Branislava Milenkovic - Academia.edu (original) (raw)
Papers by Branislava Milenkovic
European Respiratory Journal, 2015
European Respiratory Journal, 2016
European Respiratory Journal, 2016
European Respiratory Journal, 2014
The BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index is well-valida... more The BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index is well-validated for mortality prediction in chronic obstructive pulmonary disease (COPD). Concentrations of plasma pro-adrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among inpatients with COPD exacerbation. We compared accuracy of initial pro-adrenomedullin level, BODE and BODE components, alone or combined, in predicting 1-year or 2-year all-cause mortality in a multicentre, multinational observational cohort with stable, moderate to very severe COPD. Pro-adrenomedullin was significantly associated (p<0.001) with 1-year mortality (4.7%) and 2-year mortality (7.8%) and comparably predictive to BODE regarding both (C statistics 0.691 versus 0.745 and 0.635 versus 0.679, respectively). Relative to using BODE alone, adding pro-adrenomedullin significantly improved 1-year and 2-year mortality prognostication (C statistics 0.750 and 0.818, respectively; both p<0.001). Pro-adrenomedullin plus BOD was more predictive than the original BODE including 6-min walk distance. In multivariable analysis, pro-adrenomedullin (likelihood ratio Chi-squared 13.0, p<0.001), body mass index (8.5, p=0.004) and 6-min walk distance (7.5, p=0.006) independently foretold 2-year survival, but modified Medical Research Council dyspnoea score (2.2, p=0.14) and forced expiratory volume in 1 s % predicted (0.3, p=0.60) did not. Pro-adrenomedullin plus BODE better predicts mortality in COPD patients than does BODE alone; pro-adrenomedullin may substitute for 6-min walk distance in BODE when 6-min walk testing is unavailable.
Case reports in surgery, 2017
New onset of electrocardiographic (ECG) abnormalities can occur after lung surgery due to the cha... more New onset of electrocardiographic (ECG) abnormalities can occur after lung surgery due to the changes in the position of structures and organs in the chest cavity. The most common heart rhythm disorder is atrial fibrillation. So-called "pseudoischemic" ECG changes that mimic classic ECG signs of acute myocardial ischemia are also often noticed. We report the case of a 68-year-old male, with no prior cardiovascular disease, who underwent extensive surgical resection for lung cancer. On a second postoperative day, clinical and electrocardiographic signs of acute myocardial ischemia occurred. According to clinical course, diagnostic procedures, and therapeutic response, we excluded acute coronary syndrome. We concluded that physical lesion of the pericardium, caused by extended pneumonectomy with resection of the pericardium, provoked the symptoms and ECG signs that mimic acute coronary syndrome. Our final diagnosis was postpericardiotomy syndrome after extended pneumonectomy...
Med Oncol, 2009
The patient suffered loss of consciousness, dysarthria and right sided hemiparesis. The CT scan a... more The patient suffered loss of consciousness, dysarthria and right sided hemiparesis. The CT scan and MRI scans were negative. These findings are more in keeping with a diagnosis of Transient Ischemic Attack (TIA) or mild CVA. Hypoglycemia per se does not usually cause hemiparesis. The blood glucose level was low but I am not sure if one can conclude that hypoglycemia caused the above noted neurological signs and symptoms. The authors do not present any data to prove that this patient had ''hypoglycemic coma''.
Srpski Arhiv Za Celokupno Lekarstvo, 2007
Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod So ... more Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod So li tar nifi bro znitu mo riple u resuret ki.Ot kri va juseslu čaj noilibo le sni ciima june spe ci fič nere spi ra ci o nesimp to me.Isto vre me nopo sto ja weso li tar nogfi bro znogtu mo reple u reihi po gli ke mi jena zi vaseDe ge-Po te rov (Do e ge-Pot ter)sin drom. Pri kaz bo le sni ka Bo le sni casta ra68go di napri mqe najeuIn sti tutzapluć nebo le stiitu ber ku lo zuKli nič kogcen tra Sr bi jeuBe o gra dura diis pi ti va waeti o lo gi jeve li kogtu mo raple u re.Ne ko li kogo di naseža li lanagla vo bo quisla bukon cen tra ci ju,apo sled wihgo di nuda nanapro gre siv nudisp no juibolugru di made sno.Nara di o gra mugrud nogko šauoče no jeogrom noza sen če weko jejeza hva ti losko roceode snihe mi to raks.En do kri no lo škimis pi ti va wi majeot kri veniz u zet noni zakni vogli ke mi jeuse ru mu,doksukon cen tra ci jein su li na,Cpep ti da,glu ka go na,hor mo nara staika te ho la mi nabi le nor mal ne.Hi sto lo škaiimu no hi sto he mij skaana li zama te ri ja lado bi je nogbi op si jomiglompo tvr di lajedi jag no zube nig nogso li tar nogfi bro znogtu mo raple u re.Iakojehi rur škole če webiome todiz bo razaovubo le sni cusogrom nimtu mo romihi po gli ke mi jom,onajeod bi laope ra ci juiod lu či lasezakon zer va tiv nole če wein tra ven skompri me nomglu ko ze. Za kqu čak Le ka ritre badais kqu čefi bro znetu mo reple u reuto kuis pi ti va wabo le sni kasahi po gli ke mi jom,iakosuove neo pla zmere dak,alizna ča jan,uzrokhi po gli ke mi ja. Kquč ne re či:so li tar nifi bro znitu morple u re;hi po gli ke mi ja;Dege-Poterovsindrom
Annals of the Academy of Medicine Singapore, May 1, 2012
INTRODUCTION: Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonar... more INTRODUCTION: Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonary infections. Although rare, they are an important differential diagnosis as they may mimic other conditions and diseases. This paper aims to analyse clinical, radiological and histological characteristics of the patients with tracheobronchial tumours diagnosed for a period of 7 years.MATERIALS AND METHODS: In this retrospective, observational study, we carefully reviewed 65 patients who were diagnosed with tracheal and endobronchial tumours, and performed statistical analysis on the results.RESULTS: Among these 65 patients (36 men and 29 women) with a mean age of 48.8 years (range, 15 to 75), 50 had malignant tumours while 15 had benign ones. The most common symptoms were cough, chest pain and haemoptysis. Cough was a more frequent symptom in patients with benign tumours (P <0.0014). Only 2 patients were asymptomatic. Tumours were predominantly localised in the large airways (46 in large bronchi and 2 in trachea). The most common radiological manifestation of malignant tumours was tumour mass (46%) followed by atelectasis. One third benign tumour caused atelectasis, while tumour mass and consolidation were found in 3 patients each. Computerised tomography revealed endoluminal tumour mass in 29.2% of the cases, which was more frequently found in benign than malignant tumours (47% vs 24%, respectively). On bronchoscopy, tumours were visible in 73% and 70% benign and malignant cases respectively.CONCLUSION: Tracheobronchial tumours should be ruled as a possible diagnosis in patients with cough, haemoptysis, dyspnoea and chest pain. The imaging techniques and histological examination of the tissue would subsequently lead to correct diagnosis and proper treatment can be administered.
European Respiratory Journal, Sep 1, 2011
European Respiratory Journal, Sep 1, 2012
Number: 2381 Publication Number: P629 Abstract Group: 1.2. Rehabilitation and Chronic Care Keywor... more Number: 2381 Publication Number: P629 Abstract Group: 1.2. Rehabilitation and Chronic Care Keyword 1: Asthma -management Keyword 2: COPD -management Keyword 3: Physiological diagnostic services Title: Psychologicl distress in asthma and COPD Prof. Dr Branislava 17046 Milenkovic branislava.milenkovic@kcs.ac.rs MD 1,2 , Prof. Dr Aleksandra 17047 Ilic sanjadudvarski@yahoo.com MD 1,2 and Dr. Sanja 17048 Dimic-Janjic sanjadimic77@yahoo.com MD 2 .
Medicinski Pregled, Sep 1, 2014
Acta Dermatovenerologica Croatica, Jul 15, 2011
Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of... more Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of the neck with acral progression, sparing hands and feet. We report on a 57-year-old male with severe SA associated with paraproteinemia, treated with methotrexate. Such widespread skin thickening followed by severe movement restriction and inability to function on daily basis, as in our patient, has never been described. Severe osteoarthritis and finding of HLA-B39 allele in association with SA has not been previously described either. To the best of our knowledge, up to 40 patients with SA associated with paraproteinemia has been reported so far, and currently, there is no established effective treatment protocol. In our patient, low-dose methotrexate resulted in stiffness reduction, increased motility of the trunk and extremities, and ability to function on daily basis. We believe that any information about treatment outcome in SA patients should be disseminated in order to establish consensual treatment protocol for this rare disease.
Collegium Antropologicum, Jun 1, 2012
Diagnosis of Wegener&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;... more Diagnosis of Wegener&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s granulomatosis at the early stage is difficult because of the nonspecific symptoms which mimic other disorders. The aim of this paper is to describe clinical and radiological features of Wegener&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s granulomatosis (WG) in a Serbian population at initial presentation. A retrospective review of 37 patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s case records was carried out. All those patients were diagnosed with WG and they attended the Institute for lung diseases in Belgrade over the period of 15 years. There were 20 males and 17 females, ranging in age from 18 to 73 years (mean age 46.2 years). The mean period from the onset of the first symptoms to diagnosis of WG was 4.59 +/- 6.15 months. The criteria of American College of Rheumatology were fulfilled in all patients. Twenty-five of 37 patients had systemic, generalized form of WG and while 12 of them had a limited involvement of upper and lower respiratory system. The frequency of different system involvement was: upper respiratory tract 64.8%, lower respiratory tract 100%, kidneys 67.5%, musculoskeletal system 40.5%, skin 27.2%, eyes 8.1%, and nervous system two patients. ANCA (antineutrophil cytoplasmic antibodies) test was positive in 32 ((86.5%) patients, and negative in 5 (13.5%). All patients were ANA negative. Histological evidence of granulomatous vasculitis was obtained in 34 (91.9%), whereas in three patients the diagnosis was based on clinical manifestations and positive c-ANCA test. There are minor variations in our data when compared with those reported in literature.
European Respiratory Journal, 2015
Annals of the Academy of Medicine, Singapore, 2012
Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonary infections. ... more Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonary infections. Although rare, they are an important differential diagnosis as they may mimic other conditions and diseases. This paper aims to analyse clinical, radiological and histological characteristics of the patients with tracheobronchial tumours diagnosed for a period of 7 years. In this retrospective, observational study, we carefully reviewed 65 patients who were diagnosed with tracheal and endobronchial tumours, and performed statistical analysis on the results. Among these 65 patients (36 men and 29 women) with a mean age of 48.8 years (range, 15 to 75), 50 had malignant tumours while 15 had benign ones. The most common symptoms were cough, chest pain and haemoptysis. Cough was a more frequent symptom in patients with benign tumours (P <0.0014). Only 2 patients were asymptomatic. Tumours were predominantly localised in the large airways (46 in large bronchi and 2 in trachea). The most com...
Acta dermatovenerologica Croatica : ADC, 2011
Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of... more Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of the neck with acral progression, sparing hands and feet. We report on a 57-year-old male with severe SA associated with paraproteinemia, treated with methotrexate. Such widespread skin thickening followed by severe movement restriction and inability to function on daily basis, as in our patient, has never been described. Severe osteoarthritis and finding of HLA-B39 allele in association with SA has not been previously described either. To the best of our knowledge, up to 40 patients with SA associated with paraproteinemia has been reported so far, and currently, there is no established effective treatment protocol. In our patient, low-dose methotrexate resulted in stiffness reduction, increased motility of the trunk and extremities, and ability to function on daily basis. We believe that any information about treatment outcome in SA patients should be disseminated in order to establish ...
Medicinski pregled, 2010
Klinika za plućne bolesti i tuberkulozu, Knez Selo, Niš Originalni naučni rad Institut za plućne ... more Klinika za plućne bolesti i tuberkulozu, Knez Selo, Niš Originalni naučni rad Institut za plućne bolesti i tuberkulozu, Beograd 2
Medicinski pregled, 2013
Uvod. Plućna funkcija je poremećena kod približno 20% bolesnika u najranijem stadijumu sarkoidoze... more Uvod. Plućna funkcija je poremećena kod približno 20% bolesnika u najranijem stadijumu sarkoidoze (radiografski I stadijum), dok se kod pacijenata sa parenhimskim infiltratima (stadijumi II, III i IV) oštećenje plućne funkcije sreće kod 40−80% bolesnika. Diskusija i pregled literature. Smanjenje plućnih volumena (vitalni kapacitet) i totalnog plućnog kapaciteta uobičajeni su. Difuzijski kapacitet je često smanjen, ali je to manje izraženo nego kod idiopatske plućne fibroze. Čak i u slučaju normalnog nalaza na radiografiji grudnog koša, smanjenje forsiranog vitalnog kapaciteta se javlja u 15-25%, a redukcija difuzijskog kapaciteta pluća u 25-50% slučajeva. Oksigenacija je obično očuvana sve do kasnih stadijuma bolesti. Opstrukcija u disajnim putevima i bronhijalna hiperreaktivnost javljaju se kod 30−50% pacijenata obolelih od sarkoidoze, kod kojih postoje promene u parenhimu. Na opstruktivni poremećaj ventilacije možemo posumnjati ukoliko se na kompjuterizovanoj tomografiji grudnog koša registruje zadebljanje zida bronhija, suženje malih disajnih puteva ili mestimične zone zarobljavanja vazduha (air trapping). Zaključak. Ispitivanje plućne funkcije je neophodno uraditi kod svih pacijenata obolelih od sarkoidoze, naročito u toku praćenja toka bolesti. S obzirom na to da je ograničenje protoka vazduha u disajnim putevima udruženo sa lošom prognozom bolesti, pravovremeno ispitivanje i praćenje je posebno značajno. Ključne reči: Sarkoidoza; Opstrukcija disajnih puteva; Bronhijalna oboljenja; Testovi respiratorne funkcije; Prognoza; Kompjuterizovana tomografija Summary Introduction. Aberrations in pulmonary function test are present in about 20% of patients with radiographic stage I sarcoidosis, whereas the pulmonary function is damaged in 40-80% of patients with parenchymal infiltrates (stages II, III or IV). Discussion and Review of Literature. Reductions in lung volumes (vital capacity and total lung capacity) are characteristic. The diffusing capacity of lungs is often reduced, but it is less pronounced in sarcoidosis than in idiopathic pulmonary fibrosis. Oxygenation is usually preserved until late in the course of sarcoidosis. Airflow obstruction (reduced forced expiratory volume in one second and expiratory flow rates) and bronchial hyper-reactivity occur in 30-50% of sarcoidosis patients with pulmonary parenchymal involvement. Conclusion. While restrictive spirometry pattern could easily be explained by fibrous changes in lung parenchyma, especially in late stages of the lung disease, pathogenesis of airflow limitation can be attributed mostly to endobronchial involvement (intraluminal granuloma or fibrous scars formation), airway compression due to enlarged lymph nodes and to distortion of small airways due to established pulmonary fibrosis.
European Respiratory Journal, 2015
European Respiratory Journal, 2016
European Respiratory Journal, 2016
European Respiratory Journal, 2014
The BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index is well-valida... more The BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index is well-validated for mortality prediction in chronic obstructive pulmonary disease (COPD). Concentrations of plasma pro-adrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among inpatients with COPD exacerbation. We compared accuracy of initial pro-adrenomedullin level, BODE and BODE components, alone or combined, in predicting 1-year or 2-year all-cause mortality in a multicentre, multinational observational cohort with stable, moderate to very severe COPD. Pro-adrenomedullin was significantly associated (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) with 1-year mortality (4.7%) and 2-year mortality (7.8%) and comparably predictive to BODE regarding both (C statistics 0.691 versus 0.745 and 0.635 versus 0.679, respectively). Relative to using BODE alone, adding pro-adrenomedullin significantly improved 1-year and 2-year mortality prognostication (C statistics 0.750 and 0.818, respectively; both p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). Pro-adrenomedullin plus BOD was more predictive than the original BODE including 6-min walk distance. In multivariable analysis, pro-adrenomedullin (likelihood ratio Chi-squared 13.0, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), body mass index (8.5, p=0.004) and 6-min walk distance (7.5, p=0.006) independently foretold 2-year survival, but modified Medical Research Council dyspnoea score (2.2, p=0.14) and forced expiratory volume in 1 s % predicted (0.3, p=0.60) did not. Pro-adrenomedullin plus BODE better predicts mortality in COPD patients than does BODE alone; pro-adrenomedullin may substitute for 6-min walk distance in BODE when 6-min walk testing is unavailable.
Case reports in surgery, 2017
New onset of electrocardiographic (ECG) abnormalities can occur after lung surgery due to the cha... more New onset of electrocardiographic (ECG) abnormalities can occur after lung surgery due to the changes in the position of structures and organs in the chest cavity. The most common heart rhythm disorder is atrial fibrillation. So-called "pseudoischemic" ECG changes that mimic classic ECG signs of acute myocardial ischemia are also often noticed. We report the case of a 68-year-old male, with no prior cardiovascular disease, who underwent extensive surgical resection for lung cancer. On a second postoperative day, clinical and electrocardiographic signs of acute myocardial ischemia occurred. According to clinical course, diagnostic procedures, and therapeutic response, we excluded acute coronary syndrome. We concluded that physical lesion of the pericardium, caused by extended pneumonectomy with resection of the pericardium, provoked the symptoms and ECG signs that mimic acute coronary syndrome. Our final diagnosis was postpericardiotomy syndrome after extended pneumonectomy...
Med Oncol, 2009
The patient suffered loss of consciousness, dysarthria and right sided hemiparesis. The CT scan a... more The patient suffered loss of consciousness, dysarthria and right sided hemiparesis. The CT scan and MRI scans were negative. These findings are more in keeping with a diagnosis of Transient Ischemic Attack (TIA) or mild CVA. Hypoglycemia per se does not usually cause hemiparesis. The blood glucose level was low but I am not sure if one can conclude that hypoglycemia caused the above noted neurological signs and symptoms. The authors do not present any data to prove that this patient had ''hypoglycemic coma''.
Srpski Arhiv Za Celokupno Lekarstvo, 2007
Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod So ... more Institut za plućne bolesti i tuberkulozu, Klinički centar Srbije, Beograd KRATAK SADRŽAJ Uvod So li tar nifi bro znitu mo riple u resuret ki.Ot kri va juseslu čaj noilibo le sni ciima june spe ci fič nere spi ra ci o nesimp to me.Isto vre me nopo sto ja weso li tar nogfi bro znogtu mo reple u reihi po gli ke mi jena zi vaseDe ge-Po te rov (Do e ge-Pot ter)sin drom. Pri kaz bo le sni ka Bo le sni casta ra68go di napri mqe najeuIn sti tutzapluć nebo le stiitu ber ku lo zuKli nič kogcen tra Sr bi jeuBe o gra dura diis pi ti va waeti o lo gi jeve li kogtu mo raple u re.Ne ko li kogo di naseža li lanagla vo bo quisla bukon cen tra ci ju,apo sled wihgo di nuda nanapro gre siv nudisp no juibolugru di made sno.Nara di o gra mugrud nogko šauoče no jeogrom noza sen če weko jejeza hva ti losko roceode snihe mi to raks.En do kri no lo škimis pi ti va wi majeot kri veniz u zet noni zakni vogli ke mi jeuse ru mu,doksukon cen tra ci jein su li na,Cpep ti da,glu ka go na,hor mo nara staika te ho la mi nabi le nor mal ne.Hi sto lo škaiimu no hi sto he mij skaana li zama te ri ja lado bi je nogbi op si jomiglompo tvr di lajedi jag no zube nig nogso li tar nogfi bro znogtu mo raple u re.Iakojehi rur škole če webiome todiz bo razaovubo le sni cusogrom nimtu mo romihi po gli ke mi jom,onajeod bi laope ra ci juiod lu či lasezakon zer va tiv nole če wein tra ven skompri me nomglu ko ze. Za kqu čak Le ka ritre badais kqu čefi bro znetu mo reple u reuto kuis pi ti va wabo le sni kasahi po gli ke mi jom,iakosuove neo pla zmere dak,alizna ča jan,uzrokhi po gli ke mi ja. Kquč ne re či:so li tar nifi bro znitu morple u re;hi po gli ke mi ja;Dege-Poterovsindrom
Annals of the Academy of Medicine Singapore, May 1, 2012
INTRODUCTION: Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonar... more INTRODUCTION: Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonary infections. Although rare, they are an important differential diagnosis as they may mimic other conditions and diseases. This paper aims to analyse clinical, radiological and histological characteristics of the patients with tracheobronchial tumours diagnosed for a period of 7 years.MATERIALS AND METHODS: In this retrospective, observational study, we carefully reviewed 65 patients who were diagnosed with tracheal and endobronchial tumours, and performed statistical analysis on the results.RESULTS: Among these 65 patients (36 men and 29 women) with a mean age of 48.8 years (range, 15 to 75), 50 had malignant tumours while 15 had benign ones. The most common symptoms were cough, chest pain and haemoptysis. Cough was a more frequent symptom in patients with benign tumours (P <0.0014). Only 2 patients were asymptomatic. Tumours were predominantly localised in the large airways (46 in large bronchi and 2 in trachea). The most common radiological manifestation of malignant tumours was tumour mass (46%) followed by atelectasis. One third benign tumour caused atelectasis, while tumour mass and consolidation were found in 3 patients each. Computerised tomography revealed endoluminal tumour mass in 29.2% of the cases, which was more frequently found in benign than malignant tumours (47% vs 24%, respectively). On bronchoscopy, tumours were visible in 73% and 70% benign and malignant cases respectively.CONCLUSION: Tracheobronchial tumours should be ruled as a possible diagnosis in patients with cough, haemoptysis, dyspnoea and chest pain. The imaging techniques and histological examination of the tissue would subsequently lead to correct diagnosis and proper treatment can be administered.
European Respiratory Journal, Sep 1, 2011
European Respiratory Journal, Sep 1, 2012
Number: 2381 Publication Number: P629 Abstract Group: 1.2. Rehabilitation and Chronic Care Keywor... more Number: 2381 Publication Number: P629 Abstract Group: 1.2. Rehabilitation and Chronic Care Keyword 1: Asthma -management Keyword 2: COPD -management Keyword 3: Physiological diagnostic services Title: Psychologicl distress in asthma and COPD Prof. Dr Branislava 17046 Milenkovic branislava.milenkovic@kcs.ac.rs MD 1,2 , Prof. Dr Aleksandra 17047 Ilic sanjadudvarski@yahoo.com MD 1,2 and Dr. Sanja 17048 Dimic-Janjic sanjadimic77@yahoo.com MD 2 .
Medicinski Pregled, Sep 1, 2014
Acta Dermatovenerologica Croatica, Jul 15, 2011
Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of... more Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of the neck with acral progression, sparing hands and feet. We report on a 57-year-old male with severe SA associated with paraproteinemia, treated with methotrexate. Such widespread skin thickening followed by severe movement restriction and inability to function on daily basis, as in our patient, has never been described. Severe osteoarthritis and finding of HLA-B39 allele in association with SA has not been previously described either. To the best of our knowledge, up to 40 patients with SA associated with paraproteinemia has been reported so far, and currently, there is no established effective treatment protocol. In our patient, low-dose methotrexate resulted in stiffness reduction, increased motility of the trunk and extremities, and ability to function on daily basis. We believe that any information about treatment outcome in SA patients should be disseminated in order to establish consensual treatment protocol for this rare disease.
Collegium Antropologicum, Jun 1, 2012
Diagnosis of Wegener&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;... more Diagnosis of Wegener&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s granulomatosis at the early stage is difficult because of the nonspecific symptoms which mimic other disorders. The aim of this paper is to describe clinical and radiological features of Wegener&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s granulomatosis (WG) in a Serbian population at initial presentation. A retrospective review of 37 patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s case records was carried out. All those patients were diagnosed with WG and they attended the Institute for lung diseases in Belgrade over the period of 15 years. There were 20 males and 17 females, ranging in age from 18 to 73 years (mean age 46.2 years). The mean period from the onset of the first symptoms to diagnosis of WG was 4.59 +/- 6.15 months. The criteria of American College of Rheumatology were fulfilled in all patients. Twenty-five of 37 patients had systemic, generalized form of WG and while 12 of them had a limited involvement of upper and lower respiratory system. The frequency of different system involvement was: upper respiratory tract 64.8%, lower respiratory tract 100%, kidneys 67.5%, musculoskeletal system 40.5%, skin 27.2%, eyes 8.1%, and nervous system two patients. ANCA (antineutrophil cytoplasmic antibodies) test was positive in 32 ((86.5%) patients, and negative in 5 (13.5%). All patients were ANA negative. Histological evidence of granulomatous vasculitis was obtained in 34 (91.9%), whereas in three patients the diagnosis was based on clinical manifestations and positive c-ANCA test. There are minor variations in our data when compared with those reported in literature.
European Respiratory Journal, 2015
Annals of the Academy of Medicine, Singapore, 2012
Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonary infections. ... more Tracheobronchial tumours usually cause an airway obstruction and secondary pulmonary infections. Although rare, they are an important differential diagnosis as they may mimic other conditions and diseases. This paper aims to analyse clinical, radiological and histological characteristics of the patients with tracheobronchial tumours diagnosed for a period of 7 years. In this retrospective, observational study, we carefully reviewed 65 patients who were diagnosed with tracheal and endobronchial tumours, and performed statistical analysis on the results. Among these 65 patients (36 men and 29 women) with a mean age of 48.8 years (range, 15 to 75), 50 had malignant tumours while 15 had benign ones. The most common symptoms were cough, chest pain and haemoptysis. Cough was a more frequent symptom in patients with benign tumours (P <0.0014). Only 2 patients were asymptomatic. Tumours were predominantly localised in the large airways (46 in large bronchi and 2 in trachea). The most com...
Acta dermatovenerologica Croatica : ADC, 2011
Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of... more Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of the neck with acral progression, sparing hands and feet. We report on a 57-year-old male with severe SA associated with paraproteinemia, treated with methotrexate. Such widespread skin thickening followed by severe movement restriction and inability to function on daily basis, as in our patient, has never been described. Severe osteoarthritis and finding of HLA-B39 allele in association with SA has not been previously described either. To the best of our knowledge, up to 40 patients with SA associated with paraproteinemia has been reported so far, and currently, there is no established effective treatment protocol. In our patient, low-dose methotrexate resulted in stiffness reduction, increased motility of the trunk and extremities, and ability to function on daily basis. We believe that any information about treatment outcome in SA patients should be disseminated in order to establish ...
Medicinski pregled, 2010
Klinika za plućne bolesti i tuberkulozu, Knez Selo, Niš Originalni naučni rad Institut za plućne ... more Klinika za plućne bolesti i tuberkulozu, Knez Selo, Niš Originalni naučni rad Institut za plućne bolesti i tuberkulozu, Beograd 2
Medicinski pregled, 2013
Uvod. Plućna funkcija je poremećena kod približno 20% bolesnika u najranijem stadijumu sarkoidoze... more Uvod. Plućna funkcija je poremećena kod približno 20% bolesnika u najranijem stadijumu sarkoidoze (radiografski I stadijum), dok se kod pacijenata sa parenhimskim infiltratima (stadijumi II, III i IV) oštećenje plućne funkcije sreće kod 40−80% bolesnika. Diskusija i pregled literature. Smanjenje plućnih volumena (vitalni kapacitet) i totalnog plućnog kapaciteta uobičajeni su. Difuzijski kapacitet je često smanjen, ali je to manje izraženo nego kod idiopatske plućne fibroze. Čak i u slučaju normalnog nalaza na radiografiji grudnog koša, smanjenje forsiranog vitalnog kapaciteta se javlja u 15-25%, a redukcija difuzijskog kapaciteta pluća u 25-50% slučajeva. Oksigenacija je obično očuvana sve do kasnih stadijuma bolesti. Opstrukcija u disajnim putevima i bronhijalna hiperreaktivnost javljaju se kod 30−50% pacijenata obolelih od sarkoidoze, kod kojih postoje promene u parenhimu. Na opstruktivni poremećaj ventilacije možemo posumnjati ukoliko se na kompjuterizovanoj tomografiji grudnog koša registruje zadebljanje zida bronhija, suženje malih disajnih puteva ili mestimične zone zarobljavanja vazduha (air trapping). Zaključak. Ispitivanje plućne funkcije je neophodno uraditi kod svih pacijenata obolelih od sarkoidoze, naročito u toku praćenja toka bolesti. S obzirom na to da je ograničenje protoka vazduha u disajnim putevima udruženo sa lošom prognozom bolesti, pravovremeno ispitivanje i praćenje je posebno značajno. Ključne reči: Sarkoidoza; Opstrukcija disajnih puteva; Bronhijalna oboljenja; Testovi respiratorne funkcije; Prognoza; Kompjuterizovana tomografija Summary Introduction. Aberrations in pulmonary function test are present in about 20% of patients with radiographic stage I sarcoidosis, whereas the pulmonary function is damaged in 40-80% of patients with parenchymal infiltrates (stages II, III or IV). Discussion and Review of Literature. Reductions in lung volumes (vital capacity and total lung capacity) are characteristic. The diffusing capacity of lungs is often reduced, but it is less pronounced in sarcoidosis than in idiopathic pulmonary fibrosis. Oxygenation is usually preserved until late in the course of sarcoidosis. Airflow obstruction (reduced forced expiratory volume in one second and expiratory flow rates) and bronchial hyper-reactivity occur in 30-50% of sarcoidosis patients with pulmonary parenchymal involvement. Conclusion. While restrictive spirometry pattern could easily be explained by fibrous changes in lung parenchyma, especially in late stages of the lung disease, pathogenesis of airflow limitation can be attributed mostly to endobronchial involvement (intraluminal granuloma or fibrous scars formation), airway compression due to enlarged lymph nodes and to distortion of small airways due to established pulmonary fibrosis.