Michael Friebe - Academia.edu (original) (raw)
I have always been interested in new technological and managerial challenges. In the last 25 years I have been involved in diagnostic imaging and image guided therapeutic products and services as well as other related Medical Technology ventures, as founder / innovator / CEO and investor. I previously was the Founder and CEO of Tomovation Alliance Medical Northern and Central Europe (Alliance bought Tomovation in 2008 - both radiology services companies) and prior to that of NEUROMED AG (acquired by UMS AG in 2001). Currently I am a Board Member of three startup R
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Papers by Michael Friebe
Nuklearmedizin-nuclear Medicine, Apr 1, 2020
Rentgenologiya i Radiologiya, 1995
DOAJ (DOAJ: Directory of Open Access Journals), Jul 1, 2016
Current Directions in Biomedical Engineering, Sep 1, 2020
The short-range and sharp dose fall-off of beta particles in tissue make them an interesting opti... more The short-range and sharp dose fall-off of beta particles in tissue make them an interesting option for use in the radiation therapy of superficial skin tumors. This can be used to protect bony or other sensitive structures located right beneath the tumor. In a previous study, we studied the feasibility of using 3D printing technology to create 2D radioactive models for the treatment of skin tumors. In the current study, the Monte Carlo method was used to simulate the transverse dose profile form 3D printed extruded line containing yttrium-90 (Y-90) particles. The time and activity required for treating a superficial skin tumor using these extruded lines were also calculated.
Minimally Invasive Therapy & Allied Technologies, May 10, 2016
Abstract Techniques for intraoperative radiation therapy (IORT), the applications of tumor bed ra... more Abstract Techniques for intraoperative radiation therapy (IORT), the applications of tumor bed radiation immediately after surgery or utilising intracavitary access, have evolved in recent years. They are designed to substitute or complement conventional external beam radiation therapy in selected patients. IORT has become an excellent treatment option because of good long-term therapy outcomes. The combination of IORT with external beam radiation therapy has the potential to improve local control. The purpose of this paper is to present IORT techniques using gamma and electronic sources, as well as more conventional nuclide-based approaches and to evaluate their effectiveness. Common techniques for radiation of tumor cavities are listed and compared. Radionuclide IORT methods are represented by balloon and hybrid multi-catheter devices in combination with appropriate afterloaders. Electron beam therapy dedicated for use as intraoperative radiation system is reviewed and miniature x-ray sources in electronic radiation therapy are presented. These systems could further simplify IORT, because they are easy to use and require no shielding due to their relatively low photon energies. In combination with additional imaging techniques (MRI, US, CT and NucMed) the application of these miniature x-ray sources or catheter-based nuclide therapies could be the future of IORT.
Proceedings of SPIE, Mar 13, 2017
Thyroid segmentation in tracked 2D ultrasound (US) using active contours has a low segmentation a... more Thyroid segmentation in tracked 2D ultrasound (US) using active contours has a low segmentation accuracy mainly due to the fact that smaller structures cannot be efficiently recognized and segmented. To address this issue, we propose a new similarity indicator with the main objective to provide information to the active contour algorithm concerning the regions that the active contour should continue to expand or should stop. First, a preprocessing step is carried out in order to attenuate the noise present in the US image and to increase its contrast, using histogram equalization and a median filter. In the second step, active contours are used to segment the thyroid in each 2D image of the dataset. After performing a first segmentation, two similarity indicators (ratio of mean square error, MSE and correlation between histograms) are computed at each contour point of the initial segmented thyroid between rectangles located inside and outside the obtained contour. A threshold is used on a final indicator computed from the other two indicators to find the probable regions for further segmentation using active contours. This process is repeated until no new segmentation region is identified. Finally, all the segmented thyroid images passed through a 3D reconstruction algorithm to obtain a 3D volume segmented thyroid. The results showed that including similarity indicators based on histogram equalization and MSE between inside and outside regions of the contour can help to segment difficult areas that active contours have problem to segment.
Frontiers in Public Health, Sep 3, 2021
Minimally Invasive Therapy & Allied Technologies, 1995
ABSTRACT
Nuklearmedizin-nuclear Medicine, Apr 1, 2020
Rentgenologiya i Radiologiya, 1995
DOAJ (DOAJ: Directory of Open Access Journals), Jul 1, 2016
Current Directions in Biomedical Engineering, Sep 1, 2020
The short-range and sharp dose fall-off of beta particles in tissue make them an interesting opti... more The short-range and sharp dose fall-off of beta particles in tissue make them an interesting option for use in the radiation therapy of superficial skin tumors. This can be used to protect bony or other sensitive structures located right beneath the tumor. In a previous study, we studied the feasibility of using 3D printing technology to create 2D radioactive models for the treatment of skin tumors. In the current study, the Monte Carlo method was used to simulate the transverse dose profile form 3D printed extruded line containing yttrium-90 (Y-90) particles. The time and activity required for treating a superficial skin tumor using these extruded lines were also calculated.
Minimally Invasive Therapy & Allied Technologies, May 10, 2016
Abstract Techniques for intraoperative radiation therapy (IORT), the applications of tumor bed ra... more Abstract Techniques for intraoperative radiation therapy (IORT), the applications of tumor bed radiation immediately after surgery or utilising intracavitary access, have evolved in recent years. They are designed to substitute or complement conventional external beam radiation therapy in selected patients. IORT has become an excellent treatment option because of good long-term therapy outcomes. The combination of IORT with external beam radiation therapy has the potential to improve local control. The purpose of this paper is to present IORT techniques using gamma and electronic sources, as well as more conventional nuclide-based approaches and to evaluate their effectiveness. Common techniques for radiation of tumor cavities are listed and compared. Radionuclide IORT methods are represented by balloon and hybrid multi-catheter devices in combination with appropriate afterloaders. Electron beam therapy dedicated for use as intraoperative radiation system is reviewed and miniature x-ray sources in electronic radiation therapy are presented. These systems could further simplify IORT, because they are easy to use and require no shielding due to their relatively low photon energies. In combination with additional imaging techniques (MRI, US, CT and NucMed) the application of these miniature x-ray sources or catheter-based nuclide therapies could be the future of IORT.
Proceedings of SPIE, Mar 13, 2017
Thyroid segmentation in tracked 2D ultrasound (US) using active contours has a low segmentation a... more Thyroid segmentation in tracked 2D ultrasound (US) using active contours has a low segmentation accuracy mainly due to the fact that smaller structures cannot be efficiently recognized and segmented. To address this issue, we propose a new similarity indicator with the main objective to provide information to the active contour algorithm concerning the regions that the active contour should continue to expand or should stop. First, a preprocessing step is carried out in order to attenuate the noise present in the US image and to increase its contrast, using histogram equalization and a median filter. In the second step, active contours are used to segment the thyroid in each 2D image of the dataset. After performing a first segmentation, two similarity indicators (ratio of mean square error, MSE and correlation between histograms) are computed at each contour point of the initial segmented thyroid between rectangles located inside and outside the obtained contour. A threshold is used on a final indicator computed from the other two indicators to find the probable regions for further segmentation using active contours. This process is repeated until no new segmentation region is identified. Finally, all the segmented thyroid images passed through a 3D reconstruction algorithm to obtain a 3D volume segmented thyroid. The results showed that including similarity indicators based on histogram equalization and MSE between inside and outside regions of the contour can help to segment difficult areas that active contours have problem to segment.
Frontiers in Public Health, Sep 3, 2021
Minimally Invasive Therapy & Allied Technologies, 1995
ABSTRACT