Mili Gupta - Academia.edu (original) (raw)
Papers by Mili Gupta
1. Department of Anatomy, Institute of Medical Education and Research, Chandigarh-160012, India. ... more 1. Department of Anatomy, Institute of Medical Education and Research, Chandigarh-160012, India. 2. Department of Biochemistry, Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh-160012, India. 3. Department of Neurosurgery, Institute of Medical Education and Research, Chandigarh160012, India. 4. Department of Neurology, Institute of Medical Education and Research, Chandigarh-160012, India. 5. Department of Forensic Medicine, Institute of Medical Education and Research, Chandigarh160012, India. 6. Department of Histopathology, Institute of Medical Education and Research, Chandigarh160012, India.
About 30% of patients with epilepsy do not respond to anti-epileptic drugs leading to refractory ... more About 30% of patients with epilepsy do not respond to anti-epileptic drugs leading to refractory seizures. The pathogenesis of drug-resistance in Mesial Temporal Lobe Epilepsy (MTLE) is not completely understood. Increased activity of drug-efflux transporters might be involved, resulting in subclinical concentrations of the drug at the target site. The major drug-efflux transporters are permeability glycoprotein (P-gp) and multidrug-resistance protein-1 (MRP-1). We have studied these two transporters in the sclerotic hippocampal tissues resected from the epilepsy surgery and compared their expression profile with the tissues resected from non-epileptic autopsy cases. Statistically significant over expression of both P-gp (p-value<0.0001) and MRP-1 (p-value 0.01) at gene and protein levels was found in the MTLE cases. The fold change of P-gp was more pronounced than MRP-1. Immunohistochemistry of patient group showed increased immunoreactivity of P-gp at blood brain barrier and in...
Scientific Reports, 2020
Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protectiv... more Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients...
Indian Dermatology Online Journal, 2021
Basic and Clinical Neuroscience Journal, 2021
About 30% of epileptic patients do not react to anti-epileptic drugs leading to refractory seizur... more About 30% of epileptic patients do not react to anti-epileptic drugs leading to refractory seizures. The pathogenesis of drug-resistance in Mesial Temporal Lobe Epilepsy (MTLE) is not completely understood. Increased activity of drug-efflux transporters might be involved, resulting in subclinical concentrations of the drug at the target site. The major drug-efflux transporters are permeability glycoprotein (P-gp) and multidrug-resistance associated protein-1 (MRP-1). The major drawback so far is the expressional analysis of transporters in equal numbers of drug-resistant epileptic tissue and age-matched non-epileptic tissue. We have studied these two transporters in the sclerotic hippocampal tissues resected from the epilepsy surgery (n=15) and compared their expression profile with the tissues resected from non-epileptic autopsy cases (n=15). Statistically significant over expression of both P-gp (p-value <0.0001) and MRP-1 (p-value 0.01) at gene and protein levels was found in ...
International Journal of Prosthodontics and Restorative Dentistry, 2019
Aim: The aim of the study is to evaluate the influence of macro-, micro-, and miniesthetics in an... more Aim: The aim of the study is to evaluate the influence of macro-, micro-, and miniesthetics in an attractive smile. Materials and methods: The smile photographs of around 214 dental students were taken of age group 18-25 years with natural dentition with specific inclusion and exclusion criteria. Frontal photographs were taken with a Nikon DSLR 200 105 mm macro lens ratio 1:1 F/2.8 digital camera. The study was carried out in two stages: stage 1-the photographs were analyzed for beautiful smiles. Those photographs which had a mean score of 60 and above and small standard deviation (3.45) were selected. Out of 214 photographs, 33 photographs were selected for attractive smiles. Stage 2-in the second part of the study different parameters of macro-, micro-, and miniesthetics that influence attractive smile were evaluated. The data obtained were subjected to statistical analysis. Results: Facial form contributes more in an attractive smile compared with the remaining factors for macroesthetics In factors influencing microesthetics ideally tooth shade plays major role compared with other factors. Crowding ideally plays significant role compared with the remaining factors for miniesthetics. Conclusion: In restorative dentistry, all factors are to be included during the treatment to enhance the esthetic appearance of the patient thereby improving the smile.
International Journal of Prosthodontics and Restorative Dentistry, 2019
Aim: To analyze and depict the stress distribution at the bone-implant interface using four diffe... more Aim: To analyze and depict the stress distribution at the bone-implant interface using four different superstructure materials for an implantretained overdenture, through a photoelastic study. Materials and methods: The present study included construction of photoelastic models of an edentulous mandible with two implants in the parasymphseal region. On these models, the dentures were fabricated using conventional heat cure acrylic, heat cure acrylic reinforced with NiCr, heat cure acrylic reinforced with a fiber force mesh, and heat cure acrylic reinforced with PEEK. These models were then subjected to photoelastic stress analysis. Results: The results showed a higher number of fringes in the denture fabricated with heat cure acrylic reinforced with NiCr. The fringes were better distributed in the photoelastic model with denture fabricated using heat cure acrylic reinforced with PEEK. Conclusion: The stress distribution in the bone-implant interface is markedly improved when an acrylic resin prosthesis is reinforced with PEEK as a superstructure material.
Journal of Advanced Oral Research, 2015
Epigenetics encompasses all of the mechanisms involved in deploying the genetic program for the m... more Epigenetics encompasses all of the mechanisms involved in deploying the genetic program for the many processes operating during the lifespan of a cell. These are stable but can be somewhat modified by physiological, pathological conditions, and by the environment. [8-10] The recent surge in the knowledge of this field is contributing to a better understanding
Infectious disorders drug targets, Jan 31, 2018
Successful management of periodontitis requires treatment strategy that integrates therapies addr... more Successful management of periodontitis requires treatment strategy that integrates therapies addressing both pathogen and host aspects of disease etiology. To evaluate sub gingivally applied curcumin gel in treatment of chronic periodontitis based on clinical and biochemical parameters. A randomized, double blind, parallel-group trial was carried out on 30 patients suffering from chronic generalized periodontitis with probing pocket depth≥5mm on at least 4 sites who were then randomly allocated to two groups. Control group was treated with scaling and root planing (SRP) alone while experimental group was treated with SRP followed by subgingival application of curcumin gel. Saliva collection was done and the clinical parameters were recorded at baseline and follow up periods. Saliva analysis for IL-1β was done by ELISA. The statistical differences for the intra-group and intergroup measurements were analyzed by using Mann Whitney test. Spearman's rank correlation coefficient was ...
The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA), 2017
To compare the clinical parameters and levels of salivary immunoglobulin A (IgA), Interleukin-1β ... more To compare the clinical parameters and levels of salivary immunoglobulin A (IgA), Interleukin-1β (IL-1β) and matrix metalloproteinase-8 (MMP-8) in patients with moderate to severe chronic periodontitis and in individuals with healthy gingiva. Levels of clinical parameters plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) along with salivary biomarkers salivary IgA, IL-1β and MMP-8 were recorded among 50 adults (30 test subjects with moderate to severe generalised chronic periodontitis, constituting group A, and 20 periodontally healthy controls - group B). Clinical evaluation was done before oral prophylaxis, and 6 weeks and 12 weeks after oral prophylaxis, and saliva samples were obtained before and 12 weeks after oral prophylaxis. Salivary IgA, IL-1β and MMP-8 levels in saliva were assessed using enzyme-linked immunosorbent assay. In group A, there were highly significant differences in terms of PI, GI, PD, CA...
Serum Enzymes in Hepatobiliary Carcinoma, Feb 27, 2014
Indian Journal of Dental Research, 2015
Both periodontitis and cardiovascular diseases (CVD) represent chronic inflammatory conditions, a... more Both periodontitis and cardiovascular diseases (CVD) represent chronic inflammatory conditions, and periodontal infections have been postulated to perpetuate the progression of CVD&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s. However, limited evidence is available to prove the causal relationship. An effort in exploring this interrelation has been made in this study. The role of two inflammatory mediators, soluble CD40 ligand (sCD40 L) and monocyte chemoattractant protein-1 (MCP-1) has been established in progression and acute precipitation of CVD&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s. Due to a close link between these two mediators, the present study was designed to correlate the levels of sCD40 L and MCP-1 in serum and gingival crevicular fluid (GCF) of patients with chronic periodontitis. Fifteen healthy and 30 patients of severe chronic periodontitis (diseased) participated in the study. Patients of the diseased group underwent scaling/root planning. The evaluation of plaque index, gingival index, probing depth, clinical attachment level, and a collection of serum and GCF samples was done at baseline and 6 weeks following periodontal therapy. The sCD40 L and MCP-1 levels were quantified using ELISA. The sCD40 L levels correlated strongly with MCP-1 levels in both GCF (r = 0.888) and serum (r = 0.861) in patients of chronic periodontitis. The relationship between the levels of the two markers was maintained in GCF (r = 0.868) and serum (r = 0.750) after Phase I periodontal therapy. The positive correlation observed suggests this pathway as one of the mechanisms that may lead to increasing severity of periodontal disease and its systemic effects. Further research efforts should be made in designing appropriate clinical trials, starting at an early stage and monitoring the potential benefits of maintenance of oral hygiene on cardiovascular health.
Medical Journal of Indonesia, 2002
Artritis reumatoid ialah penyakit poliartritis kronik progresif yang menimbulkan deformasi, melip... more Artritis reumatoid ialah penyakit poliartritis kronik progresif yang menimbulkan deformasi, meliputi multisistem dan disertai morbiditas yang nyata. Obat-obatan imunosupresif telah digunakan untuk mengurangi/menghambat progresi penyakit. Penelitian ini diadakan untuk membandingkan keberhasilan azatioprin dan siklosporin pada penderita artritis reumatoid. Penelitian meliputi 100 penderita artritis reumatoid (sesuai kriteria American Rheumatism Association, 1987) yang dibagi atas dua kelompok: kelompok I mendapat azatioprin 1 mg/kg/h dan kelompok II mendapat siklosporin 2,5-3,0 mg/kg/h selama 16 minggu. Penilaian keberhasilan berdasarkan parameter klinis, biokimiawi dan radiologis. Semua penderita menunjukkan perbaikan nyata (nilai p < 0.001) pada semua parameter klinis, yaitu hilangnya nyeri, berkurangnya kekakuan pagi hari, sendi yang nyeri/membengkak dan waktu yang diperlukan untuk berjalan sejauh 50 kaki serta menguatnya kekuatan genggaman. Semua penderita menunjukkan penurunan LED (p < .001) tanpa perubahan apapun pada titer faktor reumatoid. Kedua obat menunjukkan keberhasilan yang sama (nilai p tidak bermakna) dalam hal perbaikan parameter klinis dan biokimiawi. Tetapi dengan siklosporin erosi tulang dan osteoporosis yukstaartikular lebih banyak berkurang. Sepuluh penderita menunjukkan nefrotoksisitas dengan siklosporin. Siklosporin lebih baik dari azatioprin dalam hal mengurangi derajat progresi kelainan sendi pada artritis reumatoid, tetapi insidens efek samping lebih tinggi, yang pada umumnya dapat diatasi.
Zeitschrift für Urologie und Nephrologie, 1972
Medical Journal of Indonesia, 2002
Evaluasi dari penyakit arteri koroner (PAK) lebih rutin dilakukan dengan uji treadmill (Treadmill... more Evaluasi dari penyakit arteri koroner (PAK) lebih rutin dilakukan dengan uji treadmill (Treadmill test, TMT, i.e. beban fisik) daripada beban mental yang lebih sering terjadi. OIeh l<arena i\u, direncanakan penelitian untuk mengukur kemungkinan terjadinta iskemi dengan berbagai tugas mental pada pasien dengan TMT positif. Tiga puluh pendeita terpelajar dengan TMT positif dimonitor selama 24 jam. Dalam waktu tersebut, penderita diukur dengan uji mental (Mental stress test, MST) melalui berbagai tugas mental : a) uji beban waktu; b) uji beban mental dalam menghitung; c) uji baca; d) uji efek Zeigamik disertai observasi kecepatan denyut jantung, tekanan darah dan respon iskemi./arttmi. Hasil penelitian menunjukkan bahwa rasio pria : wanita adalah 14 : I dengan umur ratarata 57 + 8.03 tahun. Selama MST, ditemukan perubahan dalam : a) kecepatan denyut jantung 9,16 (SD + 1.24)/menit; b) SBP 8.86 (SD + 1.32) mmHg; c) rate pressure product 82xld yang secara st(ltistik lebih rendah (p<0,001) dibandingkan dengan perubahan hemodinamik pada TMT. Iskemia terinduksi pada hanya I penderita yang diuji dengan MST dan tidak ada peningkatan terjadinya aritmi selama dilakukan MST. Rendahnya induksi iskemi tersebut mungkin karena respon hemodinamik yang lemah yang dicapai MST bila dibandingkan dengan TMT (p<0,001). Disimpulkan bahwa beban mental menghasilkan perubahan iskemik. Diperlukan MST yang lebih kuat dan berlangsung lama yang dapat menyebabkan perubahan hemodinamik untuk menginduksi iskemi seperti yang dihnsilkan dengan TMT.
European Journal of Prosthodontics, 2015
To maintain long-term stability of dental implants, it is important to minimize bone loss around ... more To maintain long-term stability of dental implants, it is important to minimize bone loss around an implant. Several clinical studies have shown a mean crestal bone loss of 1.5-2 mm around dental implants, in the first year after prosthetic restoration, as clinically acceptable. To limit this crestal bone resorption, several modifications are being tried in the implant systems. Platform Switching is one such concept, which uses prosthetic abutments with reduced diameter in relation to the implant platform diameter. This moves the implant abutment junction and supposedly the inflammatory reaction medially, away from the crestal bone, and may thus, minimize the crestal bone loss. Although, it was a serendipitous finding, an increasing number of implant systems have incorporated Platform Switching into their designs, as an innovative feature for preserving the peri-implant bone. A Medline search was carried out using the Pubmed search engine, with keywords Platform Switching in Dental Implants. Twenty-one studies (12 random-controlled trials, fourprospective-controlled clinical studies, and five clinical case series) were selected for review after screening of a total of 123 articles on the basis of the inclusion and exclusion criteria. A detailed review of these articles gave a clear tendency toward the positive impact of Platform Switching on crestal bone preservation, but further long-term, randomized-controlled trials, with uniform criteria, are required to confirm these results.
Gastrointestinal Endoscopy, 2000
Introduction: Proficiency in performing EUS is dependent upon accurate interpretation of structur... more Introduction: Proficiency in performing EUS is dependent upon accurate interpretation of structures seen during imaging. A lack of good anatomic correlates contributes to a long learning curve. Moreover, EUS is a dynamic imaging process where structures are sometimes identified by their changing relative orientations. Methods utilizing still images are unable to provide a spatial orientation in more than one plane. We describe a method of teaching EUS using the digitally correlated anatomy database (DCAD). This database has been created using images derived from the Visible Human Project (a comprehensive database of digital anatomy) and digitized EUS images. Methods: EUS images, both radial and linear, were captured to SVHS tapes during indicated procedures performed at the UCHSC, Denver. An image library was constructed by review of the tapes and digital capture of still EUS images as well as series of frames as videofiles (AVI format). The DCAD was constructed in a sequence of steps consisting of data manipulation, image correlation and digital animation. Initially, manipulation of the Visible Human database was performed on an advanced graphics workstation to obtain images corresponding to the selected EUS images. The thorax was divided into zones and correlated images were arranged in groups within each zone, focusing on structures of interest in different orientations. Each group contained both radial and linear correlated EUS and Visible Human images, video sequence of the EUS pull-through in that segment of thorax, animated sequences and the parent template (transverse and linear) from the Visible Human image pool. After organizing these data into anatomic segments, structures of interest were studied and identified by review of the still images, video sequences and animations within each group. Results: Study of the correlated still images suggested the identity of structures in question. The parent templates, animated anatomy along with the EUS video sequences from the DCAD confirmed the identity of structures seen in the still images. Future directions: Studies are being designed to objectively test whether the digitally correlated anatomy database shortens the learning curve when applied to prospective endosonographers in training. We plan to compile similar databases for the rectum, stomach and duodenum.
Clinical Oral Investigations, 2014
Periodontitis involves a complex interplay of micro-organisms and host immune response via numero... more Periodontitis involves a complex interplay of micro-organisms and host immune response via numerous mediator molecules playing strategic roles in its pathogenesis. Soluble CD40L (sCD40L) is one such co-stimulatory molecule which is essential for T-helper cell activation and is a well-known risk indicator of cardiovascular diseases. The levels of this marker in crevicular fluid of patients of chronic periodontitis have been explored in the present study for the first time along with an analysis of its association with levels in serum in otherwise systemically healthy patients. Sixty patients 20 healthy and 40 of chronic periodontitis (18 moderate and 22 severe) participated in the study. Patients of the diseased group underwent non-surgical periodontal therapy. Clinical evaluation and collection of gingival crevicular fluid (GCF) and serum samples was done at baseline, and 6 weeks after phase I periodontal therapy. sCD40L levels were quantified in the fluids using ELISA. Levels of sCD40L in GCF were significantly higher in the diseased group (p ≤ 0.001) and strongly correlated not only with increasing severity of disease but also with levels in serum. In post-treatment, the levels decreased significantly in both the biological fluids (p ≤ 0.001). The present study brings to light the role of sCD40L as a novel marker in mediating periodontal destruction and disease progression. Evaluation of local treatment outcomes seems promising in minimizing these effects. Positive association of its local levels with those in serum further implicates the possibility of widespread systemic effects of this infection.
1. Department of Anatomy, Institute of Medical Education and Research, Chandigarh-160012, India. ... more 1. Department of Anatomy, Institute of Medical Education and Research, Chandigarh-160012, India. 2. Department of Biochemistry, Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh-160012, India. 3. Department of Neurosurgery, Institute of Medical Education and Research, Chandigarh160012, India. 4. Department of Neurology, Institute of Medical Education and Research, Chandigarh-160012, India. 5. Department of Forensic Medicine, Institute of Medical Education and Research, Chandigarh160012, India. 6. Department of Histopathology, Institute of Medical Education and Research, Chandigarh160012, India.
About 30% of patients with epilepsy do not respond to anti-epileptic drugs leading to refractory ... more About 30% of patients with epilepsy do not respond to anti-epileptic drugs leading to refractory seizures. The pathogenesis of drug-resistance in Mesial Temporal Lobe Epilepsy (MTLE) is not completely understood. Increased activity of drug-efflux transporters might be involved, resulting in subclinical concentrations of the drug at the target site. The major drug-efflux transporters are permeability glycoprotein (P-gp) and multidrug-resistance protein-1 (MRP-1). We have studied these two transporters in the sclerotic hippocampal tissues resected from the epilepsy surgery and compared their expression profile with the tissues resected from non-epileptic autopsy cases. Statistically significant over expression of both P-gp (p-value<0.0001) and MRP-1 (p-value 0.01) at gene and protein levels was found in the MTLE cases. The fold change of P-gp was more pronounced than MRP-1. Immunohistochemistry of patient group showed increased immunoreactivity of P-gp at blood brain barrier and in...
Scientific Reports, 2020
Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protectiv... more Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients...
Indian Dermatology Online Journal, 2021
Basic and Clinical Neuroscience Journal, 2021
About 30% of epileptic patients do not react to anti-epileptic drugs leading to refractory seizur... more About 30% of epileptic patients do not react to anti-epileptic drugs leading to refractory seizures. The pathogenesis of drug-resistance in Mesial Temporal Lobe Epilepsy (MTLE) is not completely understood. Increased activity of drug-efflux transporters might be involved, resulting in subclinical concentrations of the drug at the target site. The major drug-efflux transporters are permeability glycoprotein (P-gp) and multidrug-resistance associated protein-1 (MRP-1). The major drawback so far is the expressional analysis of transporters in equal numbers of drug-resistant epileptic tissue and age-matched non-epileptic tissue. We have studied these two transporters in the sclerotic hippocampal tissues resected from the epilepsy surgery (n=15) and compared their expression profile with the tissues resected from non-epileptic autopsy cases (n=15). Statistically significant over expression of both P-gp (p-value <0.0001) and MRP-1 (p-value 0.01) at gene and protein levels was found in ...
International Journal of Prosthodontics and Restorative Dentistry, 2019
Aim: The aim of the study is to evaluate the influence of macro-, micro-, and miniesthetics in an... more Aim: The aim of the study is to evaluate the influence of macro-, micro-, and miniesthetics in an attractive smile. Materials and methods: The smile photographs of around 214 dental students were taken of age group 18-25 years with natural dentition with specific inclusion and exclusion criteria. Frontal photographs were taken with a Nikon DSLR 200 105 mm macro lens ratio 1:1 F/2.8 digital camera. The study was carried out in two stages: stage 1-the photographs were analyzed for beautiful smiles. Those photographs which had a mean score of 60 and above and small standard deviation (3.45) were selected. Out of 214 photographs, 33 photographs were selected for attractive smiles. Stage 2-in the second part of the study different parameters of macro-, micro-, and miniesthetics that influence attractive smile were evaluated. The data obtained were subjected to statistical analysis. Results: Facial form contributes more in an attractive smile compared with the remaining factors for macroesthetics In factors influencing microesthetics ideally tooth shade plays major role compared with other factors. Crowding ideally plays significant role compared with the remaining factors for miniesthetics. Conclusion: In restorative dentistry, all factors are to be included during the treatment to enhance the esthetic appearance of the patient thereby improving the smile.
International Journal of Prosthodontics and Restorative Dentistry, 2019
Aim: To analyze and depict the stress distribution at the bone-implant interface using four diffe... more Aim: To analyze and depict the stress distribution at the bone-implant interface using four different superstructure materials for an implantretained overdenture, through a photoelastic study. Materials and methods: The present study included construction of photoelastic models of an edentulous mandible with two implants in the parasymphseal region. On these models, the dentures were fabricated using conventional heat cure acrylic, heat cure acrylic reinforced with NiCr, heat cure acrylic reinforced with a fiber force mesh, and heat cure acrylic reinforced with PEEK. These models were then subjected to photoelastic stress analysis. Results: The results showed a higher number of fringes in the denture fabricated with heat cure acrylic reinforced with NiCr. The fringes were better distributed in the photoelastic model with denture fabricated using heat cure acrylic reinforced with PEEK. Conclusion: The stress distribution in the bone-implant interface is markedly improved when an acrylic resin prosthesis is reinforced with PEEK as a superstructure material.
Journal of Advanced Oral Research, 2015
Epigenetics encompasses all of the mechanisms involved in deploying the genetic program for the m... more Epigenetics encompasses all of the mechanisms involved in deploying the genetic program for the many processes operating during the lifespan of a cell. These are stable but can be somewhat modified by physiological, pathological conditions, and by the environment. [8-10] The recent surge in the knowledge of this field is contributing to a better understanding
Infectious disorders drug targets, Jan 31, 2018
Successful management of periodontitis requires treatment strategy that integrates therapies addr... more Successful management of periodontitis requires treatment strategy that integrates therapies addressing both pathogen and host aspects of disease etiology. To evaluate sub gingivally applied curcumin gel in treatment of chronic periodontitis based on clinical and biochemical parameters. A randomized, double blind, parallel-group trial was carried out on 30 patients suffering from chronic generalized periodontitis with probing pocket depth≥5mm on at least 4 sites who were then randomly allocated to two groups. Control group was treated with scaling and root planing (SRP) alone while experimental group was treated with SRP followed by subgingival application of curcumin gel. Saliva collection was done and the clinical parameters were recorded at baseline and follow up periods. Saliva analysis for IL-1β was done by ELISA. The statistical differences for the intra-group and intergroup measurements were analyzed by using Mann Whitney test. Spearman's rank correlation coefficient was ...
The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA), 2017
To compare the clinical parameters and levels of salivary immunoglobulin A (IgA), Interleukin-1β ... more To compare the clinical parameters and levels of salivary immunoglobulin A (IgA), Interleukin-1β (IL-1β) and matrix metalloproteinase-8 (MMP-8) in patients with moderate to severe chronic periodontitis and in individuals with healthy gingiva. Levels of clinical parameters plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) along with salivary biomarkers salivary IgA, IL-1β and MMP-8 were recorded among 50 adults (30 test subjects with moderate to severe generalised chronic periodontitis, constituting group A, and 20 periodontally healthy controls - group B). Clinical evaluation was done before oral prophylaxis, and 6 weeks and 12 weeks after oral prophylaxis, and saliva samples were obtained before and 12 weeks after oral prophylaxis. Salivary IgA, IL-1β and MMP-8 levels in saliva were assessed using enzyme-linked immunosorbent assay. In group A, there were highly significant differences in terms of PI, GI, PD, CA...
Serum Enzymes in Hepatobiliary Carcinoma, Feb 27, 2014
Indian Journal of Dental Research, 2015
Both periodontitis and cardiovascular diseases (CVD) represent chronic inflammatory conditions, a... more Both periodontitis and cardiovascular diseases (CVD) represent chronic inflammatory conditions, and periodontal infections have been postulated to perpetuate the progression of CVD&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s. However, limited evidence is available to prove the causal relationship. An effort in exploring this interrelation has been made in this study. The role of two inflammatory mediators, soluble CD40 ligand (sCD40 L) and monocyte chemoattractant protein-1 (MCP-1) has been established in progression and acute precipitation of CVD&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s. Due to a close link between these two mediators, the present study was designed to correlate the levels of sCD40 L and MCP-1 in serum and gingival crevicular fluid (GCF) of patients with chronic periodontitis. Fifteen healthy and 30 patients of severe chronic periodontitis (diseased) participated in the study. Patients of the diseased group underwent scaling/root planning. The evaluation of plaque index, gingival index, probing depth, clinical attachment level, and a collection of serum and GCF samples was done at baseline and 6 weeks following periodontal therapy. The sCD40 L and MCP-1 levels were quantified using ELISA. The sCD40 L levels correlated strongly with MCP-1 levels in both GCF (r = 0.888) and serum (r = 0.861) in patients of chronic periodontitis. The relationship between the levels of the two markers was maintained in GCF (r = 0.868) and serum (r = 0.750) after Phase I periodontal therapy. The positive correlation observed suggests this pathway as one of the mechanisms that may lead to increasing severity of periodontal disease and its systemic effects. Further research efforts should be made in designing appropriate clinical trials, starting at an early stage and monitoring the potential benefits of maintenance of oral hygiene on cardiovascular health.
Medical Journal of Indonesia, 2002
Artritis reumatoid ialah penyakit poliartritis kronik progresif yang menimbulkan deformasi, melip... more Artritis reumatoid ialah penyakit poliartritis kronik progresif yang menimbulkan deformasi, meliputi multisistem dan disertai morbiditas yang nyata. Obat-obatan imunosupresif telah digunakan untuk mengurangi/menghambat progresi penyakit. Penelitian ini diadakan untuk membandingkan keberhasilan azatioprin dan siklosporin pada penderita artritis reumatoid. Penelitian meliputi 100 penderita artritis reumatoid (sesuai kriteria American Rheumatism Association, 1987) yang dibagi atas dua kelompok: kelompok I mendapat azatioprin 1 mg/kg/h dan kelompok II mendapat siklosporin 2,5-3,0 mg/kg/h selama 16 minggu. Penilaian keberhasilan berdasarkan parameter klinis, biokimiawi dan radiologis. Semua penderita menunjukkan perbaikan nyata (nilai p < 0.001) pada semua parameter klinis, yaitu hilangnya nyeri, berkurangnya kekakuan pagi hari, sendi yang nyeri/membengkak dan waktu yang diperlukan untuk berjalan sejauh 50 kaki serta menguatnya kekuatan genggaman. Semua penderita menunjukkan penurunan LED (p < .001) tanpa perubahan apapun pada titer faktor reumatoid. Kedua obat menunjukkan keberhasilan yang sama (nilai p tidak bermakna) dalam hal perbaikan parameter klinis dan biokimiawi. Tetapi dengan siklosporin erosi tulang dan osteoporosis yukstaartikular lebih banyak berkurang. Sepuluh penderita menunjukkan nefrotoksisitas dengan siklosporin. Siklosporin lebih baik dari azatioprin dalam hal mengurangi derajat progresi kelainan sendi pada artritis reumatoid, tetapi insidens efek samping lebih tinggi, yang pada umumnya dapat diatasi.
Zeitschrift für Urologie und Nephrologie, 1972
Medical Journal of Indonesia, 2002
Evaluasi dari penyakit arteri koroner (PAK) lebih rutin dilakukan dengan uji treadmill (Treadmill... more Evaluasi dari penyakit arteri koroner (PAK) lebih rutin dilakukan dengan uji treadmill (Treadmill test, TMT, i.e. beban fisik) daripada beban mental yang lebih sering terjadi. OIeh l<arena i\u, direncanakan penelitian untuk mengukur kemungkinan terjadinta iskemi dengan berbagai tugas mental pada pasien dengan TMT positif. Tiga puluh pendeita terpelajar dengan TMT positif dimonitor selama 24 jam. Dalam waktu tersebut, penderita diukur dengan uji mental (Mental stress test, MST) melalui berbagai tugas mental : a) uji beban waktu; b) uji beban mental dalam menghitung; c) uji baca; d) uji efek Zeigamik disertai observasi kecepatan denyut jantung, tekanan darah dan respon iskemi./arttmi. Hasil penelitian menunjukkan bahwa rasio pria : wanita adalah 14 : I dengan umur ratarata 57 + 8.03 tahun. Selama MST, ditemukan perubahan dalam : a) kecepatan denyut jantung 9,16 (SD + 1.24)/menit; b) SBP 8.86 (SD + 1.32) mmHg; c) rate pressure product 82xld yang secara st(ltistik lebih rendah (p<0,001) dibandingkan dengan perubahan hemodinamik pada TMT. Iskemia terinduksi pada hanya I penderita yang diuji dengan MST dan tidak ada peningkatan terjadinya aritmi selama dilakukan MST. Rendahnya induksi iskemi tersebut mungkin karena respon hemodinamik yang lemah yang dicapai MST bila dibandingkan dengan TMT (p<0,001). Disimpulkan bahwa beban mental menghasilkan perubahan iskemik. Diperlukan MST yang lebih kuat dan berlangsung lama yang dapat menyebabkan perubahan hemodinamik untuk menginduksi iskemi seperti yang dihnsilkan dengan TMT.
European Journal of Prosthodontics, 2015
To maintain long-term stability of dental implants, it is important to minimize bone loss around ... more To maintain long-term stability of dental implants, it is important to minimize bone loss around an implant. Several clinical studies have shown a mean crestal bone loss of 1.5-2 mm around dental implants, in the first year after prosthetic restoration, as clinically acceptable. To limit this crestal bone resorption, several modifications are being tried in the implant systems. Platform Switching is one such concept, which uses prosthetic abutments with reduced diameter in relation to the implant platform diameter. This moves the implant abutment junction and supposedly the inflammatory reaction medially, away from the crestal bone, and may thus, minimize the crestal bone loss. Although, it was a serendipitous finding, an increasing number of implant systems have incorporated Platform Switching into their designs, as an innovative feature for preserving the peri-implant bone. A Medline search was carried out using the Pubmed search engine, with keywords Platform Switching in Dental Implants. Twenty-one studies (12 random-controlled trials, fourprospective-controlled clinical studies, and five clinical case series) were selected for review after screening of a total of 123 articles on the basis of the inclusion and exclusion criteria. A detailed review of these articles gave a clear tendency toward the positive impact of Platform Switching on crestal bone preservation, but further long-term, randomized-controlled trials, with uniform criteria, are required to confirm these results.
Gastrointestinal Endoscopy, 2000
Introduction: Proficiency in performing EUS is dependent upon accurate interpretation of structur... more Introduction: Proficiency in performing EUS is dependent upon accurate interpretation of structures seen during imaging. A lack of good anatomic correlates contributes to a long learning curve. Moreover, EUS is a dynamic imaging process where structures are sometimes identified by their changing relative orientations. Methods utilizing still images are unable to provide a spatial orientation in more than one plane. We describe a method of teaching EUS using the digitally correlated anatomy database (DCAD). This database has been created using images derived from the Visible Human Project (a comprehensive database of digital anatomy) and digitized EUS images. Methods: EUS images, both radial and linear, were captured to SVHS tapes during indicated procedures performed at the UCHSC, Denver. An image library was constructed by review of the tapes and digital capture of still EUS images as well as series of frames as videofiles (AVI format). The DCAD was constructed in a sequence of steps consisting of data manipulation, image correlation and digital animation. Initially, manipulation of the Visible Human database was performed on an advanced graphics workstation to obtain images corresponding to the selected EUS images. The thorax was divided into zones and correlated images were arranged in groups within each zone, focusing on structures of interest in different orientations. Each group contained both radial and linear correlated EUS and Visible Human images, video sequence of the EUS pull-through in that segment of thorax, animated sequences and the parent template (transverse and linear) from the Visible Human image pool. After organizing these data into anatomic segments, structures of interest were studied and identified by review of the still images, video sequences and animations within each group. Results: Study of the correlated still images suggested the identity of structures in question. The parent templates, animated anatomy along with the EUS video sequences from the DCAD confirmed the identity of structures seen in the still images. Future directions: Studies are being designed to objectively test whether the digitally correlated anatomy database shortens the learning curve when applied to prospective endosonographers in training. We plan to compile similar databases for the rectum, stomach and duodenum.
Clinical Oral Investigations, 2014
Periodontitis involves a complex interplay of micro-organisms and host immune response via numero... more Periodontitis involves a complex interplay of micro-organisms and host immune response via numerous mediator molecules playing strategic roles in its pathogenesis. Soluble CD40L (sCD40L) is one such co-stimulatory molecule which is essential for T-helper cell activation and is a well-known risk indicator of cardiovascular diseases. The levels of this marker in crevicular fluid of patients of chronic periodontitis have been explored in the present study for the first time along with an analysis of its association with levels in serum in otherwise systemically healthy patients. Sixty patients 20 healthy and 40 of chronic periodontitis (18 moderate and 22 severe) participated in the study. Patients of the diseased group underwent non-surgical periodontal therapy. Clinical evaluation and collection of gingival crevicular fluid (GCF) and serum samples was done at baseline, and 6 weeks after phase I periodontal therapy. sCD40L levels were quantified in the fluids using ELISA. Levels of sCD40L in GCF were significantly higher in the diseased group (p ≤ 0.001) and strongly correlated not only with increasing severity of disease but also with levels in serum. In post-treatment, the levels decreased significantly in both the biological fluids (p ≤ 0.001). The present study brings to light the role of sCD40L as a novel marker in mediating periodontal destruction and disease progression. Evaluation of local treatment outcomes seems promising in minimizing these effects. Positive association of its local levels with those in serum further implicates the possibility of widespread systemic effects of this infection.