Mitsue Bicudo - Academia.edu (original) (raw)
Papers by Mitsue Bicudo
Nutrition, 2000
Fish oil ω-3 fatty acids exert antiinflammatory effects on patients with ulcerative colitis. Howe... more Fish oil ω-3 fatty acids exert antiinflammatory effects on patients with ulcerative colitis. However, a comparative study in patients with mild to moderate ulcerative colitis receiving only sulfasalazine or ω-3 fatty acids has not been performed. We sought to detect changes in the inflammatory disease activity with the use of either fish oil ω-3 fatty acids or sulfasalazine in patients
A assimilacao da proteina dietetica por pacientes cirroticos apresentando desnutricao proteico-ca... more A assimilacao da proteina dietetica por pacientes cirroticos apresentando desnutricao proteico-calorica, avaliada por indicadores antropometricos (pregas cutâneas e musculatura braquial) e bioquimicos (proteina ligadora do retinol e pre-albumina) foi investigada em cinco individuos adultos, do sexo masculino, apresentando cirrose hepatica (com diagnotico histologico) em grau leve (Child Turcotte-Pugh: Grau A). Durante os 9 dias de estudo dietetico, os pacientes receberam via oral, dietas regionais completas, contendo diferentes proporcoes de proteinas/calorias/Kg/dia, identificadas como hipoproteica-hipocalorica (DO) = 0,42/20,9; normoproteica (DI) = 0,91/37,5; normoproteica-hipercalorica (D2) = 0,99/47,9 e hiperproteica-normocalorica (D3) = 1,60/40,5. Os respectivos valores para o balanco nitrogenado (X n s) foram (g/dia): DO = 2,46; DI = 0,66 n 1,99; D2 = 1,14 n 2,54 e D3 = 5,12 n 2,48. A excrecao ureica correspondente foi de (g/Kg/di): DO = 0,22 n 0,10; D1 = 0,24 n 0,10; D2 = 0,20 n 0,06 e D3 = 0,31 n 0,12. A melhoria observada no balanco nitrogenado sugere que pacientes, neste grau clinico de cirrose, apresentam melhor resposta ao incremento proteico do que energetico, na dieta, tendo boa tolerância aos niveis normais e, ate mesmo, elevados de proteina dietetica
Nutrition, 2001
The purpose of this study was to determine the rate of whole-body protein turnover in moderately ... more The purpose of this study was to determine the rate of whole-body protein turnover in moderately and severely alcoholic, malnourished, cirrhotic patients fed with different amounts of protein or energy. Six male patients (Child classes B and C) and four age-and sex-matched healthy control subjects were studied for 18 d in fasting and feeding states; a single oral dose of [ 15 N]glycine was used as a tracer and urinary ammonia was the end product. The kinetic study showed that patients had higher protein catabolism while fasting (patients: 3.14 Ϯ 1.2 g of lean body mass/9 h; controls: 1.8 Ϯ 0.3 g of lean body mass/9 h; P Ͻ 0.02). Although not statistically significant, protein catabolism (grams of lean body mass/9 h) was lower with the hyperproteic/hyperenergetic diet when compared with fasting. Nitrogen retention was consistent with the lower protein-catabolism rate; a statistically significant increase in nitrogen balance was observed when patients were fed with the hyperproteic/hyperenergetic diet compared with fasting (4.3 Ϯ 3.2 g of nitrogen/d and Ϫ2.2 Ϯ 1.9 g of nitrogen/d, respectively; P Ͻ 0.01). These data indicate that Child class B and C cirrhotic patients are hypercatabolic and that long-term nutritional intervention with a hyperproteic/hyperenergetic diet is likely needed to improve their clinical and nutritional status.
Archivos latinoamericanos de nutrición, 1996
Chemical and biological evaluation of ripe banana peel was conducted, aiming its potential use as... more Chemical and biological evaluation of ripe banana peel was conducted, aiming its potential use as a source of dietary fiber in human nutrition. Two types of flour were prepared from banana peel: a) untreated (UT), using washed and dried peel; b) treated (SMB), using peel treated with sodium metabisulfite and citric acid, in attempt to minimize the darkening of the flour. As expected, banana peel flour revealed to be an important source of fiber (NDF), corresponding about 32% of its dried weight. The addition of this flour to a basal casein diet lowered its protein digestibility and increased the fecal bulk of the rats, which are the known effects of dietary fiber. However, it did not alter the protein quality, since there was no difference in the PER values of the diets studied; in addition, the growth of the rats fed diets containing banana peel did not differ from those fed control diet. These results suggest the feasibility of technological studies aiming the development of food ...
Nutrition, 1996
In five male cirrhotic patients (Child A) and in four age-and sex-matched healthy control subject... more In five male cirrhotic patients (Child A) and in four age-and sex-matched healthy control subjects, whole-body protein turnover was measured using a single oral dose of "N-glycine as a tracer and urinary ammonia as end product. Subjects were studied in the fasting and feeding state, with different levels of protein and energy intake. The patients were underweight and presented lower plasma transthyretin and retinol-binding protein levels. When compared with controls, the kinetic studies showed patients to be hypometabolic in the fasting (Do) state and with the control diet [D, = (0.85 g of protein/ 154 kJ) * kg-'. day-'I. However, when corrected by body weight, the kinetic differences between groups disappeared, whereas the N-retention in the feeding state showed better results for the patients due mainly to their efficient breakdown decrease. When fed high-level protein or energy diets [D 2 = (0.9 g protein095 k.l) and D3 = (1.56 g protein058 W-kg ' *day-'], the patients showed Do = D, = Dz < D3 for N-flux and (DO = D,) < D3 (D2 is intermediary) for protein synthesis. Thus, the present data suggest that the remaining mass of the undernourished mild cirrhotic patients has fairly good protein synthesis activity and also that protein, rather than energy intake, would be the limiting factor for increasing their whole-body protein synthesis. Nutrition 1996; 12519-523
Semina: Ciências Biológicas e da Saúde, 1990
Quality Protein Maize, 1964
Despite the advances in nutrition science during the last decades, malnutrition is still a widesp... more Despite the advances in nutrition science during the last decades, malnutrition is still a widespread problem in developing countries, where financial and human resources are scarce. Poverty is the ultirnate effect of this situation. ln Brazil, the most populous country ...
Arquivos de gastroenterologia
This study was performed to evaluate the effect of lactose induced diarrhea on the key enzymes of... more This study was performed to evaluate the effect of lactose induced diarrhea on the key enzymes of glutamine metabolism in skeletal muscle and small intestine, in rats. As compared to weight paired controls, animals with diarrhea presented higher muscle glutamine synthetase activity associated with reduced skeletal muscle glutamine concentration with a fall in arterial glutamine and an increased intestinal glutaminase activity. These alterations are similar to those reported by others in conditions in which accelerated muscle proteolysis is likely to occur such as in sepsis and after surgery. Besides the data suggestive of an overall alterations in glutamine metabolism, an important finding of this study was the increase in specific activity of intestinal phosphate dependent glutaminase in rats with diarrhea. This enzyme has been shown not to respond to many conditions such as acidosis, alkalosis or increased glutamine ingestion through drinking water or diet.
Nutrition, 2000
Fish oil ω-3 fatty acids exert antiinflammatory effects on patients with ulcerative colitis. Howe... more Fish oil ω-3 fatty acids exert antiinflammatory effects on patients with ulcerative colitis. However, a comparative study in patients with mild to moderate ulcerative colitis receiving only sulfasalazine or ω-3 fatty acids has not been performed. We sought to detect changes in the inflammatory disease activity with the use of either fish oil ω-3 fatty acids or sulfasalazine in patients
A assimilacao da proteina dietetica por pacientes cirroticos apresentando desnutricao proteico-ca... more A assimilacao da proteina dietetica por pacientes cirroticos apresentando desnutricao proteico-calorica, avaliada por indicadores antropometricos (pregas cutâneas e musculatura braquial) e bioquimicos (proteina ligadora do retinol e pre-albumina) foi investigada em cinco individuos adultos, do sexo masculino, apresentando cirrose hepatica (com diagnotico histologico) em grau leve (Child Turcotte-Pugh: Grau A). Durante os 9 dias de estudo dietetico, os pacientes receberam via oral, dietas regionais completas, contendo diferentes proporcoes de proteinas/calorias/Kg/dia, identificadas como hipoproteica-hipocalorica (DO) = 0,42/20,9; normoproteica (DI) = 0,91/37,5; normoproteica-hipercalorica (D2) = 0,99/47,9 e hiperproteica-normocalorica (D3) = 1,60/40,5. Os respectivos valores para o balanco nitrogenado (X n s) foram (g/dia): DO = 2,46; DI = 0,66 n 1,99; D2 = 1,14 n 2,54 e D3 = 5,12 n 2,48. A excrecao ureica correspondente foi de (g/Kg/di): DO = 0,22 n 0,10; D1 = 0,24 n 0,10; D2 = 0,20 n 0,06 e D3 = 0,31 n 0,12. A melhoria observada no balanco nitrogenado sugere que pacientes, neste grau clinico de cirrose, apresentam melhor resposta ao incremento proteico do que energetico, na dieta, tendo boa tolerância aos niveis normais e, ate mesmo, elevados de proteina dietetica
Nutrition, 2001
The purpose of this study was to determine the rate of whole-body protein turnover in moderately ... more The purpose of this study was to determine the rate of whole-body protein turnover in moderately and severely alcoholic, malnourished, cirrhotic patients fed with different amounts of protein or energy. Six male patients (Child classes B and C) and four age-and sex-matched healthy control subjects were studied for 18 d in fasting and feeding states; a single oral dose of [ 15 N]glycine was used as a tracer and urinary ammonia was the end product. The kinetic study showed that patients had higher protein catabolism while fasting (patients: 3.14 Ϯ 1.2 g of lean body mass/9 h; controls: 1.8 Ϯ 0.3 g of lean body mass/9 h; P Ͻ 0.02). Although not statistically significant, protein catabolism (grams of lean body mass/9 h) was lower with the hyperproteic/hyperenergetic diet when compared with fasting. Nitrogen retention was consistent with the lower protein-catabolism rate; a statistically significant increase in nitrogen balance was observed when patients were fed with the hyperproteic/hyperenergetic diet compared with fasting (4.3 Ϯ 3.2 g of nitrogen/d and Ϫ2.2 Ϯ 1.9 g of nitrogen/d, respectively; P Ͻ 0.01). These data indicate that Child class B and C cirrhotic patients are hypercatabolic and that long-term nutritional intervention with a hyperproteic/hyperenergetic diet is likely needed to improve their clinical and nutritional status.
Archivos latinoamericanos de nutrición, 1996
Chemical and biological evaluation of ripe banana peel was conducted, aiming its potential use as... more Chemical and biological evaluation of ripe banana peel was conducted, aiming its potential use as a source of dietary fiber in human nutrition. Two types of flour were prepared from banana peel: a) untreated (UT), using washed and dried peel; b) treated (SMB), using peel treated with sodium metabisulfite and citric acid, in attempt to minimize the darkening of the flour. As expected, banana peel flour revealed to be an important source of fiber (NDF), corresponding about 32% of its dried weight. The addition of this flour to a basal casein diet lowered its protein digestibility and increased the fecal bulk of the rats, which are the known effects of dietary fiber. However, it did not alter the protein quality, since there was no difference in the PER values of the diets studied; in addition, the growth of the rats fed diets containing banana peel did not differ from those fed control diet. These results suggest the feasibility of technological studies aiming the development of food ...
Nutrition, 1996
In five male cirrhotic patients (Child A) and in four age-and sex-matched healthy control subject... more In five male cirrhotic patients (Child A) and in four age-and sex-matched healthy control subjects, whole-body protein turnover was measured using a single oral dose of "N-glycine as a tracer and urinary ammonia as end product. Subjects were studied in the fasting and feeding state, with different levels of protein and energy intake. The patients were underweight and presented lower plasma transthyretin and retinol-binding protein levels. When compared with controls, the kinetic studies showed patients to be hypometabolic in the fasting (Do) state and with the control diet [D, = (0.85 g of protein/ 154 kJ) * kg-'. day-'I. However, when corrected by body weight, the kinetic differences between groups disappeared, whereas the N-retention in the feeding state showed better results for the patients due mainly to their efficient breakdown decrease. When fed high-level protein or energy diets [D 2 = (0.9 g protein095 k.l) and D3 = (1.56 g protein058 W-kg ' *day-'], the patients showed Do = D, = Dz < D3 for N-flux and (DO = D,) < D3 (D2 is intermediary) for protein synthesis. Thus, the present data suggest that the remaining mass of the undernourished mild cirrhotic patients has fairly good protein synthesis activity and also that protein, rather than energy intake, would be the limiting factor for increasing their whole-body protein synthesis. Nutrition 1996; 12519-523
Semina: Ciências Biológicas e da Saúde, 1990
Quality Protein Maize, 1964
Despite the advances in nutrition science during the last decades, malnutrition is still a widesp... more Despite the advances in nutrition science during the last decades, malnutrition is still a widespread problem in developing countries, where financial and human resources are scarce. Poverty is the ultirnate effect of this situation. ln Brazil, the most populous country ...
Arquivos de gastroenterologia
This study was performed to evaluate the effect of lactose induced diarrhea on the key enzymes of... more This study was performed to evaluate the effect of lactose induced diarrhea on the key enzymes of glutamine metabolism in skeletal muscle and small intestine, in rats. As compared to weight paired controls, animals with diarrhea presented higher muscle glutamine synthetase activity associated with reduced skeletal muscle glutamine concentration with a fall in arterial glutamine and an increased intestinal glutaminase activity. These alterations are similar to those reported by others in conditions in which accelerated muscle proteolysis is likely to occur such as in sepsis and after surgery. Besides the data suggestive of an overall alterations in glutamine metabolism, an important finding of this study was the increase in specific activity of intestinal phosphate dependent glutaminase in rats with diarrhea. This enzyme has been shown not to respond to many conditions such as acidosis, alkalosis or increased glutamine ingestion through drinking water or diet.