Mina Lotfi - Academia.edu (original) (raw)
Papers by Mina Lotfi
ACS Chemical Neuroscience, 2013
Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with ... more Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with several neuronaldiseases (e.g. Alzheimer's disease). We report here an importance of slight temperature changes, in the physiological range (35-42°C), on the amyloid fibrillation process in the presence and absence of hydrophilic (silica) and hydrophobic (polystyrene) nanoparticles (NPs). The results highlight the fact that slight increases in temperature can induce inhibitory and acceleratory effects of hydrophobic and hydrophilic NPs on the fibrillation process, respectively. Using further in vivo considerations, the outcomes of this study can be used for considerable modifications on the current diagnosis and treatment approaches in amyloid-involved diseases.
SSRN Electronic Journal, 2017
Suku Banjar yang merupakan suku asli di Kalimantan Selatan sejak dulu mengenal mantra. Mantra pak... more Suku Banjar yang merupakan suku asli di Kalimantan Selatan sejak dulu mengenal mantra. Mantra pakasih dan papikat adalah salah satu jenis mantra yang dipercaya dapat menimbulkan rasa kasih (pakasih) dan membuat rasa ketertarikan lawan jenis, dalam arti lain sebagai pemikat atau pelet (papikat). Sebagai salah satu genre sastra tradisional, mantra memiliki gaya bahasa yang berbeda dari genre sastra tradisional lainnya baik dari pola bentuk maupun pilihan bahasa yang digunakan. Selain itu, keberadaan mantra tidak terlepas dari unsur kealaman yang terdapat di alam semesta. Pemerian nama-nama tumbuhan dan hewan memiliki peran dalam hadirnya sebuah mantra pakasih dan papikat pada masyarakat suku Banjar. Melalui artikel ini dideskripsikan gaya bahasa dan wujud unsur kealaman yang terdapat dalam mantra pakasih dan papikat masyarakat suku Banjar. Penelitian ini menggunakan metode deskriptif kualitatif. Adapun hasil penelitian yang diperoleh dalam penelitian ini yakni (1) bentuk fisik mantra mantra pakasih dan papikat terdiri atas pola bentuk mantra bebas dan pola bentuk mantra terikat, (2) unsur kealaman mantra pakasih dan papikat seperti unsur alam semesta, hewan/binatang dan tumbuhan. Dalam penelitian ini mantra dikaji dengan kajian stilistika bertitik pada kajian gaya bahasanya dan kajian ekokritik (ekologi) untuk menganalisis unsur lingkungan atau kealaman yang terdapat dalam mantra pakasih dan papikat.
According to PMBOK standard, eighth process of project management is risk management. Technique o... more According to PMBOK standard, eighth process of project management is risk management. Technique of Earned Value Management (EVM) as well as project planning and control system in recent decades has been widely used. Integration of risk management and earned value management to predict and estimate the cost and time of completion of the project is an effective tool in the management and control of the project. Each of these techniques has at least one key weakness; the main weakness of EVM is focus of this way on predicting future development based on past progresses. The event that has happened in the past is not concerned by risk management; now according to this importance, in this paper outlines two methods and explains benefits of integrating earned value management with risk management in order to achieve maximum performance.
Design, build, and sell a safe automated primary color dye mixer to schools for the purpose of te... more Design, build, and sell a safe automated primary color dye mixer to schools for the purpose of teaching children how 12 secondary colors (and shades) on a color wheel can be made via the primary colors. The user will select the desired color and then the machine will automatically deposit the correct amount of each primary color to create the selected color. Either water-based paint or dye will be used in the machine so that if a mess is made, the cleanup is easy. The cup with the colors will then be mixed automatically. From here, the final dye mixture will match the desired color chosen at the beginning.
Chemistry – A European Journal, 2021
Organic resin cross-linking ZIF-67/SiO2 superhydrophobic (SHPB) multilayer coating was successful... more Organic resin cross-linking ZIF-67/SiO2 superhydrophobic (SHPB) multilayer coating was successfully fabricated on metal substrate. The perfluoro-octyl-triethoxy silane (POTS) modified ZIF-67 and SiO2 coating was applied on primary coated polytetrafluoroethylene (PTFE) and epoxy resin (EP) via spray coating method. Here, we present that the robust superhydrophobicity can be realized by structuring surfaces at two different length scales, with a nanostructure design to provide water repellency and a microstructure design to provide durability. The as-fabricated multilayer coating displayed superior water-repellency (CA=167.4°), chemical robustness (pH=1-14) and mechanical durability undergoing 120th linear abrasion or 35th rotatory abrasion cycle. By applying different acidic and basic corrosive media and various weathering conditions, it can still maintain superior-hydrophobicity. To get a better insight of interaction between inhibitor molecules and metal surface, density functional theory (DFT) calculations were performed, showing lower energy gap and increased binding energy of ZPS/SiO2/PTFE/EP (ZPS=ZIF-67+POTS) multilayer coating compared to the ZIF/SiO2/PTFE/EP, thereby supporting the experimental findings. Additionally, such coatings may be useful for applications such as anti-corrosion, self-cleaning, and anti-icing multi-functionalities.
Sustainable Energy & Fuels, 2021
A metal–organic framework mediated nickel doped ferrite composite with superior lithium storage p... more A metal–organic framework mediated nickel doped ferrite composite with superior lithium storage properties was successfully synthesized. A DFT study also elucidated the reaction pathway for Cu1−xNixFe2O4.
Journal of Computational and Applied Mathematics, 2020
Hieraus entsteht die Aufgabe, die einfachsten Thatsachen aufzusuchen, aus denen sich die Massverh... more Hieraus entsteht die Aufgabe, die einfachsten Thatsachen aufzusuchen, aus denen sich die Massverhältnisse des Raumes bestimmen lassen. Der nächst einfache Fall würde wohl die Mannigfaltigkeiten umfassen, in welchen sich das Linienelement durch die vierte Wurzel aus einem Differentialausdrucke vierten Grades ausdrücken lässt. Riemann, 1854 Resumen. Las formas de rango superior son generalizaciones de las formas cuadráticas, mientras que la geometría de rango superior es una generalización de la geometría riemanniana (la cual está basada en una forma cuadrática: el tensor métrico). Hasta el momento existen pocos resultados matemáticos que permitan caracterizar las formas y la geometría de rango superior y sus propiedades. Se presentan las motivaciones, matemáticas y físicas, para considerar estas generalizaciones y algunos resultados obtenidos hasta el momento.
Applied Surface Science, 2018
Using molecular models for pristine (NT) and COOH (FNT) functionalized carbon nanotube, ten nonco... more Using molecular models for pristine (NT) and COOH (FNT) functionalized carbon nanotube, ten noncovalent configurations and four mechanisms of covalent functionalization of NT and FNT with cladribine anticancer drug (CDA) were studied. Quantum molecular descriptors, free energies of solvation and binding energies of noncovalent interactions were investigated in H 2 O and DMF solvents and gas phase. The calculation of binding energies confirmed the energetic stability of all CDA/NT and CDA/FNT configurations. The free energies of solvation show that NT and FNT solubility increases in all drug-nanotube configurations which is a main factor for its applicability in the drug delivery. Quantum molecular descriptors of drug such as global hardness and HOMO-LUMO energy gap are higher than those of drug-nanotube complexes, showing the reactivity of the drug increases. The AIM analysis for the most stable configuration (CDA/FNT2) demonstrated that the intermolecular hydrogen bonding plays a main role in this system. For the covalent functionalization COOH (FNT) and COCl (NTCOCl) functionalized carbon nanotubes were considered. Cladribine may bond to FNT and NTCOCl through NH 2 and OH groups. The activation parameters of all pathways were calculated, indicating the activation energies and Gibbs free energies related to FNT mechanisms are higher than those of NTCOCl mechanisms.
Emergency Radiology, 2018
Purpose Spinal MRI is the exam of choice for the workup of patients with suspected spinal infecti... more Purpose Spinal MRI is the exam of choice for the workup of patients with suspected spinal infection. In this retrospective study, we assess the value of obtaining contrast-enhanced spinal MRI for patients presenting to the emergency department (ED) with acute back pain and a history of intravenous drug use (IVDU). Methods A retrospective IRB-approved, HIPAA compliant review of the imaging findings, reports and electronic charts of 167 consecutive IV drug-using patients (M/F = 96:71, mean age = 40 years) that presented to the ED with acute back pain over a 55month period and underwent contrast-enhanced spinal MRI within 24 h. Fisher's exact test was used to identify statistically significant (p < 0.05) associations with MRI findings. Results Evidence of infectious spondylitis was demonstrated on the spinal MRIs of 39.5% (n = 66) of 167 patients, all of whom were admitted, and nearly half (48.5%; 32/66) underwent surgical or percutaneous intervention. Statistically significant differences in the decision to admit, blood cultures, and the type of treatment was demonstrated in patients with findings of spinal infection on MRI (p < 0.05). Conclusion Use of emergent spinal MRI in the workup of IVDU patients with acute back pain is justified despite the resultant pressure on MRI scanner, technologist, and interpretation time.
AJR. American journal of roentgenology, Jan 31, 2018
The purpose of this article is to describe knee abnormalities and the occurrence of MRI-detected ... more The purpose of this article is to describe knee abnormalities and the occurrence of MRI-detected sports-related knee abnormalities by evaluating MRI examinations performed during the Rio de Janeiro Olympic Games held in August 2016. There were 11,274 athletes at the Rio 2016 Olympic Games, and 113 of them underwent at least one knee MRI in the Olympic Village. Cartilage abnormalities, followed by meniscal tears and ligament sprains, were the most frequent abnormalities.
Journal of Alzheimer's disease : JAD, 2014
Two decades of the amyloid-β (Aβ) hypothesis in Alzheimer's disease (AD) and the prominence o... more Two decades of the amyloid-β (Aβ) hypothesis in Alzheimer's disease (AD) and the prominence of Aβ-targeting strategies have yet to meet the levels of original expectation. Disappointing results in numerous Phase II/III studies have called for a re-examination of the validity of the Aβ-targeting approaches as an intervention strategy in AD. The mid-life onset of chronic conditions (e.g., hypertension, diabetes, insulin intolerance, and depression nominated as risk factors for the later development of AD) points to the possibility that each condition could involve mechanisms, which while relatively modest over a short-term, could have significant accumulative effects. What may also not be fully appreciated is that a number of these conditions involve potential disturbances to multivalent cations (MC) levels through various mechanisms such as autophagy, oxidative stress, and apoptosis. Furthermore, some MCs have intimate associations with the mechanisms by which Aβ pathology manife...
![Research paper thumbnail of QTAIM study of substituent effects on the intramolecular hydrogen bond in 3,3′-dihydroxy-4,4′-[5-methyl-1,3-phenylenebis(nitrilomethylidyne)]-bis-phenol](https://attachments.academia-assets.com/90841973/thumbnails/1.jpg)
](Journal of Molecular Structure, 2015
The effects of various substituent groups on the hydrogen bond energy in the 3,3'-dihydroxy-4,4'-... more The effects of various substituent groups on the hydrogen bond energy in the 3,3'-dihydroxy-4,4'-[5-methyl-1,3-phenylenebis(nitrilomethylidyne)]-bis-phenol (L(CH 3)pnp) molecules is one of the factors controlling intramolecular proton transfer process in the molecule's functional group. In this work, we focused on the influence of different groups on this phenomenon, into the framework of the atom in molecules (AIM) theory. In addition, the calculations of transition state were performed to evaluate the proton transfer's energy barrier of the proton transfer in the Schiff base molecule Lpnp. Investigation the effect of the electron withdrawing groups including, CHO, CN, CF 3 ,NO 2 , COOH, COCH 3 , F, Cl And that of electron donating species consisting of NH 2 , OH, C 2 H 5 , CH 3 on the covalent nature of the intramolecular hydrogen bond shows different results: decrease in the electron withdrawing ability reduces the covalent nature whereas, electron donating substituents increase it. The topological properties such as the bond critical point (BCP), ring critical point (RCP), the delocalization index DI, and the integrated properties of the interatomic surface δ (O, H), δ (N, H) and H (G+V) can all be considered as indicators to determine the strength of the intramolecular hydrogen bond.
ACS Chemical Neuroscience, 2013
Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with ... more Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with several neuronaldiseases (e.g. Alzheimer's disease). We report here an importance of slight temperature changes, in the physiological range (35-42°C), on the amyloid fibrillation process in the presence and absence of hydrophilic (silica) and hydrophobic (polystyrene) nanoparticles (NPs). The results highlight the fact that slight increases in temperature can induce inhibitory and acceleratory effects of hydrophobic and hydrophilic NPs on the fibrillation process, respectively. Using further in vivo considerations, the outcomes of this study can be used for considerable modifications on the current diagnosis and treatment approaches in amyloid-involved diseases.
SSRN Electronic Journal, 2017
Suku Banjar yang merupakan suku asli di Kalimantan Selatan sejak dulu mengenal mantra. Mantra pak... more Suku Banjar yang merupakan suku asli di Kalimantan Selatan sejak dulu mengenal mantra. Mantra pakasih dan papikat adalah salah satu jenis mantra yang dipercaya dapat menimbulkan rasa kasih (pakasih) dan membuat rasa ketertarikan lawan jenis, dalam arti lain sebagai pemikat atau pelet (papikat). Sebagai salah satu genre sastra tradisional, mantra memiliki gaya bahasa yang berbeda dari genre sastra tradisional lainnya baik dari pola bentuk maupun pilihan bahasa yang digunakan. Selain itu, keberadaan mantra tidak terlepas dari unsur kealaman yang terdapat di alam semesta. Pemerian nama-nama tumbuhan dan hewan memiliki peran dalam hadirnya sebuah mantra pakasih dan papikat pada masyarakat suku Banjar. Melalui artikel ini dideskripsikan gaya bahasa dan wujud unsur kealaman yang terdapat dalam mantra pakasih dan papikat masyarakat suku Banjar. Penelitian ini menggunakan metode deskriptif kualitatif. Adapun hasil penelitian yang diperoleh dalam penelitian ini yakni (1) bentuk fisik mantra mantra pakasih dan papikat terdiri atas pola bentuk mantra bebas dan pola bentuk mantra terikat, (2) unsur kealaman mantra pakasih dan papikat seperti unsur alam semesta, hewan/binatang dan tumbuhan. Dalam penelitian ini mantra dikaji dengan kajian stilistika bertitik pada kajian gaya bahasanya dan kajian ekokritik (ekologi) untuk menganalisis unsur lingkungan atau kealaman yang terdapat dalam mantra pakasih dan papikat.
According to PMBOK standard, eighth process of project management is risk management. Technique o... more According to PMBOK standard, eighth process of project management is risk management. Technique of Earned Value Management (EVM) as well as project planning and control system in recent decades has been widely used. Integration of risk management and earned value management to predict and estimate the cost and time of completion of the project is an effective tool in the management and control of the project. Each of these techniques has at least one key weakness; the main weakness of EVM is focus of this way on predicting future development based on past progresses. The event that has happened in the past is not concerned by risk management; now according to this importance, in this paper outlines two methods and explains benefits of integrating earned value management with risk management in order to achieve maximum performance.
Design, build, and sell a safe automated primary color dye mixer to schools for the purpose of te... more Design, build, and sell a safe automated primary color dye mixer to schools for the purpose of teaching children how 12 secondary colors (and shades) on a color wheel can be made via the primary colors. The user will select the desired color and then the machine will automatically deposit the correct amount of each primary color to create the selected color. Either water-based paint or dye will be used in the machine so that if a mess is made, the cleanup is easy. The cup with the colors will then be mixed automatically. From here, the final dye mixture will match the desired color chosen at the beginning.
Chemistry – A European Journal, 2021
Organic resin cross-linking ZIF-67/SiO2 superhydrophobic (SHPB) multilayer coating was successful... more Organic resin cross-linking ZIF-67/SiO2 superhydrophobic (SHPB) multilayer coating was successfully fabricated on metal substrate. The perfluoro-octyl-triethoxy silane (POTS) modified ZIF-67 and SiO2 coating was applied on primary coated polytetrafluoroethylene (PTFE) and epoxy resin (EP) via spray coating method. Here, we present that the robust superhydrophobicity can be realized by structuring surfaces at two different length scales, with a nanostructure design to provide water repellency and a microstructure design to provide durability. The as-fabricated multilayer coating displayed superior water-repellency (CA=167.4°), chemical robustness (pH=1-14) and mechanical durability undergoing 120th linear abrasion or 35th rotatory abrasion cycle. By applying different acidic and basic corrosive media and various weathering conditions, it can still maintain superior-hydrophobicity. To get a better insight of interaction between inhibitor molecules and metal surface, density functional theory (DFT) calculations were performed, showing lower energy gap and increased binding energy of ZPS/SiO2/PTFE/EP (ZPS=ZIF-67+POTS) multilayer coating compared to the ZIF/SiO2/PTFE/EP, thereby supporting the experimental findings. Additionally, such coatings may be useful for applications such as anti-corrosion, self-cleaning, and anti-icing multi-functionalities.
Sustainable Energy & Fuels, 2021
A metal–organic framework mediated nickel doped ferrite composite with superior lithium storage p... more A metal–organic framework mediated nickel doped ferrite composite with superior lithium storage properties was successfully synthesized. A DFT study also elucidated the reaction pathway for Cu1−xNixFe2O4.
Journal of Computational and Applied Mathematics, 2020
Hieraus entsteht die Aufgabe, die einfachsten Thatsachen aufzusuchen, aus denen sich die Massverh... more Hieraus entsteht die Aufgabe, die einfachsten Thatsachen aufzusuchen, aus denen sich die Massverhältnisse des Raumes bestimmen lassen. Der nächst einfache Fall würde wohl die Mannigfaltigkeiten umfassen, in welchen sich das Linienelement durch die vierte Wurzel aus einem Differentialausdrucke vierten Grades ausdrücken lässt. Riemann, 1854 Resumen. Las formas de rango superior son generalizaciones de las formas cuadráticas, mientras que la geometría de rango superior es una generalización de la geometría riemanniana (la cual está basada en una forma cuadrática: el tensor métrico). Hasta el momento existen pocos resultados matemáticos que permitan caracterizar las formas y la geometría de rango superior y sus propiedades. Se presentan las motivaciones, matemáticas y físicas, para considerar estas generalizaciones y algunos resultados obtenidos hasta el momento.
Applied Surface Science, 2018
Using molecular models for pristine (NT) and COOH (FNT) functionalized carbon nanotube, ten nonco... more Using molecular models for pristine (NT) and COOH (FNT) functionalized carbon nanotube, ten noncovalent configurations and four mechanisms of covalent functionalization of NT and FNT with cladribine anticancer drug (CDA) were studied. Quantum molecular descriptors, free energies of solvation and binding energies of noncovalent interactions were investigated in H 2 O and DMF solvents and gas phase. The calculation of binding energies confirmed the energetic stability of all CDA/NT and CDA/FNT configurations. The free energies of solvation show that NT and FNT solubility increases in all drug-nanotube configurations which is a main factor for its applicability in the drug delivery. Quantum molecular descriptors of drug such as global hardness and HOMO-LUMO energy gap are higher than those of drug-nanotube complexes, showing the reactivity of the drug increases. The AIM analysis for the most stable configuration (CDA/FNT2) demonstrated that the intermolecular hydrogen bonding plays a main role in this system. For the covalent functionalization COOH (FNT) and COCl (NTCOCl) functionalized carbon nanotubes were considered. Cladribine may bond to FNT and NTCOCl through NH 2 and OH groups. The activation parameters of all pathways were calculated, indicating the activation energies and Gibbs free energies related to FNT mechanisms are higher than those of NTCOCl mechanisms.
Emergency Radiology, 2018
Purpose Spinal MRI is the exam of choice for the workup of patients with suspected spinal infecti... more Purpose Spinal MRI is the exam of choice for the workup of patients with suspected spinal infection. In this retrospective study, we assess the value of obtaining contrast-enhanced spinal MRI for patients presenting to the emergency department (ED) with acute back pain and a history of intravenous drug use (IVDU). Methods A retrospective IRB-approved, HIPAA compliant review of the imaging findings, reports and electronic charts of 167 consecutive IV drug-using patients (M/F = 96:71, mean age = 40 years) that presented to the ED with acute back pain over a 55month period and underwent contrast-enhanced spinal MRI within 24 h. Fisher's exact test was used to identify statistically significant (p < 0.05) associations with MRI findings. Results Evidence of infectious spondylitis was demonstrated on the spinal MRIs of 39.5% (n = 66) of 167 patients, all of whom were admitted, and nearly half (48.5%; 32/66) underwent surgical or percutaneous intervention. Statistically significant differences in the decision to admit, blood cultures, and the type of treatment was demonstrated in patients with findings of spinal infection on MRI (p < 0.05). Conclusion Use of emergent spinal MRI in the workup of IVDU patients with acute back pain is justified despite the resultant pressure on MRI scanner, technologist, and interpretation time.
AJR. American journal of roentgenology, Jan 31, 2018
The purpose of this article is to describe knee abnormalities and the occurrence of MRI-detected ... more The purpose of this article is to describe knee abnormalities and the occurrence of MRI-detected sports-related knee abnormalities by evaluating MRI examinations performed during the Rio de Janeiro Olympic Games held in August 2016. There were 11,274 athletes at the Rio 2016 Olympic Games, and 113 of them underwent at least one knee MRI in the Olympic Village. Cartilage abnormalities, followed by meniscal tears and ligament sprains, were the most frequent abnormalities.
Journal of Alzheimer's disease : JAD, 2014
Two decades of the amyloid-β (Aβ) hypothesis in Alzheimer's disease (AD) and the prominence o... more Two decades of the amyloid-β (Aβ) hypothesis in Alzheimer's disease (AD) and the prominence of Aβ-targeting strategies have yet to meet the levels of original expectation. Disappointing results in numerous Phase II/III studies have called for a re-examination of the validity of the Aβ-targeting approaches as an intervention strategy in AD. The mid-life onset of chronic conditions (e.g., hypertension, diabetes, insulin intolerance, and depression nominated as risk factors for the later development of AD) points to the possibility that each condition could involve mechanisms, which while relatively modest over a short-term, could have significant accumulative effects. What may also not be fully appreciated is that a number of these conditions involve potential disturbances to multivalent cations (MC) levels through various mechanisms such as autophagy, oxidative stress, and apoptosis. Furthermore, some MCs have intimate associations with the mechanisms by which Aβ pathology manife...
Journal of Molecular Structure, 2015
The effects of various substituent groups on the hydrogen bond energy in the 3,3'-dihydroxy-4,4'-... more The effects of various substituent groups on the hydrogen bond energy in the 3,3'-dihydroxy-4,4'-[5-methyl-1,3-phenylenebis(nitrilomethylidyne)]-bis-phenol (L(CH 3)pnp) molecules is one of the factors controlling intramolecular proton transfer process in the molecule's functional group. In this work, we focused on the influence of different groups on this phenomenon, into the framework of the atom in molecules (AIM) theory. In addition, the calculations of transition state were performed to evaluate the proton transfer's energy barrier of the proton transfer in the Schiff base molecule Lpnp. Investigation the effect of the electron withdrawing groups including, CHO, CN, CF 3 ,NO 2 , COOH, COCH 3 , F, Cl And that of electron donating species consisting of NH 2 , OH, C 2 H 5 , CH 3 on the covalent nature of the intramolecular hydrogen bond shows different results: decrease in the electron withdrawing ability reduces the covalent nature whereas, electron donating substituents increase it. The topological properties such as the bond critical point (BCP), ring critical point (RCP), the delocalization index DI, and the integrated properties of the interatomic surface δ (O, H), δ (N, H) and H (G+V) can all be considered as indicators to determine the strength of the intramolecular hydrogen bond.