Mingjie Li - Academia.edu (original) (raw)

Papers by Mingjie Li

Earth and Space 2010, 2010

ABSTRACT

2008 Second International Symposium on Intelligent Information Technology Application, 2008

Iris registration aims at processing many iris images which collected from the same person, these... more Iris registration aims at processing many iris images which collected from the same person, these images are different in pupil size, texture and so on. The study in this research field is very valuable. In this paper we have proposed that apply curve fitting technology in iris registration. First, the Harris corner detection has been employed to check the feature

CLEO: 2013, 2013

ABSTRACT Transient absorption spectroscopy uncovered the first experimental evidence of ZnO green... more ABSTRACT Transient absorption spectroscopy uncovered the first experimental evidence of ZnO green emission originating from charge transitions of ZnO di-vacancies proposed recently in DFT calculations. Hole trapping to this state occurs via an ultrafast Auger-like process.

Physical Review B, 2013

The origins of the commonly observed green emission (GE) from ZnO nanostructures remain highly co... more The origins of the commonly observed green emission (GE) from ZnO nanostructures remain highly controversial despite extensive studies over the past few decades. Herein, through a comprehensive ultrafast optical spectroscopy study, new insights into its origin and the charge trapping dynamics at the GE centers in ZnO nanowires prepared by the vapor transport method are gained. Transient absorption spectroscopy (TAS) revealed a sub-band-gap absorption bleaching band arising from the state filling of the electrons in the conduction band and holes trapped in the GE centers. The GE originates from the recombination between the electrons in the conduction band and/or shallow donor levels and the holes trapped at the GE centers (which are located at ∼0.88 eV above the valence band). Importantly, an ultrafast excitonic Auger-type hole trapping process to the GE centers occurring in a subpicosecond time scale was also uncovered by TAS-shedding new light on the mechanism behind the fast and efficient charge trapping of photoexcited carriers. The knowledge gained is crucial for the development of ZnO-based optoelectronic devices.

Nature Biotechnology, 2006

RNA interference occurs when cytoplasmic small interfering RNAs (siRNAs) enter the RNA-induced si... more RNA interference occurs when cytoplasmic small interfering RNAs (siRNAs) enter the RNA-induced silencing complex and one strand guides cleavage of the target RNA by the Argonaute 2 protein 1-3 . A significant concern when applying siRNAs or expressing small hairpin RNAs (shRNAs) in human cells is activation of the interferon (IFN) response 4-10 . Synthetic siRNAs harboring certain motifs can induce an immune response when delivered to mouse and human immune cells such as peripheral blood mononuclear cells, monocytes, plasmacytoid dendritic cells (pDCs) and nonplasmacytoid dendritic cells (mDCs) . In the present study we have tested the immunostimulatory effects of lipid-delivered siRNAs versus Pol III promoter-expressed shRNAs in primary CD34 + progenitor-derived hematopoietic cells. We show that in this system, lipid-delivered siRNAs are potent inducers of IFNa and type I IFN gene expression, whereas the same sequences when expressed endogenously are nonimmunostimulatory.

Molecular Therapy, 2005

Methylation of cytosines in CpG motifs is an important mechanism for epigenetic regulation of gen... more Methylation of cytosines in CpG motifs is an important mechanism for epigenetic regulation of gene expression in mammalian cells. The initiating event(s) for de novo methylation in mammalian cells, particularly in cancer, is unknown. In plants, short RNAs homologous to DNA sequences are known to initiate de novo methylation. To investigate whether short hairpin RNAs (shRNAs) may also serve as initiators for de novo methylation in human cells we have expressed short hairpin RNAs complementary to the CpG island including the promoter and early transcribed regions of the human RASSF1A gene. RASSF1A encodes a putative tumor suppressor that is hypermethylated in a variety of human cancers, whereas in some human cell lines, such as HeLa, RASSF1A is unmethylated and transcriptionally active. We demonstrate that shRNAs complementary to the RASSF1A promoter or early transcribed regions can direct low levels of de novo DNA methylation and partial gene silencing in HeLa cells. In contrast, an shRNA harboring four central mismatches with the target cannot direct such methylation. The results presented suggest provocative potential mechanisms for transcriptional gene silencing via DNA methylation in cancer cells.

IEEE Microwave and Wireless Components Letters, 2000

A wideband superconducting interdigital-like filter at UHF band has been successfully designed an... more A wideband superconducting interdigital-like filter at UHF band has been successfully designed and fabricated. An interdigital-like resonator is proposed to realize both strong coupling and compact size. A ten-pole demonstration high temperature superconducting filter is developed with a center frequency of approximately 340 MHz and a fractional bandwidth of 26%. The measurements show that the insertion loss of the filter

Frontiers in Systems Neuroscience, 2009

British Journal of Haematology, 2010

The anti-multiple myeloma (MM) efficacy of bortezomib has led to the development of other proteas... more The anti-multiple myeloma (MM) efficacy of bortezomib has led to the development of other proteasome inhibitors (PI), including CEP-18770 which has shown anti-MM effects in preclinical studies. However, the efficacy of orally (PO) or intravenously (IV) administered CEP-18770 in multiple MM models and in combination with conventional anti-MM therapies has not been evaluated. Herein, we show that CEP-18770 combined with melphalan or bortezomib induces synergistic inhibition of MM cell viability in vitro. In MM xenograft models, the addition of CEP-18770 IV to melphalan completely prevented the growth of both melphalan-sensitive and melphalan-resistant tumours. The combination of CEP-18770 IV and bortezomib induced complete regression of bortezomib-sensitive tumours and markedly delayed progression of bortezomib-resistant tumours compared to treatment with either agent alone. Single agent CEP-18770 PO also showed marked anti-MM effects in these xenograft models. These studies provide strong preclinical rationale for further development of this novel PI in the treatment of MM as a monotherapy as well as combined with either melphalan or bortezomib.

Applied Physics Letters, 2012

Ultrafast optical-pump terahertz probe spectroscopy was performed over a graduated size distribut... more Ultrafast optical-pump terahertz probe spectroscopy was performed over a graduated size distribution of CdS nanobelts to investigate the size and surface effects on the transient photoconductivity. It was found that the nanobelt size has a profound influence on the carrier localization and photoconductivity dynamics, brought about by the carrier trapping at surface defects. The strong carrier localization in the nanobelt is ascribed to the internal surface boundaries arising from the surface depletion layer. The increased thickness of surface depletion layer due to a continuous trapping of photocarriers at surface defects results in more pronounced carrier localization after photoexcitation. V C 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4748300]

It is well-known that one-dimensional isentropic gas dynamics has two elementary waves, i.e., sho... more It is well-known that one-dimensional isentropic gas dynamics has two elementary waves, i.e., shock wave and rarefaction wave. Among the two waves, only the rarefaction wave can be connected with vacuum. Given a rarefaction wave with one-side vacuum state to the compressible Euler equations, we can construct a sequence of solutions to one-dimensional compressible isentropic Navier-Stokes equations which converge to

Ash Annual Meeting Abstracts, Nov 16, 2005

Neurobiology of Aging, 2016

The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-... more The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-onset Alzheimer's disease, with the ε4 allele increasing risk and reducing the age of onset and the ε2 allele decreasing risk and markedly delaying the age of onset. Preclinical and clinical studies have shown that apolipoprotein E (APOE) genotype also predicts the timing and amount of brain amyloid-β (Aβ) peptide deposition and amyloid burden (ε4 >ε3 >ε2). Using several administration protocols, we now report that direct intracerebral adeno-associated virus (AAV)-mediated delivery of APOE2 markedly reduces brain soluble (including oligomeric) and insoluble Aβ levels as well as amyloid burden in 2 mouse models of brain amyloidosis whose pathology is dependent on either the expression of murine Apoe or more importantly on human APOE4. The efficacy of APOE2 to reduce brain Aβ burden in either model, however, was highly dependent on brain APOE2 levels and the amount of pre-existing Aβ and amyloid deposition. We further demonstrate that a widespread reduction of brain Aβ burden can be achieved through a single injection of vector via intrathalamic delivery of AAV expressing APOE2 gene. Our results demonstrate that AAV gene delivery of APOE2 using an AAV vector rescues the detrimental effects of APOE4 on brain amyloid pathology and may represent a viable therapeutic approach for treating or preventing Alzheimer's disease especially if sufficient brain APOE2 levels can be achieved early in the course of the disease.

Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 9, 2016

Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma (MM). We previou... more Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma (MM). We previously showed that B-cell maturation antigen (BCMA) is solubilized and at high levels in MM patient serum. We hypothesize that soluble BCMA binds B cell activating factor (BAFF) preventing its function to stimulate late B cells, and would result in lower polyclonal antibody levels in these patients. Mice were dosed with recombinant human BCMA (rhBCMA) and BCMA-BAFF complexes were analyzed in plasma and its effects on antibody and Ig heavy chain mRNA levels determined. Using flow, BAFF binding to B-cells was examined in the presence of rhBCMA and sera from MM patients. In MM sera, BCMA BAFF complex formation and BCMA, IgA, IgG levels, and heavy light chain isoform pair levels were determined. rhBCMA-BAFF complexes formed in immune competent and deficient mice. Human MM xenografts, which contain plasma hBCMA and hBCMA BAFF complexes, showed reduced plasma free BAFF levels. rhBCMA administered...

International Journal of Oncology, Jul 1, 2010

Enhanced angiogenesis is a hallmark of solid tumors and hematological malignancies. Anti-angiogen... more Enhanced angiogenesis is a hallmark of solid tumors and hematological malignancies. Anti-angiogenic therapeutic approaches have recently been shown to be effective for the treatment of certain cancers. Endothelial cells migrating to tumors provide them with new blood vessels that are critical for their growth and survival. We have developed a novel and rapid method to evaluate the anti-angiogenic activity of new agents consisting of a combined chorioallantoic membrane (CAM) and feather bud (FB) assay. Unlike previous assays, this new assay assesses the effects of drugs on the ability of tissues to attract and develop their own blood supply. The CAM already has a well-developed vascular network that is capable of providing blood vessels to the non-vascularized FB, allowing for this tissue to develop feathers. As a result, the exposure of the FB to drugs for 2 days followed by attachment to the CAM for 4 days allows evaluation of the compound's ability to impact blood vessel and feather formation within the CAM-attached FB tissue. Feather formation is determined as well as expression of endothelial cell genes and proteins analyzed. Using agents with known anti-angiogenic activity including fumagillin, minocycline, zoledronic acid, doxorubicin and agents lacking anti-angiogenic activity such as melphalan, we have shown that the CAM/FB assay can accurately and rapidly assess the ability of agents to prevent blood vessel and feather development within non-vascularized tissues.

Proceedings 2011 IEEE International Conference on Spatial Data Mining and Geographical Knowledge Services, 2011

ABSTRACT

2008 Conference on Human System Interactions, 2008

Abstract — For most image fusion algorithms split relationship among pixels and treat them more o... more Abstract — For most image fusion algorithms split relationship among pixels and treat them more or less independently, this paper proposes a region based multi-focus image fusion scheme using quality assessment of spatial domain and genetic algorithm, which combines ...

Nature Communications, 2015

Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging f... more Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging fields of nonlinear optofluidics and bio-photonics, conventionally used organic dyes are often rendered unsuitable because of relatively small multiphoton absorption cross-sections and low photostability. Here, we demonstrate highly photostable, ultralow-threshold multiphoton-pumped biexcitonic lasing from a solution of colloidal CdSe/CdS nanoplatelets within a cuvette-based Fabry-Pérot optical resonator. We find that colloidal nanoplatelets surprisingly exhibit an optimal lateral size that minimizes lasing threshold. These nanoplatelets possess very large gain cross-sections of 7.3 × 10(-14) cm(2) and ultralow lasing thresholds of 1.2 and 4.3 mJ cm(-2) under two-photon (λexc=800 nm) and three-photon (λexc=1.3 μm) excitation, respectively. The highly polarized emission from the nanoplatelet laser shows no significant photodegradation over 10(7) laser shots. These findings constitute a more comprehensive understanding of the utility of colloidal semiconductor nanoparticles as the gain medium in high-performance frequency-upconversion liquid lasers.

Earth and Space 2010, 2010

ABSTRACT

2008 Second International Symposium on Intelligent Information Technology Application, 2008

Iris registration aims at processing many iris images which collected from the same person, these... more Iris registration aims at processing many iris images which collected from the same person, these images are different in pupil size, texture and so on. The study in this research field is very valuable. In this paper we have proposed that apply curve fitting technology in iris registration. First, the Harris corner detection has been employed to check the feature

CLEO: 2013, 2013

ABSTRACT Transient absorption spectroscopy uncovered the first experimental evidence of ZnO green... more ABSTRACT Transient absorption spectroscopy uncovered the first experimental evidence of ZnO green emission originating from charge transitions of ZnO di-vacancies proposed recently in DFT calculations. Hole trapping to this state occurs via an ultrafast Auger-like process.

Physical Review B, 2013

The origins of the commonly observed green emission (GE) from ZnO nanostructures remain highly co... more The origins of the commonly observed green emission (GE) from ZnO nanostructures remain highly controversial despite extensive studies over the past few decades. Herein, through a comprehensive ultrafast optical spectroscopy study, new insights into its origin and the charge trapping dynamics at the GE centers in ZnO nanowires prepared by the vapor transport method are gained. Transient absorption spectroscopy (TAS) revealed a sub-band-gap absorption bleaching band arising from the state filling of the electrons in the conduction band and holes trapped in the GE centers. The GE originates from the recombination between the electrons in the conduction band and/or shallow donor levels and the holes trapped at the GE centers (which are located at ∼0.88 eV above the valence band). Importantly, an ultrafast excitonic Auger-type hole trapping process to the GE centers occurring in a subpicosecond time scale was also uncovered by TAS-shedding new light on the mechanism behind the fast and efficient charge trapping of photoexcited carriers. The knowledge gained is crucial for the development of ZnO-based optoelectronic devices.

Nature Biotechnology, 2006

RNA interference occurs when cytoplasmic small interfering RNAs (siRNAs) enter the RNA-induced si... more RNA interference occurs when cytoplasmic small interfering RNAs (siRNAs) enter the RNA-induced silencing complex and one strand guides cleavage of the target RNA by the Argonaute 2 protein 1-3 . A significant concern when applying siRNAs or expressing small hairpin RNAs (shRNAs) in human cells is activation of the interferon (IFN) response 4-10 . Synthetic siRNAs harboring certain motifs can induce an immune response when delivered to mouse and human immune cells such as peripheral blood mononuclear cells, monocytes, plasmacytoid dendritic cells (pDCs) and nonplasmacytoid dendritic cells (mDCs) . In the present study we have tested the immunostimulatory effects of lipid-delivered siRNAs versus Pol III promoter-expressed shRNAs in primary CD34 + progenitor-derived hematopoietic cells. We show that in this system, lipid-delivered siRNAs are potent inducers of IFNa and type I IFN gene expression, whereas the same sequences when expressed endogenously are nonimmunostimulatory.

Molecular Therapy, 2005

Methylation of cytosines in CpG motifs is an important mechanism for epigenetic regulation of gen... more Methylation of cytosines in CpG motifs is an important mechanism for epigenetic regulation of gene expression in mammalian cells. The initiating event(s) for de novo methylation in mammalian cells, particularly in cancer, is unknown. In plants, short RNAs homologous to DNA sequences are known to initiate de novo methylation. To investigate whether short hairpin RNAs (shRNAs) may also serve as initiators for de novo methylation in human cells we have expressed short hairpin RNAs complementary to the CpG island including the promoter and early transcribed regions of the human RASSF1A gene. RASSF1A encodes a putative tumor suppressor that is hypermethylated in a variety of human cancers, whereas in some human cell lines, such as HeLa, RASSF1A is unmethylated and transcriptionally active. We demonstrate that shRNAs complementary to the RASSF1A promoter or early transcribed regions can direct low levels of de novo DNA methylation and partial gene silencing in HeLa cells. In contrast, an shRNA harboring four central mismatches with the target cannot direct such methylation. The results presented suggest provocative potential mechanisms for transcriptional gene silencing via DNA methylation in cancer cells.

IEEE Microwave and Wireless Components Letters, 2000

A wideband superconducting interdigital-like filter at UHF band has been successfully designed an... more A wideband superconducting interdigital-like filter at UHF band has been successfully designed and fabricated. An interdigital-like resonator is proposed to realize both strong coupling and compact size. A ten-pole demonstration high temperature superconducting filter is developed with a center frequency of approximately 340 MHz and a fractional bandwidth of 26%. The measurements show that the insertion loss of the filter

Frontiers in Systems Neuroscience, 2009

British Journal of Haematology, 2010

The anti-multiple myeloma (MM) efficacy of bortezomib has led to the development of other proteas... more The anti-multiple myeloma (MM) efficacy of bortezomib has led to the development of other proteasome inhibitors (PI), including CEP-18770 which has shown anti-MM effects in preclinical studies. However, the efficacy of orally (PO) or intravenously (IV) administered CEP-18770 in multiple MM models and in combination with conventional anti-MM therapies has not been evaluated. Herein, we show that CEP-18770 combined with melphalan or bortezomib induces synergistic inhibition of MM cell viability in vitro. In MM xenograft models, the addition of CEP-18770 IV to melphalan completely prevented the growth of both melphalan-sensitive and melphalan-resistant tumours. The combination of CEP-18770 IV and bortezomib induced complete regression of bortezomib-sensitive tumours and markedly delayed progression of bortezomib-resistant tumours compared to treatment with either agent alone. Single agent CEP-18770 PO also showed marked anti-MM effects in these xenograft models. These studies provide strong preclinical rationale for further development of this novel PI in the treatment of MM as a monotherapy as well as combined with either melphalan or bortezomib.

Applied Physics Letters, 2012

Ultrafast optical-pump terahertz probe spectroscopy was performed over a graduated size distribut... more Ultrafast optical-pump terahertz probe spectroscopy was performed over a graduated size distribution of CdS nanobelts to investigate the size and surface effects on the transient photoconductivity. It was found that the nanobelt size has a profound influence on the carrier localization and photoconductivity dynamics, brought about by the carrier trapping at surface defects. The strong carrier localization in the nanobelt is ascribed to the internal surface boundaries arising from the surface depletion layer. The increased thickness of surface depletion layer due to a continuous trapping of photocarriers at surface defects results in more pronounced carrier localization after photoexcitation. V C 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4748300]

It is well-known that one-dimensional isentropic gas dynamics has two elementary waves, i.e., sho... more It is well-known that one-dimensional isentropic gas dynamics has two elementary waves, i.e., shock wave and rarefaction wave. Among the two waves, only the rarefaction wave can be connected with vacuum. Given a rarefaction wave with one-side vacuum state to the compressible Euler equations, we can construct a sequence of solutions to one-dimensional compressible isentropic Navier-Stokes equations which converge to

Ash Annual Meeting Abstracts, Nov 16, 2005

Neurobiology of Aging, 2016

The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-... more The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-onset Alzheimer's disease, with the ε4 allele increasing risk and reducing the age of onset and the ε2 allele decreasing risk and markedly delaying the age of onset. Preclinical and clinical studies have shown that apolipoprotein E (APOE) genotype also predicts the timing and amount of brain amyloid-β (Aβ) peptide deposition and amyloid burden (ε4 >ε3 >ε2). Using several administration protocols, we now report that direct intracerebral adeno-associated virus (AAV)-mediated delivery of APOE2 markedly reduces brain soluble (including oligomeric) and insoluble Aβ levels as well as amyloid burden in 2 mouse models of brain amyloidosis whose pathology is dependent on either the expression of murine Apoe or more importantly on human APOE4. The efficacy of APOE2 to reduce brain Aβ burden in either model, however, was highly dependent on brain APOE2 levels and the amount of pre-existing Aβ and amyloid deposition. We further demonstrate that a widespread reduction of brain Aβ burden can be achieved through a single injection of vector via intrathalamic delivery of AAV expressing APOE2 gene. Our results demonstrate that AAV gene delivery of APOE2 using an AAV vector rescues the detrimental effects of APOE4 on brain amyloid pathology and may represent a viable therapeutic approach for treating or preventing Alzheimer's disease especially if sufficient brain APOE2 levels can be achieved early in the course of the disease.

Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 9, 2016

Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma (MM). We previou... more Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma (MM). We previously showed that B-cell maturation antigen (BCMA) is solubilized and at high levels in MM patient serum. We hypothesize that soluble BCMA binds B cell activating factor (BAFF) preventing its function to stimulate late B cells, and would result in lower polyclonal antibody levels in these patients. Mice were dosed with recombinant human BCMA (rhBCMA) and BCMA-BAFF complexes were analyzed in plasma and its effects on antibody and Ig heavy chain mRNA levels determined. Using flow, BAFF binding to B-cells was examined in the presence of rhBCMA and sera from MM patients. In MM sera, BCMA BAFF complex formation and BCMA, IgA, IgG levels, and heavy light chain isoform pair levels were determined. rhBCMA-BAFF complexes formed in immune competent and deficient mice. Human MM xenografts, which contain plasma hBCMA and hBCMA BAFF complexes, showed reduced plasma free BAFF levels. rhBCMA administered...

International Journal of Oncology, Jul 1, 2010

Enhanced angiogenesis is a hallmark of solid tumors and hematological malignancies. Anti-angiogen... more Enhanced angiogenesis is a hallmark of solid tumors and hematological malignancies. Anti-angiogenic therapeutic approaches have recently been shown to be effective for the treatment of certain cancers. Endothelial cells migrating to tumors provide them with new blood vessels that are critical for their growth and survival. We have developed a novel and rapid method to evaluate the anti-angiogenic activity of new agents consisting of a combined chorioallantoic membrane (CAM) and feather bud (FB) assay. Unlike previous assays, this new assay assesses the effects of drugs on the ability of tissues to attract and develop their own blood supply. The CAM already has a well-developed vascular network that is capable of providing blood vessels to the non-vascularized FB, allowing for this tissue to develop feathers. As a result, the exposure of the FB to drugs for 2 days followed by attachment to the CAM for 4 days allows evaluation of the compound's ability to impact blood vessel and feather formation within the CAM-attached FB tissue. Feather formation is determined as well as expression of endothelial cell genes and proteins analyzed. Using agents with known anti-angiogenic activity including fumagillin, minocycline, zoledronic acid, doxorubicin and agents lacking anti-angiogenic activity such as melphalan, we have shown that the CAM/FB assay can accurately and rapidly assess the ability of agents to prevent blood vessel and feather development within non-vascularized tissues.

Proceedings 2011 IEEE International Conference on Spatial Data Mining and Geographical Knowledge Services, 2011

ABSTRACT

2008 Conference on Human System Interactions, 2008

Abstract — For most image fusion algorithms split relationship among pixels and treat them more o... more Abstract — For most image fusion algorithms split relationship among pixels and treat them more or less independently, this paper proposes a region based multi-focus image fusion scheme using quality assessment of spatial domain and genetic algorithm, which combines ...

Nature Communications, 2015

Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging f... more Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging fields of nonlinear optofluidics and bio-photonics, conventionally used organic dyes are often rendered unsuitable because of relatively small multiphoton absorption cross-sections and low photostability. Here, we demonstrate highly photostable, ultralow-threshold multiphoton-pumped biexcitonic lasing from a solution of colloidal CdSe/CdS nanoplatelets within a cuvette-based Fabry-Pérot optical resonator. We find that colloidal nanoplatelets surprisingly exhibit an optimal lateral size that minimizes lasing threshold. These nanoplatelets possess very large gain cross-sections of 7.3 × 10(-14) cm(2) and ultralow lasing thresholds of 1.2 and 4.3 mJ cm(-2) under two-photon (λexc=800 nm) and three-photon (λexc=1.3 μm) excitation, respectively. The highly polarized emission from the nanoplatelet laser shows no significant photodegradation over 10(7) laser shots. These findings constitute a more comprehensive understanding of the utility of colloidal semiconductor nanoparticles as the gain medium in high-performance frequency-upconversion liquid lasers.