Mithat Tabaković - Academia.edu (original) (raw)
Papers by Mithat Tabaković
Journal of clinical nephrology, Jun 17, 2020
We described a case of specifi c (tuberculous) encephalitis in a patient after kidney transplanta... more We described a case of specifi c (tuberculous) encephalitis in a patient after kidney transplantation. Immunosuppressive therapy, continuously required in post-tranplant period, may cause various complications, such as infections. Specifi c meningoencephalitis is an infection that is rarely diagnosed and more common in immunocompromised patients. Case report: A 30-year-old man had kidney transplantation (kidney donor was his father). He previously was two years on chronic hemodialysis treatment because of end-stagerenal disease based on diabetic nephropathy. He has diabetes type 1. The early post-transplant period duly passed with satisfactory clinical and laboratory parameters of renal function. Two months after transplantation, he presented with febrile condition, signs of septicemia and dehydration with signifi cant neurological defi cit and expressed meningeal signs. In cerebrospinal fl uid we found lymphocytosis, elevated proteins and positive micobacterium tuberculosis antibodies (Hexagon method) and we suspected to specifi c etiology of meningitis. Performed computed tomography (CT) scan of the brain with contrast confi rmed the expected fi nding. Due to the poor prognosis of infections of the central nervous system (CNS) in immunocompromised patients, only prompt diagnosis can improve survival in this group of patients. The therapeutic protocol after kidney transplantation include the prophylactic use of antituberculous drug (Isoniazid 300 mg) during the 9 months.
ABSTRACT Introduction. The objective of this study is to analyze complication rate associated wit... more ABSTRACT Introduction. The objective of this study is to analyze complication rate associated with ultrasound guided central venous catheter (CVC) insertion. Patients and methods. In the period of 12 months at the Department of Nephrology at Tuzla we applied ...
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, Aug 1, 2022
Aim To determine risk factors responsible for developing postoperative complications after the th... more Aim To determine risk factors responsible for developing postoperative complications after the thoracic aorta reconstructive surgery. Methods Medical records of 100 patients, who had undergone elective or emergency thoracic aorta reconstructive surgery at the Clinic for Cardiovascular Surgery, University Clinical Center Tuzla, were analysed. Intraoperative data as cross-clamp time (CCT), duration of cardiopulmonary bypass (CPBT) and hypothermic circulatory arrest time (HCAT) were evaluated. Univariate analysis was used to show risk factors for developing postoperative cardiac, respiratory, surgical and renal complications. Results Between May 2019 and April 2021, 48 Bentall procedures (BP), 23 ascending aortic replacements (AAR), 20 BP and coronary artery bypass grafting (CABG) and 9 aortic valve replacements (AVR) with AAR were performed. Incidence of postoperative complications in the elective and emergency groups was as follows: respiratory 20% vs 38% (p=0.049), cardiac 18% vs 70% (p=0.015), renal 16% vs 48% (p=0.027) and surgical 4% vs 6% (p>0.05). Intrahospital 30 days morbidity was 44% with mortality rate of 13%. The results showed that CPBT>180 minutes was a risk factor for respiratory (p=0.034), cardiac (p=0.020) and renal (p=0.027) postoperative complications after acute type A aortic dissection surgery. Conclusion CPBT > 180 min is a risk factor for postoperative development of respiratory, cardiac and renal complications. Postoperative cardiac and renal complications were associated with longer HCAT.
Health and Primary Care, 2019
Leishmaniasis is a disease caused by Leishmania parasitic protozoans affecting people in both the... more Leishmaniasis is a disease caused by Leishmania parasitic protozoans affecting people in both the Eastern and Western Hemispheres. The secreted acid phosphatase enzymes (SAPs) are reported to play a critical role in infection by Leishmania. Thus, these enzymes are potential targets for Leishmania therapy. Tryptamines have various physiological effects and thus serve different purposes socially. Tryptamines are used in ritualistic ceremonies in countries where Leishmania cases are reported. In this work, tryptamine and two other indole derivatives, harmine and harmaline, were investigated. Harmine and harmaline were selected because of their presence in the biological materials used in some South American ritualistic ceremonies. We investigated the effects on axenic Leishmania tarentolae cell shape, motility, clumping, and viability as well as on the activity of secreted acid phosphatase (SAP) from L. tarentolae. An overall decrease in cell viability over a seven-day period and a small recovery in cell viability, only at lower concentrations of test compounds, were observed. These compounds were, in general, activators of L. tarentolae SAP activity. This is the first report of effects of these compounds on Leishmania secreted acid phosphatase activity in vitro. We speculate that those with Leishmania infections may be worsening their condition with the exposure to these compounds.
Health and Primary Care, 2019
We report a case of chronic total occlusion of the aorta with critical limb ischemia (CLI) of the... more We report a case of chronic total occlusion of the aorta with critical limb ischemia (CLI) of the lower limbs due to chronic total occlusion (CTO) of infrarenal aorta and extensive bilateral iliac disease. This case was treated by open surgical revascularization, after unsuccessful attempt of percutaneous endovascular stenting treatment.
Journal of Cardiothoracic Surgery, 2013
Journal of Cardiothoracic Surgery, 2013
Acta Medica Saliniana, 2011
Acta Medica Saliniana, Vol 40, No 1 (2011). ...
Acta Medica Saliniana, Nov 11, 2021
Accurate information on the cause of death is obtained from expert teams based on pathological or... more Accurate information on the cause of death is obtained from expert teams based on pathological or forensic expertise. Reliable information can be obtained from physicians in hospital settings if the deceased person has been treated in such an institution and has previously been diagnosed with an illness (intrahospital mortality). Intrahospital mortality analysis provides reliable data that can be used in the planning of a bed fund, the amount of medication purchased, the purchase of equipment, the organization and creation of highly specialized medical teams (resuscitation team), the number of resuscitation procedures, the number of pathologists required for autopsy procedures, etc. The aim of the study was to determine the total number of deaths, to identify the most common causes of death and 10 leading diagnoses of deceased patients at the Internal Medicine Clinic, University Clinical Center Tuzla (UKC) during one calendar year (2011). Material and methodes: Archive material (case histories and reports of deceased patients of the Internal Medicine Clinic) were used. Results: During this period, 6 488 patients were treated at the Internal Medicine Clinic and 451 patients died. According to the analyzed data, the most common diagnoses and causes of death at the Internal Medicine Clinic were: cerebrovascular incidents 104 (20.84%), cardiogenic shock in 24 (5.31%), heart failure 59 (10.86%), hepatic coma with cirrhosis of the liver 25 (5.33%), sudden cardiac death 30 (6.53%), respiratory failure 15 (3.32%), myocardial infarction 41 (9.99%), multiorgan failure 18 (4.00%) , pulmonary edema 14 (3.10%), sepsis 6 (1.38%), pulmonary emboli 17 (3.82%), valvular heart disease 9 (1.92%), cardiorespiratory arrest 9 (1.92%) , malignant abdominal neoplasms in 23 (5.28%), pancreatitis 2 (0.44%), hematemesis 8 (1.76%), diabetes mellitus 4 (0.88%), lung tumor 1 (0.22%), chronic renal insufficiency 12(2.54%), suicidal intoxication 4 (0.88%), ileus 4 (0.88%), cachexia 3 (0.66%), restrictive cardiomyopathy 2 (0.44%), mesenteric thrombosis arteries 2 (0.44%), disseminated lupus erythematosus 2 (0.44%), coffee vein thrombosis inferior 2 (0.44%), and 1 (0.22%) died of an aneurysm aortic abdominalis, ventricular septal defect, amyloidosis, disseminated intravascular coagulation, systemic sclerosis, rheumatoid arthritis and breast tumors. Conclusion: During the analyzed period, 6488 patients were treated at the Internal Medicine Clinic and a total of 451 patients died. The most common cause of death in hospitalized patients is cardiovascular disease (n = 208; 41.68% of deaths), with cerebrovascular disease (n = 104; 20.84% of deaths) totaling 312 (62.25%) of deaths from cardio and cerebrovascular disease.
Cardiologia Croatica, Feb 11, 2013
Kardiovaskularne bolesti (KVB) vodeÊi su uzrok smrtnosti u pacijenata na kroniËnoj dijalizi. Paci... more Kardiovaskularne bolesti (KVB) vodeÊi su uzrok smrtnosti u pacijenata na kroniËnoj dijalizi. Pacijenti s kroniËnom bubreaenom insuficijencijom imaju 10-20 puta viπi rizik razvoja 2013;8(1-2):67.
UKC Tuzla, Bosna i Hercegovina Here we present the case of a 19 years old female who was initiall... more UKC Tuzla, Bosna i Hercegovina Here we present the case of a 19 years old female who was initially admitted in May, 2004. as renal-limited vasculitisthat proved a month lateron as P-ANCA-positive, alongvvith theoccurenceofpulmanary renal syndrome. She was treated sucessfully with pulse steroids (PS) and cyclophosphamide (CP) vvhich resulted in complete pulmonary remission, but renal failure remained, thereby necessating the need for CAPD treatment. Maintenance immunosupressive regime was azathyoprine (AZA) and tapering steroids dose. Diagnosis at discharge from the Hospital was VVegener granulomatosis (WG) vvhich was later on confirmed bythe Rheumatology Dept. Peter Deržaj Hosp. in Ljubljana (Slovenia). Shevvas re-admitted in Octoberwith severedeterioration, febrile, with signs ofmyelosupression (WBC 2,5) and herpetic keratitis. Major dilemma was if this was relaps of her original disease or sec. to drug side-effects. ANCAs were negative on this occasion. Eventualy, since the patien...
Langenbecks Archiv f�r Chirurgie, 1983
Of 271 patients with 304 kidney transplants, between 1967 and 1981, 20 (7~) have developed a mali... more Of 271 patients with 304 kidney transplants, between 1967 and 1981, 20 (7~) have developed a malignant tumor and 7 patients (2.6 ~o) have died of it. A minimal time interval for tumor induction has to be assumed. Of 154 patients under immunosuppression with a functioning graft for over 1 year, 19 have developed a tumor. The figure of 12.3% is probably more realistic than the usual 5~-7~ incidence, based on all transplanted patients. Of these 154 patients, 6 (3.9 ~) died of their tumor that is 15.4 ~ of all deaths among the 154 patients exposed to immunosuppression for over 1 year.
Many methods for inferring genetic networks have been proposed, but the regulations they infer of... more Many methods for inferring genetic networks have been proposed, but the regulations they infer often include false-positives. Several researchers have attempted to reduce these erroneous regulations by proposing the use of a priori knowledge about the properties of genetic networks such as their sparseness, scale-free structure, and so on. This study focuses on another piece of a priori knowledge, namely, that biochemical networks exhibit hierarchical structures. Based on this idea, we propose an inference approach that uses the hierarchical structure in a target genetic network. To obtain a reasonable hierarchical structure, the first step of the proposed approach is to infer multiple genetic networks from the observed gene expression data. We take this step using an existing method that combines a genetic network inference method with a bootstrap method. The next step is to extract a hierarchical structure from the inferred networks that is consistent with most of the networks. Third, we use the hierarchical structure obtained to assign confidence values to all candidate regulations. Numerical experiments are also performed to demonstrate the effectiveness of using the hierarchical structure in the genetic network inference. The improvement accomplished by the use of the hierarchical structure is small. However, the hierarchical structure could be used to improve the performances of many existing inference methods.
Journal of clinical nephrology, Jun 17, 2020
We described a case of specifi c (tuberculous) encephalitis in a patient after kidney transplanta... more We described a case of specifi c (tuberculous) encephalitis in a patient after kidney transplantation. Immunosuppressive therapy, continuously required in post-tranplant period, may cause various complications, such as infections. Specifi c meningoencephalitis is an infection that is rarely diagnosed and more common in immunocompromised patients. Case report: A 30-year-old man had kidney transplantation (kidney donor was his father). He previously was two years on chronic hemodialysis treatment because of end-stagerenal disease based on diabetic nephropathy. He has diabetes type 1. The early post-transplant period duly passed with satisfactory clinical and laboratory parameters of renal function. Two months after transplantation, he presented with febrile condition, signs of septicemia and dehydration with signifi cant neurological defi cit and expressed meningeal signs. In cerebrospinal fl uid we found lymphocytosis, elevated proteins and positive micobacterium tuberculosis antibodies (Hexagon method) and we suspected to specifi c etiology of meningitis. Performed computed tomography (CT) scan of the brain with contrast confi rmed the expected fi nding. Due to the poor prognosis of infections of the central nervous system (CNS) in immunocompromised patients, only prompt diagnosis can improve survival in this group of patients. The therapeutic protocol after kidney transplantation include the prophylactic use of antituberculous drug (Isoniazid 300 mg) during the 9 months.
ABSTRACT Introduction. The objective of this study is to analyze complication rate associated wit... more ABSTRACT Introduction. The objective of this study is to analyze complication rate associated with ultrasound guided central venous catheter (CVC) insertion. Patients and methods. In the period of 12 months at the Department of Nephrology at Tuzla we applied ...
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, Aug 1, 2022
Aim To determine risk factors responsible for developing postoperative complications after the th... more Aim To determine risk factors responsible for developing postoperative complications after the thoracic aorta reconstructive surgery. Methods Medical records of 100 patients, who had undergone elective or emergency thoracic aorta reconstructive surgery at the Clinic for Cardiovascular Surgery, University Clinical Center Tuzla, were analysed. Intraoperative data as cross-clamp time (CCT), duration of cardiopulmonary bypass (CPBT) and hypothermic circulatory arrest time (HCAT) were evaluated. Univariate analysis was used to show risk factors for developing postoperative cardiac, respiratory, surgical and renal complications. Results Between May 2019 and April 2021, 48 Bentall procedures (BP), 23 ascending aortic replacements (AAR), 20 BP and coronary artery bypass grafting (CABG) and 9 aortic valve replacements (AVR) with AAR were performed. Incidence of postoperative complications in the elective and emergency groups was as follows: respiratory 20% vs 38% (p=0.049), cardiac 18% vs 70% (p=0.015), renal 16% vs 48% (p=0.027) and surgical 4% vs 6% (p>0.05). Intrahospital 30 days morbidity was 44% with mortality rate of 13%. The results showed that CPBT>180 minutes was a risk factor for respiratory (p=0.034), cardiac (p=0.020) and renal (p=0.027) postoperative complications after acute type A aortic dissection surgery. Conclusion CPBT > 180 min is a risk factor for postoperative development of respiratory, cardiac and renal complications. Postoperative cardiac and renal complications were associated with longer HCAT.
Health and Primary Care, 2019
Leishmaniasis is a disease caused by Leishmania parasitic protozoans affecting people in both the... more Leishmaniasis is a disease caused by Leishmania parasitic protozoans affecting people in both the Eastern and Western Hemispheres. The secreted acid phosphatase enzymes (SAPs) are reported to play a critical role in infection by Leishmania. Thus, these enzymes are potential targets for Leishmania therapy. Tryptamines have various physiological effects and thus serve different purposes socially. Tryptamines are used in ritualistic ceremonies in countries where Leishmania cases are reported. In this work, tryptamine and two other indole derivatives, harmine and harmaline, were investigated. Harmine and harmaline were selected because of their presence in the biological materials used in some South American ritualistic ceremonies. We investigated the effects on axenic Leishmania tarentolae cell shape, motility, clumping, and viability as well as on the activity of secreted acid phosphatase (SAP) from L. tarentolae. An overall decrease in cell viability over a seven-day period and a small recovery in cell viability, only at lower concentrations of test compounds, were observed. These compounds were, in general, activators of L. tarentolae SAP activity. This is the first report of effects of these compounds on Leishmania secreted acid phosphatase activity in vitro. We speculate that those with Leishmania infections may be worsening their condition with the exposure to these compounds.
Health and Primary Care, 2019
We report a case of chronic total occlusion of the aorta with critical limb ischemia (CLI) of the... more We report a case of chronic total occlusion of the aorta with critical limb ischemia (CLI) of the lower limbs due to chronic total occlusion (CTO) of infrarenal aorta and extensive bilateral iliac disease. This case was treated by open surgical revascularization, after unsuccessful attempt of percutaneous endovascular stenting treatment.
Journal of Cardiothoracic Surgery, 2013
Journal of Cardiothoracic Surgery, 2013
Acta Medica Saliniana, 2011
Acta Medica Saliniana, Vol 40, No 1 (2011). ...
Acta Medica Saliniana, Nov 11, 2021
Accurate information on the cause of death is obtained from expert teams based on pathological or... more Accurate information on the cause of death is obtained from expert teams based on pathological or forensic expertise. Reliable information can be obtained from physicians in hospital settings if the deceased person has been treated in such an institution and has previously been diagnosed with an illness (intrahospital mortality). Intrahospital mortality analysis provides reliable data that can be used in the planning of a bed fund, the amount of medication purchased, the purchase of equipment, the organization and creation of highly specialized medical teams (resuscitation team), the number of resuscitation procedures, the number of pathologists required for autopsy procedures, etc. The aim of the study was to determine the total number of deaths, to identify the most common causes of death and 10 leading diagnoses of deceased patients at the Internal Medicine Clinic, University Clinical Center Tuzla (UKC) during one calendar year (2011). Material and methodes: Archive material (case histories and reports of deceased patients of the Internal Medicine Clinic) were used. Results: During this period, 6 488 patients were treated at the Internal Medicine Clinic and 451 patients died. According to the analyzed data, the most common diagnoses and causes of death at the Internal Medicine Clinic were: cerebrovascular incidents 104 (20.84%), cardiogenic shock in 24 (5.31%), heart failure 59 (10.86%), hepatic coma with cirrhosis of the liver 25 (5.33%), sudden cardiac death 30 (6.53%), respiratory failure 15 (3.32%), myocardial infarction 41 (9.99%), multiorgan failure 18 (4.00%) , pulmonary edema 14 (3.10%), sepsis 6 (1.38%), pulmonary emboli 17 (3.82%), valvular heart disease 9 (1.92%), cardiorespiratory arrest 9 (1.92%) , malignant abdominal neoplasms in 23 (5.28%), pancreatitis 2 (0.44%), hematemesis 8 (1.76%), diabetes mellitus 4 (0.88%), lung tumor 1 (0.22%), chronic renal insufficiency 12(2.54%), suicidal intoxication 4 (0.88%), ileus 4 (0.88%), cachexia 3 (0.66%), restrictive cardiomyopathy 2 (0.44%), mesenteric thrombosis arteries 2 (0.44%), disseminated lupus erythematosus 2 (0.44%), coffee vein thrombosis inferior 2 (0.44%), and 1 (0.22%) died of an aneurysm aortic abdominalis, ventricular septal defect, amyloidosis, disseminated intravascular coagulation, systemic sclerosis, rheumatoid arthritis and breast tumors. Conclusion: During the analyzed period, 6488 patients were treated at the Internal Medicine Clinic and a total of 451 patients died. The most common cause of death in hospitalized patients is cardiovascular disease (n = 208; 41.68% of deaths), with cerebrovascular disease (n = 104; 20.84% of deaths) totaling 312 (62.25%) of deaths from cardio and cerebrovascular disease.
Cardiologia Croatica, Feb 11, 2013
Kardiovaskularne bolesti (KVB) vodeÊi su uzrok smrtnosti u pacijenata na kroniËnoj dijalizi. Paci... more Kardiovaskularne bolesti (KVB) vodeÊi su uzrok smrtnosti u pacijenata na kroniËnoj dijalizi. Pacijenti s kroniËnom bubreaenom insuficijencijom imaju 10-20 puta viπi rizik razvoja 2013;8(1-2):67.
UKC Tuzla, Bosna i Hercegovina Here we present the case of a 19 years old female who was initiall... more UKC Tuzla, Bosna i Hercegovina Here we present the case of a 19 years old female who was initially admitted in May, 2004. as renal-limited vasculitisthat proved a month lateron as P-ANCA-positive, alongvvith theoccurenceofpulmanary renal syndrome. She was treated sucessfully with pulse steroids (PS) and cyclophosphamide (CP) vvhich resulted in complete pulmonary remission, but renal failure remained, thereby necessating the need for CAPD treatment. Maintenance immunosupressive regime was azathyoprine (AZA) and tapering steroids dose. Diagnosis at discharge from the Hospital was VVegener granulomatosis (WG) vvhich was later on confirmed bythe Rheumatology Dept. Peter Deržaj Hosp. in Ljubljana (Slovenia). Shevvas re-admitted in Octoberwith severedeterioration, febrile, with signs ofmyelosupression (WBC 2,5) and herpetic keratitis. Major dilemma was if this was relaps of her original disease or sec. to drug side-effects. ANCAs were negative on this occasion. Eventualy, since the patien...
Langenbecks Archiv f�r Chirurgie, 1983
Of 271 patients with 304 kidney transplants, between 1967 and 1981, 20 (7~) have developed a mali... more Of 271 patients with 304 kidney transplants, between 1967 and 1981, 20 (7~) have developed a malignant tumor and 7 patients (2.6 ~o) have died of it. A minimal time interval for tumor induction has to be assumed. Of 154 patients under immunosuppression with a functioning graft for over 1 year, 19 have developed a tumor. The figure of 12.3% is probably more realistic than the usual 5~-7~ incidence, based on all transplanted patients. Of these 154 patients, 6 (3.9 ~) died of their tumor that is 15.4 ~ of all deaths among the 154 patients exposed to immunosuppression for over 1 year.
Many methods for inferring genetic networks have been proposed, but the regulations they infer of... more Many methods for inferring genetic networks have been proposed, but the regulations they infer often include false-positives. Several researchers have attempted to reduce these erroneous regulations by proposing the use of a priori knowledge about the properties of genetic networks such as their sparseness, scale-free structure, and so on. This study focuses on another piece of a priori knowledge, namely, that biochemical networks exhibit hierarchical structures. Based on this idea, we propose an inference approach that uses the hierarchical structure in a target genetic network. To obtain a reasonable hierarchical structure, the first step of the proposed approach is to infer multiple genetic networks from the observed gene expression data. We take this step using an existing method that combines a genetic network inference method with a bootstrap method. The next step is to extract a hierarchical structure from the inferred networks that is consistent with most of the networks. Third, we use the hierarchical structure obtained to assign confidence values to all candidate regulations. Numerical experiments are also performed to demonstrate the effectiveness of using the hierarchical structure in the genetic network inference. The improvement accomplished by the use of the hierarchical structure is small. However, the hierarchical structure could be used to improve the performances of many existing inference methods.