Mohamed Fathy Abohashim - Academia.edu (original) (raw)

Papers by Mohamed Fathy Abohashim

Italian Journal of Gynaecology and Obstetrics, 2021

Background. Females presented with hydrosalpinx have lower rates of pregnancy by artificial repro... more Background. Females presented with hydrosalpinx have lower rates of pregnancy by artificial reproductive techniques. There are variable management strategies for hydrosalpinx as: salpingostomy, salpingectomy, proximal tubal ligation and trans-vaginal aspiration; but recent management techniques which proved effective in improving outcome of intracytoplasmic sperm injection (ICSI) are laparoscopic tubal ligation and salpingectomy. Aim of the present study was to compare the ovarian reserve and ICSI outcomes after performing either laparoscopic tubal separation or laparoscopic salpingectomy in females with hydrosalpinx. Patients and methods. The study was performed in Depart

The Egyptian Journal of Hospital Medicine

Background: Polycystic ovary syndrome (PCOS) is considered the most frequent ovulatory disorder. ... more Background: Polycystic ovary syndrome (PCOS) is considered the most frequent ovulatory disorder. PCOS often has a problem in (GnRH) release, with increase in the pituitary secretion of (LH) hormone and high LH/FSH ratio. Objective: The current study aimed at detecting the predictive level of LH/FSH ratio for the ovarian response, pregnancy and miscarriage rates in PCOS patients underwent mild ovarian stimulation. Patients and methods: A prospective cohort study was conducted in Gynaecology and Obstetrics Department, Zagazig University Hospitals. The study included PCOS women aged from 20 to 37 years, with at least 1 year of infertility, and normal semen analysis. The exclusion criteria were pelvic surgery and/or pathology. Cycle day 2-5 Serum LH and FSH were measured. Transvaginal ultrasound was done on cycle day 2-3 to prove quiescent ovaries, letrozole (2.5-5mg) was started from day 2-3 for successive 5 days with/without HMG (75-150IU/d) then follicular tracking was done till 1-3 follicles reached ≥18 mm upon which ovulation trigger was given. Results: A total 63 infertile women were included in the study. The mean age was 24.81 (SD 2.83) years, the mean BMI 30.65 (SD 6.58) Kg /m2. Basal FSH, LH level, and LH/FSH ratio ranged from 1.9-11.9 mIu/ml, 2.34-21 mIu/ml and 0.37-4.63, respectively. ROC curve analysis showed LH/FSH ratio to be non-useful predictor of ovarian response, occurrence of pregnancy or miscarriage in PCOS patients underwent simple ovarian induction, AUC (0.51, 0.64 and 0.69 respectively). Conclusion: LH/FSH ratio seems to have no role in prediction of stimulated cycle outcome.

The Egyptian Journal of Hospital Medicine

Human reproduction wastes resources horribly. The fact that we have been unable to use the molecu... more Human reproduction wastes resources horribly. The fact that we have been unable to use the molecular medical biology revolution to address the fundamental question of why the fate of a fertilized egg is so dangerous and unsuccessful as we are in the twenty-first century is frightening. The description that follows briefly reviews the risk factors for miscarriage before moving on to discuss some of the medical causes of miscarriage. This article also explores the issue of pregnancy loss in relation to genetic disorders.

International journal of health sciences

Background and Purpose: This study examines the effects of ultrasonic fat cavitation versus farad... more Background and Purpose: This study examines the effects of ultrasonic fat cavitation versus faradic stimulation on postnatal abdominal obesity. Subjects and Methods: It was a randomized controlled trial. Overall, 40 patients complaining of abdominal adiposity postnatal, aged 25-35 years, were randomized into two equal groups. The control group (A) received sessions of abdominal ultrasonic cavitation treatment three times per week with a frequency of 40 kHz, a power of 45 W, and a duration of 30 minutes, in addition to a balanced diet programme consisting of between 1000kcal and 1200kcal per day for six weeks. The study group (B) received faradic stimulation treatment sessions focusing on their abdomen area three times per week with a duration of 30 minutes, in addition to a healthy diet plan which ranged from 1000kcal to 1200kcal/day for six weeks. Tape measurement was used to assess waist circumference; a digital calliper was used to determine fat thickness, while body analysis was...

Background: Polycystic ovary syndrome is a hormonal disorder commonly found in women of reproduct... more Background: Polycystic ovary syndrome is a hormonal disorder commonly found in women of reproductive age affecting about 15% of them and is considered the most common cause of anovulatory infertility. Administration of metformin to these anovulatory women increase ovulation rate and continuing in first trimester improves the pregnancy outcome. Objective: To assess pregnancy outcome in women with polycystic ovary syndrome who continue metformin during first trimester with its co-morbidity and mortality. Patients and Methods: This prospective intervention study was conducted on 44 pregnant polycystic ovary syndrome women who were attending for antenatal care at Outpatient Clinic, Obstetric and Gynaecological Department, Zagazig University Hospital. These 44 women took metformin before pregnancy and was followed up by indication of ovulation and metformin (1000-1500 mg/day) until they got pregnant. Then they were divided into two group: group 1 (22) continuous metformin dose during first trimester and group 2 (22) who discontinued metformin therapy once pregnancy diagnosed. The 2 groups followed up by fasting blood glucose and fasting serum insulin at their first visit and at 28 weeks of gestation. Results: group 1 who continued (1000_1500mg /day) metformin in first trimester had good pregnancy outcomes (significantly lower weight gain, lower gastrointestinal diabetes mellitus and lower spontaneous miscarriage) than group 2 who discontinued metformin (p value: 0.001). Conclusions: good maternal outcomes in women with polycystic ovary syndrome who continued metformin during first trimester including decrease incidence of spontaneous miscarriage and gastrointestinal diabetes mellitus.

Background: Breast cancer is considered the commonest cancer in Egyptian females. Established pro... more Background: Breast cancer is considered the commonest cancer in Egyptian females. Established prognostic parameters of breast cancer patients are size, grade and stage of the tumor, presence of lymph nodes and distant metastasis in addition to assessment of hormonal receptors status. Aim of the current study was to assess ER, PR, Her2neu, Ki67 and AR status, to assess association between them, morphological and prognostic parameters in a large cohort of Egyptian females diagnosed with breast cancer. Patients and methods: This study was performed on 250 Egyptian female patients with breast cancer. All patients' data were collected and statistically analyze all data for detection of the association between ER, PR, Her2-neu, Ki 67 labeling index, AR, clinicopathological and prognostic data. Results: we found an association between positive ER and positive PR, with low grade of the tumor, absence of lymphovascular invasion, little number of metastatic lymph nodes, early stage and absence of distant metastases, favorable survival rates and lower rate of recurrence and disease progression (p<0.001). We found an association between positive AR, positive Her2-neu, high ki67 labeling index with; higher grade of the tumor, large number of metastatic lymph nodes and presence of distant metastases, unfavorable survival rates and higher rate of recurrence and disease progression (p<0.001). Conclusion: expression of ER, PR and Her2neu could be considered other prognostic parameters for patients with breast cancer and must be routinely performed for all cases to detect the prognosis and expect progression of the tumor and survival rates.

Background: Premenopausal females having early-stage EC have a favorable prognosis. The guideline... more Background: Premenopausal females having early-stage EC have a favorable prognosis. The guidelines of surgical treatment of EC have not been modified and it consists of total hysterectomy, bilateral salpingo-oophrectomy, pelvic and para-aortic lymphadenectomy, regardless of patients' age or EC stage. The drawbacks of performing bilateral BSO are induction of surgical premature menopause which subsequently disturbs physical and psychosexual life in addition to increasing risk of diseases of the cardiovascular system and bone fractures. The aim of our study was to demonstrate if performing BSO in premenopausal females patients with early stage EC had survival benefits and improving long-term outcomes or not. Patients and methods; we included sixty EC patients and we have performed ovarian conservation in 30 (50%) of them, and performed BSO in the remaining 30 patients we have followed our patients for 5 years from December 2014 to December 2019. Results: Age of patients with ovarian conservation was younger than patients with BSO (p=0.032), have smaller tumor size (p=0.02), higher degree of tumor differentiation (p=0.025), less incidence of myomertrial invasion (p=0.004), less liability of lymphovascular invasion (p=0.001), more liability to endometrioid histopathological subtype (p=0.003), and earlier stage (p=0.009) than patients with BSO. There were no significant differences between both studied groups regarding recurrence of the tumor, recurrence free survival and overall survival rates. Conclusion: The current study tried to highlight the benefits of a more conservative approach by ovarian preservation in surgical management and staging of EC patients diagnosed in the early stage in young premenopausal women.

Background: Epithelial ovarian cancer is increasingly often diagnosed in young females who wish t... more Background: Epithelial ovarian cancer is increasingly often diagnosed in young females who wish to preserve their fertility. Fertilitypreserving surgeries, where conservation of the uterus and contralateral ovary was performed, might be beneficial for patients with stage I epithelial ovarian cancer, but their safety is still controversial. In the present study, we aimed to compare radical surgery and fertility-saving surgery in females with stage IA-C epithelial ovarian cancer for recurrence and survival rates, as well as to evaluate reproductive and obstetric outcomes for stage I epithelial ovarian cancer females who were managed with fertility-saving surgery. Materials and methods: We prospectively identified 60 patients aged ≤40 years who were diagnosed with stage I epithelial ovarian cancer. The patients in the fertility-preservation group underwent salpingo-oophorectomy on the side of the affected ovary in addition to incisional biopsy or wedge excision of the ovary on the other side. The patients in the radical surgery group underwent total hysterectomy and bilateral salpingo-oophorectomy. We followed up all patients for 5 years to assess their reproductive and oncological outcomes. Results: Patients in the fertility preservation surgery group were significantly younger (30 ± 4 versus 35 ± 5 years) (p < 0.001), their tumor sizes were smaller (3.4 ± 1.3 versus 6.0 ± 2.6 cm) (p < 0.001), of lower grade (p = 0.011), earlier stage (p < 0.001) and had more mucinous histology than patients in the radical surgery group. There were no statistically significant differences between both groups regarding tumor recurrence or survival rates. Of 25 patients who underwent fertility preservation surgery, 18 (72%) attempted to conceive. A total of 15/18 (83%) pregnancies were recorded, including 13 live births, 1 miscarriage, and 1 intrauterine fetal death. Conclusion: Fertility-sparing surgery could be an adequate alternative to radical surgery for young females with stage I epithelial ovarian cancer.

Current Gynecologic Oncology

Journal of Gynecologic Surgery

Background: Although lymphadenectomy is advised for accurate surgical endometrial-carcinoma stagi... more Background: Although lymphadenectomy is advised for accurate surgical endometrial-carcinoma staging, the procedure is not performed regularly worldwide. Most studies on it include few patients and mainly compare pelvic with pelvic/para-aortic lymphadenectomy. Comparing lymphadenectomy with non-lymphadenectomy is rare. The current study examined prognostic significance and survival advantages of pelvic and pelvic/para-aortic lymphadenectomy compared to no lymphadenectomy. Materials and Methods: This was a retrospective cohort analysis of 75 patients with endometrial carcinomas. The patients were divided into 3 treatment groups based on whether or not lymph-node dissection was performed and the extent of the dissections: (1) pelvic lymphadenectomy; (2) pelvic/para-aortic lymphadenectomy; and (3) no lymphadenectomy. Correlations were analyzed among the surgical techniques used for the 3 groups with respect to the need for adjuvant radiotherapy or chemotherapy, recurrences, and survival outcomes. Results: Pelvic and pelvic/para-aortic lymphadenectomy produced more-favorable overall survival (OS) and progression-free survival (PFS) rates than no lymphadenectomy (p = 0.047). A significant difference was noted among the 3 treatment groups for OS rate and disease-free survival rates (p = 0.015 and 0.017, respectively). The recurrence rates were 47.1%, 35.7%, and 68.8% in the pelvic lymphadenectomy, and pelvic/para-aortic lymphadenectomy, and no lymphadenectomy groups, respectively (p = 0.37). Conclusions: This study showed that pelvic and para-aortic lymphadenectomy improved the OS and PFS rates of patients with endometrial cancer.

Italian Journal of Gynaecology and Obstetrics, 2021

The Egyptian Journal of Hospital Medicine

International journal of health sciences

Current Gynecologic Oncology

Journal of Gynecologic Surgery