Michael Dillon - Academia.edu (original) (raw)

Papers by Michael Dillon

Research paper thumbnail of Management of hypertensive emergencies

Archives of Disease in Childhood, Sep 1, 1992

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Research paper thumbnail of Infarction of the optic nerve head in children with accelerated hypertension

British Journal of Ophthalmology, 1981

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Research paper thumbnail of Renovascular hypertension

Journal of the Tennessee Medical Association, 1975

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Research paper thumbnail of Progression of Mineral Ion Abnormalities in Patients with Jansen's Metaphyseal Chondrodysplasia

The Journal of clinical endocrinology and metabolism, Jul 16, 2018

Five different activating PTH/PTHrP receptor (PTHR1) mutations have been reported as causes of Ja... more Five different activating PTH/PTHrP receptor (PTHR1) mutations have been reported as causes of Jansen metaphyseal chondrodysplasia (JMC), a rare disorder characterized by severe growth plate abnormalities and PTH-independent hypercalcemia. Assess the natural history of clinical and laboratory findings in twenty-four JMC patients and characterize the disease-causing mutant receptors in vitro. The H223R mutation occurred in 18 patients. T410P, I458R and I458K each occurred in single cases; T410R was present in a father and his two sons. Laboratory records were analyzed individually and in aggregate. Postnatal calcium levels were normal in most patients, but elevated between 0.15-10 years (11.8±1.37 mg/dL) and tended to normalize in adults (10.0±1.03 mg/dL). Mean phosphate levels were at the lower end of the age-specific normal ranges. Urinary calcium/creatinine (mg/mg) was consistently elevated (children: 0.80±0.40; adults: 0.28±0.19). Adult heights were well below the 3rd percentile ...

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Research paper thumbnail of Autoimmune diseases in children

Current Paediatrics

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Research paper thumbnail of Mid-aortic syndrome: long-term outcome of 36 children

Pediatr Nephrol 24 2225 2232, Jul 15, 2009

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Research paper thumbnail of Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus

Eur J Pediat, 1994

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Research paper thumbnail of Inherited disorders of sodium and water handling

In Johnson Rj and Feehally J Comprehensive Clinical Nephrology Mosby International London, 2000

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Research paper thumbnail of Investigation and management of hypertension in children: a personal perspective

Pediatric Nephrology, 1987

The prevalence of hypertension in children is of the order of 1%-3%. Of these children, 10% will ... more The prevalence of hypertension in children is of the order of 1%-3%. Of these children, 10% will have severe hypertension and in the majority the increased blood pressure will be secondary to renal disease. Nephrologically orientated investigation is therefore important. The most helpful investigations are: peripheral plasma-renin activity, 99mTc dimercaptosuccinic acid (DMSA) scan, main and segmental renal vein renin measurements and renal angiography plus 123I metaiodobenzyl guanidine (MIBG) scan in suspected phaeochromocytoma. Drug treatment of accelerated hypertension is most successfully undertaken by intravenous labetalol or sodium nitroprusside; sustained moderate-to-severe hypertension by a beta-blocker plus a vasodilator or an angiotensin-converting enzyme inhibitor with or without a diuretic; mild hypertension by diet, diuretic and if necessary by more powerful hypotensives. Surgical treatment by revascularization or nephrectomy and percutaneous transluminal angioplasty can be successful. Utilizing the current range of investigational and therapeutic tools the aetiology and appropriate management of hypertension can be effectively and safely undertaken in the majority of hypertensive children.

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Research paper thumbnail of Rare vasculitic syndromes : Special section: Paediatric rheumatology

Annals of Medicine, 1997

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Research paper thumbnail of Management of hypertensive emergencies

Pediat Nephrol, 1993

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Research paper thumbnail of Renal tubular dysfunction in methylmalonic acidaemia

Eur J Pediat, 1991

Renal tubular function was assessed in seven patients with methylmalonic acidaemia not responsive... more Renal tubular function was assessed in seven patients with methylmalonic acidaemia not responsive to vitamin B12. Five patients failed to concentrate their urine normally and in these patients the glomerular filtration rate was also reduced. Fractional excretion of sodium was increased in four patients, fractional excretion of potassium in one patient and in three there was a decreased tubular reabsorption of phosphate. Although possibly representing primary tubular damage these findings were thought to be consistent with adaptive changes secondary to the reduced glomerular filtration rate. Two patients had evidence of a defect of urinary acidification and several had a degree of hyporeninaemic hypoaldosteronism suggesting type 4 renal tubular acidosis. In one patient with a mild variant no renal disease was detected. Decreased renal function and tubular abnormalities were common in patients with methylmalonic acidaemia. It is likely that they are linked and essentially secondary to the tubulo-interstitial nephritis that is histologically demonstrable on renal biopsy. The failure of urinary concentrating ability and the disturbed urine acidification will contribute to the metabolic derangement during episodes of decompensation.

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Research paper thumbnail of Rare Vasculitic Syndromes

ABSTRACT

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Research paper thumbnail of Chronic renal failure in methylmalonic acidaemia

European Journal of Pediatrics, 1989

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Research paper thumbnail of Erratum: Immunosuppressive therapy of childhood idiopathic nephrotic syndrom (Expert Opinion on Pharmacotherapy (2002) vol. 3 (5) 513-519))

Expert Opinion on Pharmacotherapy 3, 2002

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Research paper thumbnail of Henoch-Schönlein purpura with antiphospholipid antibodies following an influenza vaccination: commentary

Pediatric Nephrology 16 460 462, Jan 4, 2001

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Research paper thumbnail of Single centre outcomes of childhood primary renovascular hypertension

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Research paper thumbnail of Treatment of severe complicated Kawasaki disease with oral prednisolone and aspirin

The Journal of Pediatrics 137 723 726, Jan 11, 2000

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Research paper thumbnail of Beh‡et's disease in UK children: clinical features and treatment including thalidomide

Rheumatology 2001 933 938, 2001

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Research paper thumbnail of Hypertension in childhood: a current assessment

Progress in Cardiology, 1988

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Research paper thumbnail of Management of hypertensive emergencies

Archives of Disease in Childhood, Sep 1, 1992

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Research paper thumbnail of Infarction of the optic nerve head in children with accelerated hypertension

British Journal of Ophthalmology, 1981

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Research paper thumbnail of Renovascular hypertension

Journal of the Tennessee Medical Association, 1975

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Research paper thumbnail of Progression of Mineral Ion Abnormalities in Patients with Jansen's Metaphyseal Chondrodysplasia

The Journal of clinical endocrinology and metabolism, Jul 16, 2018

Five different activating PTH/PTHrP receptor (PTHR1) mutations have been reported as causes of Ja... more Five different activating PTH/PTHrP receptor (PTHR1) mutations have been reported as causes of Jansen metaphyseal chondrodysplasia (JMC), a rare disorder characterized by severe growth plate abnormalities and PTH-independent hypercalcemia. Assess the natural history of clinical and laboratory findings in twenty-four JMC patients and characterize the disease-causing mutant receptors in vitro. The H223R mutation occurred in 18 patients. T410P, I458R and I458K each occurred in single cases; T410R was present in a father and his two sons. Laboratory records were analyzed individually and in aggregate. Postnatal calcium levels were normal in most patients, but elevated between 0.15-10 years (11.8±1.37 mg/dL) and tended to normalize in adults (10.0±1.03 mg/dL). Mean phosphate levels were at the lower end of the age-specific normal ranges. Urinary calcium/creatinine (mg/mg) was consistently elevated (children: 0.80±0.40; adults: 0.28±0.19). Adult heights were well below the 3rd percentile ...

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Research paper thumbnail of Autoimmune diseases in children

Current Paediatrics

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Research paper thumbnail of Mid-aortic syndrome: long-term outcome of 36 children

Pediatr Nephrol 24 2225 2232, Jul 15, 2009

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Research paper thumbnail of Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus

Eur J Pediat, 1994

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Research paper thumbnail of Inherited disorders of sodium and water handling

In Johnson Rj and Feehally J Comprehensive Clinical Nephrology Mosby International London, 2000

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Investigation and management of hypertension in children: a personal perspective

Pediatric Nephrology, 1987

The prevalence of hypertension in children is of the order of 1%-3%. Of these children, 10% will ... more The prevalence of hypertension in children is of the order of 1%-3%. Of these children, 10% will have severe hypertension and in the majority the increased blood pressure will be secondary to renal disease. Nephrologically orientated investigation is therefore important. The most helpful investigations are: peripheral plasma-renin activity, 99mTc dimercaptosuccinic acid (DMSA) scan, main and segmental renal vein renin measurements and renal angiography plus 123I metaiodobenzyl guanidine (MIBG) scan in suspected phaeochromocytoma. Drug treatment of accelerated hypertension is most successfully undertaken by intravenous labetalol or sodium nitroprusside; sustained moderate-to-severe hypertension by a beta-blocker plus a vasodilator or an angiotensin-converting enzyme inhibitor with or without a diuretic; mild hypertension by diet, diuretic and if necessary by more powerful hypotensives. Surgical treatment by revascularization or nephrectomy and percutaneous transluminal angioplasty can be successful. Utilizing the current range of investigational and therapeutic tools the aetiology and appropriate management of hypertension can be effectively and safely undertaken in the majority of hypertensive children.

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Research paper thumbnail of Rare vasculitic syndromes : Special section: Paediatric rheumatology

Annals of Medicine, 1997

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Research paper thumbnail of Management of hypertensive emergencies

Pediat Nephrol, 1993

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Research paper thumbnail of Renal tubular dysfunction in methylmalonic acidaemia

Eur J Pediat, 1991

Renal tubular function was assessed in seven patients with methylmalonic acidaemia not responsive... more Renal tubular function was assessed in seven patients with methylmalonic acidaemia not responsive to vitamin B12. Five patients failed to concentrate their urine normally and in these patients the glomerular filtration rate was also reduced. Fractional excretion of sodium was increased in four patients, fractional excretion of potassium in one patient and in three there was a decreased tubular reabsorption of phosphate. Although possibly representing primary tubular damage these findings were thought to be consistent with adaptive changes secondary to the reduced glomerular filtration rate. Two patients had evidence of a defect of urinary acidification and several had a degree of hyporeninaemic hypoaldosteronism suggesting type 4 renal tubular acidosis. In one patient with a mild variant no renal disease was detected. Decreased renal function and tubular abnormalities were common in patients with methylmalonic acidaemia. It is likely that they are linked and essentially secondary to the tubulo-interstitial nephritis that is histologically demonstrable on renal biopsy. The failure of urinary concentrating ability and the disturbed urine acidification will contribute to the metabolic derangement during episodes of decompensation.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Rare Vasculitic Syndromes

ABSTRACT

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Chronic renal failure in methylmalonic acidaemia

European Journal of Pediatrics, 1989

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Erratum: Immunosuppressive therapy of childhood idiopathic nephrotic syndrom (Expert Opinion on Pharmacotherapy (2002) vol. 3 (5) 513-519))

Expert Opinion on Pharmacotherapy 3, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Henoch-Schönlein purpura with antiphospholipid antibodies following an influenza vaccination: commentary

Pediatric Nephrology 16 460 462, Jan 4, 2001

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Single centre outcomes of childhood primary renovascular hypertension

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Treatment of severe complicated Kawasaki disease with oral prednisolone and aspirin

The Journal of Pediatrics 137 723 726, Jan 11, 2000

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Beh‡et's disease in UK children: clinical features and treatment including thalidomide

Rheumatology 2001 933 938, 2001

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Hypertension in childhood: a current assessment

Progress in Cardiology, 1988

Bookmarks Related papers MentionsView impact