Mizanur Rahaman - Academia.edu (original) (raw)
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Papers by Mizanur Rahaman
Hypertension, 2017
Oxidized soluble guanylate cyclase (sGC) heme iron (Fe 3+ ) is desensitized to nitric oxide (NO) ... more Oxidized soluble guanylate cyclase (sGC) heme iron (Fe 3+ ) is desensitized to nitric oxide (NO) and attenuates cGMP production needed for downstream activation of PKG-dependent signaling and vasodilation. While reactive oxygen species drive oxidation of sGC heme iron, the basic mechanism(s) governing sGC heme iron recycling to its NO-sensitive, reduced state (Fe 2+ ), are unknown. Here we report cytochrome b5 reductase 3 (Cyb5R3), also known as methemoglobin reductase, as a novel sGC heme iron reductase and regulator of cGMP production in vascular smooth muscle cells (VSMCs). Oxidant challenge studies demonstrate that VSMCs have an intrinsic ability to reduce oxidized sGC heme iron and form protein-protein complexes between Cyb5R3 and oxidized sGC. Genetic knockdown and pharmacological inhibition in VSMCs reveal Cyb5R3 expression and activity is critical for NO-stimulated cGMP production and vasodilation. Mechanistically, Cyb5R3 directly reduces oxidized sGC for NO sensitization as...
Hypertension, 2015
The inability nitric oxide (NO) to stimulate soluble guanylate cyclase (sGC) has been linked to n... more The inability nitric oxide (NO) to stimulate soluble guanylate cyclase (sGC) has been linked to numerous cardiovascular diseases (CVD) including hypertension. While several studies have defined the importance of sGC expression in the cardiovascular system, the basic mechanisms that regulate sGC activity remain incompletely understood. Here, we report for the first time that sGC heme iron redox state, which is essential for NO-induced sGC activation, is regulated by cytochrome B5 reductase 3 (CyB5R3). Genetic knockdown and pharmacological inhibition of CyB5R3 in primary rat vascular smooth muscle cells resulted in a 60% loss in cGMP production. Conversely, the sGC activator Bay 58-2667, which activates oxidized or heme free sGC, reversed these effects. Consistent with our cell culture work, purified protein studies demonstrate that CyB5R3 can directly reduce oxidized sGC heme iron and sensitize sGC to NO. To test the functional importance of Cyb5R3 activity, we cultured mouse thoraco...
Journal of Mathematical Physics, 2018
This paper mainly concentrates to present a technique to evaluate exactly the triangular domain i... more This paper mainly concentrates to present a technique to evaluate exactly the triangular domain integrals with satisfactory degree of accuracy. Hence, the technique instead of the usual Gaussian quadrature formula for triangle will find better place in application when high accuracy is desired. Further, the technique successfully accommodates the readily available Gaussian quadrature formulae for square and therefore it guaranties the high accuracy in evaluating such integrals.
Annales Henri Poincaré, 2021
We introduce a new class of non-local games, and corresponding densities, which we call bisynchro... more We introduce a new class of non-local games, and corresponding densities, which we call bisynchronous. Bisynchronous games are a subclass of synchronous games and exhibit many interesting symmetries when the algebra of the game is considered. We develop a close connection between these non-local games and the theory of quantum groups which recently surfaced in studies of graph isomorphism games. When the number of inputs is equal to the number of outputs, we prove that a bisynchronous density arises from a trace on the quantum permutation group. Each bisynchronous density gives rise to a completely positive map and we prove that these maps are factorizable maps.
Journal of Mathematical Physics, 2020
IEEE Transactions on Information Theory, 2019
A new bound on quantum version of Wielandt inequality for positive (not necessarily completely po... more A new bound on quantum version of Wielandt inequality for positive (not necessarily completely positive) maps has been established. Also bounds for entanglement breaking and PPT channels are put forward which are better bound than the previous bounds known. We prove that a primitive positive map E acting on M d that satisfies the Schwarz inequality becomes strictly positive after at most 2(d − 1) 2 iterations. This is to say, that after 2(d − 1) 2 iterations, such a map sends every positive semidefinite matrix to a positive definite one. This finding does not depend on the number of Kraus operators as the map may not admit any Kraus decomposition. The motivation of this work is to provide an answer to a question raised in the article [22] by Sanz-García-Wolf and Cirac.
The Crop Journal, 2018
Abstract High temperatures have a detrimental effect on growth, development, and yield of Brassic... more Abstract High temperatures have a detrimental effect on growth, development, and yield of Brassica napus . Even a short period of heat stress can lead to yield losses of 15%–20%. A collection of spring-type accessions available in Germplasm Resources Information Network (GRIN) were used to assess the effect of short periods of high-temperature stress at the early flowering stage of B. napus . Two sets of accessions with three replications per set were grown in a greenhouse at 22/18 °C day/night temperatures. Plants from the second set at the 6-day flowering stage were exposed to heat-stress conditions (maximum temperature up to 35 °C) in a plant growth chamber for five days. The heat-stressed plants were then allowed to recover in a greenhouse. Pollen sterility, sterile/aborted pods, and number of pods on main raceme were recorded for both control (set 1) and heat stressed (set 2) plants. Heat susceptibility indices for all three traits were calculated and an association-mapping study was conducted using 37,539 Single Nucleotide Polymorphisms (SNPs) to identify genomic regions controlling the heat stress traits. A total of 5, 8, and 7 quantitative trait loci (QTL) were associated with pollen sterility, sterile/aborted pods, and number of pods on main raceme, respectively. Together they explained respectively 46.3%, 60.5%, and 60.6% of phenotypic variation. Candidate genes in the QTL regions included genes associated with flowering, male sterility, pollen abortion, embryo abortion reducing pollen development, and pod development.
Journal of Mathematical Analysis and Applications, 2018
Journal of Mathematical Physics, 2018
We analyze linear maps on matrix algebras that become entanglement breaking after composing a fin... more We analyze linear maps on matrix algebras that become entanglement breaking after composing a finite or infinite number of times with themselves. This means that the Choi matrix of the iterated linear map becomes separable in the tensor product space. If a linear map becomes entanglement breaking after finitely many iterations, we say the map has a finite index of separability. In particular we show that every unital PPT-channel has a finite index of separability and that the class of unital channels that have finite index of separability is a dense subset of the unital channels. We construct concrete examples of maps which are not PPT but have finite index of separability. We prove that there is a large class of unital channels that are asymptotically entanglement breaking. This analysis is motivated by the PPT-squared conjecture made by M. Christandl that says every PPT channel, when composed with itself, becomes entanglement breaking.
Social Studies of Science, 2011
Life as Surplus: Biotechnology and Capitalism in the Neoliberal Era by Melinda Cooper (2008) is a... more Life as Surplus: Biotechnology and Capitalism in the Neoliberal Era by Melinda Cooper (2008) is a recent addition to a growing body of literature that explores with renewed energy the inter-relationship between biological reproduction and capital accumulation. Cooper's ...
Science as Culture, 2012
Writing in the mid-twentieth century, Albert Camus observed that an epidemic is not just a medico... more Writing in the mid-twentieth century, Albert Camus observed that an epidemic is not just a medico-social problem; it also represents a rupture and crisis in everyday existence and calls into question our beliefs, habits, values and pleasures (Camus, 1947/1948). This remains somewhat true in the case of a sexual epidemic, more specifically of HIV/AIDS—an infectious disease that ravaged many millions of lives all over the world within a few years of its emergence and immediately became a phantasmatic site of anxiety, intervention, surveillance, racial and sexual politics. In considering HIV/AIDS as a medico-sexual construct, the body appears as ‘an object or surface’ (Butler, 1989, p. 601) and equally as an ‘intentionally organized materiality’ (Butler, 1988, p. 521), in the sense that bodies and pleasures become a ‘strategic and discursive site’ (Butler, 1999, p. 16) with numerous possibilities of materiality as evident in the unregulated proliferation of scientific, sexual and racial epistemologies in the discourse of HIV intervention. Apart from being a ‘naturally given and utterly malleable’ entity (Waldby, 2000, p. 465), biomedicine treats the diseased body as an object of medical knowledge and, at the same time, a fleshy subject that experiences pain, agony, satisfaction and pleasure (Mol and Law, 2004, p. 43). Science as Culture Vol. 21, No. 4, 561–565, December 2012
Hypertension, 2017
Oxidized soluble guanylate cyclase (sGC) heme iron (Fe 3+ ) is desensitized to nitric oxide (NO) ... more Oxidized soluble guanylate cyclase (sGC) heme iron (Fe 3+ ) is desensitized to nitric oxide (NO) and attenuates cGMP production needed for downstream activation of PKG-dependent signaling and vasodilation. While reactive oxygen species drive oxidation of sGC heme iron, the basic mechanism(s) governing sGC heme iron recycling to its NO-sensitive, reduced state (Fe 2+ ), are unknown. Here we report cytochrome b5 reductase 3 (Cyb5R3), also known as methemoglobin reductase, as a novel sGC heme iron reductase and regulator of cGMP production in vascular smooth muscle cells (VSMCs). Oxidant challenge studies demonstrate that VSMCs have an intrinsic ability to reduce oxidized sGC heme iron and form protein-protein complexes between Cyb5R3 and oxidized sGC. Genetic knockdown and pharmacological inhibition in VSMCs reveal Cyb5R3 expression and activity is critical for NO-stimulated cGMP production and vasodilation. Mechanistically, Cyb5R3 directly reduces oxidized sGC for NO sensitization as...
Hypertension, 2015
The inability nitric oxide (NO) to stimulate soluble guanylate cyclase (sGC) has been linked to n... more The inability nitric oxide (NO) to stimulate soluble guanylate cyclase (sGC) has been linked to numerous cardiovascular diseases (CVD) including hypertension. While several studies have defined the importance of sGC expression in the cardiovascular system, the basic mechanisms that regulate sGC activity remain incompletely understood. Here, we report for the first time that sGC heme iron redox state, which is essential for NO-induced sGC activation, is regulated by cytochrome B5 reductase 3 (CyB5R3). Genetic knockdown and pharmacological inhibition of CyB5R3 in primary rat vascular smooth muscle cells resulted in a 60% loss in cGMP production. Conversely, the sGC activator Bay 58-2667, which activates oxidized or heme free sGC, reversed these effects. Consistent with our cell culture work, purified protein studies demonstrate that CyB5R3 can directly reduce oxidized sGC heme iron and sensitize sGC to NO. To test the functional importance of Cyb5R3 activity, we cultured mouse thoraco...
Journal of Mathematical Physics, 2018
This paper mainly concentrates to present a technique to evaluate exactly the triangular domain i... more This paper mainly concentrates to present a technique to evaluate exactly the triangular domain integrals with satisfactory degree of accuracy. Hence, the technique instead of the usual Gaussian quadrature formula for triangle will find better place in application when high accuracy is desired. Further, the technique successfully accommodates the readily available Gaussian quadrature formulae for square and therefore it guaranties the high accuracy in evaluating such integrals.
Annales Henri Poincaré, 2021
We introduce a new class of non-local games, and corresponding densities, which we call bisynchro... more We introduce a new class of non-local games, and corresponding densities, which we call bisynchronous. Bisynchronous games are a subclass of synchronous games and exhibit many interesting symmetries when the algebra of the game is considered. We develop a close connection between these non-local games and the theory of quantum groups which recently surfaced in studies of graph isomorphism games. When the number of inputs is equal to the number of outputs, we prove that a bisynchronous density arises from a trace on the quantum permutation group. Each bisynchronous density gives rise to a completely positive map and we prove that these maps are factorizable maps.
Journal of Mathematical Physics, 2020
IEEE Transactions on Information Theory, 2019
A new bound on quantum version of Wielandt inequality for positive (not necessarily completely po... more A new bound on quantum version of Wielandt inequality for positive (not necessarily completely positive) maps has been established. Also bounds for entanglement breaking and PPT channels are put forward which are better bound than the previous bounds known. We prove that a primitive positive map E acting on M d that satisfies the Schwarz inequality becomes strictly positive after at most 2(d − 1) 2 iterations. This is to say, that after 2(d − 1) 2 iterations, such a map sends every positive semidefinite matrix to a positive definite one. This finding does not depend on the number of Kraus operators as the map may not admit any Kraus decomposition. The motivation of this work is to provide an answer to a question raised in the article [22] by Sanz-García-Wolf and Cirac.
The Crop Journal, 2018
Abstract High temperatures have a detrimental effect on growth, development, and yield of Brassic... more Abstract High temperatures have a detrimental effect on growth, development, and yield of Brassica napus . Even a short period of heat stress can lead to yield losses of 15%–20%. A collection of spring-type accessions available in Germplasm Resources Information Network (GRIN) were used to assess the effect of short periods of high-temperature stress at the early flowering stage of B. napus . Two sets of accessions with three replications per set were grown in a greenhouse at 22/18 °C day/night temperatures. Plants from the second set at the 6-day flowering stage were exposed to heat-stress conditions (maximum temperature up to 35 °C) in a plant growth chamber for five days. The heat-stressed plants were then allowed to recover in a greenhouse. Pollen sterility, sterile/aborted pods, and number of pods on main raceme were recorded for both control (set 1) and heat stressed (set 2) plants. Heat susceptibility indices for all three traits were calculated and an association-mapping study was conducted using 37,539 Single Nucleotide Polymorphisms (SNPs) to identify genomic regions controlling the heat stress traits. A total of 5, 8, and 7 quantitative trait loci (QTL) were associated with pollen sterility, sterile/aborted pods, and number of pods on main raceme, respectively. Together they explained respectively 46.3%, 60.5%, and 60.6% of phenotypic variation. Candidate genes in the QTL regions included genes associated with flowering, male sterility, pollen abortion, embryo abortion reducing pollen development, and pod development.
Journal of Mathematical Analysis and Applications, 2018
Journal of Mathematical Physics, 2018
We analyze linear maps on matrix algebras that become entanglement breaking after composing a fin... more We analyze linear maps on matrix algebras that become entanglement breaking after composing a finite or infinite number of times with themselves. This means that the Choi matrix of the iterated linear map becomes separable in the tensor product space. If a linear map becomes entanglement breaking after finitely many iterations, we say the map has a finite index of separability. In particular we show that every unital PPT-channel has a finite index of separability and that the class of unital channels that have finite index of separability is a dense subset of the unital channels. We construct concrete examples of maps which are not PPT but have finite index of separability. We prove that there is a large class of unital channels that are asymptotically entanglement breaking. This analysis is motivated by the PPT-squared conjecture made by M. Christandl that says every PPT channel, when composed with itself, becomes entanglement breaking.
Social Studies of Science, 2011
Life as Surplus: Biotechnology and Capitalism in the Neoliberal Era by Melinda Cooper (2008) is a... more Life as Surplus: Biotechnology and Capitalism in the Neoliberal Era by Melinda Cooper (2008) is a recent addition to a growing body of literature that explores with renewed energy the inter-relationship between biological reproduction and capital accumulation. Cooper's ...
Science as Culture, 2012
Writing in the mid-twentieth century, Albert Camus observed that an epidemic is not just a medico... more Writing in the mid-twentieth century, Albert Camus observed that an epidemic is not just a medico-social problem; it also represents a rupture and crisis in everyday existence and calls into question our beliefs, habits, values and pleasures (Camus, 1947/1948). This remains somewhat true in the case of a sexual epidemic, more specifically of HIV/AIDS—an infectious disease that ravaged many millions of lives all over the world within a few years of its emergence and immediately became a phantasmatic site of anxiety, intervention, surveillance, racial and sexual politics. In considering HIV/AIDS as a medico-sexual construct, the body appears as ‘an object or surface’ (Butler, 1989, p. 601) and equally as an ‘intentionally organized materiality’ (Butler, 1988, p. 521), in the sense that bodies and pleasures become a ‘strategic and discursive site’ (Butler, 1999, p. 16) with numerous possibilities of materiality as evident in the unregulated proliferation of scientific, sexual and racial epistemologies in the discourse of HIV intervention. Apart from being a ‘naturally given and utterly malleable’ entity (Waldby, 2000, p. 465), biomedicine treats the diseased body as an object of medical knowledge and, at the same time, a fleshy subject that experiences pain, agony, satisfaction and pleasure (Mol and Law, 2004, p. 43). Science as Culture Vol. 21, No. 4, 561–565, December 2012