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Papers by Miguel Ángel Estrada

Acta Biochimica Polonica, Feb 11, 2015

There is a natural protein form, insoluble and resistant to proteolysis, adopted by many proteins... more There is a natural protein form, insoluble and resistant to proteolysis, adopted by many proteins independently of their amino acid sequences via specific misfolding-aggregation process. This dynamic process occurs in parallel with or as an alternative to physiologic folding, generating toxic protein aggregates that are deposited and accumulated in various organs and tissues. These proteinaceous deposits typically represent bundles of β-sheet-enriched fibrillar species known as the amyloid fibrils that are responsible for serious pathological conditions, including but not limited to neurodegenerative diseases, grouped under the term amyloidoses. The proteins that might adopt this fibrillar conformation are some globular proteins and natively unfolded (or intrinsically disordered) proteins. Our work shows that intrinsically disordered and intrinsically ordered proteins can be reliably identified, discriminated, and differentiated by analyzing their polarity profiles generated using a computational tool known as the polarity index method (Polanco & Samaniego, 2009; Polanco et al., 2012; 2013; 2013a; 2014; 2014a; 2014b; 2014c; 2014d). We also show that proteins expressed in neurons can be differentiated from proteins in these two groups based on their polarity profiles, and also that this computational tool can be used to identify proteins associated with amyloidoses. The efficiency of the proposed method is high (i.e. 70%) as evidenced by the analysis of peptides and proteins in the APD2 database (2012), AVPpred database (2013), and CPPsite database (2013), the set of selective antibacterial peptides from del Rio et al. (2001), the sets of natively unfolded and natively folded proteins from Oldfield et al. (2005), the set of human revised proteins expressed in neurons, and non-human revised proteins expressed in neurons, from the Uniprot database (2014), and also the set of amyloidogenic proteins from the AmyPDB database (2014).

Inventio La Genesis De La Cultura Universitaria En Morelos, 2014

Profesor e investigador, Instituto Profesional de la Región Oriente (IPRO), UAEM Doctorado en Cie... more Profesor e investigador, Instituto Profesional de la Región Oriente (IPRO), UAEM Doctorado en Ciencias Sociales, Instituto Profesional de la Región Oriente (IPRO), UAEM E n este artículo se presenta un panorama general de los vínculos entre el discurso, el poder y las instituciones. Algunas de las preguntas que se intentan responder en este trabajo son las siguientes: ¿qué es el discurso y cómo se relaciona con las instituciones?, ¿cómo el poder se vincula con el discurso?, ¿por qué es importante vislumbrar y entender las relaciones sociales considerando el discurso, las instituciones y el poder?

Embodiments of the present invention address deficiencies of the art in respect to activity threa... more Embodiments of the present invention address deficiencies of the art in respect to activity thread management and provide a method, system and computer program product for activity objectification for non-activity objects in an activity-centric collaboration tool. In an embodiment of the invention, a method for activity objectifying non-activity/task objects in an activity-centric collaboration tool can be provided. The method can include selecting a non-activity/task object in an activity thread for an activity map of the activity-centric ...

Reumatología Clínica, 2013

información del artículo Historia del artículo: Recibido el 15 de agosto de 2012 Aceptado el 21 d... more información del artículo Historia del artículo: Recibido el 15 de agosto de 2012 Aceptado el 21 de noviembre de 2012 On-line el 8 de febrero de 2013 Palabras clave: Biosimilar Biocomparable Artritis reumatoide Biológicos Biotecnológicos Fármacos innovadores

Applied Catalysis A: General, 2011

Selective oxidation of arabinose to arabinonic acid was carried out isothermally in a shaker reac... more Selective oxidation of arabinose to arabinonic acid was carried out isothermally in a shaker reactor at moderate conditions of 60 • C and pH 8 on Pd-Au catalysts supported on nanosized alumina and ceria. The gold (4 wt.%) was supported by deposition-precipitation (DP) using HAuCl 4 and urea with subsequent chemisorption of palladium (1 wt.%) using PdCl 2 . Before catalytic tests, samples were treated in hydrogen or oxygen at 300 • C, or by aqueous solution of formaldehyde at room temperature. Synthesized bimetallic Pd-Au catalysts are characterized with higher activity in the selective aqueous phase oxidation of arabinose to arabinonic acid by molecular oxygen in comparison with monometallic ones. Activity and selectivity of catalysts depend on the sample treatment and the nature of the support used. Pd-Au/CeO 2 catalyst reduced by formaldehyde manifests the highest activity and selectivity. The synthesized bimetallic catalysts have been characterized by TEM, XPS and UV-vis techniques under different stages of sample activation. Mutual interactions of supported gold and palladium species depending on the support nature and sample treatment were observed. A more pronounced interaction between gold and palladium species was observed for Pd-Au/Al 2 O 3 catalyst, while interactions of Au and Pd with reducible ceria coexist with the mutual interaction between these metals. Gold metallic species seem to be responsible for activation of arabinose while an easy redox transformation of Pd species can provoke oxygen activation. Thus, gold species or Au-Pd alloy covered with thin PdO film manifest a synergetic effect in the selective arabinose oxidation by molecular oxygen.

Applied Catalysis A: General, 2009

Catalytic deoxygenation of palmitic and stearic acids mixture was studied over four synthesized P... more Catalytic deoxygenation of palmitic and stearic acids mixture was studied over four synthesized Pd catalysts supported on synthetic carbon (Sibunit) in a semibatch reactor and dodecane as a solvent at 260-300 8C. The catalysts were prepared by precipitation deposition method using Pd chlorides as metal precursors. All catalysts contained 1 wt.% Pd, however, the metal dispersion was systematically varied. An optimum metal dispersion giving the highest reaction rate was observed. The main liquid phase products were n-heptadecane and n-pentadecane, which were formed in parallel. In addition to the particle size effect the impact of mass transfer was elucidated and a detail discussion on temperature programmed desorption of CO from the fresh and spent samples was provided.

Actualmente, en las escuelas aumenta la reproducción de dinámicas de convivencia negativas, las c... more Actualmente, en las escuelas aumenta la reproducción de dinámicas de convivencia negativas, las cuales están siendo consideradas como nuevas, aunque siempre han estado presentes, esto se debe a que se trata de un tema que recientemente retomó importancia. Dentro de las principales manifestaciones se encuentra el acoso escolar, en todas sus modalidades: mobbing, bullying, acoso del docente al alumno y acoso del alumno al docente. Algunos de los detonantes del citado fenómeno son el ambiente y el clima escolar.

Acta Biochimica Polonica, Feb 11, 2015

There is a natural protein form, insoluble and resistant to proteolysis, adopted by many proteins... more There is a natural protein form, insoluble and resistant to proteolysis, adopted by many proteins independently of their amino acid sequences via specific misfolding-aggregation process. This dynamic process occurs in parallel with or as an alternative to physiologic folding, generating toxic protein aggregates that are deposited and accumulated in various organs and tissues. These proteinaceous deposits typically represent bundles of β-sheet-enriched fibrillar species known as the amyloid fibrils that are responsible for serious pathological conditions, including but not limited to neurodegenerative diseases, grouped under the term amyloidoses. The proteins that might adopt this fibrillar conformation are some globular proteins and natively unfolded (or intrinsically disordered) proteins. Our work shows that intrinsically disordered and intrinsically ordered proteins can be reliably identified, discriminated, and differentiated by analyzing their polarity profiles generated using a computational tool known as the polarity index method (Polanco & Samaniego, 2009; Polanco et al., 2012; 2013; 2013a; 2014; 2014a; 2014b; 2014c; 2014d). We also show that proteins expressed in neurons can be differentiated from proteins in these two groups based on their polarity profiles, and also that this computational tool can be used to identify proteins associated with amyloidoses. The efficiency of the proposed method is high (i.e. 70%) as evidenced by the analysis of peptides and proteins in the APD2 database (2012), AVPpred database (2013), and CPPsite database (2013), the set of selective antibacterial peptides from del Rio et al. (2001), the sets of natively unfolded and natively folded proteins from Oldfield et al. (2005), the set of human revised proteins expressed in neurons, and non-human revised proteins expressed in neurons, from the Uniprot database (2014), and also the set of amyloidogenic proteins from the AmyPDB database (2014).

Inventio La Genesis De La Cultura Universitaria En Morelos, 2014

Profesor e investigador, Instituto Profesional de la Región Oriente (IPRO), UAEM Doctorado en Cie... more Profesor e investigador, Instituto Profesional de la Región Oriente (IPRO), UAEM Doctorado en Ciencias Sociales, Instituto Profesional de la Región Oriente (IPRO), UAEM E n este artículo se presenta un panorama general de los vínculos entre el discurso, el poder y las instituciones. Algunas de las preguntas que se intentan responder en este trabajo son las siguientes: ¿qué es el discurso y cómo se relaciona con las instituciones?, ¿cómo el poder se vincula con el discurso?, ¿por qué es importante vislumbrar y entender las relaciones sociales considerando el discurso, las instituciones y el poder?

Embodiments of the present invention address deficiencies of the art in respect to activity threa... more Embodiments of the present invention address deficiencies of the art in respect to activity thread management and provide a method, system and computer program product for activity objectification for non-activity objects in an activity-centric collaboration tool. In an embodiment of the invention, a method for activity objectifying non-activity/task objects in an activity-centric collaboration tool can be provided. The method can include selecting a non-activity/task object in an activity thread for an activity map of the activity-centric ...

Reumatología Clínica, 2013

información del artículo Historia del artículo: Recibido el 15 de agosto de 2012 Aceptado el 21 d... more información del artículo Historia del artículo: Recibido el 15 de agosto de 2012 Aceptado el 21 de noviembre de 2012 On-line el 8 de febrero de 2013 Palabras clave: Biosimilar Biocomparable Artritis reumatoide Biológicos Biotecnológicos Fármacos innovadores

Applied Catalysis A: General, 2011

Selective oxidation of arabinose to arabinonic acid was carried out isothermally in a shaker reac... more Selective oxidation of arabinose to arabinonic acid was carried out isothermally in a shaker reactor at moderate conditions of 60 • C and pH 8 on Pd-Au catalysts supported on nanosized alumina and ceria. The gold (4 wt.%) was supported by deposition-precipitation (DP) using HAuCl 4 and urea with subsequent chemisorption of palladium (1 wt.%) using PdCl 2 . Before catalytic tests, samples were treated in hydrogen or oxygen at 300 • C, or by aqueous solution of formaldehyde at room temperature. Synthesized bimetallic Pd-Au catalysts are characterized with higher activity in the selective aqueous phase oxidation of arabinose to arabinonic acid by molecular oxygen in comparison with monometallic ones. Activity and selectivity of catalysts depend on the sample treatment and the nature of the support used. Pd-Au/CeO 2 catalyst reduced by formaldehyde manifests the highest activity and selectivity. The synthesized bimetallic catalysts have been characterized by TEM, XPS and UV-vis techniques under different stages of sample activation. Mutual interactions of supported gold and palladium species depending on the support nature and sample treatment were observed. A more pronounced interaction between gold and palladium species was observed for Pd-Au/Al 2 O 3 catalyst, while interactions of Au and Pd with reducible ceria coexist with the mutual interaction between these metals. Gold metallic species seem to be responsible for activation of arabinose while an easy redox transformation of Pd species can provoke oxygen activation. Thus, gold species or Au-Pd alloy covered with thin PdO film manifest a synergetic effect in the selective arabinose oxidation by molecular oxygen.

Applied Catalysis A: General, 2009

Catalytic deoxygenation of palmitic and stearic acids mixture was studied over four synthesized P... more Catalytic deoxygenation of palmitic and stearic acids mixture was studied over four synthesized Pd catalysts supported on synthetic carbon (Sibunit) in a semibatch reactor and dodecane as a solvent at 260-300 8C. The catalysts were prepared by precipitation deposition method using Pd chlorides as metal precursors. All catalysts contained 1 wt.% Pd, however, the metal dispersion was systematically varied. An optimum metal dispersion giving the highest reaction rate was observed. The main liquid phase products were n-heptadecane and n-pentadecane, which were formed in parallel. In addition to the particle size effect the impact of mass transfer was elucidated and a detail discussion on temperature programmed desorption of CO from the fresh and spent samples was provided.

Actualmente, en las escuelas aumenta la reproducción de dinámicas de convivencia negativas, las c... more Actualmente, en las escuelas aumenta la reproducción de dinámicas de convivencia negativas, las cuales están siendo consideradas como nuevas, aunque siempre han estado presentes, esto se debe a que se trata de un tema que recientemente retomó importancia. Dentro de las principales manifestaciones se encuentra el acoso escolar, en todas sus modalidades: mobbing, bullying, acoso del docente al alumno y acoso del alumno al docente. Algunos de los detonantes del citado fenómeno son el ambiente y el clima escolar.