Min-Jæ JEON - Academia.edu (original) (raw)
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Papers by Min-Jæ JEON
Korean Circulation Journal, 2006
Background and Objectives：Recent technical developments with high-resolution real-time 3-dimensio... more Background and Objectives：Recent technical developments with high-resolution real-time 3-dimensional echocardiography (RT3DE) have facilitated the acquisition of high quality images and the analysis of segmental volumetime curves (VTCs). The purposes of this study were to assess left ventricular (LV) asynchrony with using the VTCs of 16 segments by RT3DE and to compare this with tissue Doppler imaging (TDI) as a clinical parameter. Subjects and Methods：Twenty-three heart failure (HF) patients (LVEF: 25±6%, age: 60±13 years) and 16 normal controls underwent TDI and RT3DE at baseline and 1-year. The standard deviation (SD 3) of the end systolic time to reach the minimal systolic volume for the 16 segments on VTCs was obtained by RT3DE. The standard deviation (SD 2) of the electromechanical coupling time for the 8 segments was measured using TDI. Results： SD 3 was markedly higher in the HF patients than that in the controls (7.7±2.5 vs 1.5±1.0%, respectively, p< 0.01) and it increased as the LVEF decreased (r=-0.85, p<0.01). SD 2 was also significantly higher in the HF patients (27.0±8.6 vs 12.6±5.0 msec, respectively, p<0.01) and it had good negative correlation with the LVEF (r=-0.72, p<0.01). SD 3 was well correlated with SD 2 (r=0.66, p<0.01). At 1-year, the HF patients with an increased LVEF showed a decreased SD 3 (7/13). In contrast, the patients with a decreased LVEF had an increased SD 3 (3/13). Conclusion：The analysis of VTCs for the 16 LV segments with using RT3DE from a single acoustic window may be a useful clinical parameter for evaluating the LV function, including LV asynchrony, the LV volume and the LVEF. (Korean Circulation J 2006;36:669-675) KEY WORDS：Heart failure；Echocardiography.
Molecules and Cells, 2000
The 60 amino acid long homeodomain of Antennapedia (Antp), either alone or as a fusion protein wi... more The 60 amino acid long homeodomain of Antennapedia (Antp), either alone or as a fusion protein with 30-40 amino acid long foreign polypeptides, has been reported to cross biological membranes by an energy- and receptor-protein-independent mechanism. Moreover, the 16 amino acid long third helix of the Antp homeodomain, so-called penetratin, possesses translocation properties when fused to fewer than 100 amino acids as well. These findings led us to study whether such a protein tansduction property is shared by other homeodomains. We report here that homeodomains of two homeoproteins, Fushi-tarazu and Engrailed, are able to transduce a 238 amino acid long green fluorescent protein into cultured cells as efficiently as other well-known protein transduction domains, such as an internal oligopeptide of Tat and penetratin. These findings suggest that such transduction activity of homeodomains might have some physiological roles and that it can be exploited for development of efficient transduction vectors for research use and protein therapy.
Korean Circulation Journal, 2006
Background and Objectives：Recent technical developments with high-resolution real-time 3-dimensio... more Background and Objectives：Recent technical developments with high-resolution real-time 3-dimensional echocardiography (RT3DE) have facilitated the acquisition of high quality images and the analysis of segmental volumetime curves (VTCs). The purposes of this study were to assess left ventricular (LV) asynchrony with using the VTCs of 16 segments by RT3DE and to compare this with tissue Doppler imaging (TDI) as a clinical parameter. Subjects and Methods：Twenty-three heart failure (HF) patients (LVEF: 25±6%, age: 60±13 years) and 16 normal controls underwent TDI and RT3DE at baseline and 1-year. The standard deviation (SD 3) of the end systolic time to reach the minimal systolic volume for the 16 segments on VTCs was obtained by RT3DE. The standard deviation (SD 2) of the electromechanical coupling time for the 8 segments was measured using TDI. Results： SD 3 was markedly higher in the HF patients than that in the controls (7.7±2.5 vs 1.5±1.0%, respectively, p< 0.01) and it increased as the LVEF decreased (r=-0.85, p<0.01). SD 2 was also significantly higher in the HF patients (27.0±8.6 vs 12.6±5.0 msec, respectively, p<0.01) and it had good negative correlation with the LVEF (r=-0.72, p<0.01). SD 3 was well correlated with SD 2 (r=0.66, p<0.01). At 1-year, the HF patients with an increased LVEF showed a decreased SD 3 (7/13). In contrast, the patients with a decreased LVEF had an increased SD 3 (3/13). Conclusion：The analysis of VTCs for the 16 LV segments with using RT3DE from a single acoustic window may be a useful clinical parameter for evaluating the LV function, including LV asynchrony, the LV volume and the LVEF. (Korean Circulation J 2006;36:669-675) KEY WORDS：Heart failure；Echocardiography.
Molecules and Cells, 2000
The 60 amino acid long homeodomain of Antennapedia (Antp), either alone or as a fusion protein wi... more The 60 amino acid long homeodomain of Antennapedia (Antp), either alone or as a fusion protein with 30-40 amino acid long foreign polypeptides, has been reported to cross biological membranes by an energy- and receptor-protein-independent mechanism. Moreover, the 16 amino acid long third helix of the Antp homeodomain, so-called penetratin, possesses translocation properties when fused to fewer than 100 amino acids as well. These findings led us to study whether such a protein tansduction property is shared by other homeodomains. We report here that homeodomains of two homeoproteins, Fushi-tarazu and Engrailed, are able to transduce a 238 amino acid long green fluorescent protein into cultured cells as efficiently as other well-known protein transduction domains, such as an internal oligopeptide of Tat and penetratin. These findings suggest that such transduction activity of homeodomains might have some physiological roles and that it can be exploited for development of efficient transduction vectors for research use and protein therapy.