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Papers by Mirza Čelebičić

Medicinski arhiv, 2017

Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain targ... more Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain target tissues, but without any comparative analysis of hematological parameters. Therefore, we conducted a study to assess the possible association of the implantation of titanium and plastic clips in the neurocranium with possible morphological changes in the blood cells of experimental animals. Materials and Methods: As a control, the peripheral blood smears were taken before surgery from 12 adult dogs that were divided into two experimental groups. After placing titanium and plastic clips in the neurocranium, the peripheral blood of the first group was analyzed on the seventh postoperative day, while the peripheral blood of the second group was analyzed on the sixtieth day. By microscopy of the blood smears, the following parameters were analyzed: the presence of poikilocytosis of the red blood cells, degenerative changes in the leukocytes and leukogram. Results: There were no statistically significant differences between the mean values of the groups. Monocytosis was detected (first group 22.83 % and second 16.30 %), as well as neutropenia (46.80 %, in the second group). Degenerative changes to neutrophils and the occurrence of atypical lymphocytes were observed in the second experimental group (60 th postoperative day). Conclusion: A mild adverse effect from the biomaterials present in the neurocranium of dogs was detected, affecting the majority of leukocytic cells. A chronic recurrent inflammatory process was caused by the presence of the plastic and titanium clips in the brain tissue. No adverse effect of biomaterials on erythrocytes in the neurocranium was detected in the dogs studied. Further studies are necessary to explain the occurrence of degenerative changes in the neutrophils and lymphocytes.

Veterinaria

Mytilus galloprovincialis Lamarck, 1873 is a species widespread in the Adriatic Sea. Due to its e... more Mytilus galloprovincialis Lamarck, 1873 is a species widespread in the Adriatic Sea. Due to its edibleness, it is the most important breeding species of shellfish grown in Europe. Two farms have been registered in the Neum Bay. The paper analyzes populations of M. galloprovincialis from three locations, two from the Neum Bay and one from Mali Ston in Croatia. Sampling was done during May 2019 in the tidal zone. According to the WFD and typology, these three localities belong to coastal waters of polyhialine with fine-grained sediment. According to the average values of physical and chemical parameters and chlorophyll, the Neum Bay is in the category of good ecological status, while Mali Ston is stated to be a reference site. Morphometric measurements of the right valve in 90 individuals (30 per locality) included external parameters (height, total length and width of the shell) as well as total weight, soft tissue weight and shell weight. As the internal parameters, the characteristics of the ligament, retractor muscles and adductor muscles are analyzed. Using statistical analyzes (descriptive statistics, post Hoc analysis and correlation), differences in the total weight, length and parameters of the adductor and retractor muscles have been determined. The species from Mali Ston are discriminated from the species of the Neum Bay, which indicates more pronounced anthropogenic influences in the areas of the Neum town. Morphometric analysis is a powerful tool for monitoring the state of the populations. Along with genetic analysis, it can be used for monitoring changes in the environment. Determining pathogens in mussel species in Croatia, Slovenia and Italy is an example of controling the conditions of natural and breeding species using various methods and analyses.

Veterinaria, Dec 10, 2020

Scripta Medica, 2021

Introduction: The technique of closing the appendiceal stump using linear titanium stapler clips ... more Introduction: The technique of closing the appendiceal stump using linear titanium stapler clips is being used more and more frequently in laparoscopic surgery, despite the good practice in the use of resorbable single endoloop vicryl ligatures and/or the non-resorbable plastic hem-o-lok clips. No light has been shed on potential undesirable effects on the haemathological profile of the use of titanium stapler clips. This experimental study aimed at establishing any possible undesirable effect of linear titanium stapler clips and single resorbable vicryl endoloop ligatures on the blood cells in rats following appendectomy. Methods: A total of 70 adult rats were used, divided into a control group (n = 10), and two experimental groups (n = 30 + 30). The appendices were removed from the rats in the first experimental group using titanium stapler clips and in the second experimental group the appendiceal stump using resorbable endoloop vicryl ligatures was closed. In both experimental g...

Veterinaria, Dec 10, 2020

The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during... more The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during a survey that took place in Neum Bay 37 years ago. Since then its presence has only been confirmed once although it is protected by several international protocols. The aim of this research was to collect the data that can be used for a better undersanding and preservation of P. nobilis. An area of 400 m was searched for individual shells by SCUBA diving. Five individuals found at a depth ranged between 3 and 9 m. Bosnia and Herzegovina is the only country on the Adriatic Sea that has not protected the fan shell by law. Further surveys must be undertaken as soon as possible, with the proper management of this habitat which hosts P. nobilis.

Veterinaria, 2021

The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea... more The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea and brought this species to the brink of extinction. So far, the etiology of the disease was determined to be multifactorial. Apart from a wide spectrum of pathogenic microorganisms as a key factor, the indirect role is played by climate changes, ie. the increase in sea water temperature, which rises sensitivity of P. nobilis toward pathogens. In terms of conservation measures, the IUCN guidelines are species-oriented and recommend in situ and ex situ conservation. In this study, we examined 10,920 m 2 of seabed in the territorial waters of Bosnia and Herzegovina (B&H) and confirmed the occurrence of MME with 100% mortality rate. Based on estimated Total Number of Individuals (TNI), the filtration capacity as an ecosystem service for the turbidity control in the Bay was assessed. Herein, we present a potential method for the assessment of ecosystem damages caused by the loss of fan shells and their biofiltration service. Our results showed that 58583 ± 27879 individuals were lost, which corresponds to the biomass of 11.47 t ± 6.41 t (± 55.87%). Hourly filtration potential (PRF) of P. nobilis is 68722.11 ± 38396.86 (± 55.87%) 95% CI, meaning that all populations could filter the entire sea water in the Neum Bay (0.2 km 3) in a period of 78-275 days. We also determined the Compensation Ratio (CR) for bivalve shell Ostrea edulis, i.e. how many individuals of O. edulis are required to replace the function of one P. nobilis in terms of filtration capacity, which is CR = 2.72 ± 0.30 (11.03%). This paper provides a new approach to the MME of P. nobilis indicating urgent need for the marine ecosystem remediation and replacement of the lost ecosystem service by cultivation of compensatory species.

veterinaria sarajevo, 2021

The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea... more The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea and brought this species to the brink of extinction. So far, the etiology of the disease was determined to be multifactorial. Apart from a wide spectrum of pathogenic microorganisms as a key factor, the indirect role is played by climate changes, ie. the increase in sea water temperature, which rises sensitivity of P. nobilis toward pathogens. In terms of conservation measures, the IUCN guidelines are species-oriented and recommend in situ and ex situ conservation. In this study, we examined 10,920 m 2 of seabed in the territorial waters of Bosnia and Herzegovina (B&H) and confirmed the occurrence of MME with 100% mortality rate. Based on estimated Total Number of Individuals (TNI), the filtration capacity as an ecosystem service for the turbidity control in the Bay was assessed. Herein, we present a potential method for the assessment of ecosystem damages caused by the loss of fan shells and their biofiltration service. Our results showed that 58583 ± 27879 individuals were lost, which corresponds to the biomass of 11.47 t ± 6.41 t (± 55.87%). Hourly filtration potential (PRF) of P. nobilis is 68722.11 ± 38396.86 (± 55.87%) 95% CI, meaning that all populations could filter the entire sea water in the Neum Bay (0.2 km 3) in a period of 78-275 days. We also determined the Compensation Ratio (CR) for bivalve shell Ostrea edulis, i.e. how many individuals of O. edulis are required to replace the function of one P. nobilis in terms of filtration capacity, which is CR = 2.72 ± 0.30 (11.03%). This paper provides a new approach to the MME of P. nobilis indicating urgent need for the marine ecosystem remediation and replacement of the lost ecosystem service by cultivation of compensatory species.

A rat with the mass located on the right lateral aspect of the head in the regio infraorbitalis, ... more A rat with the mass located on the right lateral aspect of the head in the regio infraorbitalis, maxillaris, lateralis nasi dextra, et regio dorsalis nasi was presented for necropsy. Clinically, a severe form of dyspnea and occasional intermittent stridor were observed. Gross examination and histopathology revealed an abscess on the rat’s head. Hematological examination showed macrocytic regenerative hypochromic anemia. In addition, in blood smears stained with May Grunwald Giemsa, numerous spherocytes and anulocytes as well as reticulocytes indicating anemia were observed. Morphological changes found in the lymphocyte (1,1%) and neutrophil cytoplasm (20%) were most probably the result of adverse, toxic effects of various products of purulent inflammation in the head abscess. Key words: abscess, anemia, reticulocytes, spherocytes, anulocytes

Journal of the Black Sea / Mediterranean Environment, 2018

The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during... more The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during a survey that took place in Neum Bay 37 years ago. Since then its presence has only been confirmed once although it is protected by several international protocols. The aim of this research was to collect the data that can be used for a better undersanding and preservation of P. nobilis. An area of 400 m 2 was searched for individual shells by SCUBA diving. Five individuals found at a depth ranged between 3 and 9 m. Bosnia and Herzegovina is the only country on the Adriatic Sea that has not protected the fan shell by law. Further surveys must be undertaken as soon as possible, with the proper management of this habitat which hosts P. nobilis.

Kafkas Universitesi Veteriner Fakultesi Dergisi

Kafkas Universitesi Veteriner Fakultesi Dergisi

Medical Archives, 2017

Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain targ... more Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain target tissues, but without any comparative analysis of hematological parameters. Therefore, we conducted a study to assess the possible association of the implantation of titanium and plastic clips in the neurocranium with possible morphological changes in the blood cells of experimental animals. Materials and Methods: As a control, the peripheral blood smears were taken before surgery from 12 adult dogs that were divided into two experimental groups. After placing titanium and plastic clips in the neurocranium, the peripheral blood of the first group was analyzed on the seventh postoperative day, while the peripheral blood of the second group was analyzed on the sixtieth day. By microscopy of the blood smears, the following parameters were analyzed: the presence of poikilocytosis of the red blood cells, degenerative changes in the leukocytes and leukogram. Results: There were no statistically significant differences between the mean values of the groups. Monocytosis was detected (first group 22.83 % and second 16.30 %), as well as neutropenia (46.80 %, in the second group). Degenerative changes to neutrophils and the occurrence of atypical lymphocytes were observed in the second experimental group (60 th postoperative day). Conclusion: A mild adverse effect from the biomaterials present in the neurocranium of dogs was detected, affecting the majority of leukocytic cells. A chronic recurrent inflammatory process was caused by the presence of the plastic and titanium clips in the brain tissue. No adverse effect of biomaterials on erythrocytes in the neurocranium was detected in the dogs studied. Further studies are necessary to explain the occurrence of degenerative changes in the neutrophils and lymphocytes.

Medicinski arhiv, 2017

Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain targ... more Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain target tissues, but without any comparative analysis of hematological parameters. Therefore, we conducted a study to assess the possible association of the implantation of titanium and plastic clips in the neurocranium with possible morphological changes in the blood cells of experimental animals. Materials and Methods: As a control, the peripheral blood smears were taken before surgery from 12 adult dogs that were divided into two experimental groups. After placing titanium and plastic clips in the neurocranium, the peripheral blood of the first group was analyzed on the seventh postoperative day, while the peripheral blood of the second group was analyzed on the sixtieth day. By microscopy of the blood smears, the following parameters were analyzed: the presence of poikilocytosis of the red blood cells, degenerative changes in the leukocytes and leukogram. Results: There were no statistically significant differences between the mean values of the groups. Monocytosis was detected (first group 22.83 % and second 16.30 %), as well as neutropenia (46.80 %, in the second group). Degenerative changes to neutrophils and the occurrence of atypical lymphocytes were observed in the second experimental group (60 th postoperative day). Conclusion: A mild adverse effect from the biomaterials present in the neurocranium of dogs was detected, affecting the majority of leukocytic cells. A chronic recurrent inflammatory process was caused by the presence of the plastic and titanium clips in the brain tissue. No adverse effect of biomaterials on erythrocytes in the neurocranium was detected in the dogs studied. Further studies are necessary to explain the occurrence of degenerative changes in the neutrophils and lymphocytes.

Veterinaria

Mytilus galloprovincialis Lamarck, 1873 is a species widespread in the Adriatic Sea. Due to its e... more Mytilus galloprovincialis Lamarck, 1873 is a species widespread in the Adriatic Sea. Due to its edibleness, it is the most important breeding species of shellfish grown in Europe. Two farms have been registered in the Neum Bay. The paper analyzes populations of M. galloprovincialis from three locations, two from the Neum Bay and one from Mali Ston in Croatia. Sampling was done during May 2019 in the tidal zone. According to the WFD and typology, these three localities belong to coastal waters of polyhialine with fine-grained sediment. According to the average values of physical and chemical parameters and chlorophyll, the Neum Bay is in the category of good ecological status, while Mali Ston is stated to be a reference site. Morphometric measurements of the right valve in 90 individuals (30 per locality) included external parameters (height, total length and width of the shell) as well as total weight, soft tissue weight and shell weight. As the internal parameters, the characteristics of the ligament, retractor muscles and adductor muscles are analyzed. Using statistical analyzes (descriptive statistics, post Hoc analysis and correlation), differences in the total weight, length and parameters of the adductor and retractor muscles have been determined. The species from Mali Ston are discriminated from the species of the Neum Bay, which indicates more pronounced anthropogenic influences in the areas of the Neum town. Morphometric analysis is a powerful tool for monitoring the state of the populations. Along with genetic analysis, it can be used for monitoring changes in the environment. Determining pathogens in mussel species in Croatia, Slovenia and Italy is an example of controling the conditions of natural and breeding species using various methods and analyses.

Veterinaria, Dec 10, 2020

Scripta Medica, 2021

Introduction: The technique of closing the appendiceal stump using linear titanium stapler clips ... more Introduction: The technique of closing the appendiceal stump using linear titanium stapler clips is being used more and more frequently in laparoscopic surgery, despite the good practice in the use of resorbable single endoloop vicryl ligatures and/or the non-resorbable plastic hem-o-lok clips. No light has been shed on potential undesirable effects on the haemathological profile of the use of titanium stapler clips. This experimental study aimed at establishing any possible undesirable effect of linear titanium stapler clips and single resorbable vicryl endoloop ligatures on the blood cells in rats following appendectomy. Methods: A total of 70 adult rats were used, divided into a control group (n = 10), and two experimental groups (n = 30 + 30). The appendices were removed from the rats in the first experimental group using titanium stapler clips and in the second experimental group the appendiceal stump using resorbable endoloop vicryl ligatures was closed. In both experimental g...

Veterinaria, Dec 10, 2020

The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during... more The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during a survey that took place in Neum Bay 37 years ago. Since then its presence has only been confirmed once although it is protected by several international protocols. The aim of this research was to collect the data that can be used for a better undersanding and preservation of P. nobilis. An area of 400 m was searched for individual shells by SCUBA diving. Five individuals found at a depth ranged between 3 and 9 m. Bosnia and Herzegovina is the only country on the Adriatic Sea that has not protected the fan shell by law. Further surveys must be undertaken as soon as possible, with the proper management of this habitat which hosts P. nobilis.

Veterinaria, 2021

The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea... more The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea and brought this species to the brink of extinction. So far, the etiology of the disease was determined to be multifactorial. Apart from a wide spectrum of pathogenic microorganisms as a key factor, the indirect role is played by climate changes, ie. the increase in sea water temperature, which rises sensitivity of P. nobilis toward pathogens. In terms of conservation measures, the IUCN guidelines are species-oriented and recommend in situ and ex situ conservation. In this study, we examined 10,920 m 2 of seabed in the territorial waters of Bosnia and Herzegovina (B&H) and confirmed the occurrence of MME with 100% mortality rate. Based on estimated Total Number of Individuals (TNI), the filtration capacity as an ecosystem service for the turbidity control in the Bay was assessed. Herein, we present a potential method for the assessment of ecosystem damages caused by the loss of fan shells and their biofiltration service. Our results showed that 58583 ± 27879 individuals were lost, which corresponds to the biomass of 11.47 t ± 6.41 t (± 55.87%). Hourly filtration potential (PRF) of P. nobilis is 68722.11 ± 38396.86 (± 55.87%) 95% CI, meaning that all populations could filter the entire sea water in the Neum Bay (0.2 km 3) in a period of 78-275 days. We also determined the Compensation Ratio (CR) for bivalve shell Ostrea edulis, i.e. how many individuals of O. edulis are required to replace the function of one P. nobilis in terms of filtration capacity, which is CR = 2.72 ± 0.30 (11.03%). This paper provides a new approach to the MME of P. nobilis indicating urgent need for the marine ecosystem remediation and replacement of the lost ecosystem service by cultivation of compensatory species.

veterinaria sarajevo, 2021

The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea... more The Mass Mortality Event (MME) of endemic bivalve Pinna nobilis occurred in the Mediterranean Sea and brought this species to the brink of extinction. So far, the etiology of the disease was determined to be multifactorial. Apart from a wide spectrum of pathogenic microorganisms as a key factor, the indirect role is played by climate changes, ie. the increase in sea water temperature, which rises sensitivity of P. nobilis toward pathogens. In terms of conservation measures, the IUCN guidelines are species-oriented and recommend in situ and ex situ conservation. In this study, we examined 10,920 m 2 of seabed in the territorial waters of Bosnia and Herzegovina (B&H) and confirmed the occurrence of MME with 100% mortality rate. Based on estimated Total Number of Individuals (TNI), the filtration capacity as an ecosystem service for the turbidity control in the Bay was assessed. Herein, we present a potential method for the assessment of ecosystem damages caused by the loss of fan shells and their biofiltration service. Our results showed that 58583 ± 27879 individuals were lost, which corresponds to the biomass of 11.47 t ± 6.41 t (± 55.87%). Hourly filtration potential (PRF) of P. nobilis is 68722.11 ± 38396.86 (± 55.87%) 95% CI, meaning that all populations could filter the entire sea water in the Neum Bay (0.2 km 3) in a period of 78-275 days. We also determined the Compensation Ratio (CR) for bivalve shell Ostrea edulis, i.e. how many individuals of O. edulis are required to replace the function of one P. nobilis in terms of filtration capacity, which is CR = 2.72 ± 0.30 (11.03%). This paper provides a new approach to the MME of P. nobilis indicating urgent need for the marine ecosystem remediation and replacement of the lost ecosystem service by cultivation of compensatory species.

A rat with the mass located on the right lateral aspect of the head in the regio infraorbitalis, ... more A rat with the mass located on the right lateral aspect of the head in the regio infraorbitalis, maxillaris, lateralis nasi dextra, et regio dorsalis nasi was presented for necropsy. Clinically, a severe form of dyspnea and occasional intermittent stridor were observed. Gross examination and histopathology revealed an abscess on the rat’s head. Hematological examination showed macrocytic regenerative hypochromic anemia. In addition, in blood smears stained with May Grunwald Giemsa, numerous spherocytes and anulocytes as well as reticulocytes indicating anemia were observed. Morphological changes found in the lymphocyte (1,1%) and neutrophil cytoplasm (20%) were most probably the result of adverse, toxic effects of various products of purulent inflammation in the head abscess. Key words: abscess, anemia, reticulocytes, spherocytes, anulocytes

Journal of the Black Sea / Mediterranean Environment, 2018

The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during... more The presence of the Mediterranean endemic bivalvia fan shell Pinna nobilis L. was recorded during a survey that took place in Neum Bay 37 years ago. Since then its presence has only been confirmed once although it is protected by several international protocols. The aim of this research was to collect the data that can be used for a better undersanding and preservation of P. nobilis. An area of 400 m 2 was searched for individual shells by SCUBA diving. Five individuals found at a depth ranged between 3 and 9 m. Bosnia and Herzegovina is the only country on the Adriatic Sea that has not protected the fan shell by law. Further surveys must be undertaken as soon as possible, with the proper management of this habitat which hosts P. nobilis.

Kafkas Universitesi Veteriner Fakultesi Dergisi

Kafkas Universitesi Veteriner Fakultesi Dergisi

Medical Archives, 2017

Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain targ... more Introduction: Various studies confirm the biocompatibility and efficacy of clips for certain target tissues, but without any comparative analysis of hematological parameters. Therefore, we conducted a study to assess the possible association of the implantation of titanium and plastic clips in the neurocranium with possible morphological changes in the blood cells of experimental animals. Materials and Methods: As a control, the peripheral blood smears were taken before surgery from 12 adult dogs that were divided into two experimental groups. After placing titanium and plastic clips in the neurocranium, the peripheral blood of the first group was analyzed on the seventh postoperative day, while the peripheral blood of the second group was analyzed on the sixtieth day. By microscopy of the blood smears, the following parameters were analyzed: the presence of poikilocytosis of the red blood cells, degenerative changes in the leukocytes and leukogram. Results: There were no statistically significant differences between the mean values of the groups. Monocytosis was detected (first group 22.83 % and second 16.30 %), as well as neutropenia (46.80 %, in the second group). Degenerative changes to neutrophils and the occurrence of atypical lymphocytes were observed in the second experimental group (60 th postoperative day). Conclusion: A mild adverse effect from the biomaterials present in the neurocranium of dogs was detected, affecting the majority of leukocytic cells. A chronic recurrent inflammatory process was caused by the presence of the plastic and titanium clips in the brain tissue. No adverse effect of biomaterials on erythrocytes in the neurocranium was detected in the dogs studied. Further studies are necessary to explain the occurrence of degenerative changes in the neutrophils and lymphocytes.