Michelle Ginsberg - Academia.edu (original) (raw)

Papers by Michelle Ginsberg

Sarcoma, 2000

Background. Subcentimeter pulmonary nodules are being detected with increasing frequency in patie... more Background. Subcentimeter pulmonary nodules are being detected with increasing frequency in patients with sarcoma due to the greater use of chest CT, the advent of helical (spiral) CT scanning and multidetector scanners, and the attendant decrease in image section thickness.Assessing the clinical significance of these pulmonary nodules is of particular importance in sarcoma patients, due to the frequent occurrence of pulmonary metastasis from sarcomas.Purpose. This article reviews the technical advances that have contributed to the increased detection of subcentimeter pulmonary nodules, statistics about subcentimeter pulmonary nodules and options for evaluating such nodules.

Human pathology, 2006

A pulmonary carcinoid tumorlet (PCT) is a nodular proliferation of neuroendocrine cells smaller t... more A pulmonary carcinoid tumorlet (PCT) is a nodular proliferation of neuroendocrine cells smaller than 0.5 cm. On computed tomographic (CT) imaging, these nodules are nonspecific in appearance and can mimic metastatic disease. Cases of multiple PCTs diagnosed between 1992 and 2003 in patients with history of breast cancer were identified through a search of the pathology files. The clinical information was abstracted from the medical records. We identified 12 women with a history of breast cancer and biopsy-proven PCTs, who were treated at our institution in a period of 12 years. Only 3 women were smokers. The mean age at diagnosis of the breast cancer was 62.8 years. The breast cancer was invasive carcinoma in 10 cases (9 ductal and 1 lobular) and ductal carcinoma in situ and malignant phyllodes tumor in 1 case each. Six women received radiotherapy; 5, chemotherapy; and 4, hormonal treatment, alone or in combination. Pulmonary carcinoid tumorlets were identified within 5 months from ...

Medical Imaging 2004: Image Processing, 2004

In this work, we present a computer-aided detection (CAD) algorithm for small lung nodules on low... more In this work, we present a computer-aided detection (CAD) algorithm for small lung nodules on low-dose MSCT images. With this technique, identification of potential lung nodules is carried out with a local density maximum (LDM) algorithm, followed by reduction of false positives from the nodule candidates using task-specific 2-D/3-D features along with a knowledge-based nodule inclusion/exclusion strategy. Twenty-eight MSCT scans

Medical Imaging 2004: Image Processing, 2004

Liver segmentation is critical for the development of algorithms to detect and define focal lesio... more Liver segmentation is critical for the development of algorithms to detect and define focal lesions. It is also helpful in presurgical planning for hepatic resection and to gauge the results of therapies. The purpose of this study was to develop a computerized method for extraction of liver contours on contrast-enhanced hepatic CT. The method is based on a snake algorithm

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2006

Ground Glass Opacity (GGO) is defined as hazy increased attenuation within a lung that is not ass... more Ground Glass Opacity (GGO) is defined as hazy increased attenuation within a lung that is not associated with obscured underlying vessels. Since pure (nonsolid) or mixed (partially solid) GGO at the thin-section CT are more likely to be malignant than those with solid opacity, early detection and treatment of GGO can improve a prognosis of lung cancer. However, due to indistinct boundaries and inter- or intra-observer variation, consistent manual detection and segmentation of GGO have proved to be problematic. In this paper, we propose a novel method for automatic detection and segmentation of GGO from chest CT images. For GGO detection, we develop a classifier by boosting k-NN whose distance measure is the Euclidean distance between the nonparametric density estimates of two examples. The detected GGO region is then automatically segmented by analyzing the texture likelihood map of the region. We applied our method to clinical chest CT volumes containing 10 GGO nodules. The propose...

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006

Ground glass opacity (GGO) is defined as hazy increased attenuation within a lung that is not ass... more Ground glass opacity (GGO) is defined as hazy increased attenuation within a lung that is not associated with obscured underlying vessels. Since pure (non-solid) or mixed (partially solid) GGO at the thin-section CT are more likely to be malignant than those with solid opacity, early detection and treatment of GGO can improve a prognosis of lung cancer. However, due to indistinct boundaries and inter-or intra-observer variation, consistent manual detection and segmentation of GGO have proved to be problematic. In this paper, we propose a novel method for automatic detection and segmentation of GGO from chest CT images. For GGO detection, we develop a classifier by boosting k-nearest neighbor (k-NN), whose distance measure is the Euclidean distance between the nonparametric density estimates of two regions. The detected GGO region is then automatically segmented by analyzing the 3D texture likelihood map of the region. We applied our method to clinical chest CT volumes containing 10 ...

Investigational new drugs, 2003

Fifty-five patients with metastatic renal cell carcinoma (RCC) were treated on a multicenter, sin... more Fifty-five patients with metastatic renal cell carcinoma (RCC) were treated on a multicenter, single-arm Phase II trial. Patients received single-agent Cetuximab (C225) administered by intravenous infusion at a loading dose of 400 or 500 mg/m2 followed by weekly maintenance doses at 250 mg/m2. None of the patients treated with C225 achieved either a complete or partial response. The median time to progression was 57 days. The most frequently reported grade 3 or 4 toxicity treatment-related adverse events were acne (17%) and rash or dry skin (4%). The lack of clinical response or suggestion of prolonging time to progression compared to historical data with interferon-alfa supports no further study of single-agent C225 in patients with metastatic RCC.

Radiologic Clinics of North America, 2007

Journal of the American College of Surgeons, 2010

BACKGROUND: CT imaging frequently detects subcentimeter pulmonary nodules (SPN) in patients under... more BACKGROUND: CT imaging frequently detects subcentimeter pulmonary nodules (SPN) in patients undergoing resection of colorectal cancer liver metastases. Their clinical significance is unknown. STUDY DESIGN: Patients were identified who underwent hepatic resection for colorectal cancer liver metastases between October 2004 and March 2006. The presence and imaging features of preoperative SPN were analyzed for their association with progression-free survival (PFS), disease-specific survival (DSS), and SPN progression.

Journal of the American College of Surgeons, 2009

BACKGROUND: Multidetector computed tomography (MDCT) scanning technology has increased the ease w... more BACKGROUND: Multidetector computed tomography (MDCT) scanning technology has increased the ease with which pulmonary emboli (PE) are evaluated. Our aim was to determine whether the incidence and severity of postoperative PE have changed since adoption of Multidetector computed tomography. STUDY DESIGN: A prospective postoperative morbidity and mortality database from a single institution was used to identify all cancer patients who experienced a PE within 30 days of thoracic, abdominal, or pelvic operations. The incidence, type (central, segmental, and subsegmental), and severity of PE were examined.

Journal of Pediatric Surgery, 2011

Purpose: To determine if selected computed tomography (CT) characteristics of pulmonary nodules i... more Purpose: To determine if selected computed tomography (CT) characteristics of pulmonary nodules in pediatric patients with osteosarcoma can help distinguish the nodules as benign or malignant. Methods: The institutional review board approved this HIPAA (Health Insurance Portability and Accountability Act-compliant, retrospective study of 30 pediatric osteosarcoma patients (median age 14 years, range 8-22) who underwent chest CT with resection of 117 pulmonary nodules from January 2001 to December 2006. Two pediatric radiologists and one chest radiologist independently and retrospectively reviewed the CT scans and classified nodules as benign, malignant, or indeterminate on the basis of nodule size, laterality, number, location, growth, density, margin appearance, and calcification. Generalized estimating equations were used to examine which characteristics were independent predictors of nodule malignancy. Results: Of the 117 nodules, 80 (68%) were malignant and 37 (32%) were benign by pathologic review. The readers correctly classified 93% to 94% of the malignant nodules. For benign lesions, the results were not as accurate, with the readers correctly classifying only 11% to 30% of lesions. Most of the benign lesions were classified as indeterminate by the readers (54%-65%). Nodule size (≥5 mm) and the presence of calcifications were associated with an increased probability of malignancy (P b .05). Conclusion: On chest CT, nodule size 5 mm or greater and the presence of calcifications are associated with an increased probability of malignant nodule histology in pediatric patients with osteosarcoma. However, nodule characteristics, apart from size and calcification, at chest CT cannot reliably distinguish benign from malignant pulmonary nodules in these patients.

Investigational New Drugs, 2007

In a phase I study, ixabepilone, a novel non-taxane microtubule-stabilizing agent, demonstrated a... more In a phase I study, ixabepilone, a novel non-taxane microtubule-stabilizing agent, demonstrated activity against both paclitaxel-sensitive and paclitaxel-refractory solid tumors. We conducted a phase II trial of this agent in patients with advanced germ cell tumors (GCT) who were resistant to conventional therapies. Patients with cisplatin-refractory GCT were enrolled in this single-institution, phase II trial. Ixabepilone was administered at a dose of 40 mg/m2 intravenously over 3 hours every 21 days. Dose modifications were planned according to a nomogram for adverse events. Responses were assessed every 6 weeks using tumor markers and radiographic imaging according to the Response Evaluation Criteria in Solid Tumors (RECIST). Patients who progressed (>or=20% increase in tumor size or rising serum tumor markers) were taken off protocol. Twenty-nine cycles of treatment were administered to 12 patients. The most common Grade 3/4 toxicities were leukopenia, lymphopenia, and neutropenia. One patient (8%) achieved a confirmed objective partial response but this patient had not received prior treatment with a taxane. Based on slow accrual and a lack of antitumor activity in patients previously treated with a taxane, the trial was closed after enrolling 12 patients. For patients who had previously received taxane therapy, ixabepilone was not efficacious in the treatment of cisplatin-refractory GCT.

CHEST Journal, 2007

Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported... more Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported. The adverse pulmonary effects of erlotinib are less well known. We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib. He had been found to have pathologic findings of usual interstitial pneumonia (UIP) on the resected lung cancer specimen prior to receiving erlotinib. This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD. Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.

The Annals of Thoracic Surgery, 1998

Background. This study was performed to assess chemical shift magnetic resonance imaging (CSMRI) ... more Background. This study was performed to assess chemical shift magnetic resonance imaging (CSMRI) for characterizing adrenal masses in patients with lung cancer, and to compare charges associated with two algorithms for assessing adrenal masses in these patients.

The Annals of Thoracic Surgery, 2002

The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over ... more The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over computed tomography alone in the staging of untreated nonsmall cell lung cancer (NSCLC). Aside from one 9-patient study, there are no data comparing FDG-PET imaging with surgical staging of NSCLC after induction therapy. We reviewed our institutional experience with FDG-PET imaging followed by surgical staging of nonsmall cell lung cancer after induction therapy. A nuclear physician blinded to surgical findings reviewed the FDG-PET scans and assigned a clinical TNM stage. A thoracic surgeon assigned a pathologic TNM stage. Then the clinical TNM stage and the pathologic TNM stage were compared. Fifty-six patients (30 males and 26 females; median, age 60) with nonsmall cell lung cancer underwent chemotherapy (40 patients), chemoradiation (11 patients), or radiation alone (5 patients) followed by PET and operations. PET had a positive predictive value of 98% for detecting residual viable disease in the primary tumor. PET over-staged nodal status in 33% of patients, under staged nodal status in 15%, and was correct in 52%. PET correctly classified all patients with M1 disease. Positron emission tomography after induction therapy accurately detects residual viable primary tumor, but not the involvement of mediastinal lymph nodes.

Annals of Oncology, 2006

Background: Accurate response assessment is essential for evaluating new cancer treatments. We ev... more Background: Accurate response assessment is essential for evaluating new cancer treatments. We evaluated the impact of Response Evaluation Criteria in Solid Tumors (RECIST), World Health Organization (WHO) criteria and tumor shape on response assessment in patients with metastatic esophageal cancer.

Academic Radiology, 2005

This document is a revision of a previously published cardiothoracic curriculum for diagnostic ra... more This document is a revision of a previously published cardiothoracic curriculum for diagnostic radiology residency (1), and reflects interval changes in the clinical practice of cardiothoracic radiology and changes in the Accreditation Council for Graduate Medical Education (ACGME) requirements for diagnostic radiology training programs. The revised ACGME Program Requirements for Residency Education in Diagnostic Radiology (2) went into effect December 2003.

Sarcoma, 2000

Background. Subcentimeter pulmonary nodules are being detected with increasing frequency in patie... more Background. Subcentimeter pulmonary nodules are being detected with increasing frequency in patients with sarcoma due to the greater use of chest CT, the advent of helical (spiral) CT scanning and multidetector scanners, and the attendant decrease in image section thickness.Assessing the clinical significance of these pulmonary nodules is of particular importance in sarcoma patients, due to the frequent occurrence of pulmonary metastasis from sarcomas.Purpose. This article reviews the technical advances that have contributed to the increased detection of subcentimeter pulmonary nodules, statistics about subcentimeter pulmonary nodules and options for evaluating such nodules.

Human pathology, 2006

A pulmonary carcinoid tumorlet (PCT) is a nodular proliferation of neuroendocrine cells smaller t... more A pulmonary carcinoid tumorlet (PCT) is a nodular proliferation of neuroendocrine cells smaller than 0.5 cm. On computed tomographic (CT) imaging, these nodules are nonspecific in appearance and can mimic metastatic disease. Cases of multiple PCTs diagnosed between 1992 and 2003 in patients with history of breast cancer were identified through a search of the pathology files. The clinical information was abstracted from the medical records. We identified 12 women with a history of breast cancer and biopsy-proven PCTs, who were treated at our institution in a period of 12 years. Only 3 women were smokers. The mean age at diagnosis of the breast cancer was 62.8 years. The breast cancer was invasive carcinoma in 10 cases (9 ductal and 1 lobular) and ductal carcinoma in situ and malignant phyllodes tumor in 1 case each. Six women received radiotherapy; 5, chemotherapy; and 4, hormonal treatment, alone or in combination. Pulmonary carcinoid tumorlets were identified within 5 months from ...

Medical Imaging 2004: Image Processing, 2004

In this work, we present a computer-aided detection (CAD) algorithm for small lung nodules on low... more In this work, we present a computer-aided detection (CAD) algorithm for small lung nodules on low-dose MSCT images. With this technique, identification of potential lung nodules is carried out with a local density maximum (LDM) algorithm, followed by reduction of false positives from the nodule candidates using task-specific 2-D/3-D features along with a knowledge-based nodule inclusion/exclusion strategy. Twenty-eight MSCT scans

Medical Imaging 2004: Image Processing, 2004

Liver segmentation is critical for the development of algorithms to detect and define focal lesio... more Liver segmentation is critical for the development of algorithms to detect and define focal lesions. It is also helpful in presurgical planning for hepatic resection and to gauge the results of therapies. The purpose of this study was to develop a computerized method for extraction of liver contours on contrast-enhanced hepatic CT. The method is based on a snake algorithm

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2006

Ground Glass Opacity (GGO) is defined as hazy increased attenuation within a lung that is not ass... more Ground Glass Opacity (GGO) is defined as hazy increased attenuation within a lung that is not associated with obscured underlying vessels. Since pure (nonsolid) or mixed (partially solid) GGO at the thin-section CT are more likely to be malignant than those with solid opacity, early detection and treatment of GGO can improve a prognosis of lung cancer. However, due to indistinct boundaries and inter- or intra-observer variation, consistent manual detection and segmentation of GGO have proved to be problematic. In this paper, we propose a novel method for automatic detection and segmentation of GGO from chest CT images. For GGO detection, we develop a classifier by boosting k-NN whose distance measure is the Euclidean distance between the nonparametric density estimates of two examples. The detected GGO region is then automatically segmented by analyzing the texture likelihood map of the region. We applied our method to clinical chest CT volumes containing 10 GGO nodules. The propose...

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006

Ground glass opacity (GGO) is defined as hazy increased attenuation within a lung that is not ass... more Ground glass opacity (GGO) is defined as hazy increased attenuation within a lung that is not associated with obscured underlying vessels. Since pure (non-solid) or mixed (partially solid) GGO at the thin-section CT are more likely to be malignant than those with solid opacity, early detection and treatment of GGO can improve a prognosis of lung cancer. However, due to indistinct boundaries and inter-or intra-observer variation, consistent manual detection and segmentation of GGO have proved to be problematic. In this paper, we propose a novel method for automatic detection and segmentation of GGO from chest CT images. For GGO detection, we develop a classifier by boosting k-nearest neighbor (k-NN), whose distance measure is the Euclidean distance between the nonparametric density estimates of two regions. The detected GGO region is then automatically segmented by analyzing the 3D texture likelihood map of the region. We applied our method to clinical chest CT volumes containing 10 ...

Investigational new drugs, 2003

Fifty-five patients with metastatic renal cell carcinoma (RCC) were treated on a multicenter, sin... more Fifty-five patients with metastatic renal cell carcinoma (RCC) were treated on a multicenter, single-arm Phase II trial. Patients received single-agent Cetuximab (C225) administered by intravenous infusion at a loading dose of 400 or 500 mg/m2 followed by weekly maintenance doses at 250 mg/m2. None of the patients treated with C225 achieved either a complete or partial response. The median time to progression was 57 days. The most frequently reported grade 3 or 4 toxicity treatment-related adverse events were acne (17%) and rash or dry skin (4%). The lack of clinical response or suggestion of prolonging time to progression compared to historical data with interferon-alfa supports no further study of single-agent C225 in patients with metastatic RCC.

Radiologic Clinics of North America, 2007

Journal of the American College of Surgeons, 2010

BACKGROUND: CT imaging frequently detects subcentimeter pulmonary nodules (SPN) in patients under... more BACKGROUND: CT imaging frequently detects subcentimeter pulmonary nodules (SPN) in patients undergoing resection of colorectal cancer liver metastases. Their clinical significance is unknown. STUDY DESIGN: Patients were identified who underwent hepatic resection for colorectal cancer liver metastases between October 2004 and March 2006. The presence and imaging features of preoperative SPN were analyzed for their association with progression-free survival (PFS), disease-specific survival (DSS), and SPN progression.

Journal of the American College of Surgeons, 2009

BACKGROUND: Multidetector computed tomography (MDCT) scanning technology has increased the ease w... more BACKGROUND: Multidetector computed tomography (MDCT) scanning technology has increased the ease with which pulmonary emboli (PE) are evaluated. Our aim was to determine whether the incidence and severity of postoperative PE have changed since adoption of Multidetector computed tomography. STUDY DESIGN: A prospective postoperative morbidity and mortality database from a single institution was used to identify all cancer patients who experienced a PE within 30 days of thoracic, abdominal, or pelvic operations. The incidence, type (central, segmental, and subsegmental), and severity of PE were examined.

Journal of Pediatric Surgery, 2011

Purpose: To determine if selected computed tomography (CT) characteristics of pulmonary nodules i... more Purpose: To determine if selected computed tomography (CT) characteristics of pulmonary nodules in pediatric patients with osteosarcoma can help distinguish the nodules as benign or malignant. Methods: The institutional review board approved this HIPAA (Health Insurance Portability and Accountability Act-compliant, retrospective study of 30 pediatric osteosarcoma patients (median age 14 years, range 8-22) who underwent chest CT with resection of 117 pulmonary nodules from January 2001 to December 2006. Two pediatric radiologists and one chest radiologist independently and retrospectively reviewed the CT scans and classified nodules as benign, malignant, or indeterminate on the basis of nodule size, laterality, number, location, growth, density, margin appearance, and calcification. Generalized estimating equations were used to examine which characteristics were independent predictors of nodule malignancy. Results: Of the 117 nodules, 80 (68%) were malignant and 37 (32%) were benign by pathologic review. The readers correctly classified 93% to 94% of the malignant nodules. For benign lesions, the results were not as accurate, with the readers correctly classifying only 11% to 30% of lesions. Most of the benign lesions were classified as indeterminate by the readers (54%-65%). Nodule size (≥5 mm) and the presence of calcifications were associated with an increased probability of malignancy (P b .05). Conclusion: On chest CT, nodule size 5 mm or greater and the presence of calcifications are associated with an increased probability of malignant nodule histology in pediatric patients with osteosarcoma. However, nodule characteristics, apart from size and calcification, at chest CT cannot reliably distinguish benign from malignant pulmonary nodules in these patients.

Investigational New Drugs, 2007

In a phase I study, ixabepilone, a novel non-taxane microtubule-stabilizing agent, demonstrated a... more In a phase I study, ixabepilone, a novel non-taxane microtubule-stabilizing agent, demonstrated activity against both paclitaxel-sensitive and paclitaxel-refractory solid tumors. We conducted a phase II trial of this agent in patients with advanced germ cell tumors (GCT) who were resistant to conventional therapies. Patients with cisplatin-refractory GCT were enrolled in this single-institution, phase II trial. Ixabepilone was administered at a dose of 40 mg/m2 intravenously over 3 hours every 21 days. Dose modifications were planned according to a nomogram for adverse events. Responses were assessed every 6 weeks using tumor markers and radiographic imaging according to the Response Evaluation Criteria in Solid Tumors (RECIST). Patients who progressed (>or=20% increase in tumor size or rising serum tumor markers) were taken off protocol. Twenty-nine cycles of treatment were administered to 12 patients. The most common Grade 3/4 toxicities were leukopenia, lymphopenia, and neutropenia. One patient (8%) achieved a confirmed objective partial response but this patient had not received prior treatment with a taxane. Based on slow accrual and a lack of antitumor activity in patients previously treated with a taxane, the trial was closed after enrolling 12 patients. For patients who had previously received taxane therapy, ixabepilone was not efficacious in the treatment of cisplatin-refractory GCT.

CHEST Journal, 2007

Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported... more Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported. The adverse pulmonary effects of erlotinib are less well known. We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib. He had been found to have pathologic findings of usual interstitial pneumonia (UIP) on the resected lung cancer specimen prior to receiving erlotinib. This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD. Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.

The Annals of Thoracic Surgery, 1998

Background. This study was performed to assess chemical shift magnetic resonance imaging (CSMRI) ... more Background. This study was performed to assess chemical shift magnetic resonance imaging (CSMRI) for characterizing adrenal masses in patients with lung cancer, and to compare charges associated with two algorithms for assessing adrenal masses in these patients.

The Annals of Thoracic Surgery, 2002

The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over ... more The 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) imaging is an advance over computed tomography alone in the staging of untreated nonsmall cell lung cancer (NSCLC). Aside from one 9-patient study, there are no data comparing FDG-PET imaging with surgical staging of NSCLC after induction therapy. We reviewed our institutional experience with FDG-PET imaging followed by surgical staging of nonsmall cell lung cancer after induction therapy. A nuclear physician blinded to surgical findings reviewed the FDG-PET scans and assigned a clinical TNM stage. A thoracic surgeon assigned a pathologic TNM stage. Then the clinical TNM stage and the pathologic TNM stage were compared. Fifty-six patients (30 males and 26 females; median, age 60) with nonsmall cell lung cancer underwent chemotherapy (40 patients), chemoradiation (11 patients), or radiation alone (5 patients) followed by PET and operations. PET had a positive predictive value of 98% for detecting residual viable disease in the primary tumor. PET over-staged nodal status in 33% of patients, under staged nodal status in 15%, and was correct in 52%. PET correctly classified all patients with M1 disease. Positron emission tomography after induction therapy accurately detects residual viable primary tumor, but not the involvement of mediastinal lymph nodes.

Annals of Oncology, 2006

Background: Accurate response assessment is essential for evaluating new cancer treatments. We ev... more Background: Accurate response assessment is essential for evaluating new cancer treatments. We evaluated the impact of Response Evaluation Criteria in Solid Tumors (RECIST), World Health Organization (WHO) criteria and tumor shape on response assessment in patients with metastatic esophageal cancer.

Academic Radiology, 2005

This document is a revision of a previously published cardiothoracic curriculum for diagnostic ra... more This document is a revision of a previously published cardiothoracic curriculum for diagnostic radiology residency (1), and reflects interval changes in the clinical practice of cardiothoracic radiology and changes in the Accreditation Council for Graduate Medical Education (ACGME) requirements for diagnostic radiology training programs. The revised ACGME Program Requirements for Residency Education in Diagnostic Radiology (2) went into effect December 2003.