Meyer Katzper - Academia.edu (original) (raw)
Papers by Meyer Katzper
American Medical Informatics Association Annual Symposium, 1996
... 1996: 823. PMCID: PMC2233107. Copyright notice. An Efficient Method for Comparison of Safety ... more ... 1996: 823. PMCID: PMC2233107. Copyright notice. An Efficient Method for Comparison of Safety Data of Drugs in the Same Pharmacological Category. Marina Chang and Meyer Katzper. Full text. Full text is available as a scanned copy of the original print version. ...
Clinical Pharmacology & Therapeutics, Feb 26, 1990
Clinical Pharmacology & Therapeutics, Feb 2, 1994
Journal of Drug Issues, Oct 1, 1978
This paper is an attempt to present the alcohol beverage industry s view of the value and role of... more This paper is an attempt to present the alcohol beverage industry s view of the value and role of advertising and its relationship to consumption. The authors suggest that regulation of price and availability of alcohol can reduce mean consumption, excess mortality, and social consequences. Although government does not accept the notions of cause and effect between advertising and consumption, the industry does. Industry advocates self-regulation. However, the aggressive posture of the companies as reflected through their media campaign is in direct contrast to their testimony in public hearings. Rather than competing for shares of an existing market, the alcohol beverage companies appear to be introducing new product lines, planning for overall expansion of the older products, and targeting new markets such as heavy drinkers, women, and teenagers. The media compete vigorously for alcohol beverage advertising dollars which also fosters targeted advertisement. Ways to control the growth of alcohol consumption through advertising are suggested.
Anesthesia & Analgesia, Jul 1, 2003
The purpose of this study was to determine whether different levels of pain would respond similar... more The purpose of this study was to determine whether different levels of pain would respond similarly to analgesia. We compared the analgesic response to ibuprofen in subjects with moderate versus severe baseline pain in clinical trials using the third molar post-extraction dental pain model. We performed a pooled raw data analysis of 517 subjects included in the ibuprofen treatment arm of 11 similar studies submitted to the Food and Drug Administration. The inclusion and exclusion criteria were similar in all studies. All studies used the same metrics and recorded pain at the same times. As expected, the well established analgesic effect of ibuprofen was confirmed. More intense baseline pain was initially associated with a larger decrease and greater fractional decreasing in pain intensity after medication. A larger percentage of those with milder baseline pain obtained relief compared with those with severe baseline pain. Reduction in pain intensity occurred mainly in the first 2 h. At later time points, the association of baseline conditions with a reduction in pain level diminished. We conclude that the intensity of initial pain is not correlated with the need for larger doses of analgesic. A person taking an analgesic wants to know when and how well it will work. People with moderate pain are more likely to get relief, whereas those with severe pain who get relief will get relatively more relief. Most relief of acute pain occurs within less than 2 h. These data indicate that most people with intense initial pain do not require larger doses of analgesics.
Archives of internal medicine, Dec 11, 2000
Background: It is generally accepted that males and females respond differently to painful condit... more Background: It is generally accepted that males and females respond differently to painful conditions. With few exceptions, according to the published literature, females demonstrate a lower pain threshold and a lower tolerance of painful stimuli. There is some support in the literature that females experience greater analgesic efficacy than do males after the administration of narcotic analgesics. We compared the analgesic response of females and males to ibuprofen in a post-third-molar extraction dental pain model. Methods: We performed a meta-analysis of 314 subjects included in the ibuprofen treatment arm of 7 doubleblind, post-third-molar extraction dental pain (moderate to severe) studies, which were submitted to the agency electronically. The inclusion and exclusion criteria were practically identical in all studies. Pain relief and pain intensity measurements used the same metrics in all studies and were recorded just before and at least at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hours after drug administration. Results: The study included 195 female subjects and 119 male subjects (mean age, 21 years). Other than requiring dental extractions, the subjects were all healthy. Postoperative baseline pain was greater in females than in
![Research paper thumbnail of Kinetic model for the fate of 6-[ 18 F]fluorodopamine in the human heart: a novel means to examine cardiac sympathetic neuronal function](https://attachments.academia-assets.com/107869237/thumbnails/1.jpg)
](Naunyn-schmiedebergs Archives of Pharmacology, 2002
After injection of 6-[ 18 F]fluorodopamine, thoracic positron emission tomographic scanning visua... more After injection of 6-[ 18 F]fluorodopamine, thoracic positron emission tomographic scanning visualizes the sympathetic innervation of the heart. This report introduces a kinetic model that relates 6-[ 18 F]fluorodopamine positron emission tomographic scanning results to specific aspects of cardiac sympathoneural function. Inputs were the 6-[ 18 F]fluorodopamine concentration in arterial blood and the estimated contribution of circulating metabolites of 6-[ 18 F]fluorodopamine. All of the three compartments in the model were intraneuronal. Two compartments corresponded to vesicles in sympathetic nerves, consistent with the "multiple vesicular pool" hypothesis from preclinical studies. The model successfully fit the empirical time-activity curve for myocardial 6-[ 18 F]fluorodopamine-derived radioactivity and predicted correctly the effects of several neuropharmacological and physiological manipulations on the time-activity curve. Myocardial cell uptake of metabolites of 6-[ 18 F]fluorodopamine from the circulation could explain an immediate peak of 6-[ 18 F]fluorodopamine-derived radioactivity. The model seems useful in predicting effects of altered cardiac sympathetic function on time-activity curves for myocardial 6-[ 18 F]fluorodopamine-derived radioactivity in humans.
Winter Simulation Conference, Dec 9, 2007
In the study of physiologic systems control, lumped parameter and differential equation technique... more In the study of physiologic systems control, lumped parameter and differential equation techniques are standard approaches. Application of these techniques to the study of oxygen supply to tissues is discussed. It is then proposed that progress in dealing with heterogeneous physiologic systems is likely to proceed from the techniques of agent based modeling in the form of autonomous physiologic agents.
Clinical Pharmacology & Therapeutics, Feb 1, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P29–P29; doi:
Winter Simulation Conference, Dec 12, 1983
Abstract In spite of the fact that air quality has been a major national concern for many years m... more Abstract In spite of the fact that air quality has been a major national concern for many years measures have not been taken to develop a methodology for evaluating the relative merit of air quality alternatives. The research to be presented explores the issue of relative air ...
Clinical Pharmacology & Therapeutics, Feb 1, 2006
BACKGROUND: The purpose of this analysis was to assess the relation between pain relief evaluatio... more BACKGROUND: The purpose of this analysis was to assess the relation between pain relief evaluation by subjects with acute pain following analgesic medication and the time elapsed to obtain pain relief. METHODS: We performed a raw data analysis of 304 subjects included in a clinical trial submitted to the Food and Drug Administration using the third molar post extraction dental pain model. The study was a randomized, double-blind, controlled trial. Eligible subjects were otherwise healthy men or nonpregnant women older than 16 years of age. The primary end point analyzed was the time to meaningful pain relief. The study design has been approved by the responsible IRB. RESULTS: The study population included 187 females and 117 males. Our breakout has been between responders and nonresponders. Pain relief responders rated the drug mainly as excellent or good. Median time for drug responders to achieve meaningful pain relief showed that 110 subjects who reported an excellent response, reported it 28 minutes following medication, 85 subjects who reported a good response, reported it 48 minutes following medication, and 19 subjects who reported a fair response, did it 60 minutes following medication. Nonresponders mainly rated the drug they took as poor or fair anytime following medication. CONCLUSIONS: Faster median response to achieve meaningful pain relief has related to the drug efficacy evaluation. It clearly demonstrates that more rapid pain relief is associated with a better rating of the drug.
Large scale health data collection under Federal auspices is examined in this paper. The system p... more Large scale health data collection under Federal auspices is examined in this paper. The system planning for establishing the data base is intertwined with the vagaries and complexities of the Federal health administrative structure. This paper addresses the problem of how data can be structured in such a manner that it will give rise to maximum utility across the Federal bureaucracy. At present, minimum linkage between Federal agency data bases is possible. Establishment of linkages between different types of data collected is vital. In the Development of the data base design, careful considerations is given to the human element within the system structure. Mechanisms for human interface in the monitoring and control of data collection and processing are vital if the data is to be put to use. The new opportunities that can be presented by large scale data collecting are explored briefly in this paper. The necessity for common coding systems and decisions as to storage of the data and form of recording are addressed. The data base is considered as the core element in an entire system design concept, which cuts across Federal, State and local levels.
Clinical Pharmacology & Therapeutics, Feb 1, 1999
Clinical Pharmacology & Therapeutics (1999) 65, 118–118; doi:
Psychiatric Annals, Aug 1, 1984
The Journal of Clinical Pharmacology, Feb 1, 2000
Clinical Pharmacology & Therapeutics, Sep 1, 2001
Our objective was to examine the placebo arms from a series of clinical trials in which the post-... more Our objective was to examine the placebo arms from a series of clinical trials in which the post-third molar extraction dental pain model was used to elucidate the time course of the placebo effect and the proportion of the population that are responders, as well as to evaluate whether the placebo analgesic response of female subjects may differ from that of male subjects. We performed a meta-analysis of 596 subjects included in the placebo treatment arm of 16 double-blind, post-third molar extraction dental pain (moderate to severe) studies submitted to the Food and Drug Administration electronically. The inclusion and exclusion criteria were practically identical in all studies. Pain relief and pain intensity measurements used the same metrics in all studies. The measurements were recorded just before drug administration and at least at postdose hours 0.5, 1, 1.5, 2, 3, 4, 5, and 6. There were 325 female subjects and 271 male subjects. They were all otherwise healthy, with a mean age of 21.6 years for female subjects and 22.3 years for male subjects. The postoperative baseline pain was greater in female subjects than in male subjects, and this difference was statistically significant. Both pain intensity and pain relief scores demonstrate the well-established placebo effect in 10% of the pooled subjects, as well as in all the individual studies. Over time, however, the mean pain intensity and pain relief scores for the female and male treatment groups were not noticeably different at any time point after medication. Further analysis of the data showed no gender difference in duration of action of the placebo. The results demonstrated no gender difference in response to placebo. These results were obtained from the post-third molar extraction situation, in which the least possible confounding factors were present. To fully establish the generality of this phenomenon, studies should be carried out in other pain models.
The Journal of Clinical Pharmacology, Apr 1, 2004
American Medical Informatics Association Annual Symposium, 1996
... 1996: 823. PMCID: PMC2233107. Copyright notice. An Efficient Method for Comparison of Safety ... more ... 1996: 823. PMCID: PMC2233107. Copyright notice. An Efficient Method for Comparison of Safety Data of Drugs in the Same Pharmacological Category. Marina Chang and Meyer Katzper. Full text. Full text is available as a scanned copy of the original print version. ...
Clinical Pharmacology & Therapeutics, Feb 26, 1990
Clinical Pharmacology & Therapeutics, Feb 2, 1994
Journal of Drug Issues, Oct 1, 1978
This paper is an attempt to present the alcohol beverage industry s view of the value and role of... more This paper is an attempt to present the alcohol beverage industry s view of the value and role of advertising and its relationship to consumption. The authors suggest that regulation of price and availability of alcohol can reduce mean consumption, excess mortality, and social consequences. Although government does not accept the notions of cause and effect between advertising and consumption, the industry does. Industry advocates self-regulation. However, the aggressive posture of the companies as reflected through their media campaign is in direct contrast to their testimony in public hearings. Rather than competing for shares of an existing market, the alcohol beverage companies appear to be introducing new product lines, planning for overall expansion of the older products, and targeting new markets such as heavy drinkers, women, and teenagers. The media compete vigorously for alcohol beverage advertising dollars which also fosters targeted advertisement. Ways to control the growth of alcohol consumption through advertising are suggested.
Anesthesia & Analgesia, Jul 1, 2003
The purpose of this study was to determine whether different levels of pain would respond similar... more The purpose of this study was to determine whether different levels of pain would respond similarly to analgesia. We compared the analgesic response to ibuprofen in subjects with moderate versus severe baseline pain in clinical trials using the third molar post-extraction dental pain model. We performed a pooled raw data analysis of 517 subjects included in the ibuprofen treatment arm of 11 similar studies submitted to the Food and Drug Administration. The inclusion and exclusion criteria were similar in all studies. All studies used the same metrics and recorded pain at the same times. As expected, the well established analgesic effect of ibuprofen was confirmed. More intense baseline pain was initially associated with a larger decrease and greater fractional decreasing in pain intensity after medication. A larger percentage of those with milder baseline pain obtained relief compared with those with severe baseline pain. Reduction in pain intensity occurred mainly in the first 2 h. At later time points, the association of baseline conditions with a reduction in pain level diminished. We conclude that the intensity of initial pain is not correlated with the need for larger doses of analgesic. A person taking an analgesic wants to know when and how well it will work. People with moderate pain are more likely to get relief, whereas those with severe pain who get relief will get relatively more relief. Most relief of acute pain occurs within less than 2 h. These data indicate that most people with intense initial pain do not require larger doses of analgesics.
Archives of internal medicine, Dec 11, 2000
Background: It is generally accepted that males and females respond differently to painful condit... more Background: It is generally accepted that males and females respond differently to painful conditions. With few exceptions, according to the published literature, females demonstrate a lower pain threshold and a lower tolerance of painful stimuli. There is some support in the literature that females experience greater analgesic efficacy than do males after the administration of narcotic analgesics. We compared the analgesic response of females and males to ibuprofen in a post-third-molar extraction dental pain model. Methods: We performed a meta-analysis of 314 subjects included in the ibuprofen treatment arm of 7 doubleblind, post-third-molar extraction dental pain (moderate to severe) studies, which were submitted to the agency electronically. The inclusion and exclusion criteria were practically identical in all studies. Pain relief and pain intensity measurements used the same metrics in all studies and were recorded just before and at least at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hours after drug administration. Results: The study included 195 female subjects and 119 male subjects (mean age, 21 years). Other than requiring dental extractions, the subjects were all healthy. Postoperative baseline pain was greater in females than in
Naunyn-schmiedebergs Archives of Pharmacology, 2002
After injection of 6-[ 18 F]fluorodopamine, thoracic positron emission tomographic scanning visua... more After injection of 6-[ 18 F]fluorodopamine, thoracic positron emission tomographic scanning visualizes the sympathetic innervation of the heart. This report introduces a kinetic model that relates 6-[ 18 F]fluorodopamine positron emission tomographic scanning results to specific aspects of cardiac sympathoneural function. Inputs were the 6-[ 18 F]fluorodopamine concentration in arterial blood and the estimated contribution of circulating metabolites of 6-[ 18 F]fluorodopamine. All of the three compartments in the model were intraneuronal. Two compartments corresponded to vesicles in sympathetic nerves, consistent with the "multiple vesicular pool" hypothesis from preclinical studies. The model successfully fit the empirical time-activity curve for myocardial 6-[ 18 F]fluorodopamine-derived radioactivity and predicted correctly the effects of several neuropharmacological and physiological manipulations on the time-activity curve. Myocardial cell uptake of metabolites of 6-[ 18 F]fluorodopamine from the circulation could explain an immediate peak of 6-[ 18 F]fluorodopamine-derived radioactivity. The model seems useful in predicting effects of altered cardiac sympathetic function on time-activity curves for myocardial 6-[ 18 F]fluorodopamine-derived radioactivity in humans.
Winter Simulation Conference, Dec 9, 2007
In the study of physiologic systems control, lumped parameter and differential equation technique... more In the study of physiologic systems control, lumped parameter and differential equation techniques are standard approaches. Application of these techniques to the study of oxygen supply to tissues is discussed. It is then proposed that progress in dealing with heterogeneous physiologic systems is likely to proceed from the techniques of agent based modeling in the form of autonomous physiologic agents.
Clinical Pharmacology & Therapeutics, Feb 1, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P29–P29; doi:
Winter Simulation Conference, Dec 12, 1983
Abstract In spite of the fact that air quality has been a major national concern for many years m... more Abstract In spite of the fact that air quality has been a major national concern for many years measures have not been taken to develop a methodology for evaluating the relative merit of air quality alternatives. The research to be presented explores the issue of relative air ...
Clinical Pharmacology & Therapeutics, Feb 1, 2006
BACKGROUND: The purpose of this analysis was to assess the relation between pain relief evaluatio... more BACKGROUND: The purpose of this analysis was to assess the relation between pain relief evaluation by subjects with acute pain following analgesic medication and the time elapsed to obtain pain relief. METHODS: We performed a raw data analysis of 304 subjects included in a clinical trial submitted to the Food and Drug Administration using the third molar post extraction dental pain model. The study was a randomized, double-blind, controlled trial. Eligible subjects were otherwise healthy men or nonpregnant women older than 16 years of age. The primary end point analyzed was the time to meaningful pain relief. The study design has been approved by the responsible IRB. RESULTS: The study population included 187 females and 117 males. Our breakout has been between responders and nonresponders. Pain relief responders rated the drug mainly as excellent or good. Median time for drug responders to achieve meaningful pain relief showed that 110 subjects who reported an excellent response, reported it 28 minutes following medication, 85 subjects who reported a good response, reported it 48 minutes following medication, and 19 subjects who reported a fair response, did it 60 minutes following medication. Nonresponders mainly rated the drug they took as poor or fair anytime following medication. CONCLUSIONS: Faster median response to achieve meaningful pain relief has related to the drug efficacy evaluation. It clearly demonstrates that more rapid pain relief is associated with a better rating of the drug.
Large scale health data collection under Federal auspices is examined in this paper. The system p... more Large scale health data collection under Federal auspices is examined in this paper. The system planning for establishing the data base is intertwined with the vagaries and complexities of the Federal health administrative structure. This paper addresses the problem of how data can be structured in such a manner that it will give rise to maximum utility across the Federal bureaucracy. At present, minimum linkage between Federal agency data bases is possible. Establishment of linkages between different types of data collected is vital. In the Development of the data base design, careful considerations is given to the human element within the system structure. Mechanisms for human interface in the monitoring and control of data collection and processing are vital if the data is to be put to use. The new opportunities that can be presented by large scale data collecting are explored briefly in this paper. The necessity for common coding systems and decisions as to storage of the data and form of recording are addressed. The data base is considered as the core element in an entire system design concept, which cuts across Federal, State and local levels.
Clinical Pharmacology & Therapeutics, Feb 1, 1999
Clinical Pharmacology & Therapeutics (1999) 65, 118–118; doi:
Psychiatric Annals, Aug 1, 1984
The Journal of Clinical Pharmacology, Feb 1, 2000
Clinical Pharmacology & Therapeutics, Sep 1, 2001
Our objective was to examine the placebo arms from a series of clinical trials in which the post-... more Our objective was to examine the placebo arms from a series of clinical trials in which the post-third molar extraction dental pain model was used to elucidate the time course of the placebo effect and the proportion of the population that are responders, as well as to evaluate whether the placebo analgesic response of female subjects may differ from that of male subjects. We performed a meta-analysis of 596 subjects included in the placebo treatment arm of 16 double-blind, post-third molar extraction dental pain (moderate to severe) studies submitted to the Food and Drug Administration electronically. The inclusion and exclusion criteria were practically identical in all studies. Pain relief and pain intensity measurements used the same metrics in all studies. The measurements were recorded just before drug administration and at least at postdose hours 0.5, 1, 1.5, 2, 3, 4, 5, and 6. There were 325 female subjects and 271 male subjects. They were all otherwise healthy, with a mean age of 21.6 years for female subjects and 22.3 years for male subjects. The postoperative baseline pain was greater in female subjects than in male subjects, and this difference was statistically significant. Both pain intensity and pain relief scores demonstrate the well-established placebo effect in 10% of the pooled subjects, as well as in all the individual studies. Over time, however, the mean pain intensity and pain relief scores for the female and male treatment groups were not noticeably different at any time point after medication. Further analysis of the data showed no gender difference in duration of action of the placebo. The results demonstrated no gender difference in response to placebo. These results were obtained from the post-third molar extraction situation, in which the least possible confounding factors were present. To fully establish the generality of this phenomenon, studies should be carried out in other pain models.
The Journal of Clinical Pharmacology, Apr 1, 2004