Mitchell Borin - Academia.edu (original) (raw)
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Papers by Mitchell Borin
Seminars in arthroplasty, Apr 1, 2024
His current research interests include shoulder arthroplasty and arthroscopic rotator cuff repair... more His current research interests include shoulder arthroplasty and arthroscopic rotator cuff repair. Visit John Barnett's Website Connect with John Barnett on LinkedIn Conflicts of Interest Statement for John Barnett Mitchell Borin a second year medical student at the Ohio State University College Of Medicine. He went to undergrad at Michigan State and is originally from Walled Lake Michigan.
Oncotarget, 2020
Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. T... more Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. The potential of endocrine disrupting chemicals to act as agonists or antagonists in critical hormonally regulated processes, such as mammary gland development and mammary tumorigenesis, demands evaluation of its potential in promoting breast cancer. This study identifies the effects of BP-3 on mammary tumorigenesis with high-fat diet during puberty versus adulthood in Trp53-null transplant BALB/c mice. Benzophenone-3 exposure yielded levels in urine similar to humans subjected to heavy topical sunscreen exposure. Benzophenone-3 was protective for epithelial tumorigenesis in mice fed lifelong low-fat diet, while promotional for epithelial tumorigenesis in mice fed adult high-fat diet. Benzophenone-3 increased tumor cell proliferation, decreased tumor cell apoptosis, and increased tumor vascularity dependent on specific dietary regimen and tumor histopathology. Even in instances of an ostensibly protective effect, other parameters suggest greater risk. Although benzophenone-3 seemed protective on low-fat diet, spindle cell tumors arising in these mice showed increased proliferation and decreased apoptosis. This points to a need for further studies of benzophenone-3 in both animal models and humans as a potential breast cancer risk factor, as well as a more general need to evaluate endocrine disrupting chemicals in varying dietary contexts.
Seminars in arthroplasty, Apr 1, 2024
His current research interests include shoulder arthroplasty and arthroscopic rotator cuff repair... more His current research interests include shoulder arthroplasty and arthroscopic rotator cuff repair. Visit John Barnett's Website Connect with John Barnett on LinkedIn Conflicts of Interest Statement for John Barnett Mitchell Borin a second year medical student at the Ohio State University College Of Medicine. He went to undergrad at Michigan State and is originally from Walled Lake Michigan.
Oncotarget, 2020
Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. T... more Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. The potential of endocrine disrupting chemicals to act as agonists or antagonists in critical hormonally regulated processes, such as mammary gland development and mammary tumorigenesis, demands evaluation of its potential in promoting breast cancer. This study identifies the effects of BP-3 on mammary tumorigenesis with high-fat diet during puberty versus adulthood in Trp53-null transplant BALB/c mice. Benzophenone-3 exposure yielded levels in urine similar to humans subjected to heavy topical sunscreen exposure. Benzophenone-3 was protective for epithelial tumorigenesis in mice fed lifelong low-fat diet, while promotional for epithelial tumorigenesis in mice fed adult high-fat diet. Benzophenone-3 increased tumor cell proliferation, decreased tumor cell apoptosis, and increased tumor vascularity dependent on specific dietary regimen and tumor histopathology. Even in instances of an ostensibly protective effect, other parameters suggest greater risk. Although benzophenone-3 seemed protective on low-fat diet, spindle cell tumors arising in these mice showed increased proliferation and decreased apoptosis. This points to a need for further studies of benzophenone-3 in both animal models and humans as a potential breast cancer risk factor, as well as a more general need to evaluate endocrine disrupting chemicals in varying dietary contexts.