Mira Zivkovic - Academia.edu (original) (raw)
Papers by Mira Zivkovic
PeerJ, 2017
We investigated EEG rhythms, particularly alpha activity, and their relationship to post-stroke n... more We investigated EEG rhythms, particularly alpha activity, and their relationship to post-stroke neuropathology and cognitive functions in the subacute and chronic stages of minor strokes. We included 10 patients with right middle cerebral artery (MCA) ischemic strokes and 11 healthy controls. All the assessments of stroke patients were done both in the subacute and chronic stages. Neurological impairment was measured using the National Institute of Health Stroke Scale (NIHSS), whereas cognitive functions were assessed using the Montreal Cognitive Assessment (MoCA) and MoCA memory index (MoCA-MIS). The EEG was recorded using a 19 channel EEG system with standard EEG electrode placement. In particular, we analyzed the EEGs derived from the four lateral frontal (F3, F7, F4, F8), and corresponding lateral posterior (P3, P4, T5, T6) electrodes. Quantitative EEG analysis included: the group FFT spectra, the weighted average of alpha frequency (αAVG), the group probability density distribu...
Clinical Neurology and Neurosurgery, 2017
Objectives: Headache is recognized as the main but unwarranted symptom of subarachnoid hemorrhage... more Objectives: Headache is recognized as the main but unwarranted symptom of subarachnoid hemorrhage (SAH). There are no enough findings identified as predictive for headache occurrence in SAH. We evaluated the clinical and paraclinical factors predictive for headache occurrence in SAH. Patients and methods: We retrospectively analyzed medical records of 431 consecutive non traumatic SAH patients (264 females and 167 males), ages from 19 to 91 years, presenting with headache (70.3%) and without headache (29.7%) during period of 11 years. Results: Among all tested parameters, as negative predictors for headache occurrence were recognized: patients' ages (OR 0.97 [95%CI: 0.96-0.99], p = 0.025), persistence of coagulation abnormality (OR 0.23 [95% CI: 0.08-0.67], p = 0.006), atrial fibrilation (OR 0.23 [95% CI: 0.09-0.59], p = 0.002), chronic renal failure (OR 0.26 [95% CI: 0.09-0.76], p = 0.014) and more diseases (OR 0.11 [95% CI: 0.04-0.32], p < 0.0001), as higher clinical score (OR 0.94 [95% CI: 0.90-0.99], p = 0.018) including positive neurological findings (OR 0.34 [95% CI: 0.21-0.55], p < 0.001) and loss of consciousness (OR 0.22 [95% CI: 0.12-0.39], p < 0.001) at the SAH onset, while the complaint of neck stiffness was identified as its positive predictor (OR 1.93 [95%CI: 1.19-3.10], p = 0.007). Conclusions: Although diagnosis based solely on clinical presentation is not reliable and speculative, our findings could provide physicians with evidence to consider SAH not only in conditions of its headache occurrence but also in those with headache absence.
Cellular and Molecular Neurobiology, 2015
Meždunarodnyj naučno-issledovatel'skij žurnal №2 (33) 2015 Часть 2 Периодический теоретический и ... more Meždunarodnyj naučno-issledovatel'skij žurnal №2 (33) 2015 Часть 2 Периодический теоретический и научно-практический журнал. Выходит 12 раз в год.
Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, 1995
Electroencephalography and Clinical Neurophysiology/electromyography and Motor Control, 1995
We attempted to identify possible difference between the Fenitoin and the Carbamazepine regarding... more We attempted to identify possible difference between the Fenitoin and the Carbamazepine regarding their effect on the cognitive functions of epileptic patients. We used an internationally standardised psychological test-battery and we compared the results of the two therapy-groups, correlating the duration of the treatment with their individual scores. After statistical processing and plotting we could conclude: a/the average values for concentrated attention/exactity/were significantly better by the Carbamazepinegroup; b/best scores were in the first five years of treatment with both drugs and less good during the years 6-20; c/the scores of the memory tests decrease less by Carbamazepine like by Fenitoin.
Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, 1995
Carotid cavernous fistulas (CCF) are dural arteriovenous fistulas which include pathological comm... more Carotid cavernous fistulas (CCF) are dural arteriovenous fistulas which include pathological communications between the arterial system and the venous cavernous sinus situated at the wall of the cavernous sinus. It can be demonstrated by wide range clinical presentations. The presented case shows a very modest clinical presentation of CCF which was present over a few months only as new daily persistent headache without initial positive findings on performed computer tomography of the head, but rapidly worsened over a period of few days.
Vojnosanitetski pregled, 2008
Background/Aim. Reduced systemic antioxidant defense is considered to play an important mediating... more Background/Aim. Reduced systemic antioxidant defense is considered to play an important mediating role in pathogenesis of diabetic neuropathy. The aim of this study was to evaluate if the total antioxidant blood capacity (TAC) is reduced in patients with type 2 diabetes mellitus (DM) and diabetic distal symmetrical polyneuropathy (DDSP) and to correlate this antioxidant capacity with the degree of peripheral nerve dysfunction. Methods. This study involved 100 patients with type 2 DM and signs of DDSP, as well as the control group of 50 healthy subjects. The evaluation of DDSP was based on physical examination and nerve conduction studies. The degree of peripheral nerve dysfunction was estimated by scoring and analysing sensory and motor nerve conduction parameters (distal latency and amplitude of evoked potential, conduction velocity). Laboratory analyses involved blood glucose and HbA1C levels, as well as plasma TAC. Results. Blood glucose and HbA1C level was significantly higher i...
Vojnosanitetski pregled, 2011
Clinical Neurology and Neurosurgery, 2011
The study of seasonal variability of intracerebral hemorrhage (ICH) occurrence may contribute to ... more The study of seasonal variability of intracerebral hemorrhage (ICH) occurrence may contribute to a better understanding of the nature of this disease and open up new perspectives in its prevention. The aim of this study was to test seasonal patterns in the number of admissions of ICH patients and determine which months have maximal and minimal number of admissions. The main data source for this study was a hospital-based registry at the Clinic of Neurology in Nis, Serbia. During the studied period (1997-2007) a total of 1569 ICH patients were registered. Time series, consisting of the monthly number of hospitalized patients, for the 128 months of the study duration, has been successfully modeled using the multiplicative Auto Regressive Integrated Moving Average (ARIMA) model. Using the maximum likelihood method, utilizing Melrad&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s algorithm, the parameters of this ARIMA model have been calculated: constant (estimate 12.068, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), auto regressive-AR(1) (estimate 0.866, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), moving average-MA(1) (estimate 0.775, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), seasonal moving average-SMA(12) (estimate -0.198, p=0.036). ARIMA modeling has been successful and showed that there is a clear seasonal pattern in the data analyzed. Based on the seasonal multiplicative ARIMA model and the seasonal time series decomposition, we showed that, in the period covered by the study, the peak of admissions occurred in March, and the trough of admissions was found in August.
Clinical Neurology and Neurosurgery, 2010
Weekly variability in stroke occurrence could be related to the change in behaviors of patients o... more Weekly variability in stroke occurrence could be related to the change in behaviors of patients or medical personnel that occur during certain periods of the week. The aim of the present study was to examine the weekly variation in hospital admissions for stroke in Nis (Serbia), as well as to investigate how the demographic factors influenced these changes. The main data source for this study was the Nis Stroke Registry. During the study period (1996-2007) a total of 9675 stroke patients were registered. According to stroke subtypes, all registered patients were divided into three groups: patients with subarachnoid hemorrhage (SAH) (438 or 4.5%), patients with intracerebral hemorrhage (ICH) (1576 or 16.3%) and patients with ischemic stroke (IS) (6946 or 71.8%). Analyses were conducted separately for SAH, ICH and IS. Each stroke type was stratified by gender, age group and education level. We have showed that there is a significant weekly variability in the number of SAH (p=0.028) and IS (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) admissions, with the minimum number of admissions on Sundays (39.27 and 14.04% less than expected), and the maximum one on Tuesdays (21.46% more than expected) and Wednesdays (10.96% more than expected), respectively. We have also registered more SAH (p=0.015) and IS (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) admissions on weekdays than on weekend days. Results of this hospital-based study confirm that there is a pattern in the variation of the number of stroke admissions on the weekly level. Reasons for the weekly variation of hospital admissions for stroke cannot be determined from the present study.
PeerJ, 2017
We investigated EEG rhythms, particularly alpha activity, and their relationship to post-stroke n... more We investigated EEG rhythms, particularly alpha activity, and their relationship to post-stroke neuropathology and cognitive functions in the subacute and chronic stages of minor strokes. We included 10 patients with right middle cerebral artery (MCA) ischemic strokes and 11 healthy controls. All the assessments of stroke patients were done both in the subacute and chronic stages. Neurological impairment was measured using the National Institute of Health Stroke Scale (NIHSS), whereas cognitive functions were assessed using the Montreal Cognitive Assessment (MoCA) and MoCA memory index (MoCA-MIS). The EEG was recorded using a 19 channel EEG system with standard EEG electrode placement. In particular, we analyzed the EEGs derived from the four lateral frontal (F3, F7, F4, F8), and corresponding lateral posterior (P3, P4, T5, T6) electrodes. Quantitative EEG analysis included: the group FFT spectra, the weighted average of alpha frequency (αAVG), the group probability density distribu...
Clinical Neurology and Neurosurgery, 2017
Objectives: Headache is recognized as the main but unwarranted symptom of subarachnoid hemorrhage... more Objectives: Headache is recognized as the main but unwarranted symptom of subarachnoid hemorrhage (SAH). There are no enough findings identified as predictive for headache occurrence in SAH. We evaluated the clinical and paraclinical factors predictive for headache occurrence in SAH. Patients and methods: We retrospectively analyzed medical records of 431 consecutive non traumatic SAH patients (264 females and 167 males), ages from 19 to 91 years, presenting with headache (70.3%) and without headache (29.7%) during period of 11 years. Results: Among all tested parameters, as negative predictors for headache occurrence were recognized: patients' ages (OR 0.97 [95%CI: 0.96-0.99], p = 0.025), persistence of coagulation abnormality (OR 0.23 [95% CI: 0.08-0.67], p = 0.006), atrial fibrilation (OR 0.23 [95% CI: 0.09-0.59], p = 0.002), chronic renal failure (OR 0.26 [95% CI: 0.09-0.76], p = 0.014) and more diseases (OR 0.11 [95% CI: 0.04-0.32], p < 0.0001), as higher clinical score (OR 0.94 [95% CI: 0.90-0.99], p = 0.018) including positive neurological findings (OR 0.34 [95% CI: 0.21-0.55], p < 0.001) and loss of consciousness (OR 0.22 [95% CI: 0.12-0.39], p < 0.001) at the SAH onset, while the complaint of neck stiffness was identified as its positive predictor (OR 1.93 [95%CI: 1.19-3.10], p = 0.007). Conclusions: Although diagnosis based solely on clinical presentation is not reliable and speculative, our findings could provide physicians with evidence to consider SAH not only in conditions of its headache occurrence but also in those with headache absence.
Cellular and Molecular Neurobiology, 2015
Meždunarodnyj naučno-issledovatel'skij žurnal №2 (33) 2015 Часть 2 Периодический теоретический и ... more Meždunarodnyj naučno-issledovatel'skij žurnal №2 (33) 2015 Часть 2 Периодический теоретический и научно-практический журнал. Выходит 12 раз в год.
Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, 1995
Electroencephalography and Clinical Neurophysiology/electromyography and Motor Control, 1995
We attempted to identify possible difference between the Fenitoin and the Carbamazepine regarding... more We attempted to identify possible difference between the Fenitoin and the Carbamazepine regarding their effect on the cognitive functions of epileptic patients. We used an internationally standardised psychological test-battery and we compared the results of the two therapy-groups, correlating the duration of the treatment with their individual scores. After statistical processing and plotting we could conclude: a/the average values for concentrated attention/exactity/were significantly better by the Carbamazepinegroup; b/best scores were in the first five years of treatment with both drugs and less good during the years 6-20; c/the scores of the memory tests decrease less by Carbamazepine like by Fenitoin.
Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, 1995
Carotid cavernous fistulas (CCF) are dural arteriovenous fistulas which include pathological comm... more Carotid cavernous fistulas (CCF) are dural arteriovenous fistulas which include pathological communications between the arterial system and the venous cavernous sinus situated at the wall of the cavernous sinus. It can be demonstrated by wide range clinical presentations. The presented case shows a very modest clinical presentation of CCF which was present over a few months only as new daily persistent headache without initial positive findings on performed computer tomography of the head, but rapidly worsened over a period of few days.
Vojnosanitetski pregled, 2008
Background/Aim. Reduced systemic antioxidant defense is considered to play an important mediating... more Background/Aim. Reduced systemic antioxidant defense is considered to play an important mediating role in pathogenesis of diabetic neuropathy. The aim of this study was to evaluate if the total antioxidant blood capacity (TAC) is reduced in patients with type 2 diabetes mellitus (DM) and diabetic distal symmetrical polyneuropathy (DDSP) and to correlate this antioxidant capacity with the degree of peripheral nerve dysfunction. Methods. This study involved 100 patients with type 2 DM and signs of DDSP, as well as the control group of 50 healthy subjects. The evaluation of DDSP was based on physical examination and nerve conduction studies. The degree of peripheral nerve dysfunction was estimated by scoring and analysing sensory and motor nerve conduction parameters (distal latency and amplitude of evoked potential, conduction velocity). Laboratory analyses involved blood glucose and HbA1C levels, as well as plasma TAC. Results. Blood glucose and HbA1C level was significantly higher i...
Vojnosanitetski pregled, 2011
Clinical Neurology and Neurosurgery, 2011
The study of seasonal variability of intracerebral hemorrhage (ICH) occurrence may contribute to ... more The study of seasonal variability of intracerebral hemorrhage (ICH) occurrence may contribute to a better understanding of the nature of this disease and open up new perspectives in its prevention. The aim of this study was to test seasonal patterns in the number of admissions of ICH patients and determine which months have maximal and minimal number of admissions. The main data source for this study was a hospital-based registry at the Clinic of Neurology in Nis, Serbia. During the studied period (1997-2007) a total of 1569 ICH patients were registered. Time series, consisting of the monthly number of hospitalized patients, for the 128 months of the study duration, has been successfully modeled using the multiplicative Auto Regressive Integrated Moving Average (ARIMA) model. Using the maximum likelihood method, utilizing Melrad&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s algorithm, the parameters of this ARIMA model have been calculated: constant (estimate 12.068, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), auto regressive-AR(1) (estimate 0.866, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), moving average-MA(1) (estimate 0.775, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), seasonal moving average-SMA(12) (estimate -0.198, p=0.036). ARIMA modeling has been successful and showed that there is a clear seasonal pattern in the data analyzed. Based on the seasonal multiplicative ARIMA model and the seasonal time series decomposition, we showed that, in the period covered by the study, the peak of admissions occurred in March, and the trough of admissions was found in August.
Clinical Neurology and Neurosurgery, 2010
Weekly variability in stroke occurrence could be related to the change in behaviors of patients o... more Weekly variability in stroke occurrence could be related to the change in behaviors of patients or medical personnel that occur during certain periods of the week. The aim of the present study was to examine the weekly variation in hospital admissions for stroke in Nis (Serbia), as well as to investigate how the demographic factors influenced these changes. The main data source for this study was the Nis Stroke Registry. During the study period (1996-2007) a total of 9675 stroke patients were registered. According to stroke subtypes, all registered patients were divided into three groups: patients with subarachnoid hemorrhage (SAH) (438 or 4.5%), patients with intracerebral hemorrhage (ICH) (1576 or 16.3%) and patients with ischemic stroke (IS) (6946 or 71.8%). Analyses were conducted separately for SAH, ICH and IS. Each stroke type was stratified by gender, age group and education level. We have showed that there is a significant weekly variability in the number of SAH (p=0.028) and IS (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) admissions, with the minimum number of admissions on Sundays (39.27 and 14.04% less than expected), and the maximum one on Tuesdays (21.46% more than expected) and Wednesdays (10.96% more than expected), respectively. We have also registered more SAH (p=0.015) and IS (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) admissions on weekdays than on weekend days. Results of this hospital-based study confirm that there is a pattern in the variation of the number of stroke admissions on the weekly level. Reasons for the weekly variation of hospital admissions for stroke cannot be determined from the present study.