Mohamed Elsaid - Academia.edu (original) (raw)

Papers by Mohamed Elsaid

Research paper thumbnail of Guidelines for Artificial Intelligence in Medicine: Literature Review and Content Analysis of Frameworks

Journal of Medical Internet Research

Background Artificial intelligence (AI) is rapidly expanding in medicine despite a lack of consen... more Background Artificial intelligence (AI) is rapidly expanding in medicine despite a lack of consensus on its application and evaluation. Objective We sought to identify current frameworks guiding the application and evaluation of AI for predictive analytics in medicine and to describe the content of these frameworks. We also assessed what stages along the AI translational spectrum (ie, AI development, reporting, evaluation, implementation, and surveillance) the content of each framework has been discussed. Methods We performed a literature review of frameworks regarding the oversight of AI in medicine. The search included key topics such as “artificial intelligence,” “machine learning,” “guidance as topic,” and “translational science,” and spanned the time period 2014-2022. Documents were included if they provided generalizable guidance regarding the use or evaluation of AI in medicine. Included frameworks are summarized descriptively and were subjected to content analysis. A novel e...

Research paper thumbnail of Design & Implementation of Low Power High Speed Floating Point Unit

... Floating Point Unit Lamiaa SA Hamid ECE Dept. Misr International Uni. Cairo, Egypt Lamiaa.a.h... more ... Floating Point Unit Lamiaa SA Hamid ECE Dept. Misr International Uni. Cairo, Egypt Lamiaa.a.hamid@miuegypt .edu.eg Khaled A. Shehata ECE Dept. Arab Academy for Science and Technology Cairo, Egypt K_shehata@aast.edu Hassan El-Ghitani ECE Dept. ...

Research paper thumbnail of Oversight of artificial intelligence in medicine: A review of frameworks (Preprint)

BACKGROUND Artificial intelligence (AI) is rapidly expanding in medicine even while lacking forma... more BACKGROUND Artificial intelligence (AI) is rapidly expanding in medicine even while lacking formal oversight. OBJECTIVE We sought to identify and describe considerations for the oversight of AI in medicine. We also explored where along the translational process (i.e., AI development, reporting, evaluation, implementation, and surveillance) these considerations were targeted. METHODS We conducted a targeted review of frameworks for the oversight of AI in medicine. The search included key topics such as ‘artificial intelligence,’ ‘machine learning’, ‘guidance as topic’, ‘translational science’, ‘medical device legislation’, and ‘evaluation study,’ and spanned the time period 2014-2021. Frameworks were included if they described translational considerations for AI. The included frameworks were summarized descriptively. Content analysis was used to identify considerations for the oversight of AI in medicine. An evaluation matrix methodology was used to map each consideration across the ...

Research paper thumbnail of Reply to D.A. Goldman and K.S. Panageas

JCO oncology practice, 2020

Research paper thumbnail of Improvement of sectoral horn nanoantenna based on arc directors for point to point communications

Optical and Quantum Electronics, 2021

This paper presents directivity and gain enhancement of sectoral horn nanoantenna (NA) with arc d... more This paper presents directivity and gain enhancement of sectoral horn nanoantenna (NA) with arc directors for point to point communications systems. The effect of adding three directors to the sectoral horn NA is investigated. The directors pull the NAs radiation toward its axis which concentrates the electromagnetic waves and increases the directivity. This in turn improves the radiation characteristics of the NA especially the gain and directivity. The suggested structure is simulated using finite integration technique (FIT) in terms of gain, directivity, efficiency and electric field distribution. In this regard, the directivity of the NA is increased from 13.8 to 20.7 with an enhancement of 50% at λ = 1550 nm by adding the arc directors. Further, an improvement of 82.2% is also accomplished in the NA gain. Moreover, the total efficiency has an enhancement of 10% compared to the conventional horn NA without directors. The proposed design is also used to construct optical wireless nanolink. It is found that the transmission power in the optical wireless nonalink with directors is improved. Additionally, 6 dB enhancement is attained over the nanolink based on horn NA without directors at wavelength of 1550 nm. The reported wireless nanolink covers the communications applications in the optical c-band.

Research paper thumbnail of Multisite quality improvement initiative to repair incomplete electronic medical record documentation as one contributor to provider burnout

Journal of Clinical Oncology, 2020

190 Background: Provider burnout is a challenge adversely affecting the quality, safety, and cost... more 190 Background: Provider burnout is a challenge adversely affecting the quality, safety, and cost of health care. We measured burnout among pediatric oncology providers in the St. Jude Affiliate network and used a Plan-Do-Study-Act (PDSA) improvement cycle to address one of the factors contributing to burnout. Methods: Within the framework of the American Society of Clinical Oncology (ASCO) Thematic Quality Training Program (QTP) we sent the Mini Z 2.0 Survey to 47 pediatric oncology providers. Applying a fishbone diagram and Pareto chart we analyzed potential causes of provider burnout. Based on the analysis, we used a PDSA approach to address documentation of oral chemotherapy adherence for children with acute lymphoblastic leukemia to mitigate burnout among providers. Results: The burnout survey response rate was 44.6%. Burnout was identified in 42.9% of providers. Documentation in the electronic medical record (EMR) was cited as the second most common contributor to burnout, and...

Research paper thumbnail of Voltage Stability of Electrical Power Networks​ with High Penetration Level of Wind Generation

Journal of Al-Azhar University Engineering Sector, 2020

Voltage instability is considered as one of the main threats to secure operation of power system ... more Voltage instability is considered as one of the main threats to secure operation of power system networks around the world. Nowadays, Integration of large-scale wind power may have severe impacts on the power system operation. Stable, reliable and economic operation of the power system under the massive integration of wind power is a big challenge to power system operators. This paper scrutinizes to study the voltage stability problems for the integration of wind power to the IEEE-39 bus-systems.

Research paper thumbnail of Broadband directional rhombic nanoantenna for optical wireless communications systems

Journal of the Optical Society of America B, 2020

In this paper, an optimized four-nanowire rhombic nanoantenna (RNA) is proposed and numerically a... more In this paper, an optimized four-nanowire rhombic nanoantenna (RNA) is proposed and numerically analyzed in terms of directivity and efficiency. The suggested design achieves a directivity of 23.4 with 84.5% radiation efficiency at a wavelength of 1550 nm. Further, the suggested nanoantenna (NA) design offers a high gain of 18.5 with an enhancement of 172%, compared to the previously reported plasmonic horn NA. Additionally, the wireless transmission power of the nanolink based on the optimized rhombic design is analyzed. The numerical results reveal that the RNA enjoys a much lower loss by 32 dB and 12 dB, respectively, when compared to the dipole and plasmonic horn NAs. Moreover, the reported design has broadband operation features over the optical C-band range, making it a promising candidate for applications related to optical communications nanochips.

Research paper thumbnail of Close Accord on Particle Swarm Optimization Variants for Solving Non-Linear Optimal Reactive Power Dispatch Problem

International Journal of Engineering Research in Africa, 2020

This paper employs a comparative study between three recent versions of particle swarm optimizati... more This paper employs a comparative study between three recent versions of particle swarm optimization (PSO) algorithm to find the optimal scheduling of reactive power resources. Scheduling of reactive power resources is formulated as non-linear complex optimal reactive power dispatch (ORPD) problem. The main objective function of ORPD is to minimize the transmission power losses (Ploss). For this target, three modified versions, which present three variations applied on velocity equation of PSO algorithm, are considered. To achieve fair comparative study, the competitive versions are checked through 13 studied cases on IEEE 14-, 30-, 57- and 118-bus test systems. The effectiveness of these variations is proven for the non-linear complex optimization ORPD problem with different decision variables according to the system size. The obtained results confirm that these variations on PSO algorithm can make a noticeable reduction of Ploss at acceptable level in terms of power system operatio...

Research paper thumbnail of Ultra‐wideband circularly polarized crossed‐dual‐arm bowtie dipole antenna backed by an artificial magnetic conductor

Microwave and Optical Technology Letters, 2019

An ultra-wideband antenna is suggested, simulated, and fabricated for ground penetrating radar (G... more An ultra-wideband antenna is suggested, simulated, and fabricated for ground penetrating radar (GPR) and landmine detection applications. The reported design has wideband, high gain, and high directivity. The new configuration achieves unidirectional radiation characteristics maintaining circularly polarized (CP) radiation characteristics. The whole configuration is optimized using the particle swarm optimization algorithm to achieve the optimal bandwidth, gain, and axial ratio (AR). The performance of the overall geometrical design is analyzed in terms of bandwidth, gain, directivity, and AR. The proposed antenna offers a gain of 2.66 dB in free space, which is enhanced to 8.86 by using an artificial magnetic conductor. The measured results show that the proposed configuration offers −10 dB return loss bandwidth of 540 MHz over the frequency range (0.8-1.34 GHz) with~50.5% operational bandwidth and 3-dB AR bandwidth of 295 MHz for the frequency range (0.97-1.265 GHz) with an approximate percentage of 26.4%. Furthermore, the maximum gain over the CP-operated bandwidth close to 8.86 dB, at frequency 1.05 GHz, is obtained. It is anticipated that this antenna is suitable for GPR applications as well as for employment in landmine detection.

Research paper thumbnail of Solving Reactive Power Dispatch Problem by Using JAYA Optimization Algorithm

International Journal of Engineering Research in Africa, 2018

This paper proposes a new optimization algorithm called JAYA algorithm for solving the optimal re... more This paper proposes a new optimization algorithm called JAYA algorithm for solving the optimal reactive power dispatch (ORPD) problem. Minimizing the real power losses is one of main objective functions of (ORPD) problem. The ORPD problem is subjected to non-linear equality and inequality operational constraints. The proposed JAYA is a recently developed optimization algorithm. The main merit of Jaya algorithm is that the algorithm performance is liberated of specific control parameters adjustment. Therefore, it overcomes the limitations of previous optimization algorithms in terms of achieving the global optima atless computational efforts. The effectiveness of the proposed Jaya algorithm is proven on three standard systems namely IEEE 14-bus, 30-bus and 118-bus test systems. Added to that, Jaya is successively tested on the West Delta Real Network (WDRN) as a real part of the Egyptian grid. The obtained simulation results prove that the proposed JAYA algorithm has significant redu...

Research paper thumbnail of Chemotherapy Wait Times in a Network of Pediatric Oncology Clinics

Journal of Pediatric Hematology/Oncology, 2019

Patient satisfaction with medical care delivery is an important aspect of value-based health care... more Patient satisfaction with medical care delivery is an important aspect of value-based health care. Providers strive to provide optimal patient satisfaction. Among a network of ambulatory pediatric oncology affiliate clinics, we conducted patient satisfaction surveys and found that the lowest scores were related to delays in the administration of chemotherapy. To address this shortcoming, we used continuous improvement methodologies to reduce the delay in chemotherapy administration in 3 affiliate clinics. To evaluate the efficacy of the quality improvement interventions implemented at each affiliate clinic, we measured the time from patient arrival to the start of chemotherapy administration over a 2-week period before and after the interventions. Wait times for chemotherapy administration were reduced in each clinic by 7% to 15%, exceeding the preestablished goal of a 5% reduction without affecting patient safety. Patient satisfaction for chemotherapy wait times was also marginally increased. In conclusion, implementation of quality improvement interventions across a clinical network can improve specific aspects of patient satisfaction, thereby improving the overall patient experience.

Research paper thumbnail of Enhanced Radiosensitivity in Solid Tumors using a Tumor-Selective Alkyl Phosphocholine Analog

Molecular cancer therapeutics, Jan 14, 2018

Anti-tumor alkyl phospholipid analogs comprise a group of structurally related molecules with rem... more Anti-tumor alkyl phospholipid analogs comprise a group of structurally related molecules with remarkable tumor selectivity. Some of these compounds have shown radiosensitizing capabilities. CLR127 is a novel, clinical-grade anti-tumor alkyl phospholipid ether analog, a subtype of synthetic alkyl phospholipids broadly targeting cancer cells with limited uptake in normal tissues. The purpose of this study was to investigate the effect of CLR127 to modulate radiation response across several adult and pediatric cancer types in vitro as well as in murine xenograft models of human prostate adenocarcinoma, neuroblastoma, Ewing sarcoma and rhabdomyosarcoma. In vitro, CLR127 demonstrated selective uptake in cancer cells compared to normal cells. In cancer cells, CLR127 treatment prior to radiation significantly decreased clonogenic survival in vitro, and led to increased radiation-induced dsDNA breakage compared to radiation alone, which was not observed in normal controls. In animal models,...

Research paper thumbnail of Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent

Journal of pediatric hematology/oncology, Jan 13, 2017

Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adult... more Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy. This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.

Research paper thumbnail of Diagnosis of human toxoplasmosis by a dot enzyme-linked immunosorbent assay

Revista do Instituto de Medicina Tropical de São Paulo, 1995

A Dot enzyme-linked immunosorbent assay (Dot-ELISA) was standardized and evaluated for the serodi... more A Dot enzyme-linked immunosorbent assay (Dot-ELISA) was standardized and evaluated for the serodiagnosis of human toxoplasmosis. Out of 538 serum samples tested by the immunofluorescence test for toxoplasmosis (IFAT-IgG) as reference test, 183 (34%) were positive at cut off 1:16 and 192 (36%) were positive for Dot-ELISA-IgG at cut-off 1:256. For Dot-ELISA, co-positivity was 0.94, co-negativity 0.94 and concordance 0.88 in relation to IFAT-IgG. These results suggest the usefulness of Dot-ELISA (cut-off titer of 1:256) for the serodiagnosis of human toxoplasmosis. The main advantage of this technique is simplicity, positive test can be visually identified (colored precipitate). It does not require a special equipment and it can be used as a qualitative test to screen large numbers of samples or as a quantitative assay to determine end-point titration of individual sera.

Research paper thumbnail of Design of Generic Floating Point Multiplier and Adder/Subtractor Units

2010 12th International Conference on Computer Modelling and Simulation, 2010

A high speed generic Floating Point Unit (FPU) consisting of a multiplier and adder/subtractor un... more A high speed generic Floating Point Unit (FPU) consisting of a multiplier and adder/subtractor units is proposed. A novel multiplication algorithm is proposed and used in the multiplier implementation. The new algorithm depends on dividing the multiplication operation into several smaller multiplications performed in parallel. The output from these multiplications is then manipulated in a manner to give the final result of the original multiplication operation. The adder/subtractor unit is implemented using the Leading One Detector (LOD) algorithm. In order to achieve high maximum, speed, both units were deeply pipelined. The design is written using VHDL code and mapped to Virtex2, Virtex4 and Virtex5 FPGAs. Both units can operate at more than 400 MHz on Virtex4.

Research paper thumbnail of Altitude and socio-biological determinants of pregnancy-associated hypertension

International Journal of Gynecology & Obstetrics, 1994

To study the prevalente of gestation-associated hypertension and to determirre the effect of alti... more To study the prevalente of gestation-associated hypertension and to determirre the effect of altitude and related sociobioiogicai Jraciors. METIIÛDS: A sirattj?ea' random sample of 3988 pregnant women living "4 LC.

Research paper thumbnail of Guidelines for Artificial Intelligence in Medicine: Literature Review and Content Analysis of Frameworks

Journal of Medical Internet Research

Background Artificial intelligence (AI) is rapidly expanding in medicine despite a lack of consen... more Background Artificial intelligence (AI) is rapidly expanding in medicine despite a lack of consensus on its application and evaluation. Objective We sought to identify current frameworks guiding the application and evaluation of AI for predictive analytics in medicine and to describe the content of these frameworks. We also assessed what stages along the AI translational spectrum (ie, AI development, reporting, evaluation, implementation, and surveillance) the content of each framework has been discussed. Methods We performed a literature review of frameworks regarding the oversight of AI in medicine. The search included key topics such as “artificial intelligence,” “machine learning,” “guidance as topic,” and “translational science,” and spanned the time period 2014-2022. Documents were included if they provided generalizable guidance regarding the use or evaluation of AI in medicine. Included frameworks are summarized descriptively and were subjected to content analysis. A novel e...

Research paper thumbnail of Design & Implementation of Low Power High Speed Floating Point Unit

... Floating Point Unit Lamiaa SA Hamid ECE Dept. Misr International Uni. Cairo, Egypt Lamiaa.a.h... more ... Floating Point Unit Lamiaa SA Hamid ECE Dept. Misr International Uni. Cairo, Egypt Lamiaa.a.hamid@miuegypt .edu.eg Khaled A. Shehata ECE Dept. Arab Academy for Science and Technology Cairo, Egypt K_shehata@aast.edu Hassan El-Ghitani ECE Dept. ...

Research paper thumbnail of Oversight of artificial intelligence in medicine: A review of frameworks (Preprint)

BACKGROUND Artificial intelligence (AI) is rapidly expanding in medicine even while lacking forma... more BACKGROUND Artificial intelligence (AI) is rapidly expanding in medicine even while lacking formal oversight. OBJECTIVE We sought to identify and describe considerations for the oversight of AI in medicine. We also explored where along the translational process (i.e., AI development, reporting, evaluation, implementation, and surveillance) these considerations were targeted. METHODS We conducted a targeted review of frameworks for the oversight of AI in medicine. The search included key topics such as ‘artificial intelligence,’ ‘machine learning’, ‘guidance as topic’, ‘translational science’, ‘medical device legislation’, and ‘evaluation study,’ and spanned the time period 2014-2021. Frameworks were included if they described translational considerations for AI. The included frameworks were summarized descriptively. Content analysis was used to identify considerations for the oversight of AI in medicine. An evaluation matrix methodology was used to map each consideration across the ...

Research paper thumbnail of Reply to D.A. Goldman and K.S. Panageas

JCO oncology practice, 2020

Research paper thumbnail of Improvement of sectoral horn nanoantenna based on arc directors for point to point communications

Optical and Quantum Electronics, 2021

This paper presents directivity and gain enhancement of sectoral horn nanoantenna (NA) with arc d... more This paper presents directivity and gain enhancement of sectoral horn nanoantenna (NA) with arc directors for point to point communications systems. The effect of adding three directors to the sectoral horn NA is investigated. The directors pull the NAs radiation toward its axis which concentrates the electromagnetic waves and increases the directivity. This in turn improves the radiation characteristics of the NA especially the gain and directivity. The suggested structure is simulated using finite integration technique (FIT) in terms of gain, directivity, efficiency and electric field distribution. In this regard, the directivity of the NA is increased from 13.8 to 20.7 with an enhancement of 50% at λ = 1550 nm by adding the arc directors. Further, an improvement of 82.2% is also accomplished in the NA gain. Moreover, the total efficiency has an enhancement of 10% compared to the conventional horn NA without directors. The proposed design is also used to construct optical wireless nanolink. It is found that the transmission power in the optical wireless nonalink with directors is improved. Additionally, 6 dB enhancement is attained over the nanolink based on horn NA without directors at wavelength of 1550 nm. The reported wireless nanolink covers the communications applications in the optical c-band.

Research paper thumbnail of Multisite quality improvement initiative to repair incomplete electronic medical record documentation as one contributor to provider burnout

Journal of Clinical Oncology, 2020

190 Background: Provider burnout is a challenge adversely affecting the quality, safety, and cost... more 190 Background: Provider burnout is a challenge adversely affecting the quality, safety, and cost of health care. We measured burnout among pediatric oncology providers in the St. Jude Affiliate network and used a Plan-Do-Study-Act (PDSA) improvement cycle to address one of the factors contributing to burnout. Methods: Within the framework of the American Society of Clinical Oncology (ASCO) Thematic Quality Training Program (QTP) we sent the Mini Z 2.0 Survey to 47 pediatric oncology providers. Applying a fishbone diagram and Pareto chart we analyzed potential causes of provider burnout. Based on the analysis, we used a PDSA approach to address documentation of oral chemotherapy adherence for children with acute lymphoblastic leukemia to mitigate burnout among providers. Results: The burnout survey response rate was 44.6%. Burnout was identified in 42.9% of providers. Documentation in the electronic medical record (EMR) was cited as the second most common contributor to burnout, and...

Research paper thumbnail of Voltage Stability of Electrical Power Networks​ with High Penetration Level of Wind Generation

Journal of Al-Azhar University Engineering Sector, 2020

Voltage instability is considered as one of the main threats to secure operation of power system ... more Voltage instability is considered as one of the main threats to secure operation of power system networks around the world. Nowadays, Integration of large-scale wind power may have severe impacts on the power system operation. Stable, reliable and economic operation of the power system under the massive integration of wind power is a big challenge to power system operators. This paper scrutinizes to study the voltage stability problems for the integration of wind power to the IEEE-39 bus-systems.

Research paper thumbnail of Broadband directional rhombic nanoantenna for optical wireless communications systems

Journal of the Optical Society of America B, 2020

In this paper, an optimized four-nanowire rhombic nanoantenna (RNA) is proposed and numerically a... more In this paper, an optimized four-nanowire rhombic nanoantenna (RNA) is proposed and numerically analyzed in terms of directivity and efficiency. The suggested design achieves a directivity of 23.4 with 84.5% radiation efficiency at a wavelength of 1550 nm. Further, the suggested nanoantenna (NA) design offers a high gain of 18.5 with an enhancement of 172%, compared to the previously reported plasmonic horn NA. Additionally, the wireless transmission power of the nanolink based on the optimized rhombic design is analyzed. The numerical results reveal that the RNA enjoys a much lower loss by 32 dB and 12 dB, respectively, when compared to the dipole and plasmonic horn NAs. Moreover, the reported design has broadband operation features over the optical C-band range, making it a promising candidate for applications related to optical communications nanochips.

Research paper thumbnail of Close Accord on Particle Swarm Optimization Variants for Solving Non-Linear Optimal Reactive Power Dispatch Problem

International Journal of Engineering Research in Africa, 2020

This paper employs a comparative study between three recent versions of particle swarm optimizati... more This paper employs a comparative study between three recent versions of particle swarm optimization (PSO) algorithm to find the optimal scheduling of reactive power resources. Scheduling of reactive power resources is formulated as non-linear complex optimal reactive power dispatch (ORPD) problem. The main objective function of ORPD is to minimize the transmission power losses (Ploss). For this target, three modified versions, which present three variations applied on velocity equation of PSO algorithm, are considered. To achieve fair comparative study, the competitive versions are checked through 13 studied cases on IEEE 14-, 30-, 57- and 118-bus test systems. The effectiveness of these variations is proven for the non-linear complex optimization ORPD problem with different decision variables according to the system size. The obtained results confirm that these variations on PSO algorithm can make a noticeable reduction of Ploss at acceptable level in terms of power system operatio...

Research paper thumbnail of Ultra‐wideband circularly polarized crossed‐dual‐arm bowtie dipole antenna backed by an artificial magnetic conductor

Microwave and Optical Technology Letters, 2019

An ultra-wideband antenna is suggested, simulated, and fabricated for ground penetrating radar (G... more An ultra-wideband antenna is suggested, simulated, and fabricated for ground penetrating radar (GPR) and landmine detection applications. The reported design has wideband, high gain, and high directivity. The new configuration achieves unidirectional radiation characteristics maintaining circularly polarized (CP) radiation characteristics. The whole configuration is optimized using the particle swarm optimization algorithm to achieve the optimal bandwidth, gain, and axial ratio (AR). The performance of the overall geometrical design is analyzed in terms of bandwidth, gain, directivity, and AR. The proposed antenna offers a gain of 2.66 dB in free space, which is enhanced to 8.86 by using an artificial magnetic conductor. The measured results show that the proposed configuration offers −10 dB return loss bandwidth of 540 MHz over the frequency range (0.8-1.34 GHz) with~50.5% operational bandwidth and 3-dB AR bandwidth of 295 MHz for the frequency range (0.97-1.265 GHz) with an approximate percentage of 26.4%. Furthermore, the maximum gain over the CP-operated bandwidth close to 8.86 dB, at frequency 1.05 GHz, is obtained. It is anticipated that this antenna is suitable for GPR applications as well as for employment in landmine detection.

Research paper thumbnail of Solving Reactive Power Dispatch Problem by Using JAYA Optimization Algorithm

International Journal of Engineering Research in Africa, 2018

This paper proposes a new optimization algorithm called JAYA algorithm for solving the optimal re... more This paper proposes a new optimization algorithm called JAYA algorithm for solving the optimal reactive power dispatch (ORPD) problem. Minimizing the real power losses is one of main objective functions of (ORPD) problem. The ORPD problem is subjected to non-linear equality and inequality operational constraints. The proposed JAYA is a recently developed optimization algorithm. The main merit of Jaya algorithm is that the algorithm performance is liberated of specific control parameters adjustment. Therefore, it overcomes the limitations of previous optimization algorithms in terms of achieving the global optima atless computational efforts. The effectiveness of the proposed Jaya algorithm is proven on three standard systems namely IEEE 14-bus, 30-bus and 118-bus test systems. Added to that, Jaya is successively tested on the West Delta Real Network (WDRN) as a real part of the Egyptian grid. The obtained simulation results prove that the proposed JAYA algorithm has significant redu...

Research paper thumbnail of Chemotherapy Wait Times in a Network of Pediatric Oncology Clinics

Journal of Pediatric Hematology/Oncology, 2019

Patient satisfaction with medical care delivery is an important aspect of value-based health care... more Patient satisfaction with medical care delivery is an important aspect of value-based health care. Providers strive to provide optimal patient satisfaction. Among a network of ambulatory pediatric oncology affiliate clinics, we conducted patient satisfaction surveys and found that the lowest scores were related to delays in the administration of chemotherapy. To address this shortcoming, we used continuous improvement methodologies to reduce the delay in chemotherapy administration in 3 affiliate clinics. To evaluate the efficacy of the quality improvement interventions implemented at each affiliate clinic, we measured the time from patient arrival to the start of chemotherapy administration over a 2-week period before and after the interventions. Wait times for chemotherapy administration were reduced in each clinic by 7% to 15%, exceeding the preestablished goal of a 5% reduction without affecting patient safety. Patient satisfaction for chemotherapy wait times was also marginally increased. In conclusion, implementation of quality improvement interventions across a clinical network can improve specific aspects of patient satisfaction, thereby improving the overall patient experience.

Research paper thumbnail of Enhanced Radiosensitivity in Solid Tumors using a Tumor-Selective Alkyl Phosphocholine Analog

Molecular cancer therapeutics, Jan 14, 2018

Anti-tumor alkyl phospholipid analogs comprise a group of structurally related molecules with rem... more Anti-tumor alkyl phospholipid analogs comprise a group of structurally related molecules with remarkable tumor selectivity. Some of these compounds have shown radiosensitizing capabilities. CLR127 is a novel, clinical-grade anti-tumor alkyl phospholipid ether analog, a subtype of synthetic alkyl phospholipids broadly targeting cancer cells with limited uptake in normal tissues. The purpose of this study was to investigate the effect of CLR127 to modulate radiation response across several adult and pediatric cancer types in vitro as well as in murine xenograft models of human prostate adenocarcinoma, neuroblastoma, Ewing sarcoma and rhabdomyosarcoma. In vitro, CLR127 demonstrated selective uptake in cancer cells compared to normal cells. In cancer cells, CLR127 treatment prior to radiation significantly decreased clonogenic survival in vitro, and led to increased radiation-induced dsDNA breakage compared to radiation alone, which was not observed in normal controls. In animal models,...

Research paper thumbnail of Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent

Journal of pediatric hematology/oncology, Jan 13, 2017

Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adult... more Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy. This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.

Research paper thumbnail of Diagnosis of human toxoplasmosis by a dot enzyme-linked immunosorbent assay

Revista do Instituto de Medicina Tropical de São Paulo, 1995

A Dot enzyme-linked immunosorbent assay (Dot-ELISA) was standardized and evaluated for the serodi... more A Dot enzyme-linked immunosorbent assay (Dot-ELISA) was standardized and evaluated for the serodiagnosis of human toxoplasmosis. Out of 538 serum samples tested by the immunofluorescence test for toxoplasmosis (IFAT-IgG) as reference test, 183 (34%) were positive at cut off 1:16 and 192 (36%) were positive for Dot-ELISA-IgG at cut-off 1:256. For Dot-ELISA, co-positivity was 0.94, co-negativity 0.94 and concordance 0.88 in relation to IFAT-IgG. These results suggest the usefulness of Dot-ELISA (cut-off titer of 1:256) for the serodiagnosis of human toxoplasmosis. The main advantage of this technique is simplicity, positive test can be visually identified (colored precipitate). It does not require a special equipment and it can be used as a qualitative test to screen large numbers of samples or as a quantitative assay to determine end-point titration of individual sera.

Research paper thumbnail of Design of Generic Floating Point Multiplier and Adder/Subtractor Units

2010 12th International Conference on Computer Modelling and Simulation, 2010

A high speed generic Floating Point Unit (FPU) consisting of a multiplier and adder/subtractor un... more A high speed generic Floating Point Unit (FPU) consisting of a multiplier and adder/subtractor units is proposed. A novel multiplication algorithm is proposed and used in the multiplier implementation. The new algorithm depends on dividing the multiplication operation into several smaller multiplications performed in parallel. The output from these multiplications is then manipulated in a manner to give the final result of the original multiplication operation. The adder/subtractor unit is implemented using the Leading One Detector (LOD) algorithm. In order to achieve high maximum, speed, both units were deeply pipelined. The design is written using VHDL code and mapped to Virtex2, Virtex4 and Virtex5 FPGAs. Both units can operate at more than 400 MHz on Virtex4.

Research paper thumbnail of Altitude and socio-biological determinants of pregnancy-associated hypertension

International Journal of Gynecology & Obstetrics, 1994

To study the prevalente of gestation-associated hypertension and to determirre the effect of alti... more To study the prevalente of gestation-associated hypertension and to determirre the effect of altitude and related sociobioiogicai Jraciors. METIIÛDS: A sirattj?ea' random sample of 3988 pregnant women living "4 LC.