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Papers by Miguel Angel Salazar

The Journal of Infectious Diseases, 2000

Pulmonary surfactant and its components are essential for normal lung function and are involved i... more Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A 3 , 6A 4 , and B1013_A and protective AAGG_1, and AAGG_7 marker alleles were observed. Moreover, interactions were seen between alleles 6A 2 and 1A 3 ( ) and between 1A 3 and B1013_A ( ). The P p .0064 P p .036 findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.

The journal of sexual medicine, 2010

Sexual life of psychiatric patients, including risk behaviors related to sexually transmitted dis... more Sexual life of psychiatric patients, including risk behaviors related to sexually transmitted diseases, remains a poorly studied area, especially in those with severe mental illnesses. Aims. To assess some aspects of lifetime sexual behavior of psychiatric inpatients. Methods. Patients consecutively admitted to a psychiatric unit in a general hospital were interviewed about partnerrelated lifetime sexual behavior. Main Outcome Measures. A semi-structured interview developed by the authors was used to collect information concerning their general sexual experience throughout life, homosexual and heterosexual relations, and relations with partners who were intravenous drug users (IVDU), HIV carriers or suffering from AIDS, and with sex workers. In each of these areas, time elapsed since last sexual contact; number of partners in previous year, frequency of these relations and condom use were investigated. Results. Five hundred forty-six patients (306 men and 240 women) were assessed, and 87.7% of them reported sexual relations at some point during their life. Of these, 90% reported heterosexual and 10% homosexual or bisexual sexual contacts. Further, 11.06% had had at least one partner who was an IVDU; 8.1% an HIV-positive partner, and 32.4% (50% of the men) had paid for sex. Overall 49.79% of the total sample reported never using condoms in their sexual relations, with similar percentages for those with HIV-positive (46%) and IVDU (47%) partners. Of those who paid for sex, 29% never used condoms. Conclusions. Psychiatric patients admitted to a general hospital psychiatric unit have sexual experience close to the general population, with a higher percentage of homosexual contacts and lower rates of condom use, even in higher risk situations, such as men having sex with men, and partners who are HIV-positive or IVDUs. This information obliges clinicians to systematically explore the sexual behavior of psychiatric patients, evaluate risk behaviors, and adopt measures to promote safe sex practices in this population.

CHEST Journal, 2005

METHODS: This study was a cross-sectional survey based on the retrospective analysis of data of t... more METHODS: This study was a cross-sectional survey based on the retrospective analysis of data of tuberculosis patients and was conducted at National Institute of Respiratory Diseases (INER), Mexico. RESULTS: One hundred and twenty four tuberculosis patients ...

Bioorganic & Medicinal Chemistry Letters, 1994

Heteroatom substitution within the zileuton nucleus led to a congener series which was evaluated ... more Heteroatom substitution within the zileuton nucleus led to a congener series which was evaluated for potency and rate of glucuronidation, a major route for elimination of zileuton. Subtle changes in structure were found to significantly effect glucuronidation rate.

 Cargas a tener en cuenta en el análisis  Para cada situación de diseño deben obtenerse las car... more  Cargas a tener en cuenta en el análisis  Para cada situación de diseño deben obtenerse las cargas concentradas o distribuidas que pueden afectar la estructura de contención tales como peso del suelo, la roca y el agua, presiones de tierra, presiones estáticas de agua, presiones dinámicas del agua, sobrecarga y cargas sísmicas.  Es necesario algunas veces analizar las diversas combinaciones posibles de cargas y diseñar para la condición más crítica.

The Journal of Infectious Diseases, 2000

Pulmonary surfactant and its components are essential for normal lung function and are involved i... more Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A 3 , 6A 4 , and B1013_A and protective AAGG_1, and AAGG_7 marker alleles were observed. Moreover, interactions were seen between alleles 6A 2 and 1A 3 ( ) and between 1A 3 and B1013_A ( ). The P p .0064 P p .036 findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.

The journal of sexual medicine, 2010

Sexual life of psychiatric patients, including risk behaviors related to sexually transmitted dis... more Sexual life of psychiatric patients, including risk behaviors related to sexually transmitted diseases, remains a poorly studied area, especially in those with severe mental illnesses. Aims. To assess some aspects of lifetime sexual behavior of psychiatric inpatients. Methods. Patients consecutively admitted to a psychiatric unit in a general hospital were interviewed about partnerrelated lifetime sexual behavior. Main Outcome Measures. A semi-structured interview developed by the authors was used to collect information concerning their general sexual experience throughout life, homosexual and heterosexual relations, and relations with partners who were intravenous drug users (IVDU), HIV carriers or suffering from AIDS, and with sex workers. In each of these areas, time elapsed since last sexual contact; number of partners in previous year, frequency of these relations and condom use were investigated. Results. Five hundred forty-six patients (306 men and 240 women) were assessed, and 87.7% of them reported sexual relations at some point during their life. Of these, 90% reported heterosexual and 10% homosexual or bisexual sexual contacts. Further, 11.06% had had at least one partner who was an IVDU; 8.1% an HIV-positive partner, and 32.4% (50% of the men) had paid for sex. Overall 49.79% of the total sample reported never using condoms in their sexual relations, with similar percentages for those with HIV-positive (46%) and IVDU (47%) partners. Of those who paid for sex, 29% never used condoms. Conclusions. Psychiatric patients admitted to a general hospital psychiatric unit have sexual experience close to the general population, with a higher percentage of homosexual contacts and lower rates of condom use, even in higher risk situations, such as men having sex with men, and partners who are HIV-positive or IVDUs. This information obliges clinicians to systematically explore the sexual behavior of psychiatric patients, evaluate risk behaviors, and adopt measures to promote safe sex practices in this population.

CHEST Journal, 2005

METHODS: This study was a cross-sectional survey based on the retrospective analysis of data of t... more METHODS: This study was a cross-sectional survey based on the retrospective analysis of data of tuberculosis patients and was conducted at National Institute of Respiratory Diseases (INER), Mexico. RESULTS: One hundred and twenty four tuberculosis patients ...

Bioorganic & Medicinal Chemistry Letters, 1994

Heteroatom substitution within the zileuton nucleus led to a congener series which was evaluated ... more Heteroatom substitution within the zileuton nucleus led to a congener series which was evaluated for potency and rate of glucuronidation, a major route for elimination of zileuton. Subtle changes in structure were found to significantly effect glucuronidation rate.

 Cargas a tener en cuenta en el análisis  Para cada situación de diseño deben obtenerse las car... more  Cargas a tener en cuenta en el análisis  Para cada situación de diseño deben obtenerse las cargas concentradas o distribuidas que pueden afectar la estructura de contención tales como peso del suelo, la roca y el agua, presiones de tierra, presiones estáticas de agua, presiones dinámicas del agua, sobrecarga y cargas sísmicas.  Es necesario algunas veces analizar las diversas combinaciones posibles de cargas y diseñar para la condición más crítica.