Michael Moore - Academia.edu (original) (raw)

Papers by Michael Moore

BMC evolutionary biology, Jan 5, 2015

The use of transcriptomic and genomic datasets for phylogenetic reconstruction has become increas... more The use of transcriptomic and genomic datasets for phylogenetic reconstruction has become increasingly common as researchers attempt to resolve recalcitrant nodes with increasing amounts of data. The large size and complexity of these datasets introduce significant phylogenetic noise and conflict into subsequent analyses. The sources of conflict may include hybridization, incomplete lineage sorting, or horizontal gene transfer, and may vary across the phylogeny. For phylogenetic analysis, this noise and conflict has been accommodated in one of several ways: by binning gene regions into subsets to isolate consistent phylogenetic signal; by using gene-tree methods for reconstruction, where conflict is presumed to be explained by incomplete lineage sorting (ILS); or through concatenation, where noise is presumed to be the dominant source of conflict. The results provided herein emphasize that analysis of individual homologous gene regions can greatly improve our understanding of the un...

Fourth Annual IEEE International Conference on Pervasive Computing and Communications Workshops (PERCOMW'06)

Molecular communication is one solution for nano-scale communication between nanomachines. Nanoma... more Molecular communication is one solution for nano-scale communication between nanomachines. Nanomachines (e.g., biological molecules, artificial devices) represent small devices or components that perform computation, sensing, or actuation. Molecular communication provides a mechanism for one nanomachine to encode or decode information into molecules and to send information to another nanomachine. This paper describes a molecular motor communcation system in terms of a high level architecture for molecular communication. We also briefly discuss current and future work in molecular communcation.

New South Wales Public Health Bulletin, 2006

Physical Review A, 1993

In the pseudopotential approximation the type of dynamics of two charged particles confined in a ... more In the pseudopotential approximation the type of dynamics of two charged particles confined in a Paul trap depends on the ratio A, =co, /co~of the frequencies of the axial and the radial pseudo-oscillators, respectively. For A, =-', l, 2 the classical dynamics is integrable. The classical dynamics appears to be nonintegrable for A, W 2, 1,2 and shows a mixed phase space with interspersed regular and chaotic regions. The type of classical dynamics manifests itself in the statistics of the quasienergy spectrum of the Paul trap. In the integrable case (k= z, 2) we find level clustering, whereas level repulsion is obtained in the chaotic regime. PACS number(s): 32.8O.Pj, 05.4S.+b I. INTR(ODUCTION The Paul trap [1-4] is one of the most versatile tools in modern atomic physics. Not only did it prove invaluable in ion spectroscopy [5], in the precision measurement of lepton magnetic moments [6], in the physics of quantum jumps [7-9] and as a candidate for future frequency standards [10,11],it also turned out to be a useful device for studying nonlinear dynamics [12-14], collective phenomena [15,16], and fundamental quantum mechanics [17-20]. Much of this astonishing success is due to the recent development of eKcient laser-cooling techniques [21-23]. It is the application of the Paul trap to nonlinear dynamics [24] and quantum chaos [25] that will be the focus of discussion in this paper. The quantum mechanics of the single-ion Paul trap is by now understood in detail [26-29]. The quantum 1050-2947/93/48{4

Acta Horticulturae, 2010

In just the past 20 years the use of molecular markers in systematics, evolution, and horticultur... more In just the past 20 years the use of molecular markers in systematics, evolution, and horticulture has progressed from using sequences of a few individual genes for a few taxa to using larger and larger sequence sets that are accumulating due to the routine sequencing of complete plastid genomes, transcriptomes, and even complete nuclear genomes. Here we highlight two areas in which the advances in molecular markers are transforming plant evolutionary biology: 1) assembling and exploring the plant tree of life, and 2) using genomic tools to make any "non-model" research organism more of a "model." Recent technological advances in sequencing (i.e., next-generation sequencing) and the development of computational methods and resources have made it possible to compile and analyze enormous molecular data sets for phylogenetic analyses, and the resulting topologies have in turn provided unprecedented insights into plant evolution. In the angiosperms, for example, we have obtained new insights into many of the enigmatic deep-level relationships as well as the rapid radiations that have characterized angiosperm evolution. In addition, computational advances in phylogenetics enable analyses with thousands of terminals, which help elucidate large-scale patterns of evolution within plants. Recent advances in high-throughput sequencing technology also afford the opportunity to accelerate dramatically our ability to examine genome evolution in non-model species. For example, in Tragopogon (Asteraceae), an evolutionary model for the study of recent and recurrent polyploidization, we have used a genomic approach to survey gene loss and expression changes that follow polyploidization.

American Journal of Hypertension, 2005

Hypertensive population is characterised by a high prevalence of paroxysmal atrial fibrillation (... more Hypertensive population is characterised by a high prevalence of paroxysmal atrial fibrillation (PAF). P-wave dispersion measured from signalaveraged ECG and atrial natriuretic peptide levels are correlated with the initiation of PAF. We assessed the hypothesis that hypertensive patients prone to develop PAF can be identified while in sinus rhythm by manual measuring P-wave dispersion and also by assessing the brain natriuretic peptide (BNP) plasma levels. We studied 60 hypertensive patients, 30 with a history of PAF (group A) and 30 without a history of PAF (group B). The P-wave was recorded and studied by the 24h ECG-monitoring (Holter). We measured 24h-Pmin, 24h-Pmax, 24h-P dispersion (ϭPmax-Pmin). We measured also the plasma levels of BNP. An echocardiogram was also done assessing left ventricular (LV) and left atrial (LA). There were no differences among the two groups regarding the clinical and demographic data (age: 58Ϯ12 years, sex:65% vs 60% males, body mass index:27.57Ϯ3.2 vs 27.38Ϯ4.4kg/m 2 , office blood pressure: 147Ϯ12/91Ϯ7 vs 141Ϯ11/90Ϯ9mmHg, duration of hypertension: 4.2Ϯ2.1 vs 3.9Ϯ2.3 years, pϭNS for all cases). There was also no difference in ejection fraction (EF:65%vs67%,pϭNS). The 24h-P dispersion and 24h-Pmax were longer in group A and also BNP levels were significantly higher in group A whereas 24h-Pmin was significally shorter in group A. In conclusion, P-wave dispersion as it was defined on the 24h ECGrecording and high plasma levels of BNP consist two reliable predictors for the development of PAF in essential hypertensive subjects.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, Jan 28, 2015

The dramatic rise in oropharyngeal squamous cell carcinoma associated with the human papilloma vi... more The dramatic rise in oropharyngeal squamous cell carcinoma associated with the human papilloma virus (HPV) has brought significant change to the interaction between patients and head and neck oncologists. HPV-induced cancers are generally the result of elements from the patient's sexual history, and otolaryngologists are generally less experienced than primary care physicians in addressing patient questions relating to sexual history and practices. This article addresses questions commonly posed by patients relating to HPV-induced head and neck cancers, issues related to HPV vaccination, and surveillance of HPV-related lesions. Supporting data are provided such that physicians may be better equipped to sufficiently address patient queries on this topic. Available peer-reviewed literature and clinical practice guidelines. Assessment and discussion of specific topics by authors selected from the Head and Neck Surgery Education Committee of the American Academy of Otolaryngology-He...

Southern Medical Journal, 1985

An asymptomatic adrenal mass was discovered in an elderly patient during evaluation of an abnorma... more An asymptomatic adrenal mass was discovered in an elderly patient during evaluation of an abnormal urinary sediment. Exploratory laparotomy revealed an adrenal hematoma as the cause of the mass. No clear cause of the adrenal hemorrhage was identified, and postoperatively there was no evidence of adrenal insufficiency. Though rare, signs of adrenal hemorrhage may include an asymptomatic adrenal mass, and should be considered in the differential diagnosis of this problem.

PURPOSE Dose optimization in large institutions with multiple scanners at one or more locations a... more PURPOSE Dose optimization in large institutions with multiple scanners at one or more locations and with multiple temporary or permanent radiologic technologists may require special efforts. The purpose of our study was to determine the radiation dose penalties for non-compliance with specific scanning protocols and assess effects of strategies to improve compliance with specified protocols. METHOD AND MATERIALS In phase 1 of the study, size based dose optimization protocols were implemented on eight MDCT scanners in a large academic center for scanning children according to four categories of weight (n= 138,1-18years M: F 80:58). Technologists were informed with emails and personal communication about the protocols. Next, we recorded compliance of the technologists with the protocols by matching used scan parameters with those recommended with new protocols for all pediatric CT from the date of implementation of the protocols to October 1, 2007. In the phase 2 of the study, protoco...

PURPOSE/AIM Studies have shown that follow up imaging and certain indications can also guide furt... more PURPOSE/AIM Studies have shown that follow up imaging and certain indications can also guide further dose reduction but weight based composite CT protocols to tailor dose to body region, indication, prior exams, and automatic exposure control (AEC) have not been illustrated. Our exhibit describes these composite CT protocols for managing dose in children. CONTENT ORGANIZATION 1. Justification and details of current weight based fixed mA protocols 2. Evidence for use of AEC in children 3. Scan parameters for composite CT protocols which account for patient size, body region, indication, prior studies and AEC. 4. Steps to implementations of composite CT protocols in small or large CT centers. 5. Players pertinent to compliance with composite CT protocols: The technologists and the radiologists 6. Advantages and limitations of the composite CT protocols SUMMARY From this exhibit, readers will come to know about presently used scanning protocols for optimizing dose for children. We will...

Studies in Computational Intelligence, 2011

This chapter provides a comprehensive overview of state-of-the art research on molecular communic... more This chapter provides a comprehensive overview of state-of-the art research on molecular communication-a molecule-based communication paradigm for biological machines. Unlike current telecommunications based on electric or optical signals, molecular communication exploits biological molecules as information carriers. In molecular communication, senders of communication encode information onto molecules and transmit to the environment. The information coded molecules then propagate in the environment to reach receivers of communication, which capture and biochemically react to the molecules (i.e., decode the information from the information coded molecules). Since biological molecules are compatible with biological systems, molecular communication is expected to impact medical domains such as human health monitoring where implant biological machines interact with biological cells through molecular communication. This chapter describes key concepts, architecture, potential applications of molecular communication as well as existing research on engineering molecular communication components and systems.

The Journal of Arthroplasty, 2015

Accurate risk stratification of patients undergoing total hip (THA) and knee (TKA) arthroplasty i... more Accurate risk stratification of patients undergoing total hip (THA) and knee (TKA) arthroplasty is essential in the highly scrutinized world of pay-for-performance, value-driven healthcare. We assessed the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) surgical risk calculator's ability to predict 30-day complications using 1066 publicly-reported Medicare patients undergoing primary THA or TKA. Risk estimates were significantly associated with complications in the categories of any complication (P = .005), cardiac complication (P b .001), pneumonia (P b .001) and discharge to skilled nursing facility (P b .001). However, predictability of complication occurrence was poor for all complications assessed. To facilitate the equitable provision and reimbursement of patient care, further research is needed to develop accurate risk stratification tools in TKA and THA surgery.

Journal of skin cancer, 2012

Background. Few studies have been done that characterize basal cell carcinoma (BCC) in Asians bec... more Background. Few studies have been done that characterize basal cell carcinoma (BCC) in Asians because this tumor is relatively uncommon in this population group. Objective. To characterize BCC in Asians. Methods. We retrospectively examined fifteen patient variables and eight tumor variables of ten Asian patients with BCC and compared these results to those of thirty matched Caucasian controls with BCC. Results. Asians developed their first BCC at an older age than the age of first BCC in Caucasian controls (68.9 years versus 58.3 years; P < 0.05). During their lifetime, Asians had fewer BCCs than the number of BCCs in Caucasian controls (1.11 versus 5.41; P < 0.02), despite a similar estimated lifetime daily sun exposure (hours/day) for both groups. Compared to BCCs in Caucasian controls, a higher percentage of BCCs in Asians were clinically pigmented (50.0% versus 3.3%; P < 0.01). Conclusion. Asians develop BCCs later in life and develop fewer BCCs over their lifetime tha...

World Journal of Surgery, 1989

Veterinary Surgery, 1994

The purpose of this study was to determine whether canine-derived fibrinogen concentrate applied ... more The purpose of this study was to determine whether canine-derived fibrinogen concentrate applied with bovine thrombin was a safe and effective topical hemostatic agent. A canine liver biopsy model was selected to test this product. Cryoprecipitate was prepared from frozen canine plasma using two freeze/thaw/centrifugation cycles. Six healthy adult dogs (weighing more than 18 kg) were used in the fibrin sealant study, and an additional three dogs were used as controls for the liver biopsy. A 1 X 3 cm liver biopsy specimen was obtained, digital pressure was applied to reduce bleeding, and the fibrinogen concentrate was immediately sprayed on the bleeding surface simultaneously with bovine thrombin (1,000 IU/mL). The mean f standard error of the mean (SEM) blood pressure at time of biopsy was 98 f 9 mm Hg, and the rate of hemorrhage from the cut liver edge was 8.0 ? 1.1 mL/min. The total blood loss during fibrin sealant application was 37 f 9 mL and total time for hemostasis was 5.5 f 1.3 minutes. There was no additional hemorrhage after application of the fibrin sealant. In the three control dogs, fibrin sealant was not applied and only digital compression was used to decrease hemorrhage. Before digital compression, the rate of hemorrhage from the cut liver edge was 13.1 * 3.1 mL/min. Bleeding had not stopped after 10 minutes of compression and the mean postcompression rate of hemorrhage was 4.0 f 2.6 mL/min. Signs of secondary bleeding after fibrin sealant was applied were not evident during the immediate postoperative period or over the next 14 days. The coagulation profile, alanine amino transferase (ALT), alkaline phosphatase (AP), and bile acids were not significantly different on day 14 from preoperative values, suggesting that the liver was only mildly affected. The dogs were euthanatized and gross and histological examinations of the biopsy site were performed on day 14. There were minimal or no adhesions at the biopsy site. In all dogs, the hepatic capsule was less than 1 mm thick and histological signs of secondary bleeding, hepatocellular damage, thrombosis, infection, or inflammation were not observed. In this study, canine-derived fibrin sealant was a safe and effective topical hemostatic agent.

The Journal of the American College of Certified Wound Specialists, 2011

BACKGROUND: This exploratory study was conducted in an effort to demonstrate that bioelectrical i... more BACKGROUND: This exploratory study was conducted in an effort to demonstrate that bioelectrical impedance analysis (BIA) phase angle measurement is a novel tool for monitoring the effectiveness of a wound care regimen at a regional level and is valuable in comparing that status with the overall metabolic health of the patient. Isolating and measuring the extent to which nutritional supplementation contributes to the healing process is difficult and confounded by the many treatment modalities patients undergo. OBJECTIVE: The authors conducted a limited exploratory study to determine whether regional phase angle measurements accurately reflected the status of chronic nonhealing wounds. This information would potentially provide the ability to quantitatively evaluate of the role of nutritional supplementation in wounds of varying etiologies by comparing regional BIA phase angle measurement with overall BIA phase angle measurement. METHODS: Eleven patients with wounds of varying etiologies were selected to participate. Each patient underwent a treatment regimen specific to his or her condition, and all patients were given JUVEN Ò nutritional supplement. RESULTS AND CONCLUSION: In all patients, the BIA phase angle measurement mirrored the health of the wound and provided an accurate tool for assessing the regional tissue health, a valuable insight in measuring the effectiveness of a systemic treatment.

Proceedings of the National Academy of Sciences, 2007

Although great progress has been made in clarifying deep-level angiosperm relationships, several ... more Although great progress has been made in clarifying deep-level angiosperm relationships, several early nodes in the angiosperm branch of the Tree of Life have proved difficult to resolve. Perhaps the last great question remaining in basal angiosperm phylogeny involves the branching order among the five major clades of mesangiosperms ( Ceratophyllum , Chloranthaceae, eudicots, magnoliids, and monocots). Previous analyses have found no consistent support for relationships among these clades. In an effort to resolve these relationships, we performed phylogenetic analyses of 61 plastid genes (≈42,000 bp) for 45 taxa, including members of all major basal angiosperm lineages. We also report the complete plastid genome sequence of Ceratophyllum demersum . Parsimony analyses of combined and partitioned data sets varied in the placement of several taxa, particularly Ceratophyllum , whereas maximum-likelihood (ML) trees were more topologically stable. Total evidence ML analyses recovered a cl...

Physical Review Letters, 2011

We propose a mechanism for optical trapping of dark excitons by linearly polarized unabsorbed sta... more We propose a mechanism for optical trapping of dark excitons by linearly polarized unabsorbed standing waves, with a potential depth of the order of a few meV. Since this trapping, based on carrier exchanges with virtual excitons coupled to unabsorbed photons, equally acts on bright and dark states, Bose-Einstein condensation of excitons-which occurs in dark states-must appear as dark spots in a cloud of bright excitons, at the trap potential minima, when the temperature decreases.

Physical Review Letters, 2010