Mituban Gogoi - Academia.edu (original) (raw)

Papers by Mituban Gogoi

Indian Journal of Plastic Surgery, 2003

Indian Journal of Plastic Surgery is an open access publication of Association of Plastic surgeon... more Indian Journal of Plastic Surgery is an open access publication of Association of Plastic surgeons of India.

Journal of Evolution of medical and Dental Sciences, 2015

Lumber disc prolapse as a cause of back and leg pain is quite a common presentation at a pain cli... more Lumber disc prolapse as a cause of back and leg pain is quite a common presentation at a pain clinic which results in significant disability & overall loss of productive work. This study is an uncontrolled, prospective study that included 25 patients (15 males and 10 females) during the period 2013–2014 with signs and symptoms of back pain associated with lumber disc prolapsed with lumbar radiculopathy, in whom conservative treatment of least 6 weeks had failed. The present study was undertaken with the aim to observe the effectiveness of caudal epidural injection of a combination of depomedrol (Methyl prednisolone acetate) along with a local anesthetic (0.5% bupivacaine) in relieving symptoms of lumbar disc prolapse with radiculopathy. Quantitative assessment was done for back pain & leg pain separately using the visual analogue scale and the functional disability was measured using oswestry disability index (ODI) before the procedure and at regular intervals after the procedure fo...

Background: Helicobacter pylori infection is an important triggering agent for development of gas... more Background: Helicobacter pylori infection is an important triggering agent for development of gastric malignancies, peptic ulcer disease and other dyspeptic symptoms. Therefore a crucial part in the management of infection is a fast and accurate diagnostic technique which would give reliable results in detecting infection in symptomatic patients. Aim: This study aimed to compare and evaluate the reliability of molecular technique over conventional culture method for early diagnosis of H. pylori infection in dyspeptic patients. Materials and Methods: A cross sectional hospital-based study was conducted between June 2016 and May 2017 and included 100 gastric biopsy specimens from clinically suspected dyspeptic patients undergoing routine upper gastrointestinal tract endoscopy. These specimens were analyzed using the conventional culture method as well as molecular technique (PCR assay) for species identification and virulent factor determination directly from biopsy specimens. Results...

Introduction: Laparoscopic cholecystectomy (LC) using 3 or 4 surgical ports has been previously c... more Introduction: Laparoscopic cholecystectomy (LC) using 3 or 4 surgical ports has been previously compared in various clinical trials. However, LC using 3 or 2 surgical ports has not been evaluated. Materials and Methods: Patients were randomized into two groups: L2 using 2 ports for LC and L3 using 3 standard ports for LC. Results: Pain was evaluated at recovery, 4th h and then every 24 hourly up to the 5th post-operative day, using a visual analog pain scale. Patients in Group L2 and L3 had similar post-operative pain scores and analgesic consumption. Conclusion: In terms of post-operative pain score and analgesic consumption, 2 post-LC does not offer any added benefit over 3 ports LC.

Introduction: The thyroid gland is one of the principal endocrine gland of the body with its dise... more Introduction: The thyroid gland is one of the principal endocrine gland of the body with its disease forming a major share of head and neck surgery. FNAC and USG are being used in association with clinical features for diagnosis with surgery being the mainstay of treatment. An attempt has been made in the present study to evaluate the usefulness of clinical features, FNAC and USG in managing thyroid nodule. Materials and Methods: The present study was carried out to evaluate the usefulness of clinical features and ultrasonography in managing thyroid nodules in Assam Medical College and Hospital, Dibrugarh, for a period of one year. Total of 34 patients (>12years) were selected, who had attended Outpatient Department in Assam Medical College with thyroid nodule, examined, investigated, treated surgically and complications if any were managed accordingly. Results: In our study, the sensitivity, specificity, positive predictive value and negative predictive value of FNAC for diagnos...

Introduction: Biliary leakage is the most serious and dreaded complication after cholecystectomy.... more Introduction: Biliary leakage is the most serious and dreaded complication after cholecystectomy. The early and accurate diagnosis of bile duct injury is very important for surgeons, because unrecognized bile duct injury leads to serious complications such as biliary peritonitis, hepatic failure and death and also plays a vital role in management of biliary leak after cholecystectomy. Study aimed to evaluate the various modalities of treatment and their outcome in biliary leakage following cholecystectomy. Material and methods: Prospective study. The data were obtained from the patients getting admitted with biliary leakage after cholecystectomy or developed biliary leakage after cholecystectomy at the Department of General surgery, Assam Medical College from July 2014 to June 2015 who were properly examined, investigated, treated and followed up for one month. Results: A total of 1190 Cholecystectomies were carried out in this study period in my institution, out of which 785 were o...

Introduction: The periumbilical (PU) incision is more commonly used for single incision laparosco... more Introduction: The periumbilical (PU) incision is more commonly used for single incision laparoscopic surgery than the intraumbilical (IU) incision. Till now, no study on Indian population has compared the adverse outcomes of PU and IU incisions on the post-operative outcome in patients. We observed the wound complication rates of patients undergoing appendectomy according to the types of laparoscopic surgical approach. Materials and Methods: A randomized prospective observational study was conducted on 320 patients presenting for laparscopic appendectomy. 155 patients in group IU were operated with the IU incision and 165 patients in group PU were operated with the PU incision. We compared the post-operative outcomes according to the type of laparoscopic incision. Results: In both the groups operation time, post-operative hospital stay and post-operative analgesic requirement were similar. Two cases (1.2%) in the IU group IU and five cases (3%) in the PU group PU developed wound inf...

Journal of Evidence Based Medicine and Healthcare, 2017

BACKGROUND The relationship between T1DM and CD has been known due to their identical genetic and... more BACKGROUND The relationship between T1DM and CD has been known due to their identical genetic and autoimmune background. The prevalence of CD in T1DM in Assam has not been determined. We examined the prevalence and clinical profile of CD in patient with T1DM in Assam.

Journal of Evolution of Medical and Dental Sciences, 2019

BACKGROUND Laparoscopic cholecystectomy (LC) requires the creation of a pneumoperitoneum {PNP) vi... more BACKGROUND Laparoscopic cholecystectomy (LC) requires the creation of a pneumoperitoneum {PNP) via insufflations of carbon dioxide, which may result in adverse haemodynamic disturbances leading to visceral organ ischaemia including hepatic dysfunction. The present study was undertaken to compare the changes in hepatic function during LC with standard and during LC with low pressure PNP and also to determine the clinical significances of such disturbances. METHODS A randomised prospective study was conducted among 60 patients from June 2017 to May 2018 for symptomatic gallstones who underwent LC, of which Group A (n=30) were subjected to standard pressure PNP (SPLC= 12 to 14 mmHg) and Group B (n=30) to low pressure PNP (LPLC= 7 to 10 mmHg). Blood samples for liver function test were taken preoperatively and postoperatively. All patients had normal values of preoperative liver function tests. RESULTS Twenty-four hours after the procedure, the mean liver enzymes in both groups were raised, however in SPLC group there was statistically significant elevation of AST (46.87±13.90, p<0.004) and ALT (78.88±13.86, p<0.001). But the raise was transient and fell off to normal or near normal levels in 7-10 days postoperatively. The changes in ALP and GGT measurements were found to be non-significant. CONCLUSIONS Low pressure pneumoperitoneum has minimal alterations in the liver enzymes thereby reducing the adverse effects on hepatic function, this approach can be considered for patients with compromised liver pathology, particularly in patients undergoing prolonged laparoscopic surgery.

Indian Journal of Medical Microbiology, 2018

Original Article intrODuctiOn Helicobacter pylori is a spiral, micro-aerophilic, Gram-negative pa... more Original Article intrODuctiOn Helicobacter pylori is a spiral, micro-aerophilic, Gram-negative pathogenic bacterium which colonises the human gastric mucosa in almost half of the world's population. This bacterium is responsible for a number of stomach disorders such as chronic gastritis and peptic ulcer disease and might also be a triggering agent for various kinds of gastric lymphomas. [1] The pathogenesis as well as the diversity in outcome of infection may be attributed to a variety of genetic markers-the most important being the vacuolating cytotoxin (vacA) gene and the cytotoxin-associated gene (cagA). [2] H. pylori produces a vacuolating cytotoxin, a 95-kDa highly immunogenic protein encoded by the vacA gene, which is associated with the severity of gastroduodenal diseases by significantly contributing to peptic ulceration as well as gastric carcinoma. It is a pore-forming toxin present in almost all H. pylori strains and causes massive injury to the primary gastric epithelial cells in vitro by inducing the formation of vacuoles. VacA results in the formation of membrane channel and interferes with cytoskeleton-dependent cell functions, thus inducing apoptosis as well as modulation of the immune system. [2,3] The vacA gene consists of two variable regions; the signal peptide region(s) and middle region(m) and three allelic s subtypes called s1a, s1b and s2 and two m types, called m1 and m2. There is a strong correlation between the Background: Helicobacter pylori, the gastric bacterium, is widely known to be one of the most genetically diverse group of organisms whose pathogenesis as well as the diversity in infection outcome may be attributed to a variety of virulent genes. Aim: This study aimed to study the molecular profile of H. pylori vacA gene by determining the phylogenetic relatedness and genetic diversity of the strains isolated in this region with those of other geographical regions. Materials and Methods: A total of twenty H. pylori clinical strains were isolated from randomly selected 100 patients suffering from gastroduodenal diseases as well as endoscopically normal patients in a cross-sectional hospital-based setting from January 2016 to May 2017. VacA signal sequence and mid regions of H. pylori were amplified by polymerase chain reaction followed by DNA sequencing and phylogenetic analysis. Results: VacA s1m1 allelic variant was more prevalent in our study, regardless of the clinical outcomes. Phylogenetic analysis of VacA s1 strains revealed clustering of most of the strains. VacA m1 strains clustered with Bangladesh strains which is a country nearest to India. Conclusion: Prevalence of VacA s1m1 strains may account for high risk of transmission of this gastric pathogen and the overall risk of acquiring infection. Phylogenetic analysis results suggests the prevalence of high genetic diversity in our region. Our findings may aid in developing a better understanding of the genetic structure of H. pylori and the pathophysiology of associated diseases, thus facilitating the implementation of various treatment options.

Medknow Publications on behalf of Indian Journal of Plastic Surgery, Dec 1, 2003

Indian Journal of Plastic Surgery, 2003

Indian Journal of Plastic Surgery is an open access publication of Association of Plastic surgeon... more Indian Journal of Plastic Surgery is an open access publication of Association of Plastic surgeons of India.

Journal of Evolution of medical and Dental Sciences, 2015

Lumber disc prolapse as a cause of back and leg pain is quite a common presentation at a pain cli... more Lumber disc prolapse as a cause of back and leg pain is quite a common presentation at a pain clinic which results in significant disability & overall loss of productive work. This study is an uncontrolled, prospective study that included 25 patients (15 males and 10 females) during the period 2013–2014 with signs and symptoms of back pain associated with lumber disc prolapsed with lumbar radiculopathy, in whom conservative treatment of least 6 weeks had failed. The present study was undertaken with the aim to observe the effectiveness of caudal epidural injection of a combination of depomedrol (Methyl prednisolone acetate) along with a local anesthetic (0.5% bupivacaine) in relieving symptoms of lumbar disc prolapse with radiculopathy. Quantitative assessment was done for back pain & leg pain separately using the visual analogue scale and the functional disability was measured using oswestry disability index (ODI) before the procedure and at regular intervals after the procedure fo...

Background: Helicobacter pylori infection is an important triggering agent for development of gas... more Background: Helicobacter pylori infection is an important triggering agent for development of gastric malignancies, peptic ulcer disease and other dyspeptic symptoms. Therefore a crucial part in the management of infection is a fast and accurate diagnostic technique which would give reliable results in detecting infection in symptomatic patients. Aim: This study aimed to compare and evaluate the reliability of molecular technique over conventional culture method for early diagnosis of H. pylori infection in dyspeptic patients. Materials and Methods: A cross sectional hospital-based study was conducted between June 2016 and May 2017 and included 100 gastric biopsy specimens from clinically suspected dyspeptic patients undergoing routine upper gastrointestinal tract endoscopy. These specimens were analyzed using the conventional culture method as well as molecular technique (PCR assay) for species identification and virulent factor determination directly from biopsy specimens. Results...

Introduction: Laparoscopic cholecystectomy (LC) using 3 or 4 surgical ports has been previously c... more Introduction: Laparoscopic cholecystectomy (LC) using 3 or 4 surgical ports has been previously compared in various clinical trials. However, LC using 3 or 2 surgical ports has not been evaluated. Materials and Methods: Patients were randomized into two groups: L2 using 2 ports for LC and L3 using 3 standard ports for LC. Results: Pain was evaluated at recovery, 4th h and then every 24 hourly up to the 5th post-operative day, using a visual analog pain scale. Patients in Group L2 and L3 had similar post-operative pain scores and analgesic consumption. Conclusion: In terms of post-operative pain score and analgesic consumption, 2 post-LC does not offer any added benefit over 3 ports LC.

Introduction: The thyroid gland is one of the principal endocrine gland of the body with its dise... more Introduction: The thyroid gland is one of the principal endocrine gland of the body with its disease forming a major share of head and neck surgery. FNAC and USG are being used in association with clinical features for diagnosis with surgery being the mainstay of treatment. An attempt has been made in the present study to evaluate the usefulness of clinical features, FNAC and USG in managing thyroid nodule. Materials and Methods: The present study was carried out to evaluate the usefulness of clinical features and ultrasonography in managing thyroid nodules in Assam Medical College and Hospital, Dibrugarh, for a period of one year. Total of 34 patients (>12years) were selected, who had attended Outpatient Department in Assam Medical College with thyroid nodule, examined, investigated, treated surgically and complications if any were managed accordingly. Results: In our study, the sensitivity, specificity, positive predictive value and negative predictive value of FNAC for diagnos...

Introduction: Biliary leakage is the most serious and dreaded complication after cholecystectomy.... more Introduction: Biliary leakage is the most serious and dreaded complication after cholecystectomy. The early and accurate diagnosis of bile duct injury is very important for surgeons, because unrecognized bile duct injury leads to serious complications such as biliary peritonitis, hepatic failure and death and also plays a vital role in management of biliary leak after cholecystectomy. Study aimed to evaluate the various modalities of treatment and their outcome in biliary leakage following cholecystectomy. Material and methods: Prospective study. The data were obtained from the patients getting admitted with biliary leakage after cholecystectomy or developed biliary leakage after cholecystectomy at the Department of General surgery, Assam Medical College from July 2014 to June 2015 who were properly examined, investigated, treated and followed up for one month. Results: A total of 1190 Cholecystectomies were carried out in this study period in my institution, out of which 785 were o...

Introduction: The periumbilical (PU) incision is more commonly used for single incision laparosco... more Introduction: The periumbilical (PU) incision is more commonly used for single incision laparoscopic surgery than the intraumbilical (IU) incision. Till now, no study on Indian population has compared the adverse outcomes of PU and IU incisions on the post-operative outcome in patients. We observed the wound complication rates of patients undergoing appendectomy according to the types of laparoscopic surgical approach. Materials and Methods: A randomized prospective observational study was conducted on 320 patients presenting for laparscopic appendectomy. 155 patients in group IU were operated with the IU incision and 165 patients in group PU were operated with the PU incision. We compared the post-operative outcomes according to the type of laparoscopic incision. Results: In both the groups operation time, post-operative hospital stay and post-operative analgesic requirement were similar. Two cases (1.2%) in the IU group IU and five cases (3%) in the PU group PU developed wound inf...

Journal of Evidence Based Medicine and Healthcare, 2017

BACKGROUND The relationship between T1DM and CD has been known due to their identical genetic and... more BACKGROUND The relationship between T1DM and CD has been known due to their identical genetic and autoimmune background. The prevalence of CD in T1DM in Assam has not been determined. We examined the prevalence and clinical profile of CD in patient with T1DM in Assam.

Journal of Evolution of Medical and Dental Sciences, 2019

BACKGROUND Laparoscopic cholecystectomy (LC) requires the creation of a pneumoperitoneum {PNP) vi... more BACKGROUND Laparoscopic cholecystectomy (LC) requires the creation of a pneumoperitoneum {PNP) via insufflations of carbon dioxide, which may result in adverse haemodynamic disturbances leading to visceral organ ischaemia including hepatic dysfunction. The present study was undertaken to compare the changes in hepatic function during LC with standard and during LC with low pressure PNP and also to determine the clinical significances of such disturbances. METHODS A randomised prospective study was conducted among 60 patients from June 2017 to May 2018 for symptomatic gallstones who underwent LC, of which Group A (n=30) were subjected to standard pressure PNP (SPLC= 12 to 14 mmHg) and Group B (n=30) to low pressure PNP (LPLC= 7 to 10 mmHg). Blood samples for liver function test were taken preoperatively and postoperatively. All patients had normal values of preoperative liver function tests. RESULTS Twenty-four hours after the procedure, the mean liver enzymes in both groups were raised, however in SPLC group there was statistically significant elevation of AST (46.87±13.90, p<0.004) and ALT (78.88±13.86, p<0.001). But the raise was transient and fell off to normal or near normal levels in 7-10 days postoperatively. The changes in ALP and GGT measurements were found to be non-significant. CONCLUSIONS Low pressure pneumoperitoneum has minimal alterations in the liver enzymes thereby reducing the adverse effects on hepatic function, this approach can be considered for patients with compromised liver pathology, particularly in patients undergoing prolonged laparoscopic surgery.

Indian Journal of Medical Microbiology, 2018

Original Article intrODuctiOn Helicobacter pylori is a spiral, micro-aerophilic, Gram-negative pa... more Original Article intrODuctiOn Helicobacter pylori is a spiral, micro-aerophilic, Gram-negative pathogenic bacterium which colonises the human gastric mucosa in almost half of the world's population. This bacterium is responsible for a number of stomach disorders such as chronic gastritis and peptic ulcer disease and might also be a triggering agent for various kinds of gastric lymphomas. [1] The pathogenesis as well as the diversity in outcome of infection may be attributed to a variety of genetic markers-the most important being the vacuolating cytotoxin (vacA) gene and the cytotoxin-associated gene (cagA). [2] H. pylori produces a vacuolating cytotoxin, a 95-kDa highly immunogenic protein encoded by the vacA gene, which is associated with the severity of gastroduodenal diseases by significantly contributing to peptic ulceration as well as gastric carcinoma. It is a pore-forming toxin present in almost all H. pylori strains and causes massive injury to the primary gastric epithelial cells in vitro by inducing the formation of vacuoles. VacA results in the formation of membrane channel and interferes with cytoskeleton-dependent cell functions, thus inducing apoptosis as well as modulation of the immune system. [2,3] The vacA gene consists of two variable regions; the signal peptide region(s) and middle region(m) and three allelic s subtypes called s1a, s1b and s2 and two m types, called m1 and m2. There is a strong correlation between the Background: Helicobacter pylori, the gastric bacterium, is widely known to be one of the most genetically diverse group of organisms whose pathogenesis as well as the diversity in infection outcome may be attributed to a variety of virulent genes. Aim: This study aimed to study the molecular profile of H. pylori vacA gene by determining the phylogenetic relatedness and genetic diversity of the strains isolated in this region with those of other geographical regions. Materials and Methods: A total of twenty H. pylori clinical strains were isolated from randomly selected 100 patients suffering from gastroduodenal diseases as well as endoscopically normal patients in a cross-sectional hospital-based setting from January 2016 to May 2017. VacA signal sequence and mid regions of H. pylori were amplified by polymerase chain reaction followed by DNA sequencing and phylogenetic analysis. Results: VacA s1m1 allelic variant was more prevalent in our study, regardless of the clinical outcomes. Phylogenetic analysis of VacA s1 strains revealed clustering of most of the strains. VacA m1 strains clustered with Bangladesh strains which is a country nearest to India. Conclusion: Prevalence of VacA s1m1 strains may account for high risk of transmission of this gastric pathogen and the overall risk of acquiring infection. Phylogenetic analysis results suggests the prevalence of high genetic diversity in our region. Our findings may aid in developing a better understanding of the genetic structure of H. pylori and the pathophysiology of associated diseases, thus facilitating the implementation of various treatment options.

Medknow Publications on behalf of Indian Journal of Plastic Surgery, Dec 1, 2003