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Papers by Miriam Pillerová

Research paper thumbnail of Testosterone, personality traits and aggressive driving among young male drivers

Bratislava Medical Journal, 2021

INTRODUCTION: Psychological testing to examine potentially aggressive behaviour is a gold standar... more INTRODUCTION: Psychological testing to examine potentially aggressive behaviour is a gold standard, but it is not suffi cient. Testosterone might increase an aggressive behaviour. AIM: The aim of this study was to evaluate whether testosterone along with psychological assessment of fi tness to drive could help to identify aggressive drivers. METHODS: Male participants (n = 150) aged from 20 to 25, who possessed a driving license and drive at least 100 km per week, were evaluated in this study using an Inventory of traffi c-relevant personality characteristics, the Sensation Seeking Scale and the Buss-Durkee Aggression Inventory. Saliva was collected for testosterone and cortisol measurements. The fi ve binomial logistic models with dependent variables Caused an accident, Driving license taken away, Court trial, Intoxicated driving and Sporty self-report were tested in this study. RESULTS: The 'Intoxicated driving' model, was found to be statistically highly signifi cant, explaining 48.8 % of the dependent variable's variance (χ 2 (16) = 36.145, p < 0.01). In this model with sensation seeking, actual testosterone and their interaction was highly signifi cant and explained 20.4 % of intoxicated driving variability (χ 2 (3)=14.283, p<0.01). This was higher than sensation seeking scores only. CONCLUSION: To conclude, salivary testosterone might prove a biological marker that improves the identifi cation of those with a high probability of aggressive driving or its subtypes (Tab.

Research paper thumbnail of Aggressive drivers data

Data about participants from psychological tests and non-biochemical measurements were acquired f... more Data about participants from psychological tests and non-biochemical measurements were acquired from the Department of Psychology, Faculty of Arts, Faculty of Philosophy of Palacký University Olomouc, Czech Republic. The participants were recruited for the study by advertisements on the relevant social networks groups and by leaflets hanged out in the University or public premises (libraries, refectory etc.). Inventory of traffic-relevant personality characteristics (shortened version, TVP), Sensation Seeking Scale form, and Buss a Durkee aggression inventory were performed for psychological testing. Salivary testosterone and cortisol were measured from saliva obtained at 8:00am for each participant. Obtained data were transformed into data matrix, where only relevant data were kept. One participant was excluded from the study, due to corticosteroid medication. Overall, analysis was performed using 149 participants. Binomial models were employed with five dependent variables, which we assumed to reflect driver's tendency to aggressive behaviour: 1. Caused an accident, 2. Driving license taken away, 3. Court trial, 4. Intoxicated driving, 5. Sporty self-report.

Research paper thumbnail of Sex Steroid Hormones in Depressive Disorders as a Basis for New Potential Treatment Strategies

Physiological Research

The sex steroid hormones (SSHs) such as testosterone, estradiol, progesterone, and their metaboli... more The sex steroid hormones (SSHs) such as testosterone, estradiol, progesterone, and their metabolites have important organizational and activational impacts on the brain during critical periods of brain development and in adulthood. A variety of slow and rapid mechanisms mediate both organizational and activational processes via intracellular or membrane receptors for SSHs. Physiological concentrations and distribution of SSHs in the brain result in normal brain development. Nevertheless, dysregulation of hormonal equilibrium may result in several mood disorders, including depressive disorders, later in adolescence or adulthood. Gender differences in cognitive abilities, emotions as well as the 2-3 times higher prevalence of depressive disorders in females, were already described. This implies that SSHs may play a role in the development of depressive disorders. In this review, we discuss preclinical and clinical studies linked to SSHs and development of depressive disorders. Our sec...

Research paper thumbnail of Molecular actions of sex hormones in the brain and their potential treatment use in anxiety disorders

Frontiers in Psychiatry

Anxiety disorders are one of the most prevalent mood disorders that can lead to impaired quality ... more Anxiety disorders are one of the most prevalent mood disorders that can lead to impaired quality of life. Current treatment of anxiety disorders has various adverse effects, safety concerns, or restricted efficacy; therefore, novel therapeutic targets need to be studied. Sex steroid hormones (SSHs) play a crucial role in the formation of brain structures, including regions of the limbic system and prefrontal cortex during perinatal development. In the brain, SSHs have activational and organizational effects mediated by either intracellular or transmembrane G-protein coupled receptors. During perinatal developmental periods, the physiological concentrations of SSHs lead to the normal development of the brain; however, the early hormonal dysregulation could result in various anxiety diorders later in life. Sex differences in the prevalence of anxiety disorders suggest that SSHs might be implicated in their development. In this review, we discuss preclinical and clinical studies regard...

Research paper thumbnail of Neuromotor Development in the Shank3 Mouse Model of Autism Spectrum Disorder

SSRN Electronic Journal, 2022

Research paper thumbnail of 1 a Brief Survey of Christendom 500 1100

Research paper thumbnail of On the role of sex steroids in biological functions by classical and non-classical pathways. An update

Frontiers in Neuroendocrinology

Research paper thumbnail of Multiple neuropeptides produced by sex-specific neurons control activity of the male accessory glands and gonoducts in the silkworm Bombyx mori

Scientific Reports

the male accessory glands (AG) and gonoducts of moths develop during metamorphosis and are essent... more the male accessory glands (AG) and gonoducts of moths develop during metamorphosis and are essential for successful fertilization of females. We found that these reproductive organs are innervated by a sex-specific cluster of peptidergic neurons in the posterior 9 th neuromere of the terminal abdominal ganglion (TAG). This cluster of ~20 neurons differentiate during metamorphosis to innervate the accessory glands and sperm ducts. Using immunohistochemistry and in situ hybridization (IsH) we showed that these neurons express four neuropeptide precursors encoding calcitonin-like diuretic hormone (Ct-DH), allatotropin (At) and At-like peptides (AtLI-III), allatostatin C (Ast-C), and myoinhibitory peptides (MIps). We used contraction bioassay in vitro to determine roles of these neuropeptides in the gonoduct and accessory gland activity. spontaneous contractions of the seminal vesicle and AG were stimulated in a dose depended manner by Ct-DH and At, whereas Ast-C and MIp elicited dose dependent inhibition. Using quantitative RT-PCR we confirmed expression of receptors for these neuropeptides in organs innervated by the male specific cluster of neurons. Our results suggest a role of these neuropeptides in regulation of seminal fluid movements during copulation.

Research paper thumbnail of Testosterone, personality traits and aggressive driving among young male drivers

Bratislava Medical Journal, 2021

INTRODUCTION: Psychological testing to examine potentially aggressive behaviour is a gold standar... more INTRODUCTION: Psychological testing to examine potentially aggressive behaviour is a gold standard, but it is not suffi cient. Testosterone might increase an aggressive behaviour. AIM: The aim of this study was to evaluate whether testosterone along with psychological assessment of fi tness to drive could help to identify aggressive drivers. METHODS: Male participants (n = 150) aged from 20 to 25, who possessed a driving license and drive at least 100 km per week, were evaluated in this study using an Inventory of traffi c-relevant personality characteristics, the Sensation Seeking Scale and the Buss-Durkee Aggression Inventory. Saliva was collected for testosterone and cortisol measurements. The fi ve binomial logistic models with dependent variables Caused an accident, Driving license taken away, Court trial, Intoxicated driving and Sporty self-report were tested in this study. RESULTS: The 'Intoxicated driving' model, was found to be statistically highly signifi cant, explaining 48.8 % of the dependent variable's variance (χ 2 (16) = 36.145, p < 0.01). In this model with sensation seeking, actual testosterone and their interaction was highly signifi cant and explained 20.4 % of intoxicated driving variability (χ 2 (3)=14.283, p<0.01). This was higher than sensation seeking scores only. CONCLUSION: To conclude, salivary testosterone might prove a biological marker that improves the identifi cation of those with a high probability of aggressive driving or its subtypes (Tab.

Research paper thumbnail of Aggressive drivers data

Data about participants from psychological tests and non-biochemical measurements were acquired f... more Data about participants from psychological tests and non-biochemical measurements were acquired from the Department of Psychology, Faculty of Arts, Faculty of Philosophy of Palacký University Olomouc, Czech Republic. The participants were recruited for the study by advertisements on the relevant social networks groups and by leaflets hanged out in the University or public premises (libraries, refectory etc.). Inventory of traffic-relevant personality characteristics (shortened version, TVP), Sensation Seeking Scale form, and Buss a Durkee aggression inventory were performed for psychological testing. Salivary testosterone and cortisol were measured from saliva obtained at 8:00am for each participant. Obtained data were transformed into data matrix, where only relevant data were kept. One participant was excluded from the study, due to corticosteroid medication. Overall, analysis was performed using 149 participants. Binomial models were employed with five dependent variables, which we assumed to reflect driver's tendency to aggressive behaviour: 1. Caused an accident, 2. Driving license taken away, 3. Court trial, 4. Intoxicated driving, 5. Sporty self-report.

Research paper thumbnail of Sex Steroid Hormones in Depressive Disorders as a Basis for New Potential Treatment Strategies

Physiological Research

The sex steroid hormones (SSHs) such as testosterone, estradiol, progesterone, and their metaboli... more The sex steroid hormones (SSHs) such as testosterone, estradiol, progesterone, and their metabolites have important organizational and activational impacts on the brain during critical periods of brain development and in adulthood. A variety of slow and rapid mechanisms mediate both organizational and activational processes via intracellular or membrane receptors for SSHs. Physiological concentrations and distribution of SSHs in the brain result in normal brain development. Nevertheless, dysregulation of hormonal equilibrium may result in several mood disorders, including depressive disorders, later in adolescence or adulthood. Gender differences in cognitive abilities, emotions as well as the 2-3 times higher prevalence of depressive disorders in females, were already described. This implies that SSHs may play a role in the development of depressive disorders. In this review, we discuss preclinical and clinical studies linked to SSHs and development of depressive disorders. Our sec...

Research paper thumbnail of Molecular actions of sex hormones in the brain and their potential treatment use in anxiety disorders

Frontiers in Psychiatry

Anxiety disorders are one of the most prevalent mood disorders that can lead to impaired quality ... more Anxiety disorders are one of the most prevalent mood disorders that can lead to impaired quality of life. Current treatment of anxiety disorders has various adverse effects, safety concerns, or restricted efficacy; therefore, novel therapeutic targets need to be studied. Sex steroid hormones (SSHs) play a crucial role in the formation of brain structures, including regions of the limbic system and prefrontal cortex during perinatal development. In the brain, SSHs have activational and organizational effects mediated by either intracellular or transmembrane G-protein coupled receptors. During perinatal developmental periods, the physiological concentrations of SSHs lead to the normal development of the brain; however, the early hormonal dysregulation could result in various anxiety diorders later in life. Sex differences in the prevalence of anxiety disorders suggest that SSHs might be implicated in their development. In this review, we discuss preclinical and clinical studies regard...

Research paper thumbnail of Neuromotor Development in the Shank3 Mouse Model of Autism Spectrum Disorder

SSRN Electronic Journal, 2022

Research paper thumbnail of 1 a Brief Survey of Christendom 500 1100

Research paper thumbnail of On the role of sex steroids in biological functions by classical and non-classical pathways. An update

Frontiers in Neuroendocrinology

Research paper thumbnail of Multiple neuropeptides produced by sex-specific neurons control activity of the male accessory glands and gonoducts in the silkworm Bombyx mori

Scientific Reports

the male accessory glands (AG) and gonoducts of moths develop during metamorphosis and are essent... more the male accessory glands (AG) and gonoducts of moths develop during metamorphosis and are essential for successful fertilization of females. We found that these reproductive organs are innervated by a sex-specific cluster of peptidergic neurons in the posterior 9 th neuromere of the terminal abdominal ganglion (TAG). This cluster of ~20 neurons differentiate during metamorphosis to innervate the accessory glands and sperm ducts. Using immunohistochemistry and in situ hybridization (IsH) we showed that these neurons express four neuropeptide precursors encoding calcitonin-like diuretic hormone (Ct-DH), allatotropin (At) and At-like peptides (AtLI-III), allatostatin C (Ast-C), and myoinhibitory peptides (MIps). We used contraction bioassay in vitro to determine roles of these neuropeptides in the gonoduct and accessory gland activity. spontaneous contractions of the seminal vesicle and AG were stimulated in a dose depended manner by Ct-DH and At, whereas Ast-C and MIp elicited dose dependent inhibition. Using quantitative RT-PCR we confirmed expression of receptors for these neuropeptides in organs innervated by the male specific cluster of neurons. Our results suggest a role of these neuropeptides in regulation of seminal fluid movements during copulation.