Miljanka Vuksanovic - Academia.edu (original) (raw)

Papers by Miljanka Vuksanovic

Research paper thumbnail of The effects of early short-term insulin treatment vs. glimepiride on beta cell function in newly diagnosed type 2 diabetes with HbA1c above 9%

Turkish Journal of Medical Sciences

Research paper thumbnail of Capture the vertebral fracture: Risk factors as a prediction

Journal of Back and Musculoskeletal Rehabilitation, 2019

OBJECTIVE: Vertebral fractures are the most common osteoporotic fractures occurring due to low bo... more OBJECTIVE: Vertebral fractures are the most common osteoporotic fractures occurring due to low bone mineral density, as well as other risk factors. The aim of the paper is to investigate risk factors for vertebral osteoporotic fracture occurrence in postmenopausal women. METHODS: Retrospective analysis of data pertaining to 651 postmenopausal women obtained from the National Osteoporosis Registry of Serbia was conducted. Further analyses were performed on 217 osteoporotic women identified from those records, whereby those in the experimental group (n = 110) had a vertebral fracture, while those assigned to the control group (n = 107) did not. The two groups were comparable in terms of age (t = 0.450; p > 0.01). Risk factors that could serve as the best predictors of vertebral fracture occurrence were investigated. Multivariate logistic regression analysis was used for testing effect of several factors on vertebral fracture occurrence as the dependent variable. RESULTS: Patients that have never suffered a vertebral fracture had a significantly higher bone mineral density (t = 8.161; p < 0.01) in comparison to those with a verified vertebral fracture. Factors that significantly contributed to the risk of vertebral fracture were presence of kyphosis (OR 708.338; 95% CI 19.238-26.081.950), use of glucocorticoids (OR 87.618; 95% CI 9.175-836.707), and presence of comorbidities (OR 7.327; 95% CI 1.500-35.793). Moreover, a unit increase in body mass index (BMI) was found to lower the probability of vertebral fracture by a factor of 0.846. Women that entered menopause later have lower chance of suffering a vertebral fracture (OR = 0.539; 95% CI 0.400-0.726). CONCLUSION: Lower body mass index, presence of kyphosis, use of glucocorticoids, early menopause onset, and presence of comorbidities are the factors that contribute the most to vertebral osteoporotic fracture occurrence.

Research paper thumbnail of The Role of Radiation Therapy in Today's Management of Invasive Carcinoma of the Urinary Bladder

Research paper thumbnail of Letter to the Editor Thyroid Dysfunction in the Elderly with Hearth Failure Dear Editor-in-Chief

Research paper thumbnail of Thyroid Dysfunction in the Elderly with Hearth Failure

Iranian journal of public health, 2017

Research paper thumbnail of Importance of MMP-2 and MMP-9 gene polymorphism in the delopment of microvascular complications in type 2 diabetes patients

Research paper thumbnail of C-peptide response to standardized test meal in patients with newly diagnosed type 2 diabetes mellitus

Research paper thumbnail of Obesity and metabolic syndrome during the menopausal transition of women in Serbia

Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to... more Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause. Both are well recognized predictors of cardiovascular disease and diabetes in women. Aims The primary objective of this study was to assess the presence of obesity and metabolic syndrome during the menopause transition in Serbian women who attended health-care centers. The secondary objective was to evaluate the prevalence of ischemic heart disease, stroke and diabetes in this group. Our results present a part of the national epidemiological cross-sectional study assessing prevalence of metabolic syndrome and obesity in Serbia. In all, 1076 women attending 20 health-care centers were assessed. Women were divided into five groups: premenopausal, perimenopausal, early and late postmenopausal and geripausal. Medical history, waist circumference, blood glucose, lipids, and blood pressure were recorded. The mean body mass index of all women was 28.5 ± 4.9 kg/m(2). The mean waist circumference of all women was 92 ± 12.5 cm. Both were significantly lower in premenopausal women than in other women. Metabolic syndrome was present in 72% of women, with a significant difference in prevalence between premenopausal women and other groups. High triglyceride levels and hypertension were the most commonly present components of metabolic syndrome. Ischemic heart disease, stroke and diabetes occurred significantly more often in postmenopausal and geripausal women. The majority of Serbian women attending health-care centers have abdominal obesity and metabolic syndrome which significantly increase in prevalence in the perimenopausal years. This indicates that preventive measures should be focused on diabetes and cardiovascular disease in the perimenopause.

Research paper thumbnail of Assessment of cardiovascular disease risk in subjects with pre-diabetes

Endocrine Abstracts, 2019

Research paper thumbnail of 78 Obesity and Metabolic Syndrome During Menopause Transition in Women with Diabetes

Maturitas, 2012

contraceptives as well as a history of thrombosis even while being under anticoagulant treatment.... more contraceptives as well as a history of thrombosis even while being under anticoagulant treatment. On the basis of recently published studies recommendations for thrombophilia screening as well as management of high risk women for thrombosis applying for hormonal treatment will be given.

Research paper thumbnail of Lower levels of vitamin D as a predictor of reduced muscle strength in moderately obese postmenopausal women

Endocrine Abstracts, 2015

Research paper thumbnail of Cardiometabolic Risk in Postmenopausal Women in Serbia

Maturitas, 2009

Conclusion: Hypoestrogenic status of only 1-2 years increase cholesterol, especially LDL, and inc... more Conclusion: Hypoestrogenic status of only 1-2 years increase cholesterol, especially LDL, and increase atherogenesis rate. That period is too short for increasing BP. Appropriate estro/progestagen therapy, initiating in POF patients on time reduced infavourable changes on blood vessels and cardiovascular complications including higher mortality rate.

Research paper thumbnail of Obesity and metabolic syndrome during the menopause transition in Serbian women

Climacteric, 2011

Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to... more Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause. Both are well recognized predictors of cardiovascular disease and diabetes in women. Aims The primary objective of this study was to assess the presence of obesity and metabolic syndrome during the menopause transition in Serbian women who attended health-care centers. The secondary objective was to evaluate the prevalence of ischemic heart disease, stroke and diabetes in this group. Our results present a part of the national epidemiological cross-sectional study assessing prevalence of metabolic syndrome and obesity in Serbia. In all, 1076 women attending 20 health-care centers were assessed. Women were divided into five groups: premenopausal, perimenopausal, early and late postmenopausal and geripausal. Medical history, waist circumference, blood glucose, lipids, and blood pressure were recorded. The mean body mass index of all women was 28.5 ± 4.9 kg/m(2). The mean waist circumference of all women was 92 ± 12.5 cm. Both were significantly lower in premenopausal women than in other women. Metabolic syndrome was present in 72% of women, with a significant difference in prevalence between premenopausal women and other groups. High triglyceride levels and hypertension were the most commonly present components of metabolic syndrome. Ischemic heart disease, stroke and diabetes occurred significantly more often in postmenopausal and geripausal women. The majority of Serbian women attending health-care centers have abdominal obesity and metabolic syndrome which significantly increase in prevalence in the perimenopausal years. This indicates that preventive measures should be focused on diabetes and cardiovascular disease in the perimenopause.

Research paper thumbnail of Cross-talk between muscle and bone in postmenopausal women with hypovitaminosis D

Climacteric, 2016

Abstract Objectives: Visceral fat is more harmful than subcutaneous fat. Women with high amounts ... more Abstract Objectives: Visceral fat is more harmful than subcutaneous fat. Women with high amounts of visceral fat have an increased risk of metabolic syndrome (MetS), insulin resistance and low level of serum vitamin D. Methods: This was a prospective, randomized and controlled study. Postmenopausal women (n = 101) aged 45–70 years were included. The assessed parameters were: body mass index (BMI), waist circumference (WC), 25-hydroxyvitamin D (25-OHD) status, serum insulin and HOMA-IR, bone mineral density, total fat mass, fat mass index (FMI) measured by DXA, and muscle strength. Results: Significantly lower values of 25-OHD (35.26 ± 1.61 nmol/l) were found in women with MetS compared to those without MetS (47.52 ± 3.47nmol/l) (t = 3.699; p < 0.000). A significant negative correlation was observed between 25-OHD levels and: WC (rhoWC = −0.94; p < 0.004), BMI (rhoBMI = −0.80; p < 0.002), FMI (rhoFMI = −0.31; p < 0.002) and impaired fasting glucose (IFG) (rhoIFG = −0.23; p < 0.001). The percentage of body fat was statistically significantly higher in the group with insufficient 25-OHD (39.6%) and in the group with a deficit of 25-OHD (48.2%), compared with the maximum permitted percentage body fat of 35% for a female (t = −22.63; p < 0.002). The average hand grip strength of these moderately obese participants was 27.4 ± 4.7 kg. It was significantly lower than the normative grip strength for referent range groups (t = −21.65; p < 0.001). Conclusion: A low 25-OHD level in postmenopausal women is associated with high body fat, metabolic syndrome, low muscular strength and osteopenia.

Research paper thumbnail of Capture the fracture - use of bone turnover markers in clinical practice

Srpski arhiv za celokupno lekarstvo, 2016

Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per y... more Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoclasts and bone formation maintained osteoblasts. Loss of bone remodeling balance, with increased bone resorption, leads to osteoporosis. Bone turnover markers are classified as markers of bone formation and of bone resorption. During the growth and development of skeleton, bone turnover markers show higher levels of activity than in the adult period. The increase in biochemical markers peaks again in the postmenopausal period, indicating accelerated bone remodeling. Bone mineral density is an important predictor of an osteoporotic fracture. Timely assessment of risk factors of osteoporosis and bone markers can detect subjects with accelerated bone remodeling and osteoporosis. This may introduce adequate therapy and prevent fracture.

Research paper thumbnail of Thyroid and parathyroid secretion disorders in senile osteoporosis

Endocrine Abstracts, 2016

Research paper thumbnail of Coronary artery calcium score in prediabetes - preliminary results

Endocrine Abstracts, 2017

Research paper thumbnail of The association of 25 hydroxyvitamin D and hand grip strength in postmenopausal women

Research paper thumbnail of Menopausal Women, Suffering from Osteopenia and Vitamin D Deficiency

Maturitas, 2009

The purpose of our study is to demonstrate the efficacy of osteoporosis treatment with tibolone, ... more The purpose of our study is to demonstrate the efficacy of osteoporosis treatment with tibolone, conjugated estrogen therapy, raloxifene and alendronate respectively. Methods: The study included 120 postmenopausal women who were conducted at the outpatient clinic for the years 2001 to 2008. They were separated in four groups. The first group of 30 women was treated with 2.5mg of tibolone per day (peros). The second group of 30 women was treated with 0.625mg conjugated equine estrogen + 5mg Medroxyprogesterone Acetate, for two years. The third group of 30 women were given Raloxifene for two years. The fourth group was treated with alendronate for two years. All women received 1000 mgr of Calcium and 0.5 micrograms of Vitamin D. All women had between 12 months to two years of amenorrhea and had increase of the gonadotropins level in the laboratory findings. The mean bone mineral density in the lumbar spine was measured. The statistic analysis of the results was done by SPSS (p<0.05) was considered as statistically important. Results: After two years of treatment the results were: The first group had a significant increase of 5.9% in the mean bone mineral density, the second group had a 5.8% increase, the third group had a 2.9% increase and the fourth group had a 5.6% increase in the bone marrow density. Conclusions: The osteoporosis treatment with tibolone, conjugated estrogen therapy, raloxifene and alendronate is beneficial to the increase of the mean bone mineral density

Research paper thumbnail of Social and mental functioning in postmenopausal women with low bone mineral density

Medicinski pregled, 2018

Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by re... more Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by reduced bone mineral density leading to bone fragility and reduced quality of life. The objective of this study was to examine the quality of social and mental functioning in postmenopausal women with reduced mineral bone density. Material and Methods. This prospective cross-sectional study included 210 postmenopausal women aged ≥ 50 years, who were referred for osteodensitometry to the Special Hospital for Rheumatic Diseases Novi Sad, Serbia. The study was conducted in the period from February 24 to April 3, 2017. All women completed the Serbian version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (41). They all underwent bone mineral density measurement in two regions of interest, and the results were interpreted according to the current definition of osteoporosis. The participants' social and mental functioning was analyzed including the following variables: age, place of residence, educational attainment, employment, nutritional status, bone mineral density, and low-trauma fractures. Statistical processing and analyses were performed using Statistical Package for the Social Sciences, version 20. Results. A statistically significant negative correlation was noted between social functioning and the T-score for the femoral neck (r =-0.438), hip (r =-0.412) and spine (r =-0.226), as well as mental functioning with the T-score for the femoral neck (r =-0.424), hip (r =-0.454) and spine (r =-0.319). Patients with a history of fractures had a poorer quality of social functioning (t = 2.17, p < 0.05). Conclusion. The examinees of older age, with poor socio-demographic status, reduced bone mineral density, history of low-trauma fractures presented with lower quality of social and mental functioning.

Research paper thumbnail of The effects of early short-term insulin treatment vs. glimepiride on beta cell function in newly diagnosed type 2 diabetes with HbA1c above 9%

Turkish Journal of Medical Sciences

Research paper thumbnail of Capture the vertebral fracture: Risk factors as a prediction

Journal of Back and Musculoskeletal Rehabilitation, 2019

OBJECTIVE: Vertebral fractures are the most common osteoporotic fractures occurring due to low bo... more OBJECTIVE: Vertebral fractures are the most common osteoporotic fractures occurring due to low bone mineral density, as well as other risk factors. The aim of the paper is to investigate risk factors for vertebral osteoporotic fracture occurrence in postmenopausal women. METHODS: Retrospective analysis of data pertaining to 651 postmenopausal women obtained from the National Osteoporosis Registry of Serbia was conducted. Further analyses were performed on 217 osteoporotic women identified from those records, whereby those in the experimental group (n = 110) had a vertebral fracture, while those assigned to the control group (n = 107) did not. The two groups were comparable in terms of age (t = 0.450; p > 0.01). Risk factors that could serve as the best predictors of vertebral fracture occurrence were investigated. Multivariate logistic regression analysis was used for testing effect of several factors on vertebral fracture occurrence as the dependent variable. RESULTS: Patients that have never suffered a vertebral fracture had a significantly higher bone mineral density (t = 8.161; p < 0.01) in comparison to those with a verified vertebral fracture. Factors that significantly contributed to the risk of vertebral fracture were presence of kyphosis (OR 708.338; 95% CI 19.238-26.081.950), use of glucocorticoids (OR 87.618; 95% CI 9.175-836.707), and presence of comorbidities (OR 7.327; 95% CI 1.500-35.793). Moreover, a unit increase in body mass index (BMI) was found to lower the probability of vertebral fracture by a factor of 0.846. Women that entered menopause later have lower chance of suffering a vertebral fracture (OR = 0.539; 95% CI 0.400-0.726). CONCLUSION: Lower body mass index, presence of kyphosis, use of glucocorticoids, early menopause onset, and presence of comorbidities are the factors that contribute the most to vertebral osteoporotic fracture occurrence.

Research paper thumbnail of The Role of Radiation Therapy in Today's Management of Invasive Carcinoma of the Urinary Bladder

Research paper thumbnail of Letter to the Editor Thyroid Dysfunction in the Elderly with Hearth Failure Dear Editor-in-Chief

Research paper thumbnail of Thyroid Dysfunction in the Elderly with Hearth Failure

Iranian journal of public health, 2017

Research paper thumbnail of Importance of MMP-2 and MMP-9 gene polymorphism in the delopment of microvascular complications in type 2 diabetes patients

Research paper thumbnail of C-peptide response to standardized test meal in patients with newly diagnosed type 2 diabetes mellitus

Research paper thumbnail of Obesity and metabolic syndrome during the menopausal transition of women in Serbia

Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to... more Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause. Both are well recognized predictors of cardiovascular disease and diabetes in women. Aims The primary objective of this study was to assess the presence of obesity and metabolic syndrome during the menopause transition in Serbian women who attended health-care centers. The secondary objective was to evaluate the prevalence of ischemic heart disease, stroke and diabetes in this group. Our results present a part of the national epidemiological cross-sectional study assessing prevalence of metabolic syndrome and obesity in Serbia. In all, 1076 women attending 20 health-care centers were assessed. Women were divided into five groups: premenopausal, perimenopausal, early and late postmenopausal and geripausal. Medical history, waist circumference, blood glucose, lipids, and blood pressure were recorded. The mean body mass index of all women was 28.5 ± 4.9 kg/m(2). The mean waist circumference of all women was 92 ± 12.5 cm. Both were significantly lower in premenopausal women than in other women. Metabolic syndrome was present in 72% of women, with a significant difference in prevalence between premenopausal women and other groups. High triglyceride levels and hypertension were the most commonly present components of metabolic syndrome. Ischemic heart disease, stroke and diabetes occurred significantly more often in postmenopausal and geripausal women. The majority of Serbian women attending health-care centers have abdominal obesity and metabolic syndrome which significantly increase in prevalence in the perimenopausal years. This indicates that preventive measures should be focused on diabetes and cardiovascular disease in the perimenopause.

Research paper thumbnail of Assessment of cardiovascular disease risk in subjects with pre-diabetes

Endocrine Abstracts, 2019

Research paper thumbnail of 78 Obesity and Metabolic Syndrome During Menopause Transition in Women with Diabetes

Maturitas, 2012

contraceptives as well as a history of thrombosis even while being under anticoagulant treatment.... more contraceptives as well as a history of thrombosis even while being under anticoagulant treatment. On the basis of recently published studies recommendations for thrombophilia screening as well as management of high risk women for thrombosis applying for hormonal treatment will be given.

Research paper thumbnail of Lower levels of vitamin D as a predictor of reduced muscle strength in moderately obese postmenopausal women

Endocrine Abstracts, 2015

Research paper thumbnail of Cardiometabolic Risk in Postmenopausal Women in Serbia

Maturitas, 2009

Conclusion: Hypoestrogenic status of only 1-2 years increase cholesterol, especially LDL, and inc... more Conclusion: Hypoestrogenic status of only 1-2 years increase cholesterol, especially LDL, and increase atherogenesis rate. That period is too short for increasing BP. Appropriate estro/progestagen therapy, initiating in POF patients on time reduced infavourable changes on blood vessels and cardiovascular complications including higher mortality rate.

Research paper thumbnail of Obesity and metabolic syndrome during the menopause transition in Serbian women

Climacteric, 2011

Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to... more Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause. Both are well recognized predictors of cardiovascular disease and diabetes in women. Aims The primary objective of this study was to assess the presence of obesity and metabolic syndrome during the menopause transition in Serbian women who attended health-care centers. The secondary objective was to evaluate the prevalence of ischemic heart disease, stroke and diabetes in this group. Our results present a part of the national epidemiological cross-sectional study assessing prevalence of metabolic syndrome and obesity in Serbia. In all, 1076 women attending 20 health-care centers were assessed. Women were divided into five groups: premenopausal, perimenopausal, early and late postmenopausal and geripausal. Medical history, waist circumference, blood glucose, lipids, and blood pressure were recorded. The mean body mass index of all women was 28.5 ± 4.9 kg/m(2). The mean waist circumference of all women was 92 ± 12.5 cm. Both were significantly lower in premenopausal women than in other women. Metabolic syndrome was present in 72% of women, with a significant difference in prevalence between premenopausal women and other groups. High triglyceride levels and hypertension were the most commonly present components of metabolic syndrome. Ischemic heart disease, stroke and diabetes occurred significantly more often in postmenopausal and geripausal women. The majority of Serbian women attending health-care centers have abdominal obesity and metabolic syndrome which significantly increase in prevalence in the perimenopausal years. This indicates that preventive measures should be focused on diabetes and cardiovascular disease in the perimenopause.

Research paper thumbnail of Cross-talk between muscle and bone in postmenopausal women with hypovitaminosis D

Climacteric, 2016

Abstract Objectives: Visceral fat is more harmful than subcutaneous fat. Women with high amounts ... more Abstract Objectives: Visceral fat is more harmful than subcutaneous fat. Women with high amounts of visceral fat have an increased risk of metabolic syndrome (MetS), insulin resistance and low level of serum vitamin D. Methods: This was a prospective, randomized and controlled study. Postmenopausal women (n = 101) aged 45–70 years were included. The assessed parameters were: body mass index (BMI), waist circumference (WC), 25-hydroxyvitamin D (25-OHD) status, serum insulin and HOMA-IR, bone mineral density, total fat mass, fat mass index (FMI) measured by DXA, and muscle strength. Results: Significantly lower values of 25-OHD (35.26 ± 1.61 nmol/l) were found in women with MetS compared to those without MetS (47.52 ± 3.47nmol/l) (t = 3.699; p < 0.000). A significant negative correlation was observed between 25-OHD levels and: WC (rhoWC = −0.94; p < 0.004), BMI (rhoBMI = −0.80; p < 0.002), FMI (rhoFMI = −0.31; p < 0.002) and impaired fasting glucose (IFG) (rhoIFG = −0.23; p < 0.001). The percentage of body fat was statistically significantly higher in the group with insufficient 25-OHD (39.6%) and in the group with a deficit of 25-OHD (48.2%), compared with the maximum permitted percentage body fat of 35% for a female (t = −22.63; p < 0.002). The average hand grip strength of these moderately obese participants was 27.4 ± 4.7 kg. It was significantly lower than the normative grip strength for referent range groups (t = −21.65; p < 0.001). Conclusion: A low 25-OHD level in postmenopausal women is associated with high body fat, metabolic syndrome, low muscular strength and osteopenia.

Research paper thumbnail of Capture the fracture - use of bone turnover markers in clinical practice

Srpski arhiv za celokupno lekarstvo, 2016

Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per y... more Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoclasts and bone formation maintained osteoblasts. Loss of bone remodeling balance, with increased bone resorption, leads to osteoporosis. Bone turnover markers are classified as markers of bone formation and of bone resorption. During the growth and development of skeleton, bone turnover markers show higher levels of activity than in the adult period. The increase in biochemical markers peaks again in the postmenopausal period, indicating accelerated bone remodeling. Bone mineral density is an important predictor of an osteoporotic fracture. Timely assessment of risk factors of osteoporosis and bone markers can detect subjects with accelerated bone remodeling and osteoporosis. This may introduce adequate therapy and prevent fracture.

Research paper thumbnail of Thyroid and parathyroid secretion disorders in senile osteoporosis

Endocrine Abstracts, 2016

Research paper thumbnail of Coronary artery calcium score in prediabetes - preliminary results

Endocrine Abstracts, 2017

Research paper thumbnail of The association of 25 hydroxyvitamin D and hand grip strength in postmenopausal women

Research paper thumbnail of Menopausal Women, Suffering from Osteopenia and Vitamin D Deficiency

Maturitas, 2009

The purpose of our study is to demonstrate the efficacy of osteoporosis treatment with tibolone, ... more The purpose of our study is to demonstrate the efficacy of osteoporosis treatment with tibolone, conjugated estrogen therapy, raloxifene and alendronate respectively. Methods: The study included 120 postmenopausal women who were conducted at the outpatient clinic for the years 2001 to 2008. They were separated in four groups. The first group of 30 women was treated with 2.5mg of tibolone per day (peros). The second group of 30 women was treated with 0.625mg conjugated equine estrogen + 5mg Medroxyprogesterone Acetate, for two years. The third group of 30 women were given Raloxifene for two years. The fourth group was treated with alendronate for two years. All women received 1000 mgr of Calcium and 0.5 micrograms of Vitamin D. All women had between 12 months to two years of amenorrhea and had increase of the gonadotropins level in the laboratory findings. The mean bone mineral density in the lumbar spine was measured. The statistic analysis of the results was done by SPSS (p<0.05) was considered as statistically important. Results: After two years of treatment the results were: The first group had a significant increase of 5.9% in the mean bone mineral density, the second group had a 5.8% increase, the third group had a 2.9% increase and the fourth group had a 5.6% increase in the bone marrow density. Conclusions: The osteoporosis treatment with tibolone, conjugated estrogen therapy, raloxifene and alendronate is beneficial to the increase of the mean bone mineral density

Research paper thumbnail of Social and mental functioning in postmenopausal women with low bone mineral density

Medicinski pregled, 2018

Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by re... more Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by reduced bone mineral density leading to bone fragility and reduced quality of life. The objective of this study was to examine the quality of social and mental functioning in postmenopausal women with reduced mineral bone density. Material and Methods. This prospective cross-sectional study included 210 postmenopausal women aged ≥ 50 years, who were referred for osteodensitometry to the Special Hospital for Rheumatic Diseases Novi Sad, Serbia. The study was conducted in the period from February 24 to April 3, 2017. All women completed the Serbian version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (41). They all underwent bone mineral density measurement in two regions of interest, and the results were interpreted according to the current definition of osteoporosis. The participants' social and mental functioning was analyzed including the following variables: age, place of residence, educational attainment, employment, nutritional status, bone mineral density, and low-trauma fractures. Statistical processing and analyses were performed using Statistical Package for the Social Sciences, version 20. Results. A statistically significant negative correlation was noted between social functioning and the T-score for the femoral neck (r =-0.438), hip (r =-0.412) and spine (r =-0.226), as well as mental functioning with the T-score for the femoral neck (r =-0.424), hip (r =-0.454) and spine (r =-0.319). Patients with a history of fractures had a poorer quality of social functioning (t = 2.17, p < 0.05). Conclusion. The examinees of older age, with poor socio-demographic status, reduced bone mineral density, history of low-trauma fractures presented with lower quality of social and mental functioning.