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Papers by Minhyuk Bang
Food Science and Biotechnology, 2010
To identify antitumor materials, oriental herb extracts were investigated in the present study. T... more To identify antitumor materials, oriental herb extracts were investigated in the present study. The effects of individual oriental herb extracts (OHE) and a mixture of these extracts (MOHE) for antioxidant, free radical scavenging, and tumoricidal activities were determined. The OHEs and MOHE exhibited relatively high free radical scavenging and antioxidant activities, in a concentration dependent manner. The total phenolic contents of the extracts suggest that these compounds may have played a role, at least in part, in the free radical scavenging and antioxidant effects. Since the MOHE showed the highest toxicity against tumor cell lines, the MOHE was administrated in cancer mice models. Consistent with the in vitro studies, the MOHE resulted in prolonged life spans in cancer mice possibly by combination of its anticancer and antioxidant activities. Our data indicate the possibilities of using the MOHE to counteract carcinogenesis as well as other forms of electrophilic toxicity.
Journal of medicinal food, 2014
Pathological increases in adipogenic potential with decreases in osteogenic differentiation occur... more Pathological increases in adipogenic potential with decreases in osteogenic differentiation occur in osteoporotic bone marrow cells. Previous studies have shown that bioactive materials isolated from natural products can reciprocally regulate adipogenic and osteogenic fates of bone marrow cells. In this study, we showed that Eupatorium japonicum stem extracts (EJE) suppressed lipid accumulation and inhibited the expression of adipocyte markers in multipotent C3H10T1/2 and primary bone marrow cells. Conversely, EJE stimulated alkaline phosphatase activity and induced the expression of osteoblast markers in C3H10T1/2 and primary bone marrow cells. Daily oral administration of 50 mg/kg of EJE for 6 weeks to ovariectomized rats prevented body weight increase and bone mineral density decrease. Finally, activity-guided fractionation led to the identification of coumaric acid and coumaric acid methyl ester as bioactive anti-adipogenic and pro-osteogenic components in EJE. Taken together, o...
Food Science and Biotechnology, 2010
To identify antitumor materials, oriental herb extracts were investigated in the present study. T... more To identify antitumor materials, oriental herb extracts were investigated in the present study. The effects of individual oriental herb extracts (OHE) and a mixture of these extracts (MOHE) for antioxidant, free radical scavenging, and tumoricidal activities were determined. The OHEs and MOHE exhibited relatively high free radical scavenging and antioxidant activities, in a concentration dependent manner. The total phenolic contents of the extracts suggest that these compounds may have played a role, at least in part, in the free radical scavenging and antioxidant effects. Since the MOHE showed the highest toxicity against tumor cell lines, the MOHE was administrated in cancer mice models. Consistent with the in vitro studies, the MOHE resulted in prolonged life spans in cancer mice possibly by combination of its anticancer and antioxidant activities. Our data indicate the possibilities of using the MOHE to counteract carcinogenesis as well as other forms of electrophilic toxicity.
Journal of medicinal food, 2014
Pathological increases in adipogenic potential with decreases in osteogenic differentiation occur... more Pathological increases in adipogenic potential with decreases in osteogenic differentiation occur in osteoporotic bone marrow cells. Previous studies have shown that bioactive materials isolated from natural products can reciprocally regulate adipogenic and osteogenic fates of bone marrow cells. In this study, we showed that Eupatorium japonicum stem extracts (EJE) suppressed lipid accumulation and inhibited the expression of adipocyte markers in multipotent C3H10T1/2 and primary bone marrow cells. Conversely, EJE stimulated alkaline phosphatase activity and induced the expression of osteoblast markers in C3H10T1/2 and primary bone marrow cells. Daily oral administration of 50 mg/kg of EJE for 6 weeks to ovariectomized rats prevented body weight increase and bone mineral density decrease. Finally, activity-guided fractionation led to the identification of coumaric acid and coumaric acid methyl ester as bioactive anti-adipogenic and pro-osteogenic components in EJE. Taken together, o...