neurosurgery, 1990
La Chirurgia degli organi di movimento
Between 1982 and 1992 a total of 211 fractures of the acetabulum were operated. There was lesion ... more Between 1982 and 1992 a total of 211 fractures of the acetabulum were operated. There was lesion of the sciatic nerve in 21 cases, the pathogenesis and evolution of which were studied. Clinical follow-up was obtained at least 2 years after occurrence of neurological deficit and supported in 13 cases by electromyography. Based on an analysis of the literature and of these series it is observed how spontaneous recovery of paralysis is not rare, even if it requires a long period of time. The presence of various levels of lesion, which are not easily diagnosed, and which are not easily attacked surgically, calls for a prudent attitude with regard to neurolysis.
![Research paper thumbnail of [Proprioceptive neuromuscular facilitation in paralysis of the anterior serratus]](https://attachments.academia-assets.com/42382059/thumbnails/1.jpg)
](La Chirurgia degli organi di movimento
La Chirurgia degli organi di movimento
La Chirurgia degli organi di movimento
Italian journal of orthopaedics and traumatology, 1982
Instability of the cervical spine gives rise to vertebral and neurological symptoms which may be ... more Instability of the cervical spine gives rise to vertebral and neurological symptoms which may be progressive. The principal causes of instability are: trauma, sequelae of laminectomy, malformations, vertebral infections, rheumatoid arthritis, primary tumours (benign and malignant), metastases, and chronic degenerative disease of the discs. Each of these forms of instability must be identified and, depending on the symptoms and pathogenesis, is capable of responding to the appropriate treatment.
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Italian journal of orthopaedics and traumatology, 1983
The Authors describe the technique of lateral laminectomy devised by Gui in 1965 for the treatmen... more The Authors describe the technique of lateral laminectomy devised by Gui in 1965 for the treatment of cervical myelopathy secondary to cervical spondylosis. Spinal cord decompression is obtained by a lateral laminectomy with the maximum saving of bone, ligaments and muscles of the cervical spine. CAT scan demonstrated very well the effective decompression of the spinal cord achieved with this technique. The results of 87 cases treated in this way between 1968 and 1980 are reported. The average follow-up was 2.5 years. There was an improvement in the neurological symptoms in 82% of the cases.
Acta Neuropathologica, 2000
Abstract Muscle biopsy tissue from a patient with chronic hepatitis, who was hepatitis C virus (H... more Abstract Muscle biopsy tissue from a patient with chronic hepatitis, who was hepatitis C virus (HCV) posi-tive and showed slight weakness of the right arm and leg associated with increased serum creatine kinase levels, was studied using immunocytochemical and polymerase ...
BMC Medical Genetics, 2012
Frontiers in Aging Neuroscience, 2015
Neuromuscular disorders : NMD, 1998
Journal of submicroscopic cytology and pathology, 1997
Using specific monoclonal antibodies against different subunits of laminin, we studied the differ... more Using specific monoclonal antibodies against different subunits of laminin, we studied the differential distribution pattern of several laminin chains in the central (CNS) and peripheral (PNS) nervous system. Laminin chains alpha 1, beta 1 and gamma 1, were found in the basement membrane (BM) of blood vessels in both CNS and PNS. In contrast, laminin alpha 2 though present in the BM of capillaries in the CNS, was completely absent from PNS capillaries. Laminins alpha 2, beta 1, gamma 1 could be detected in peripheral nerve, in the BM of Schwann cells, which did not contain Laminin alpha 1. The possible importance of laminin alpha 2 for myelination in the PNS as well as in the function of the blood-brain barrier in the CNS, and its potential relevance to the pathology of congenital muscular dystrophy associated with deficiency of this laminin chain, is discussed.
La Chirurgia degli organi di movimento
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 1990
A traditional knee-ankle-foot orthosis (KAFO) for myopathic patients has been studied for the ass... more A traditional knee-ankle-foot orthosis (KAFO) for myopathic patients has been studied for the assessment of loads and fatigue resistance. Starting from this basis a thermoplastic matrix carbon fibre reinforced plastic composite (CFRP) KAFO has been developed in order to reduce the weight. A finite-element simulation programme for deformation analysis was used to compare the behaviour of conventional and CFRP orthosis. There were no breakages either of the prototype or of its parts. The CFRP orthosis allows a weight reduction of more than 40 per cent.
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Neuromuscular disorders : NMD, 2014
European journal of histochemistry : EJH
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly s... more The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins. A common feature of these diseases, named laminopathies, is the occurrence of major chromatin defects. We previously reported that cells from laminopathic patients show an altered nuclear profile, and loss or detachment of heterochromatin from the nuclear envelope. Recent evidence indicates that processing of the lamin A precursor is altered in laminopathies featuring pre-mature aging and/or lipodystrophy phenotype. In these cases, pre-lamin A is accumulated in the nucleus and heterochromatin is severely disorganized. Here we report evidence indicating that pre-lamin A is mis-localized in the nuclei of Emery-Dreifuss muscular dystrophy fibroblasts, either bearing lamin A/C or emerin mutations. Abnormal pre-lamin A-containing structures are formed following treatment with a farnesyl-transfer...
Spinal cord, 2000
The surgical correction of spinal deformities carries a small but significant risk of injury to t... more The surgical correction of spinal deformities carries a small but significant risk of injury to the spinal cord. To detect the onset and possibly reverse the effects of surgical complication, a variety of neurophysiological monitoring procedures can be employed. The purpose of this review is to provide information regarding the various methodologies available for monitoring spinal cord and nerve root function during orthopaedic procedures. Intra-operative monitoring of cortically recorded somatosensory evoked potentials (SEPs) by peripheral nerve stimulation is of value during orthopaedic surgery and is the state-of-the-art in terms of non-invasiveness, versatility, time requirement, lateral discrimination, and ease of electrode placement. Monitoring of motor evoked potentials (MEPs) is useful particularly in combination with SEPs but is still considered investigational. Root function monitoring has limited application and requires more clinical research.
Current opinion in neurology and neurosurgery, 1990
La Chirurgia degli organi di movimento
Between 1982 and 1992 a total of 211 fractures of the acetabulum were operated. There was lesion ... more Between 1982 and 1992 a total of 211 fractures of the acetabulum were operated. There was lesion of the sciatic nerve in 21 cases, the pathogenesis and evolution of which were studied. Clinical follow-up was obtained at least 2 years after occurrence of neurological deficit and supported in 13 cases by electromyography. Based on an analysis of the literature and of these series it is observed how spontaneous recovery of paralysis is not rare, even if it requires a long period of time. The presence of various levels of lesion, which are not easily diagnosed, and which are not easily attacked surgically, calls for a prudent attitude with regard to neurolysis.
La Chirurgia degli organi di movimento
La Chirurgia degli organi di movimento
La Chirurgia degli organi di movimento
Italian journal of orthopaedics and traumatology, 1982
Instability of the cervical spine gives rise to vertebral and neurological symptoms which may be ... more Instability of the cervical spine gives rise to vertebral and neurological symptoms which may be progressive. The principal causes of instability are: trauma, sequelae of laminectomy, malformations, vertebral infections, rheumatoid arthritis, primary tumours (benign and malignant), metastases, and chronic degenerative disease of the discs. Each of these forms of instability must be identified and, depending on the symptoms and pathogenesis, is capable of responding to the appropriate treatment.
Rivista di neurobiologia : organo ufficiale della Società dei neurologi, neuroradiologi e neurochirurghi ospedalieri
Italian journal of orthopaedics and traumatology, 1983
The Authors describe the technique of lateral laminectomy devised by Gui in 1965 for the treatmen... more The Authors describe the technique of lateral laminectomy devised by Gui in 1965 for the treatment of cervical myelopathy secondary to cervical spondylosis. Spinal cord decompression is obtained by a lateral laminectomy with the maximum saving of bone, ligaments and muscles of the cervical spine. CAT scan demonstrated very well the effective decompression of the spinal cord achieved with this technique. The results of 87 cases treated in this way between 1968 and 1980 are reported. The average follow-up was 2.5 years. There was an improvement in the neurological symptoms in 82% of the cases.