Milosavljevic Milutin - Academia.edu (original) (raw)
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Papers by Milosavljevic Milutin
Chemical Industry and Chemical Engineering Quarterly, 2015
The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from a... more The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work. Therefore, thioureas synthesis was developed in two ways: Method I reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, 1 H and 13 C NMR and MS instrumental methods, and purity was determined by highperformance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described, environmentally benign process of thioureas synthesis, represent a suitable option to existing methods.
The reaction kinetics of the synthesis of sodium ethyl xanthogeneacetate from potassium ethylxant... more The reaction kinetics of the synthesis of sodium ethyl xanthogeneacetate from potassium ethylxanthogenate and sodium chloroacetate in distilled water as the reaction medium at 25, 30, 35 and 40 °C, were investigated. The obtained reaction mixture was a complex system which demanded the use of two methods for the kinetic measurements. The reaction was followed using the conductrometric and UV/Vis spectrophotometric method with equimolar initial concentrations of the re-actants and under pseudo-first order conditions with respect to one of the reactants. The rate constants of the pseudo-first order and second order reactions were calculated from the data. On the basis of the reaction constants, the activation parameters were calculated and are discussed.
Chemical Industry and Chemical Engineering Quarterly, 2015
The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from a... more The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work. Therefore, thioureas synthesis was developed in two ways: Method I reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, 1 H and 13 C NMR and MS instrumental methods, and purity was determined by highperformance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described, environmentally benign process of thioureas synthesis, represent a suitable option to existing methods.
The reaction kinetics of the synthesis of sodium ethyl xanthogeneacetate from potassium ethylxant... more The reaction kinetics of the synthesis of sodium ethyl xanthogeneacetate from potassium ethylxanthogenate and sodium chloroacetate in distilled water as the reaction medium at 25, 30, 35 and 40 °C, were investigated. The obtained reaction mixture was a complex system which demanded the use of two methods for the kinetic measurements. The reaction was followed using the conductrometric and UV/Vis spectrophotometric method with equimolar initial concentrations of the re-actants and under pseudo-first order conditions with respect to one of the reactants. The rate constants of the pseudo-first order and second order reactions were calculated from the data. On the basis of the reaction constants, the activation parameters were calculated and are discussed.