Miguel Martins - Academia.edu (original) (raw)
Papers by Miguel Martins
Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 2017
Portugal is one of the European countries with the highest antibiotic consumption rate and, conse... more Portugal is one of the European countries with the highest antibiotic consumption rate and, consequently, the highest rates of bacterial resistance. Dentistry's contribution to that problem can be substantial because dentists prescribe approximately 10% of all common antibiotics. The purpose of this study was to characterize the prescription of systemic antibiotics for pulpal and periapical pathology in a sample of Portuguese dentists. Methods: A cross-sectional study was conducted in dentists working in the city of Viseu. A total of 135 questionnaires were distributed among all dental clinics and dental offices of Viseu. Results: The overall response rate was 70% (n = 95). The vast majority of dentists prescribed antibiotics for 8 days (78.9%). The most commonly prescribed antibiotic therapy was the association 875-mg amoxicillin with 125-mg clavulanic acid (82.1%). In cases of sensitivity to penicillin, the most prescribed antibiotics were 500-mg clarithromycin (34.7%) and 500-mg azithromycin (33.7%). A considerable percentage of dentists prescribed antibiotics for situations of irreversible pulpitis, pulp necrosis without systemic involvement, fistula and endodontic retreatment. Conclusions: A considerable part of the inquired dentists prescribed antibiotics inappropriately for endodontic inflammatory conditions such as pulpitis. This kind of behavior could contribute to the world problem of antimicrobial resistance. It is important that dentists understand the importance of restricting the use of antibiotics for cases of severe infection, when they are truly needed.
Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 2014
r e v p o r t e s t o m a t o l m e d d e n t c i r m a x i l o f a c. 2 0 1 4;5 5(S 1):e1-e44 e1... more r e v p o r t e s t o m a t o l m e d d e n t c i r m a x i l o f a c. 2 0 1 4;5 5(S 1):e1-e44 e15 Resultados: O valor médio de HK no topo variou entre 33,0 (Silorane, 6 mm, fabricante) e 66,3 (GrandioSO, 0 mm, 2 x fabricante) e na base entre 22,7 (Herculite, 6 mm, fabricante) e 64,8 (GrandioSO, 0 mm, 2 x fabricante). Tanto o tipo de compósito (p < 0,001) como a distância da luz (p = 0,003) influenciaram de forma significativa a HK do topo dos espécimes. No entanto, a HK do topo não foi influenciada pelo tempo de exposição à luz (p = 0,457). O aumento do tempo de exposiç ão permitiu, com uma distância de 4 mm, obter um ratio de microdureza igual ou superior a 0,80 em todos os compósitos estudados. Em nenhuma das situaç ões experimentais com a fonte de luz a 6 mm foi obtida uma correta polimerização. Conclusões: O aumento da distância à luz diminuiu a capacidade de fotopolimerizaç ão do compósito. A duplicação do tempo de fotopolimerizaç ão permitiu a obtenç ão de um adequado grau de conversão com a fonte de luz a 4 mm.
Biology of Blood and Marrow Transplantation, 2013
Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternativ... more Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternative for patients lacking a human leukocyte antigen (HLA)-matched donor. Although the use of haploidentical donors is increasingly common, the long-term impact of generating a donor-derived immune system in the context of an HLA-mismatched thymic environment remains poorly characterized. We performed an in-depth assessment of immune reconstitution in a group of haploidentical HSCT recipients 4 to 6 years posttransplantation, in parallel with the respective parental donors and age-matched healthy control subjects. Our data show that the proportion of naive and memory subsets in the recipients, both within CD8 þ and CD4 þ T cells, more closely resembled that observed in age-matched control subjects than in the donors. HSCT recipients displayed relatively high signal-joint T cellereceptor excision circle levels and a high frequency of the recent thymic emigranteenriched CD31 þ subset within naive CD4 þ and naive regulatory T cells. Moreover, CD8 þ , CD4 þ , and regulatory T cells from HSCT recipients displayed a diverse T cell repertoire. These results support a key role for thymic output in T cell reconstitution. Nevertheless, HSCT recipients had significantly shorter telomeres within a naive-enriched CD4 þ T cell population than age-matched control subjects, despite the similar telomere length observed within the most differentiated CD8 þ and CD4 þ T cell subsets. Overall, our data suggest that long-term immune reconstitution was successfully achieved after haploidentical HSCT, a process that appears to have largely relied on de novo T cell production.
Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 2017
Portugal is one of the European countries with the highest antibiotic consumption rate and, conse... more Portugal is one of the European countries with the highest antibiotic consumption rate and, consequently, the highest rates of bacterial resistance. Dentistry's contribution to that problem can be substantial because dentists prescribe approximately 10% of all common antibiotics. The purpose of this study was to characterize the prescription of systemic antibiotics for pulpal and periapical pathology in a sample of Portuguese dentists. Methods: A cross-sectional study was conducted in dentists working in the city of Viseu. A total of 135 questionnaires were distributed among all dental clinics and dental offices of Viseu. Results: The overall response rate was 70% (n = 95). The vast majority of dentists prescribed antibiotics for 8 days (78.9%). The most commonly prescribed antibiotic therapy was the association 875-mg amoxicillin with 125-mg clavulanic acid (82.1%). In cases of sensitivity to penicillin, the most prescribed antibiotics were 500-mg clarithromycin (34.7%) and 500-mg azithromycin (33.7%). A considerable percentage of dentists prescribed antibiotics for situations of irreversible pulpitis, pulp necrosis without systemic involvement, fistula and endodontic retreatment. Conclusions: A considerable part of the inquired dentists prescribed antibiotics inappropriately for endodontic inflammatory conditions such as pulpitis. This kind of behavior could contribute to the world problem of antimicrobial resistance. It is important that dentists understand the importance of restricting the use of antibiotics for cases of severe infection, when they are truly needed.
Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 2014
r e v p o r t e s t o m a t o l m e d d e n t c i r m a x i l o f a c. 2 0 1 4;5 5(S 1):e1-e44 e1... more r e v p o r t e s t o m a t o l m e d d e n t c i r m a x i l o f a c. 2 0 1 4;5 5(S 1):e1-e44 e15 Resultados: O valor médio de HK no topo variou entre 33,0 (Silorane, 6 mm, fabricante) e 66,3 (GrandioSO, 0 mm, 2 x fabricante) e na base entre 22,7 (Herculite, 6 mm, fabricante) e 64,8 (GrandioSO, 0 mm, 2 x fabricante). Tanto o tipo de compósito (p < 0,001) como a distância da luz (p = 0,003) influenciaram de forma significativa a HK do topo dos espécimes. No entanto, a HK do topo não foi influenciada pelo tempo de exposição à luz (p = 0,457). O aumento do tempo de exposiç ão permitiu, com uma distância de 4 mm, obter um ratio de microdureza igual ou superior a 0,80 em todos os compósitos estudados. Em nenhuma das situaç ões experimentais com a fonte de luz a 6 mm foi obtida uma correta polimerização. Conclusões: O aumento da distância à luz diminuiu a capacidade de fotopolimerizaç ão do compósito. A duplicação do tempo de fotopolimerizaç ão permitiu a obtenç ão de um adequado grau de conversão com a fonte de luz a 4 mm.
Biology of Blood and Marrow Transplantation, 2013
Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternativ... more Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternative for patients lacking a human leukocyte antigen (HLA)-matched donor. Although the use of haploidentical donors is increasingly common, the long-term impact of generating a donor-derived immune system in the context of an HLA-mismatched thymic environment remains poorly characterized. We performed an in-depth assessment of immune reconstitution in a group of haploidentical HSCT recipients 4 to 6 years posttransplantation, in parallel with the respective parental donors and age-matched healthy control subjects. Our data show that the proportion of naive and memory subsets in the recipients, both within CD8 þ and CD4 þ T cells, more closely resembled that observed in age-matched control subjects than in the donors. HSCT recipients displayed relatively high signal-joint T cellereceptor excision circle levels and a high frequency of the recent thymic emigranteenriched CD31 þ subset within naive CD4 þ and naive regulatory T cells. Moreover, CD8 þ , CD4 þ , and regulatory T cells from HSCT recipients displayed a diverse T cell repertoire. These results support a key role for thymic output in T cell reconstitution. Nevertheless, HSCT recipients had significantly shorter telomeres within a naive-enriched CD4 þ T cell population than age-matched control subjects, despite the similar telomere length observed within the most differentiated CD8 þ and CD4 þ T cell subsets. Overall, our data suggest that long-term immune reconstitution was successfully achieved after haploidentical HSCT, a process that appears to have largely relied on de novo T cell production.