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Research paper thumbnail of The Rate of Hospitalization of Pregnant Women with Multiple Sclerosis in Poland

Journal of Clinical Medicine

Multiple sclerosis (MS) is most often diagnosed in women of childbearing age. Therefore, it is im... more Multiple sclerosis (MS) is most often diagnosed in women of childbearing age. Therefore, it is important to examine the impact of pregnancy on the course of MS and to enable patients to make decisions about motherhood based on reliable data. The main objective of this study was to assess the impact of pregnancy on the course of MS by comparing the frequency of MS-related hospitalizations during pregnancy and 40 weeks postpartum versus 40 weeks before pregnancy. We used administrative health claims to identify female patients with MS, their deliveries, and their MS-related hospital admissions and calculated the frequency of MS-related hospital admissions before, during, and after pregnancy. We observed that MS is diagnosed approximately three times less often during pregnancy than before or after pregnancy. The number of MS-related hospital admissions decreased during pregnancy, especially in the third trimester. In contrast with other studies, we did not observe an increased level o...

Research paper thumbnail of Analysis of 622 pediatric hospitalizations due to arterial ischemic stroke in Poland – National Health Fund registry-based study from 2011 to 2020

Archives of Medical Science

IntroductionThe present study aimed to evaluate the prevalence of the arterial ischaemic stroke (... more IntroductionThe present study aimed to evaluate the prevalence of the arterial ischaemic stroke (AIS) in Polish children, as well as to analyse the parameters related to AIS hospitalization, including age, gender, region, month and season of a year at admission, duration and costs based on data from National Health Fund (NHF) registery in 2011–2020.Material and methodsData from the NHF were analysed statistically. The disease was identified according to the codes I63 and I64 of the International Classification of Diseases, Tenth Revision (ICD-10), and patients included only individuals up to 18 years of age. Results We identified 622 hospitalisations due to paediatric AIS in Poland in the study period.ResultsThe most frequent age subgroups were adolescents, followed by toddlers or pre-school children (34.73% and 24.12%, respectively), while the least frequent – neonates or infants (9.81%). ICD-10 procedures did significantly affect the duration and costs of hospitalisation (p<0.0...

Research paper thumbnail of Biologic treatment of inflammatory bowel disease in Poland, 2012–2020: nationwide data

Polish Archives of Internal Medicine

To the best of our knowledge, this article is the first to describe the population of Polish pati... more To the best of our knowledge, this article is the first to describe the population of Polish patients suffering from inflammatory bowel diseases (IBDs) and treated with innovative biologic drugs, which are the best treatment options known for patients with moderate to severe disease courses. Using administrative data, we estimate and discuss the significant differences in the use of biologic drugs across different regions of the country. We also show a higher treatment rate for men, compared to women, as well as a high and growing rate for the youngest population. Access to modern therapies is crucial for improving quality of life for the substantially growing population of IBD patients. We believe our work will be a helpful reference for evaluating the current situation of those patients and for predicting future demands.

Research paper thumbnail of Ostre krwawienia z górnego odcinka przewodu pokarmowego o etiologii nieżylakowej: epidemiologia, etiologia i wyniki leczenia w Polsce w 2014 roku

Ostre krwawienia z gornego odcinka przewodu pokarmowego (GOPP) stanowią najczestszy stan nagly w ... more Ostre krwawienia z gornego odcinka przewodu pokarmowego (GOPP) stanowią najczestszy stan nagly w gastroenterologii. Na świecie wystepują z szacowaną roczną czestością wynoszącą 40/150 przypadkow na 100 000 ludności. Wiekszośc z nich to krwawienia o tak zwanej etiologii niezylakowej. W 16–20% przypadkow w trakcie diagnostyki endoskopowej identyfikuje sie wiecej niz jedno źrodlo krwawienia, natomiast w 7–25% przypadkow nie udaje sie uwidocznic miejsca krwawienia w endoskopii. Ostre krwawienia z GOPP o etiologii niezylakowej wymagają hospitalizacji cześciej niz krwawienia z dolnego odcinka przewodu pokarmowego, ponadto są potencjalną przyczyną zgonow. Leczenie powinno odbywac sie w ośrodkach zapewniających odpowiedni sprzet i przeszkoloną zaloge. Celem artykulu jest oszacowanie skali zjawiska krwawien z GOPP w Polsce na podstawie danych pochodzących z Narodowego Funduszu Zdrowia, zebranych w 2014 roku. Omowiona zostanie czestośc hospitalizacji, sposoby leczenia, nawrotowośc krwawienia...

Research paper thumbnail of Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims

Multiple Sclerosis and Related Disorders, 2021

BACKGROUND The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based ... more BACKGROUND The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund. METHODS We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Three different algorithms for identification of MS cases were used: based on studies performed in German population (type 1), tested in the United States (type 2), and one created for the purpose of this study (type 3) that required at least 3 AHCs since 2009 with G35 ICD-10 diagnosis in outpatient specialist care, during hospitalization, and/or at rehabilitation service in any combination within maximally 3 years between the first and the last AHC, and provided that at least one AHC was either in neurological outpatient care or during hospitalization at a neurological ward or prescription of disease-modifying therapy. The American algorithm (type 2) required 3 AHCs within the analyzed year, while the German algorithm (type 1) required only one AHC in the analyzed year. RESULTS According to the type 3 algorithm, age-adjusted MS incidence and prevalence in 2019 was 6.6 and 131.2 / 100,000 inhabitants, respectively. From 2014 to 2019, the significant trend in increasing prevalence and decreasing incidence of MS was observed (p<0.001). Median age of prevalent MS patients was 50 years (interquartile range, IQR 39-61) whereas median age of incident MS cases was 37 years (IQR 28-48). Female-to-male ratio in MS patients was 2.4. According to the type 1 algorithm, age-adjusted MS incidence and prevalence in 2019 was 11.6 and 244.9 / 100,000 inhabitants, respectively. Use of the type 2 algorithm resulted in estimated age-adjusted MS incidence and prevalence values in 2019 of 6.2 and 120.1 / 100,000 inhabitants, respectively. CONCLUSIONS Multiple sclerosis incidence and prevalence in Poland are higher than previously reported and similar to the numbers shown for central European countries.

Research paper thumbnail of Remote Monitoring Reduces Mortality and Hospitalizations Among COVID-19 Patients. Data from the Polish Nationwide Program

SSRN Electronic Journal, 2021

Research paper thumbnail of Decreasing access to cancer diagnosis and treatment during the COVID-19 pandemic in Poland

Research paper thumbnail of Differences in acute ischaemic stroke care in Poland: analysis of claims database of National Health Fund in 2017

Neurologia i Neurochirurgia Polska, 2020

Selected and basic indicators of acute ischaemic stroke care in Poland are reported cross-regiona... more Selected and basic indicators of acute ischaemic stroke care in Poland are reported cross-regionally based on the analysis of claims data of the National Health Fund (NFZ) in 2017, the most reliable source of healthcare funding in the country, being a single public payer. For research purposes, a selection algorithm based on the diagnosis coded as I63 according to the International Classification of Diseases (ICD-10) was used to identify all ischaemic stroke patients in the claims database provided by the NFZ. Stroke units and other centres providing treatment for acute ischaemic stroke patients were examined. The analysis showed marked differences between provinces in terms of stroke unit treatment availability. The crude and standardised rates of acute ischaemic stroke admissions to stroke units varied between provinces. Moreover, substantial differences were observed for the thrombolysis implementation rate, access to rehabilitation, hospital stay and early prognosis. As the leading cause of disability and the second leading cause of death in developed countries, stroke requires a well-organised, evidence-based healthcare system provided for both acute treatment and rehabilitation. Continuous monitoring of healthcare is crucial to identify weaknesses and areas for improvement.

Research paper thumbnail of Epidemiology of inflammatory bowel disease in adults who refer to gastroenterology care in Romania

European Journal of Gastroenterology & Hepatology, 2004

The incidence of inflammatory bowel diseases is similar throughout Italy. Two prospective multice... more The incidence of inflammatory bowel diseases is similar throughout Italy. Two prospective multicentre studies in the same period have shown an incidence very similar to Northern Europe. The incidence of ulcerative colitis ranged from 3.4 to 10.5. The incidence of Crohn&#39;s disease ranged from 1.9 to 6.6. The time trends seem to indicate an increase in both diseases. The need to set up General Registries of disease is underlined. The clinical behaviour and the diagnostic approach are homogeneous throughout the country. Compared to Northern Europe, surgery was less common in ulcerative colitis. Among the risk factors, familial occurrence has been shown to have the same prevalence as in Northern Europe suggesting a common genetic background. Studies on other risk factors are warranted considering the lack of data. Data on mortality show that there is a decrease in deaths in ulcerative colitis and a slight increase in mortality for Crohn&#39;s disease in the first few years after diagnosis. A retrospective study on costs has shown a greater economic burden from ulcerative colitis, however, new multicentre prospective studies are necessary.

Research paper thumbnail of Trends of stroke hospitalisation and fatality rates in young vs. elderly people in Poland during 2010–2019 decade

Neurologia i Neurochirurgia Polska

Research paper thumbnail of Gender-Related Differences in Prodromal Multiple Sclerosis Characteristics: A 7-Year Observation Study

Journal of Clinical Medicine

Increasing evidence supports the observation that multiple sclerosis (MS) has a preclinical perio... more Increasing evidence supports the observation that multiple sclerosis (MS) has a preclinical period, with various prodromal signs and symptoms more frequently represented in patients with confirmed MS many years later. Considering the apparent gender differences in the incidence and clinical course of MS, it remains unclear whether it could be reflected in prodromal symptom features. This study aimed to compare a broad spectrum of prodromal signs and symptoms between males and females in the 7-year period before the definite diagnosis of MS. Data came from the central register of the national payer of services, financed under the public healthcare system in Poland. They covered a 7-year period of patient health record claims, from 2009 to 2016. The following groups of symptoms were significant with women: musculoskeletal (p < 0.001), ophthalmic (p < 0.001), laryngological (p < 0.001), digestive system (p < 0.001), urinary tract (p < 0.001), mental (p < 0.001), cardi...

Research paper thumbnail of The Rate of Hospitalization of Pregnant Women with Multiple Sclerosis in Poland

Journal of Clinical Medicine

Multiple sclerosis (MS) is most often diagnosed in women of childbearing age. Therefore, it is im... more Multiple sclerosis (MS) is most often diagnosed in women of childbearing age. Therefore, it is important to examine the impact of pregnancy on the course of MS and to enable patients to make decisions about motherhood based on reliable data. The main objective of this study was to assess the impact of pregnancy on the course of MS by comparing the frequency of MS-related hospitalizations during pregnancy and 40 weeks postpartum versus 40 weeks before pregnancy. We used administrative health claims to identify female patients with MS, their deliveries, and their MS-related hospital admissions and calculated the frequency of MS-related hospital admissions before, during, and after pregnancy. We observed that MS is diagnosed approximately three times less often during pregnancy than before or after pregnancy. The number of MS-related hospital admissions decreased during pregnancy, especially in the third trimester. In contrast with other studies, we did not observe an increased level o...

Research paper thumbnail of Analysis of 622 pediatric hospitalizations due to arterial ischemic stroke in Poland – National Health Fund registry-based study from 2011 to 2020

Archives of Medical Science

IntroductionThe present study aimed to evaluate the prevalence of the arterial ischaemic stroke (... more IntroductionThe present study aimed to evaluate the prevalence of the arterial ischaemic stroke (AIS) in Polish children, as well as to analyse the parameters related to AIS hospitalization, including age, gender, region, month and season of a year at admission, duration and costs based on data from National Health Fund (NHF) registery in 2011–2020.Material and methodsData from the NHF were analysed statistically. The disease was identified according to the codes I63 and I64 of the International Classification of Diseases, Tenth Revision (ICD-10), and patients included only individuals up to 18 years of age. Results We identified 622 hospitalisations due to paediatric AIS in Poland in the study period.ResultsThe most frequent age subgroups were adolescents, followed by toddlers or pre-school children (34.73% and 24.12%, respectively), while the least frequent – neonates or infants (9.81%). ICD-10 procedures did significantly affect the duration and costs of hospitalisation (p<0.0...

Research paper thumbnail of Biologic treatment of inflammatory bowel disease in Poland, 2012–2020: nationwide data

Polish Archives of Internal Medicine

To the best of our knowledge, this article is the first to describe the population of Polish pati... more To the best of our knowledge, this article is the first to describe the population of Polish patients suffering from inflammatory bowel diseases (IBDs) and treated with innovative biologic drugs, which are the best treatment options known for patients with moderate to severe disease courses. Using administrative data, we estimate and discuss the significant differences in the use of biologic drugs across different regions of the country. We also show a higher treatment rate for men, compared to women, as well as a high and growing rate for the youngest population. Access to modern therapies is crucial for improving quality of life for the substantially growing population of IBD patients. We believe our work will be a helpful reference for evaluating the current situation of those patients and for predicting future demands.

Research paper thumbnail of Ostre krwawienia z górnego odcinka przewodu pokarmowego o etiologii nieżylakowej: epidemiologia, etiologia i wyniki leczenia w Polsce w 2014 roku

Ostre krwawienia z gornego odcinka przewodu pokarmowego (GOPP) stanowią najczestszy stan nagly w ... more Ostre krwawienia z gornego odcinka przewodu pokarmowego (GOPP) stanowią najczestszy stan nagly w gastroenterologii. Na świecie wystepują z szacowaną roczną czestością wynoszącą 40/150 przypadkow na 100 000 ludności. Wiekszośc z nich to krwawienia o tak zwanej etiologii niezylakowej. W 16–20% przypadkow w trakcie diagnostyki endoskopowej identyfikuje sie wiecej niz jedno źrodlo krwawienia, natomiast w 7–25% przypadkow nie udaje sie uwidocznic miejsca krwawienia w endoskopii. Ostre krwawienia z GOPP o etiologii niezylakowej wymagają hospitalizacji cześciej niz krwawienia z dolnego odcinka przewodu pokarmowego, ponadto są potencjalną przyczyną zgonow. Leczenie powinno odbywac sie w ośrodkach zapewniających odpowiedni sprzet i przeszkoloną zaloge. Celem artykulu jest oszacowanie skali zjawiska krwawien z GOPP w Polsce na podstawie danych pochodzących z Narodowego Funduszu Zdrowia, zebranych w 2014 roku. Omowiona zostanie czestośc hospitalizacji, sposoby leczenia, nawrotowośc krwawienia...

Research paper thumbnail of Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims

Multiple Sclerosis and Related Disorders, 2021

BACKGROUND The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based ... more BACKGROUND The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund. METHODS We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Three different algorithms for identification of MS cases were used: based on studies performed in German population (type 1), tested in the United States (type 2), and one created for the purpose of this study (type 3) that required at least 3 AHCs since 2009 with G35 ICD-10 diagnosis in outpatient specialist care, during hospitalization, and/or at rehabilitation service in any combination within maximally 3 years between the first and the last AHC, and provided that at least one AHC was either in neurological outpatient care or during hospitalization at a neurological ward or prescription of disease-modifying therapy. The American algorithm (type 2) required 3 AHCs within the analyzed year, while the German algorithm (type 1) required only one AHC in the analyzed year. RESULTS According to the type 3 algorithm, age-adjusted MS incidence and prevalence in 2019 was 6.6 and 131.2 / 100,000 inhabitants, respectively. From 2014 to 2019, the significant trend in increasing prevalence and decreasing incidence of MS was observed (p<0.001). Median age of prevalent MS patients was 50 years (interquartile range, IQR 39-61) whereas median age of incident MS cases was 37 years (IQR 28-48). Female-to-male ratio in MS patients was 2.4. According to the type 1 algorithm, age-adjusted MS incidence and prevalence in 2019 was 11.6 and 244.9 / 100,000 inhabitants, respectively. Use of the type 2 algorithm resulted in estimated age-adjusted MS incidence and prevalence values in 2019 of 6.2 and 120.1 / 100,000 inhabitants, respectively. CONCLUSIONS Multiple sclerosis incidence and prevalence in Poland are higher than previously reported and similar to the numbers shown for central European countries.

Research paper thumbnail of Remote Monitoring Reduces Mortality and Hospitalizations Among COVID-19 Patients. Data from the Polish Nationwide Program

SSRN Electronic Journal, 2021

Research paper thumbnail of Decreasing access to cancer diagnosis and treatment during the COVID-19 pandemic in Poland

Research paper thumbnail of Differences in acute ischaemic stroke care in Poland: analysis of claims database of National Health Fund in 2017

Neurologia i Neurochirurgia Polska, 2020

Selected and basic indicators of acute ischaemic stroke care in Poland are reported cross-regiona... more Selected and basic indicators of acute ischaemic stroke care in Poland are reported cross-regionally based on the analysis of claims data of the National Health Fund (NFZ) in 2017, the most reliable source of healthcare funding in the country, being a single public payer. For research purposes, a selection algorithm based on the diagnosis coded as I63 according to the International Classification of Diseases (ICD-10) was used to identify all ischaemic stroke patients in the claims database provided by the NFZ. Stroke units and other centres providing treatment for acute ischaemic stroke patients were examined. The analysis showed marked differences between provinces in terms of stroke unit treatment availability. The crude and standardised rates of acute ischaemic stroke admissions to stroke units varied between provinces. Moreover, substantial differences were observed for the thrombolysis implementation rate, access to rehabilitation, hospital stay and early prognosis. As the leading cause of disability and the second leading cause of death in developed countries, stroke requires a well-organised, evidence-based healthcare system provided for both acute treatment and rehabilitation. Continuous monitoring of healthcare is crucial to identify weaknesses and areas for improvement.

Research paper thumbnail of Epidemiology of inflammatory bowel disease in adults who refer to gastroenterology care in Romania

European Journal of Gastroenterology & Hepatology, 2004

The incidence of inflammatory bowel diseases is similar throughout Italy. Two prospective multice... more The incidence of inflammatory bowel diseases is similar throughout Italy. Two prospective multicentre studies in the same period have shown an incidence very similar to Northern Europe. The incidence of ulcerative colitis ranged from 3.4 to 10.5. The incidence of Crohn&#39;s disease ranged from 1.9 to 6.6. The time trends seem to indicate an increase in both diseases. The need to set up General Registries of disease is underlined. The clinical behaviour and the diagnostic approach are homogeneous throughout the country. Compared to Northern Europe, surgery was less common in ulcerative colitis. Among the risk factors, familial occurrence has been shown to have the same prevalence as in Northern Europe suggesting a common genetic background. Studies on other risk factors are warranted considering the lack of data. Data on mortality show that there is a decrease in deaths in ulcerative colitis and a slight increase in mortality for Crohn&#39;s disease in the first few years after diagnosis. A retrospective study on costs has shown a greater economic burden from ulcerative colitis, however, new multicentre prospective studies are necessary.

Research paper thumbnail of Trends of stroke hospitalisation and fatality rates in young vs. elderly people in Poland during 2010–2019 decade

Neurologia i Neurochirurgia Polska

Research paper thumbnail of Gender-Related Differences in Prodromal Multiple Sclerosis Characteristics: A 7-Year Observation Study

Journal of Clinical Medicine

Increasing evidence supports the observation that multiple sclerosis (MS) has a preclinical perio... more Increasing evidence supports the observation that multiple sclerosis (MS) has a preclinical period, with various prodromal signs and symptoms more frequently represented in patients with confirmed MS many years later. Considering the apparent gender differences in the incidence and clinical course of MS, it remains unclear whether it could be reflected in prodromal symptom features. This study aimed to compare a broad spectrum of prodromal signs and symptoms between males and females in the 7-year period before the definite diagnosis of MS. Data came from the central register of the national payer of services, financed under the public healthcare system in Poland. They covered a 7-year period of patient health record claims, from 2009 to 2016. The following groups of symptoms were significant with women: musculoskeletal (p < 0.001), ophthalmic (p < 0.001), laryngological (p < 0.001), digestive system (p < 0.001), urinary tract (p < 0.001), mental (p < 0.001), cardi...