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Papers by Mesele Admassie
Physiological and Molecular Plant Pathology
Agricultural Water Management
BioMed Research International
Phytophthora capsici is one of the most devastating fungal pathogens, causing severe diseases tha... more Phytophthora capsici is one of the most devastating fungal pathogens, causing severe diseases that lead to economic loss in the pepper industry. As a result of the infections, the chemical approach is becoming more popular. Biological control, on the other hand, is better suited to controlling fungal pathogens. The biological control approach significantly reduces the problems associated with chemical applications while restoring natural environmental balance. As a result, the overall findings indicate that certain bacterial isolates play a beneficial role in lytic enzyme production and biocontrol activities against P. capsici. Bacterial isolates obtained from the pepper plants were screened for lytic enzyme and anti-oomycete activity against Phytophthora capsici in Ethiopia. Sixty bacterial isolates were isolated and tested against Phytophthora capsici. From these bacterial isolates, different inhibition zones and hydrolytic enzyme production were detected. Biochemical tests using ...
Pakistan Journal of Phytopathology, 2019
International Cosmic Ray Conference, 1977
Muon spectral data obtained with a multilayer solid-iron magnetic spectrograph in the period from... more Muon spectral data obtained with a multilayer solid-iron magnetic spectrograph in the period from 1973 to 1976 are presented. The data analysis method is outlined, and the observations are compared with theoretical calculations. The data are shown to be in agreement with previous observations over the momentum range from 150 to 500 GeV/c
Plant growth promoting rhizo and endophytic bacteria were isolated from different parts of pepper... more Plant growth promoting rhizo and endophytic bacteria were isolated from different parts of pepper from south eastern Ethiopia. Plant growth promoting bacteria (PGP) are those that may be used to promote plant growth and suppress plant diseases. The objectives of this study were to identify and characterize PGPB indigenous to pepper rhizosphere and endophyte bacteria in Ethiopia, and to determine their capacity to suppress Phytophthora capsici in pepper. From a total of 60 isolates, 20 were selected based on their in vitro antagonism activity of phytopathogens and plant growth promoting traits. From the total 60 strains representing, 38 rhizosphere, and 22 endophytic bacteria were identified based on biochemical assays of semi-automated Vitec 2 compact and ten potential bacteria further identified by molecular methods. Results revealed that only one isolate of rhizosphere and three endophytic bacteria showed more than 50% suppression of test pathogens. The isolates were evaluated for...
Over 100 trillion symbiotic microorganisms live on and within human beings and have a diverse fun... more Over 100 trillion symbiotic microorganisms live on and within human beings and have a diverse function in human health and disease. But there are a variety of environmental and other factors that affect intestinal microbial dysbiosis, which has a close relationship with human health and disease. The pathogen microbes colonize intestinal mucosa this leading in the induction of a strong inflammatory response, followed by the translocation of the intestinal bacteria into other parts of the body. The imbalance of intestinal microbiota influences the production of immune mediators and stimulates both chronic inflammation and metabolic dysfunction. The wall of the bowel is highly permeable, and this leads to bacteria and/or endotoxin translocation, and it is an important stimulus for inflammatory cytokine that causes chronic heart failure. The variations of the microbiota are directly associated with the pathogenesis of other diseases, such as food allergies, severe asthma, autism, and de...
Clinical Medicine Research, 2018
Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the ... more Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the spectrum of bacterial etiological agents and their drug susceptibility profile is critical. A prospective study was conducted at Arsho Advanced Medical Laboratory from June 2016 to July 2017. Wound specimens were collected from 366 patients following standard procedures. Specimens were plated and incubated at 37°C for 48 hours. Identification and drug susceptibility testing of cultures were carried out by using the VITEK 2 compact system. Among 366 wound samples cultured, bacteria grew in 271(74%) samples. The highest (81.9%) wound infections were documented among patients with an age group of 15-64 years. Two hundred twenty one bacterial isolates were recovered of which 43.2% were Gram-negative while, 56.8% were Grampositive. Staphylococcus aureus and Coagulase-Negative Staphylococci were major Gram-positive bacteria while Escherichia coli and Pseudomonas spp. were the commonest Gram-negative bacteria. Gram-negative bacteria had the highest overall drug resistance rate against ampicillin. Tobramycin and piperacillin/tazobactam combination were effective antimicrobial agents against Gram-negative bacteria. The highest overall resistance rate to Gram-positive bacteria was observed against erythromycin. Vancomycin and linezolid were the most active antimicrobial agents against Gram-positive bacteria. High culture positivity rate of wound infections reported in the present study initiates many similar studies to be conducted on wound in the country. High level of drug resistance to the commonly prescribed drugs dictates a search for better choices.
Science Journal of Clinical Medicine, 2018
Antibiotic-resistant bacteria that are difficult to treat are becoming increasingly common and ar... more Antibiotic-resistant bacteria that are difficult to treat are becoming increasingly common and are causing a global health crisis. molecular mechanism bacterial resistance of antibiotic is, necessary in order to find ways to avoid conditions that promote disobedient pathogens. The objectives of this seminar paper are to review the genetics of molecular mechanism of antibiotic resistance and to describe different molecular intrinsic, acquired, circumstantial resistance; genetics of antibiotic resistance and phenotypic drug resistance those specified by mechanisms confer antibiotic resistance. These drug resistance mechanisms allow bacteria that harbor these mechanisms to survive, or even to actively grow, in the presence of a given anti-microbial agent. Furthermore, certain bacterial variants have evolved mechanisms to resist multiple drugs, making such variants recalcitrant to chemotherapy against such bacterial strains that are the causative agents of infection in patients. Knowing the molecular mechanisms of antibiotic resistance is essential for developing new approaches to overcome and prevent drug resistance problems. Studding of development and mechanisms of resistance should be known at an early stage of drug development and strategies to improve the delivery or to enhancing the accessibility of antibiotics to their sites of action should be known.
World Journal of Food Science and Technology, 2018
Fermented foods are among the first processed food products consumed since the development of hum... more Fermented foods are among the first processed food products consumed since the development of human civilizations. Food fermentation processes can be categorized by the primary metabolites and microorganisms involved. Lactic acid bacteria (LAB) are a large group of closely related bacteria that have similar properties such as lactic acid production, which is an end product of the fermentation. Biotechnology is the use of living systems and organisms to develop or make useful products, or any technological applications that uses biological systems, living organisms or derivatives, to make or modify products or processes for specific use. Depending on the tools and applications, it often overlaps with the fields of bioengineering and biomedical engineering. Some of the applications were identified in this paper to include biotechnology in food fermentation to enhance properties such as the taste, aroma, shelf-life, texture and nutritional value of food. When used regularly, LAB fermented foods boost the immune system and strengthen the body in the fight against pathogenic bacterial infections, bacteriocins produced by LAB may become a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens in the future. The modern extension of food/feed fermentation technology consists of processes designed to obtain particular compounds using microbial metabolism as the chemical machinery. Thus, LAB fermentation is not only of a major economic importance, and the starting food materials, but it also promotes human health and increase food/feed production in the world.
Agricultural Water Management
Physiological and Molecular Plant Pathology
Agricultural Water Management
BioMed Research International
Phytophthora capsici is one of the most devastating fungal pathogens, causing severe diseases tha... more Phytophthora capsici is one of the most devastating fungal pathogens, causing severe diseases that lead to economic loss in the pepper industry. As a result of the infections, the chemical approach is becoming more popular. Biological control, on the other hand, is better suited to controlling fungal pathogens. The biological control approach significantly reduces the problems associated with chemical applications while restoring natural environmental balance. As a result, the overall findings indicate that certain bacterial isolates play a beneficial role in lytic enzyme production and biocontrol activities against P. capsici. Bacterial isolates obtained from the pepper plants were screened for lytic enzyme and anti-oomycete activity against Phytophthora capsici in Ethiopia. Sixty bacterial isolates were isolated and tested against Phytophthora capsici. From these bacterial isolates, different inhibition zones and hydrolytic enzyme production were detected. Biochemical tests using ...
Pakistan Journal of Phytopathology, 2019
International Cosmic Ray Conference, 1977
Muon spectral data obtained with a multilayer solid-iron magnetic spectrograph in the period from... more Muon spectral data obtained with a multilayer solid-iron magnetic spectrograph in the period from 1973 to 1976 are presented. The data analysis method is outlined, and the observations are compared with theoretical calculations. The data are shown to be in agreement with previous observations over the momentum range from 150 to 500 GeV/c
Plant growth promoting rhizo and endophytic bacteria were isolated from different parts of pepper... more Plant growth promoting rhizo and endophytic bacteria were isolated from different parts of pepper from south eastern Ethiopia. Plant growth promoting bacteria (PGP) are those that may be used to promote plant growth and suppress plant diseases. The objectives of this study were to identify and characterize PGPB indigenous to pepper rhizosphere and endophyte bacteria in Ethiopia, and to determine their capacity to suppress Phytophthora capsici in pepper. From a total of 60 isolates, 20 were selected based on their in vitro antagonism activity of phytopathogens and plant growth promoting traits. From the total 60 strains representing, 38 rhizosphere, and 22 endophytic bacteria were identified based on biochemical assays of semi-automated Vitec 2 compact and ten potential bacteria further identified by molecular methods. Results revealed that only one isolate of rhizosphere and three endophytic bacteria showed more than 50% suppression of test pathogens. The isolates were evaluated for...
Over 100 trillion symbiotic microorganisms live on and within human beings and have a diverse fun... more Over 100 trillion symbiotic microorganisms live on and within human beings and have a diverse function in human health and disease. But there are a variety of environmental and other factors that affect intestinal microbial dysbiosis, which has a close relationship with human health and disease. The pathogen microbes colonize intestinal mucosa this leading in the induction of a strong inflammatory response, followed by the translocation of the intestinal bacteria into other parts of the body. The imbalance of intestinal microbiota influences the production of immune mediators and stimulates both chronic inflammation and metabolic dysfunction. The wall of the bowel is highly permeable, and this leads to bacteria and/or endotoxin translocation, and it is an important stimulus for inflammatory cytokine that causes chronic heart failure. The variations of the microbiota are directly associated with the pathogenesis of other diseases, such as food allergies, severe asthma, autism, and de...
Clinical Medicine Research, 2018
Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the ... more Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the spectrum of bacterial etiological agents and their drug susceptibility profile is critical. A prospective study was conducted at Arsho Advanced Medical Laboratory from June 2016 to July 2017. Wound specimens were collected from 366 patients following standard procedures. Specimens were plated and incubated at 37°C for 48 hours. Identification and drug susceptibility testing of cultures were carried out by using the VITEK 2 compact system. Among 366 wound samples cultured, bacteria grew in 271(74%) samples. The highest (81.9%) wound infections were documented among patients with an age group of 15-64 years. Two hundred twenty one bacterial isolates were recovered of which 43.2% were Gram-negative while, 56.8% were Grampositive. Staphylococcus aureus and Coagulase-Negative Staphylococci were major Gram-positive bacteria while Escherichia coli and Pseudomonas spp. were the commonest Gram-negative bacteria. Gram-negative bacteria had the highest overall drug resistance rate against ampicillin. Tobramycin and piperacillin/tazobactam combination were effective antimicrobial agents against Gram-negative bacteria. The highest overall resistance rate to Gram-positive bacteria was observed against erythromycin. Vancomycin and linezolid were the most active antimicrobial agents against Gram-positive bacteria. High culture positivity rate of wound infections reported in the present study initiates many similar studies to be conducted on wound in the country. High level of drug resistance to the commonly prescribed drugs dictates a search for better choices.
Science Journal of Clinical Medicine, 2018
Antibiotic-resistant bacteria that are difficult to treat are becoming increasingly common and ar... more Antibiotic-resistant bacteria that are difficult to treat are becoming increasingly common and are causing a global health crisis. molecular mechanism bacterial resistance of antibiotic is, necessary in order to find ways to avoid conditions that promote disobedient pathogens. The objectives of this seminar paper are to review the genetics of molecular mechanism of antibiotic resistance and to describe different molecular intrinsic, acquired, circumstantial resistance; genetics of antibiotic resistance and phenotypic drug resistance those specified by mechanisms confer antibiotic resistance. These drug resistance mechanisms allow bacteria that harbor these mechanisms to survive, or even to actively grow, in the presence of a given anti-microbial agent. Furthermore, certain bacterial variants have evolved mechanisms to resist multiple drugs, making such variants recalcitrant to chemotherapy against such bacterial strains that are the causative agents of infection in patients. Knowing the molecular mechanisms of antibiotic resistance is essential for developing new approaches to overcome and prevent drug resistance problems. Studding of development and mechanisms of resistance should be known at an early stage of drug development and strategies to improve the delivery or to enhancing the accessibility of antibiotics to their sites of action should be known.
World Journal of Food Science and Technology, 2018
Fermented foods are among the first processed food products consumed since the development of hum... more Fermented foods are among the first processed food products consumed since the development of human civilizations. Food fermentation processes can be categorized by the primary metabolites and microorganisms involved. Lactic acid bacteria (LAB) are a large group of closely related bacteria that have similar properties such as lactic acid production, which is an end product of the fermentation. Biotechnology is the use of living systems and organisms to develop or make useful products, or any technological applications that uses biological systems, living organisms or derivatives, to make or modify products or processes for specific use. Depending on the tools and applications, it often overlaps with the fields of bioengineering and biomedical engineering. Some of the applications were identified in this paper to include biotechnology in food fermentation to enhance properties such as the taste, aroma, shelf-life, texture and nutritional value of food. When used regularly, LAB fermented foods boost the immune system and strengthen the body in the fight against pathogenic bacterial infections, bacteriocins produced by LAB may become a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens in the future. The modern extension of food/feed fermentation technology consists of processes designed to obtain particular compounds using microbial metabolism as the chemical machinery. Thus, LAB fermentation is not only of a major economic importance, and the starting food materials, but it also promotes human health and increase food/feed production in the world.
Agricultural Water Management