Mitsuhiko NODA - Academia.edu (original) (raw)

Mitsuhiko NODA

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Papers by Mitsuhiko NODA

JMA journal, Oct 17, 2022

PubMed, 2008

Objective: To evaluate the association between alcohol consumption and the risk for type 2 diabet... more Objective: To evaluate the association between alcohol consumption and the risk for type 2 diabetes (DM) in Japanese. Methods: We searched the MEDLINE data base with the key words 'alcohol intake' (or 'alcohol consumption') and 'Japanese' cross-linked with 'diabetes mellitus' (or 'impaired glucose tolerance'). The reports we sought were restricted to prospective cohort studies, randomized controlled trials, meta-analyses and systematic reviews. Computerized and hand searches were conducted in June 2007. Results: Seven prospective cohort studies were adopted. We previously reported that in lean Japanese men (BMI < or =22.0 kg/m2), moderate to heavy alcohol intake is a risk factor for diabetes. One study found heavy alcohol intake to be associated with an increased risk in low-BMI men while moderate alcohol intake was associated with a reduced risk in higher-BMI men. Another study suggested daily alcohol consumption to be a risk factor in low-BMI participants, while being protective in middle-BMI participants. Yet another study demonstrated a U-shaped association between alcohol consumption and the risk of diabetes in men. Three other studies, which did not divide the subjects in terms of BMI values, indicated alcohol intake to be an increased risk for diabetes, two being in men and one being in women, respectively. Conclusion: For a large number of Japanese men who have relatively low BMI, alcohol intake is an established risk factor for diabetes.

Epidemiologic Research on Real-World Medical Data in Japan, 2022

Diabetologia, May 26, 2005

Diabetes Research and Clinical Practice, Jun 1, 2020

Clinical Nutrition, Apr 1, 2020

Journal of Epidemiology, May 5, 2020

Journal of Clinical Medicine Research, 2018

Diabetes Research and Clinical Practice, Feb 1, 2005

Journal of Epidemiology, 2023

Journal of Diabetes Investigation, Apr 6, 2023

Aims/IntroductionResearch on the incidence and underlying mechanisms of rapid renal function decl... more Aims/IntroductionResearch on the incidence and underlying mechanisms of rapid renal function decline in patients with type 2 diabetes mellitus with preserved renal function and normoalbuminuria is limited. This study aimed to investigate the involvement of hemoglobin level as a risk factor for rapid decliners among patients with type 2 diabetes with preserved renal function and normoalbuminuria.Materials and MethodsThis was a retrospective observational study of 242 patients with type 2 diabetes with a baseline estimated glomerular filtration rate of ≥60 mL/min/1.73 m2 and normoalbuminuria (<30 mg/gCr), followed up for >1 year. The annual rate of estimated glomerular filtration rate decline during the follow‐up period was calculated using least square regression analysis; rapid decliners defined at ≥3.3%/year. Risk factors associated with rapid decliners were identified using a logistic regression analysis of variables previously identified as risk factors of rapid decliners.ResultsThe median follow‐up period was 6.7 years, and 34 patients showed rapid decliners. On multivariate analysis, lower baseline hemoglobin level was a risk factor of rapid decliners (odds ratio 0.69, 95% confidence interval 0.47–0.99; P = 0.045). Furthermore, the baseline hemoglobin levels were correlated positively with iron and ferritin levels, implying that an impaired iron metabolism might cause lower hemoglobin levels in rapid decliners.ConclusionsIn patients with type 2 diabetes with preserved renal function and normoalbuminuria, lower hemoglobin levels were a risk factor for rapid decliners, where disturbed iron metabolism might precede the development of diabetic kidney disease.

Journal of Diabetes Investigation, Apr 5, 2023