Minh Nguyễn - Academia.edu (original) (raw)
Papers by Minh Nguyễn
SHS web of conferences, 2016
Dans la grammaire française, l'impératif est considéré comme le moyen typique pour exprimer l'inj... more Dans la grammaire française, l'impératif est considéré comme le moyen typique pour exprimer l'injonction. Il peut être utilisé pour tout but injonctif, du plus léger (prière, sollicitation) au plus péremptoire (ordre, commandement). Cependant, l'impératif n'exprime pas toujours la valeur injonctive proprement dite, les locuteurs peuvent l'utiliser pour d'autres buts tels que l'expression de la condition ou de l'interrogation, etc. Partant de l'idée qu'à l'oral chaque genre a son vocabulaire de construction, ses formes d'organisation, ses contenus attendus, ses modes productifs, la caractérisation des genres est un préalable à la constitution de corpus utilisables pour des tâches de l'étude. Je présenterai dans cet article l'analyse des caractéristiques pragmatiques des énoncés impératifs et de leur répartition en m'appuyant sur l'analyse des occurrences retirées de 5 situations différentes.
Transportation Science
In this paper, we study a new variant of the parallel drone scheduling traveling salesman problem... more In this paper, we study a new variant of the parallel drone scheduling traveling salesman problem that aims to increase the utilization of drones, particularly for heavy item deliveries. The system under consideration adopts a technology that combines multiple drones to form a collective drone (c-drone) capable of transporting heavier items. The innovative concept is expected to add further flexibility in vehicle assignment decisions. An especially difficult challenge to address is the collaboration among drones because it requires temporal synchronization between their delivery tours. To better model the reality, we also consider that drone power consumption is a nonlinear function of both speed and parcel weight. We first develop a two-index mixed integer linear programming (MILP) formulation from which a simple branch and cut is developed to solve small-size instances to optimality. To efficiently handle larger problem instances, we propose a ruin-and-recreate metaheuristic with ...
4OR
We propose an efficient branch-and-cut algorithm to exactly solve the parallel drone scheduling t... more We propose an efficient branch-and-cut algorithm to exactly solve the parallel drone scheduling traveling salesman problem. Our algorithm can find optimal solutions for all but two existing instances with up to 229 customers in a reasonable running time. To make the problem more challenging for future methods, we introduce two new sets of 120 larger instances with the number of customers varying from 318 to 783 and test our algorithm and investigate the performance of state-of-the-art metaheuristics on these instances.
ABSTRACTType I interferons (IFN) induce powerful anti-viral and innate immune responses via the t... more ABSTRACTType I interferons (IFN) induce powerful anti-viral and innate immune responses via the transcription factor, IFN-stimulated gene factor (ISGF3). However, in some pathological contexts type I IFNs are responsible for exacerbating inflammation. Here, we show that a high dose of IFN-β also activates an inflammatory gene expression program in contrast to IFN-λ3, a type III IFN, which elicits only the common anti-viral gene program. We show that the inflammatory gene program depends on a second, potentiated phase in ISGF3 activation. Iterating between mathematical modeling and experimental analysis we show that the ISGF3 activation network may engage a positive feedback loop with its subunits IRF9 and STAT2. This network motif mediates stimulus-specific ISGF3 dynamics that are dependent on ligand, dose, and duration of exposure, and when engaged activates the inflammatory gene expression program. Our results reveal a previously underappreciated dynamical control of the JAK-STAT/...
Post-pandemic recovery plans will play an important role in strengthening healthcare systems and ... more Post-pandemic recovery plans will play an important role in strengthening healthcare systems and rebuilding economies. These stimulus packages and policy responses present a unique opportunity to steer the global economy towards sustainable growth, increase resilience and bolster efforts to tackle the challenge of climate change. This IASS Discussion Paper shows how policymakers could align post-pandemic recovery planning with existing climate goals to unlock co-benefits for sustainable development and climate change mitigation and adaptation.
Syftet med den har studien var att fa en ogonblicksbild av halterna av flamskyddsmedel i svenska ... more Syftet med den har studien var att fa en ogonblicksbild av halterna av flamskyddsmedel i svenska vattendrag. Provtagningen agde rum i oktober 2013, och resultaten fran den provtagningen har rapport ...
International journal of scientific research, 2021
Three-dimensional (3D) was not commonly used in the underground construction field as the stimula... more Three-dimensional (3D) was not commonly used in the underground construction field as the stimulation process was quite complex and timeconsuming. Recently, thanks to high precise calculator, the underground construction surveys by using 3D model gives more accurate results than that of 2D model. The reason is that 3D model represents not only all boundary conditions as theoretical models but also deformation area in two directions. Besides, it is possible for 3D model to analyse the tunnel stability and the balance pressure with the aim of ensuring the tunnel stability during the construction process. This article mentions the application of 3D finite element analysis on tunnel face failure mechanism and passive failure pressure in twolayer soils.
Today’s business environment is complex, very competitive, and global. In order to remain competi... more Today’s business environment is complex, very competitive, and global. In order to remain competitive, organisations are increasingly engaging in international business ventures. As internation ...
European Journal of Operational Research, 2021
Adopting unmanned aerial vehicles (UAV), also known as drones, into the last-mile-delivery sector... more Adopting unmanned aerial vehicles (UAV), also known as drones, into the last-mile-delivery sector and having them work alongside trucks with the aim of improving service quality and reducing the transportation cost gives rise to a new class of Vehicle Routing Problems (VRPs). In this paper, we introduce a new optimization problem called the min-cost Parallel Drone Scheduling Vehicle Routing Problem (PDSVRP). This problem is a variant of the well-known Parallel Drone Scheduling Traveling Salesman Problem (PDSTSP) recently introduced in the literature in which we allow multiple trucks and consider the objective of minimizing the total transportation costs. We formulate the problem as a Mixed Integer Linear Program and then develop a Ruin and Recreate (R&R) algorithm. Exploiting PDSVRP solution characteristics in an effective manner, our heuristic manages to introduce "sufficient" rooms to a solution via new removal operators during the ruin phase. It is expected to enhance the possibilities for improving solutions later in the recreate phase. Multiple experiments on a new set of randomly generated instances confirm the performance of our approach. To explore the benefits of drone delivery as well as the insight into the impact of related factors on the contribution of drones' use to operational cost, a sensitivity analysis is conducted. We also adapt the proposed algorithm to solve the PDSTSP and validate it via benchmarks available in the literature. It is shown that our algorithm outperforms state-of-the-art algorithms in terms of solution quality. Out of 90 considered instances, it finds 26 new best known solutions.
Nature Communications, 2021
INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role... more INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rpt1/IN-CTD interface residues overlap with those required for IN/RNA interaction. Mutational analyses validate our model and indicate that the same IN residues are involved in both INI1 and RNA binding. INI1-Rpt1 and TAR RNA compete with each other for IN binding with similar IC50 values. INI1-interaction-defective IN mutant viruses are impaired for incorporation of INI1 into virions and for particle morphogenesis. Computational modeling of IN-CTD/TAR complex indicates that the TAR interface phosphates overlap with negatively charged surface residues of INI1-Rpt1 in three-dimensional space, suggesting that INI1-Rpt1 domain structurally mimics TAR. This possible mimicry between INI1-Rpt1 and TAR explains the mechanism by which INI1/SMARCB1...
Environmental Research, 2021
PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the E... more PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the European Food Safety Authority (EFSA) presented a draft opinion on a tolerable intake of 8 ng/kg/week for the sum of these four substances (equaling 0.42 μg/kg if expressed as an annual dose). Diet is usually the dominating exposure pathway, and in particular the intake of PFOS has been shown to be strongly related to the consumption of fish and seafood. Those who eat freshwater fish may be especially at risk since freshwater and its biota typically display higher PFOS concentrations than marine systems. In this study, we estimated the range in PFOS intake among average Swedish "normal" and "high" consumers of freshwater fish. By average we mean persons of average weight who eat average-sized portions. The "normal consumers" were assumed to eat freshwater fish 3 times per year, and the "high consumers" once a week. Under these assumptions, the yearly tolerable intake for "normal" and "high" consumers is reached when the PFOS concentrations in fish equals 59 and 3.4 μg per kg fish meat. For this study, PFOS concentrations in the muscle tissue of edible-sized perch, pike and pikeperch were retrieved from three different Swedish datasets, covering both rural and urban regions and a total of 78 different inland waters. Mean PFOS concentrations in fish from these sites varied from 0.3 to 750 μg/ kg. From the available data, the annual min-max dietary PFOS intake for male "normal consumers" was found to be in the range 0.0021-5.4 μg/kg/yr for the evaluated scenarios, with median values of 0.02-0.16 μg/kg/yr. For male "high consumers", the total intake range was estimated to be 0.04-93 μg/kg/yr, with median values being 0.27-1.6 μg/kg/yr. For women, the exposure estimates were slightly lower, about 79% of the exposure in men. Despite highly variable PFOS concentrations in fish from different sites, we conclude that the three most commonly consumed freshwater species in Sweden constitute an important source for the total annual intake even for people who eat this kind of fish only a few times per year. The analyses of PFOA, PFNA and PFHxS showed values which were all below detection limit, and their contribution to the total PFAS intake via freshwater fish consumption is negligible in comparison to PFOS.
Environmental Research, 2021
PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the E... more PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the European Food Safety Authority (EFSA) presented a draft opinion on a tolerable intake of 8 ng/kg/week for the sum of these four substances (equaling 0.42 μg/kg if expressed as an annual dose). Diet is usually the dominating exposure pathway, and in particular the intake of PFOS has been shown to be strongly related to the consumption of fish and seafood. Those who eat freshwater fish may be especially at risk since freshwater and its biota typically display higher PFOS concentrations than marine systems. In this study, we estimated the range in PFOS intake among average Swedish "normal" and "high" consumers of freshwater fish. By average we mean persons of average weight who eat average-sized portions. The "normal consumers" were assumed to eat freshwater fish 3 times per year, and the "high consumers" once a week. Under these assumptions, the yearly tolerable intake for "normal" and "high" consumers is reached when the PFOS concentrations in fish equals 59 and 3.4 μg per kg fish meat. For this study, PFOS concentrations in the muscle tissue of edible-sized perch, pike and pikeperch were retrieved from three different Swedish datasets, covering both rural and urban regions and a total of 78 different inland waters. Mean PFOS concentrations in fish from these sites varied from 0.3 to 750 μg/ kg. From the available data, the annual min-max dietary PFOS intake for male "normal consumers" was found to be in the range 0.0021-5.4 μg/kg/yr for the evaluated scenarios, with median values of 0.02-0.16 μg/kg/yr. For male "high consumers", the total intake range was estimated to be 0.04-93 μg/kg/yr, with median values being 0.27-1.6 μg/kg/yr. For women, the exposure estimates were slightly lower, about 79% of the exposure in men. Despite highly variable PFOS concentrations in fish from different sites, we conclude that the three most commonly consumed freshwater species in Sweden constitute an important source for the total annual intake even for people who eat this kind of fish only a few times per year. The analyses of PFOA, PFNA and PFHxS showed values which were all below detection limit, and their contribution to the total PFAS intake via freshwater fish consumption is negligible in comparison to PFOS.
Cardiology in the Young, 2021
There is minimal data regarding antegrade-only accessory pathways in young patients. Given evolvi... more There is minimal data regarding antegrade-only accessory pathways in young patients. Given evolving recommendations and treatments, retrospective analysis of the clinical and electrophysiologic properties of antegrade-only pathways in patients <21 years old was performed, with subsequent comparison of electrophysiology properties to age-matched controls with bidirectional pathways. Of 522 consecutive young patients with ventricular pre-excitation referred for electrophysiology study, 33 (6.3%) had antegrade-only accessory pathways. Indications included palpitations (47%), chest pain (25%), and syncope (22%). The shortest value for either the accessory pathway effective refractory period or the pre-excited R-R interval was taken for each patient, with the median of the antegrade-only group significantly greater than shortest values for the bidirectional group (310 [280–360] ms versus 270 [240–302] ms, p < 0.001). However, the prevalence of pathways with high-risk properties (ef...
Can Tho University Journal of Science, 2021
Trong nghiên cứu này, mô hình phân tích nhân tố khám phá (exploratory factor analysis – EFA) và m... more Trong nghiên cứu này, mô hình phân tích nhân tố khám phá (exploratory factor analysis – EFA) và mô hình hồi quy tuyến tính đa biến được sử dụng nhằm xác định các yếu tố ảnh hưởng đến quy hoạch sử dụng đất đai trên địa bàn thành phố Cần Thơ. Thông qua thực hiện phỏng vấn điều tra với 100 người sử dụng đất trong vùng quy hoạch trên địa bàn thành phố Cần Thơ, kết quả phân tích hồi quy tuyến tính đa biến cho thấy quy hoạch sử dụng đất thành phố Cần Thơ bị ảnh hưởng 55,1% bởi các nhóm yếu tố đưa vào mô hình nghiên cứu. Theo kết quả nghiên cứu, có 5 nhóm yếu tố có ảnh hưởng tích cực đến quy hoạch sử dụng đất tại thành phố Cần Thơ theo góc nhìn người sử dụng đất với mức ý nghĩa thống kê là 1% (xếp theo mức độ từ mạnh đến yếu) gồm: nhóm yếu tố kinh tế, nhóm yếu tố môi trường, nhóm các yếu tố khác, nhóm yếu tố xã hội, nhóm yếu tố thể chế, pháp lý.
Interferon β (IFN-β) signaling activates the transcription factor complex ISGF3 to induce gene ex... more Interferon β (IFN-β) signaling activates the transcription factor complex ISGF3 to induce gene expression programs critical for antiviral defense and host immune responses. It has also been observed that IFN-β activates a second transcription factor, γ-activated factor (GAF), but the significance of this coordinated activation is unclear. We report that in respiratory epithelial cells high doses of IFN-β indeed activate both ISGF3 and GAF, which bind to distinct genomic locations defined by their respective DNA sequence motifs. In contrast, low doses of IFN-β preferentially activate ISGF3 but not GAF. Surprisingly, in epithelial cells GAF binding does not induce nearby gene expression even when strongly bound to the promoter. Yet expression of interferon stimulated genes is enhanced when GAF and ISGF3 are both active compared to ISGF3 alone. Our data suggest that GAF enhances ISGF3 target gene expression by co-localizing with ISGF3 at some promoters and facilitating chromosome loopi...
Science of The Total Environment, 2019
• FR levels in streams found highly variable with season, highest during spring flood. • Average ... more • FR levels in streams found highly variable with season, highest during spring flood. • Average bulk concentrations were: ∑HFR N ∑OPFR ≫ ∑PBDE. • Hydrophobicity fractionation observed within the snowpack • ∑FR levels in streams generally higher at the mire site than at the forested site • Fluxes~15× higher downstream Umeå city than at the outlet of the pristine catchment
Environment International, 2019
Consumer goods and building materials present in the preschool environment can be important sourc... more Consumer goods and building materials present in the preschool environment can be important sources of hazardous chemicals, such as plasticizers, bisphenols, organophosphorus and brominated flame retardants, poly- and perfluoroalkyl substances, which may pose a health risk to children. Even though exposure occurs via many different pathways, such as food intake, inhalation, dermal exposure, mouthing of toys etc., dust has been identified as a valuable indicator for indoor exposure. In the present study, we evaluate the efficiency of product substitution actions taken in 20 Swedish preschools from the Stockholm area to reduce the presence of hazardous substances in indoor environments. Dust samples were collected from elevated surfaces in rooms where children have their everyday activities, and the concentrations found were compared to the levels from a previous study conducted in 2015 at the same preschools. It was possible to lower levels of hazardous substances in dust, but their continued presence in the everyday environment of children was confirmed since bisphenol A, restricted phthalates and organophosphate esters were still detectable in all preschools. Also, an increase in the levels of some of the substitutes for the nowadays restricted substances was noted; some of the alternative plasticizers to phthalates, such as DEHA and DEHT, were found with increased concentrations. DINP was the dominant plasticizer in preschool dust with a median concentration of 389 μg/g, while its level was significantly (p = 0.012) higher at 716 μg/g in preschools with polyvinyl chloride (PVC) flooring. PBDEs were now less frequently detected in dust and their levels decreased 20% to 30%. This was one of the few times that PFAS were analyzed in preschool dust, where 6:2 diPAP was found to be most abundant with a median concentration of 1140 ng/g, followed by 6:2 PAP 151 ng/g, 8:2 diPAP 36 ng/g, N-Et-FOSAA 18 ng/g, PFOS 12 ng/g, PFOA 7.7 ng/g and PFNA 1.1 ng/g. In addition, fluorotelomer alcohols were detected in 65-90% of the samples. Children's exposure via dust ingestion was evaluated using intermediate and high daily intake rates of the targeted chemicals and established health limit values. In each case, the hazard quotients (HQs) were < 1, and the risk for children to have adverse health effects from the hazardous chemicals analyzed in this study via dust ingestion was even lower after the product substitution actions were taken in preschools.
SHS web of conferences, 2016
Dans la grammaire française, l'impératif est considéré comme le moyen typique pour exprimer l'inj... more Dans la grammaire française, l'impératif est considéré comme le moyen typique pour exprimer l'injonction. Il peut être utilisé pour tout but injonctif, du plus léger (prière, sollicitation) au plus péremptoire (ordre, commandement). Cependant, l'impératif n'exprime pas toujours la valeur injonctive proprement dite, les locuteurs peuvent l'utiliser pour d'autres buts tels que l'expression de la condition ou de l'interrogation, etc. Partant de l'idée qu'à l'oral chaque genre a son vocabulaire de construction, ses formes d'organisation, ses contenus attendus, ses modes productifs, la caractérisation des genres est un préalable à la constitution de corpus utilisables pour des tâches de l'étude. Je présenterai dans cet article l'analyse des caractéristiques pragmatiques des énoncés impératifs et de leur répartition en m'appuyant sur l'analyse des occurrences retirées de 5 situations différentes.
Transportation Science
In this paper, we study a new variant of the parallel drone scheduling traveling salesman problem... more In this paper, we study a new variant of the parallel drone scheduling traveling salesman problem that aims to increase the utilization of drones, particularly for heavy item deliveries. The system under consideration adopts a technology that combines multiple drones to form a collective drone (c-drone) capable of transporting heavier items. The innovative concept is expected to add further flexibility in vehicle assignment decisions. An especially difficult challenge to address is the collaboration among drones because it requires temporal synchronization between their delivery tours. To better model the reality, we also consider that drone power consumption is a nonlinear function of both speed and parcel weight. We first develop a two-index mixed integer linear programming (MILP) formulation from which a simple branch and cut is developed to solve small-size instances to optimality. To efficiently handle larger problem instances, we propose a ruin-and-recreate metaheuristic with ...
4OR
We propose an efficient branch-and-cut algorithm to exactly solve the parallel drone scheduling t... more We propose an efficient branch-and-cut algorithm to exactly solve the parallel drone scheduling traveling salesman problem. Our algorithm can find optimal solutions for all but two existing instances with up to 229 customers in a reasonable running time. To make the problem more challenging for future methods, we introduce two new sets of 120 larger instances with the number of customers varying from 318 to 783 and test our algorithm and investigate the performance of state-of-the-art metaheuristics on these instances.
ABSTRACTType I interferons (IFN) induce powerful anti-viral and innate immune responses via the t... more ABSTRACTType I interferons (IFN) induce powerful anti-viral and innate immune responses via the transcription factor, IFN-stimulated gene factor (ISGF3). However, in some pathological contexts type I IFNs are responsible for exacerbating inflammation. Here, we show that a high dose of IFN-β also activates an inflammatory gene expression program in contrast to IFN-λ3, a type III IFN, which elicits only the common anti-viral gene program. We show that the inflammatory gene program depends on a second, potentiated phase in ISGF3 activation. Iterating between mathematical modeling and experimental analysis we show that the ISGF3 activation network may engage a positive feedback loop with its subunits IRF9 and STAT2. This network motif mediates stimulus-specific ISGF3 dynamics that are dependent on ligand, dose, and duration of exposure, and when engaged activates the inflammatory gene expression program. Our results reveal a previously underappreciated dynamical control of the JAK-STAT/...
Post-pandemic recovery plans will play an important role in strengthening healthcare systems and ... more Post-pandemic recovery plans will play an important role in strengthening healthcare systems and rebuilding economies. These stimulus packages and policy responses present a unique opportunity to steer the global economy towards sustainable growth, increase resilience and bolster efforts to tackle the challenge of climate change. This IASS Discussion Paper shows how policymakers could align post-pandemic recovery planning with existing climate goals to unlock co-benefits for sustainable development and climate change mitigation and adaptation.
Syftet med den har studien var att fa en ogonblicksbild av halterna av flamskyddsmedel i svenska ... more Syftet med den har studien var att fa en ogonblicksbild av halterna av flamskyddsmedel i svenska vattendrag. Provtagningen agde rum i oktober 2013, och resultaten fran den provtagningen har rapport ...
International journal of scientific research, 2021
Three-dimensional (3D) was not commonly used in the underground construction field as the stimula... more Three-dimensional (3D) was not commonly used in the underground construction field as the stimulation process was quite complex and timeconsuming. Recently, thanks to high precise calculator, the underground construction surveys by using 3D model gives more accurate results than that of 2D model. The reason is that 3D model represents not only all boundary conditions as theoretical models but also deformation area in two directions. Besides, it is possible for 3D model to analyse the tunnel stability and the balance pressure with the aim of ensuring the tunnel stability during the construction process. This article mentions the application of 3D finite element analysis on tunnel face failure mechanism and passive failure pressure in twolayer soils.
Today’s business environment is complex, very competitive, and global. In order to remain competi... more Today’s business environment is complex, very competitive, and global. In order to remain competitive, organisations are increasingly engaging in international business ventures. As internation ...
European Journal of Operational Research, 2021
Adopting unmanned aerial vehicles (UAV), also known as drones, into the last-mile-delivery sector... more Adopting unmanned aerial vehicles (UAV), also known as drones, into the last-mile-delivery sector and having them work alongside trucks with the aim of improving service quality and reducing the transportation cost gives rise to a new class of Vehicle Routing Problems (VRPs). In this paper, we introduce a new optimization problem called the min-cost Parallel Drone Scheduling Vehicle Routing Problem (PDSVRP). This problem is a variant of the well-known Parallel Drone Scheduling Traveling Salesman Problem (PDSTSP) recently introduced in the literature in which we allow multiple trucks and consider the objective of minimizing the total transportation costs. We formulate the problem as a Mixed Integer Linear Program and then develop a Ruin and Recreate (R&R) algorithm. Exploiting PDSVRP solution characteristics in an effective manner, our heuristic manages to introduce "sufficient" rooms to a solution via new removal operators during the ruin phase. It is expected to enhance the possibilities for improving solutions later in the recreate phase. Multiple experiments on a new set of randomly generated instances confirm the performance of our approach. To explore the benefits of drone delivery as well as the insight into the impact of related factors on the contribution of drones' use to operational cost, a sensitivity analysis is conducted. We also adapt the proposed algorithm to solve the PDSTSP and validate it via benchmarks available in the literature. It is shown that our algorithm outperforms state-of-the-art algorithms in terms of solution quality. Out of 90 considered instances, it finds 26 new best known solutions.
Nature Communications, 2021
INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role... more INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rpt1/IN-CTD interface residues overlap with those required for IN/RNA interaction. Mutational analyses validate our model and indicate that the same IN residues are involved in both INI1 and RNA binding. INI1-Rpt1 and TAR RNA compete with each other for IN binding with similar IC50 values. INI1-interaction-defective IN mutant viruses are impaired for incorporation of INI1 into virions and for particle morphogenesis. Computational modeling of IN-CTD/TAR complex indicates that the TAR interface phosphates overlap with negatively charged surface residues of INI1-Rpt1 in three-dimensional space, suggesting that INI1-Rpt1 domain structurally mimics TAR. This possible mimicry between INI1-Rpt1 and TAR explains the mechanism by which INI1/SMARCB1...
Environmental Research, 2021
PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the E... more PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the European Food Safety Authority (EFSA) presented a draft opinion on a tolerable intake of 8 ng/kg/week for the sum of these four substances (equaling 0.42 μg/kg if expressed as an annual dose). Diet is usually the dominating exposure pathway, and in particular the intake of PFOS has been shown to be strongly related to the consumption of fish and seafood. Those who eat freshwater fish may be especially at risk since freshwater and its biota typically display higher PFOS concentrations than marine systems. In this study, we estimated the range in PFOS intake among average Swedish "normal" and "high" consumers of freshwater fish. By average we mean persons of average weight who eat average-sized portions. The "normal consumers" were assumed to eat freshwater fish 3 times per year, and the "high consumers" once a week. Under these assumptions, the yearly tolerable intake for "normal" and "high" consumers is reached when the PFOS concentrations in fish equals 59 and 3.4 μg per kg fish meat. For this study, PFOS concentrations in the muscle tissue of edible-sized perch, pike and pikeperch were retrieved from three different Swedish datasets, covering both rural and urban regions and a total of 78 different inland waters. Mean PFOS concentrations in fish from these sites varied from 0.3 to 750 μg/ kg. From the available data, the annual min-max dietary PFOS intake for male "normal consumers" was found to be in the range 0.0021-5.4 μg/kg/yr for the evaluated scenarios, with median values of 0.02-0.16 μg/kg/yr. For male "high consumers", the total intake range was estimated to be 0.04-93 μg/kg/yr, with median values being 0.27-1.6 μg/kg/yr. For women, the exposure estimates were slightly lower, about 79% of the exposure in men. Despite highly variable PFOS concentrations in fish from different sites, we conclude that the three most commonly consumed freshwater species in Sweden constitute an important source for the total annual intake even for people who eat this kind of fish only a few times per year. The analyses of PFOA, PFNA and PFHxS showed values which were all below detection limit, and their contribution to the total PFAS intake via freshwater fish consumption is negligible in comparison to PFOS.
Environmental Research, 2021
PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the E... more PFHxS are the PFAS substances that currently contribute most to human exposure, and in 2020 the European Food Safety Authority (EFSA) presented a draft opinion on a tolerable intake of 8 ng/kg/week for the sum of these four substances (equaling 0.42 μg/kg if expressed as an annual dose). Diet is usually the dominating exposure pathway, and in particular the intake of PFOS has been shown to be strongly related to the consumption of fish and seafood. Those who eat freshwater fish may be especially at risk since freshwater and its biota typically display higher PFOS concentrations than marine systems. In this study, we estimated the range in PFOS intake among average Swedish "normal" and "high" consumers of freshwater fish. By average we mean persons of average weight who eat average-sized portions. The "normal consumers" were assumed to eat freshwater fish 3 times per year, and the "high consumers" once a week. Under these assumptions, the yearly tolerable intake for "normal" and "high" consumers is reached when the PFOS concentrations in fish equals 59 and 3.4 μg per kg fish meat. For this study, PFOS concentrations in the muscle tissue of edible-sized perch, pike and pikeperch were retrieved from three different Swedish datasets, covering both rural and urban regions and a total of 78 different inland waters. Mean PFOS concentrations in fish from these sites varied from 0.3 to 750 μg/ kg. From the available data, the annual min-max dietary PFOS intake for male "normal consumers" was found to be in the range 0.0021-5.4 μg/kg/yr for the evaluated scenarios, with median values of 0.02-0.16 μg/kg/yr. For male "high consumers", the total intake range was estimated to be 0.04-93 μg/kg/yr, with median values being 0.27-1.6 μg/kg/yr. For women, the exposure estimates were slightly lower, about 79% of the exposure in men. Despite highly variable PFOS concentrations in fish from different sites, we conclude that the three most commonly consumed freshwater species in Sweden constitute an important source for the total annual intake even for people who eat this kind of fish only a few times per year. The analyses of PFOA, PFNA and PFHxS showed values which were all below detection limit, and their contribution to the total PFAS intake via freshwater fish consumption is negligible in comparison to PFOS.
Cardiology in the Young, 2021
There is minimal data regarding antegrade-only accessory pathways in young patients. Given evolvi... more There is minimal data regarding antegrade-only accessory pathways in young patients. Given evolving recommendations and treatments, retrospective analysis of the clinical and electrophysiologic properties of antegrade-only pathways in patients <21 years old was performed, with subsequent comparison of electrophysiology properties to age-matched controls with bidirectional pathways. Of 522 consecutive young patients with ventricular pre-excitation referred for electrophysiology study, 33 (6.3%) had antegrade-only accessory pathways. Indications included palpitations (47%), chest pain (25%), and syncope (22%). The shortest value for either the accessory pathway effective refractory period or the pre-excited R-R interval was taken for each patient, with the median of the antegrade-only group significantly greater than shortest values for the bidirectional group (310 [280–360] ms versus 270 [240–302] ms, p < 0.001). However, the prevalence of pathways with high-risk properties (ef...
Can Tho University Journal of Science, 2021
Trong nghiên cứu này, mô hình phân tích nhân tố khám phá (exploratory factor analysis – EFA) và m... more Trong nghiên cứu này, mô hình phân tích nhân tố khám phá (exploratory factor analysis – EFA) và mô hình hồi quy tuyến tính đa biến được sử dụng nhằm xác định các yếu tố ảnh hưởng đến quy hoạch sử dụng đất đai trên địa bàn thành phố Cần Thơ. Thông qua thực hiện phỏng vấn điều tra với 100 người sử dụng đất trong vùng quy hoạch trên địa bàn thành phố Cần Thơ, kết quả phân tích hồi quy tuyến tính đa biến cho thấy quy hoạch sử dụng đất thành phố Cần Thơ bị ảnh hưởng 55,1% bởi các nhóm yếu tố đưa vào mô hình nghiên cứu. Theo kết quả nghiên cứu, có 5 nhóm yếu tố có ảnh hưởng tích cực đến quy hoạch sử dụng đất tại thành phố Cần Thơ theo góc nhìn người sử dụng đất với mức ý nghĩa thống kê là 1% (xếp theo mức độ từ mạnh đến yếu) gồm: nhóm yếu tố kinh tế, nhóm yếu tố môi trường, nhóm các yếu tố khác, nhóm yếu tố xã hội, nhóm yếu tố thể chế, pháp lý.
Interferon β (IFN-β) signaling activates the transcription factor complex ISGF3 to induce gene ex... more Interferon β (IFN-β) signaling activates the transcription factor complex ISGF3 to induce gene expression programs critical for antiviral defense and host immune responses. It has also been observed that IFN-β activates a second transcription factor, γ-activated factor (GAF), but the significance of this coordinated activation is unclear. We report that in respiratory epithelial cells high doses of IFN-β indeed activate both ISGF3 and GAF, which bind to distinct genomic locations defined by their respective DNA sequence motifs. In contrast, low doses of IFN-β preferentially activate ISGF3 but not GAF. Surprisingly, in epithelial cells GAF binding does not induce nearby gene expression even when strongly bound to the promoter. Yet expression of interferon stimulated genes is enhanced when GAF and ISGF3 are both active compared to ISGF3 alone. Our data suggest that GAF enhances ISGF3 target gene expression by co-localizing with ISGF3 at some promoters and facilitating chromosome loopi...
Science of The Total Environment, 2019
• FR levels in streams found highly variable with season, highest during spring flood. • Average ... more • FR levels in streams found highly variable with season, highest during spring flood. • Average bulk concentrations were: ∑HFR N ∑OPFR ≫ ∑PBDE. • Hydrophobicity fractionation observed within the snowpack • ∑FR levels in streams generally higher at the mire site than at the forested site • Fluxes~15× higher downstream Umeå city than at the outlet of the pristine catchment
Environment International, 2019
Consumer goods and building materials present in the preschool environment can be important sourc... more Consumer goods and building materials present in the preschool environment can be important sources of hazardous chemicals, such as plasticizers, bisphenols, organophosphorus and brominated flame retardants, poly- and perfluoroalkyl substances, which may pose a health risk to children. Even though exposure occurs via many different pathways, such as food intake, inhalation, dermal exposure, mouthing of toys etc., dust has been identified as a valuable indicator for indoor exposure. In the present study, we evaluate the efficiency of product substitution actions taken in 20 Swedish preschools from the Stockholm area to reduce the presence of hazardous substances in indoor environments. Dust samples were collected from elevated surfaces in rooms where children have their everyday activities, and the concentrations found were compared to the levels from a previous study conducted in 2015 at the same preschools. It was possible to lower levels of hazardous substances in dust, but their continued presence in the everyday environment of children was confirmed since bisphenol A, restricted phthalates and organophosphate esters were still detectable in all preschools. Also, an increase in the levels of some of the substitutes for the nowadays restricted substances was noted; some of the alternative plasticizers to phthalates, such as DEHA and DEHT, were found with increased concentrations. DINP was the dominant plasticizer in preschool dust with a median concentration of 389 μg/g, while its level was significantly (p = 0.012) higher at 716 μg/g in preschools with polyvinyl chloride (PVC) flooring. PBDEs were now less frequently detected in dust and their levels decreased 20% to 30%. This was one of the few times that PFAS were analyzed in preschool dust, where 6:2 diPAP was found to be most abundant with a median concentration of 1140 ng/g, followed by 6:2 PAP 151 ng/g, 8:2 diPAP 36 ng/g, N-Et-FOSAA 18 ng/g, PFOS 12 ng/g, PFOA 7.7 ng/g and PFNA 1.1 ng/g. In addition, fluorotelomer alcohols were detected in 65-90% of the samples. Children's exposure via dust ingestion was evaluated using intermediate and high daily intake rates of the targeted chemicals and established health limit values. In each case, the hazard quotients (HQs) were < 1, and the risk for children to have adverse health effects from the hazardous chemicals analyzed in this study via dust ingestion was even lower after the product substitution actions were taken in preschools.