Michael Spring - Academia.edu (original) (raw)

Papers by Michael Spring

Gynecologic Oncology, 2017

PTEN, and TP53. A Pap or plasma test was considered "positive" if it harbored at least 1 driver m... more PTEN, and TP53. A Pap or plasma test was considered "positive" if it harbored at least 1 driver mutation noted above. Results: In total, 88 OC patients underwent both Pap and plasma testing at the time of primary surgery and were compared with 97 controls. Overall, 33% of OC patients had stage I-II, and the remainder had stage III-IV disease. The majority (80%) had high-grade serous carcinoma. The overall detection rate of a driver gene mutation was 76.1%. Specifically, 63.6% of those with stage I-II disease and 97.1% of those with stage III-IV disease had either a positive Pap and/or CT-DNA plasma test. Conversely, in the control population, the false positive rate was 1.5% (specificity 98.5%) Conclusion: Combination liquid-based Pap and CT-DNA plasma testing detected a substantial number of tumor-derived driver DNA mutations (76.1%) with high specificity in patients with primary OC. In those with early-stage disease, approximately two-thirds of patients (63.6%) had tumoral DNA mutations detected by these techniques. A prospective validation trial is underway at our institution to define the utility of combination Pap and plasma testing in OC screening.

JMIR human factors, Jan 5, 2017

eHealth technologies offer great potential for improving the use and effectiveness of treatments ... more eHealth technologies offer great potential for improving the use and effectiveness of treatments for those with severe mental illness (SMI), including schizophrenia and schizoaffective disorder. This potential can be muted by poor design. There is limited research on designing eHealth technologies for those with SMI, others with cognitive impairments, and those who are not technology savvy. We previously tested a design model, the Flat Explicit Design Model (FEDM), to create eHealth interventions for individuals with SMI. Subsequently, we developed the design concept page complexity, defined via the design variables we created of distinct topic areas, distinct navigation areas, and number of columns used to organize contents and the variables of text reading level, text reading ease (a newly added variable to the FEDM), and the number of hyperlinks and number of words on a page. The objective of our study was to report the influence that the 19 variables of the FEDM have on the abil...

Software development is constrained by time, cost and quality requirements. Software defects are ... more Software development is constrained by time, cost and quality requirements. Software defects are one of the most influential factors affecting the success of a software project. Software inspection has become an essential solution for managing software defects. A variety of software inspection techniques have been developed. Traditionally, software inspections are performed manually and require meeting-based activities. New inspection techniques have challenged the conventions by eliminating the defect collection meeting. The original asynchronous software inspection consists of private and public reviews, and it has been proven as effective as traditional ones. Different kinds of computer technologies are used to augment the software inspection process. This study empirically examined the effects of annotations of shared defect detection in asynchronous software inspection in which the private review is absent and all annotations are visible to members of the inspection team at all times. A Latin square experimental design was employed, and twenty-seven novices participated in the experiment as inspector subjects. The study results show that the defect discovery ratio is not affected by the number of annotations in the target materials under inspection. Thus, the study suggests that defect detection task and defect review task can be combined without loss. This basic finding of this research supports the proposition that more flexible focus of software inspection (i.e. asynchronous and shared annotation) may be adopted without negative impacts on defect detection. The analysis study also addresses additional issues related to software inspection, augmentation, cognition, and research design. i Acknowledgements

Concepts, Methodologies, Tools, and Applications

This chapter discusses the design of Web sites to be used as the basis of medical research. It is... more This chapter discusses the design of Web sites to be used as the basis of medical research. It is broken down into three sections: Part 1 discusses the various issues that have to be addressed in the design of a Web site that will be used to assess some intervention based on the Web site. Part 2 discusses the design of such a Web site and the development of a tool to facilitate this process. Part 3 presents the results of preliminary usability analysis for the tool to assist medical researchers in constructing Web sites that can meet the needs and requirements of medical intervention studies. The results of the preliminary interviews, prototype walkthroughs, and preliminary usability studies are presented laying the groundwork for future development and more formal usability studies.

Developments in processing multimedia and distributed documents are reviewed. The evolution of st... more Developments in processing multimedia and distributed documents are reviewed. The evolution of structured documents is traced leading to recommendations for additional levels of structure in the production of large multi-author documents. Large multi-author documents include documents such as training manuals, reference materials, and documentation. A model for a multi-author distributed document database is presented. The model focuses on the importance of multi-author interaction in the creation of a modular document that appears in final composition to be seamless. particular attention is paid to voice annotation, a capability to process information dynamically for inclusion in the file, issues in the management of documents in a network environment, and authoring and management control issues. A prototype of the control files and a system to manage multimedia documents created by groups of people is described.

2015 IEEE 9th International Conference on Standardization and Innovation in Information Technology (SIIT), 2015

Corporate and Global Standardization Initiatives in Contemporary Society, 2018

This chapter explores opportunities to manage standards and standardization with a particular foc... more This chapter explores opportunities to manage standards and standardization with a particular focus on the information and communication technologies (ICT) sector. It looks at the historical “management” of standards primarily in the United States, highlighting government and industrial approaches and the forces that have shaped the management process. It then turns to the current pressures and forces facing the management of ICT standards and standardization and makes some suggestions for activities that might enhance the management of standards.

This book/disk package deals with the page description language PostScript and how to best exploi... more This book/disk package deals with the page description language PostScript and how to best exploit it for use with laser printers. The computer disk contains programming examples for stand-alone printing projects.

Introduction There are a variety of approaches to teaching standards. Historically, there have be... more Introduction There are a variety of approaches to teaching standards. Historically, there have been a number of efforts to include standards as economic tools and much of the very early research on standards was from this perspective. Standards may also be viewed as social efforts to provide for the common good. They may also be viewed as a component of business activity—an approach that has been championed by much of the more recent work in Europe and Asia. Finally, they may be viewed from a “standards” perspective in which various disciplines are combined to study the social dynamics of the process, the technical evolution of the standards and the economic and business impacts of the standards. This article examines an effort at the University of Pittsburgh that was funded by a contract from the National Institute of Standards and Technology (Project 70NANB13H206). We begin with a history of standards education efforts at the University of Pittsburgh and conclude with a descriptio...

Journal of Medical Internet Research, 2021

Rotondi et al JOURNAL OF MEDICAL INTERNET RESEARCH XSL • FO RenderX repositories, the corrected a... more Rotondi et al JOURNAL OF MEDICAL INTERNET RESEARCH XSL • FO RenderX repositories, the corrected article has also been resubmitted to those repositories.

This paper describes the use of specialized software to assist editors in the conduct of an IEEE ... more This paper describes the use of specialized software to assist editors in the conduct of an IEEE mock ballot. Specifically, the CASCADE (Computer Augmented Support of Collaborative Authoring and Document Editing( system was configured to support a mock ballot for IEEE 1003.21(POSIX:Real Time Distributed System Communication). CASCADE is an experimental system for the development and exploration of agents to support the authoring and editing processes. The mock ballot of IEEE 1003.21 presented an opportunity to examine the applicability of real time collaborative systems as an assist to the document editing process. This study describes the development and testing of functions to assist editors in the management and disposition of comments that are normally made during the refinement and balloting of a standard. The results of the field test were disappointing due in large part to delayed software delivery. Cultural expectations and technological limitations also had negative impacts...

International Journal of Standardization Research, 2016

The history of modern standards development provides support for the argument that the process of... more The history of modern standards development provides support for the argument that the process of standardization has evolved in response to crises and opportunities. In the information and communication technologies (ICT) sector, many new groups have become involved in standards setting. In a period of rapid change, standards development in these areas has focused primarily on the provision of functionality. That is, there are few overarching roadmaps for development and issues such as security and interoperability are of less concern for many of the new standards developers. In addition, new oversight structures have emerged that appear to be more responsive to the particular needs of developers in the ICT arena. It may be important for nation states to consider assisting in roadmap development in the ICT arena to insure security and privacy issues are addressed such that these increasingly essential systems are less vulnerable.

International Journal of Pharmaceutics, 1981